[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100370696":3},{"organization":4,"armGroups":7,"interventions":32,"overallOfficials":42,"centralContacts":46,"locations":51,"responsibleParty":65,"collaborators":28,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":28,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":53,"whyStopped":28,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Institute of Mental Health, Singapore","OTHER",[8,14,19,24,29],{"label":9,"type":10,"description":11,"interventionNames":12},"Individual Therapy","EXPERIMENTAL","The individual therapy program will differ in orientation according to therapist and session notes will be coded according to the Comparative Psychotherapy Process Scale. Therapy sessions take place approximately once every fortnight, with 8 sessions in total, according to the agreed-upon schedule.",[13],"Behavioral: Individual Psychotherapy",{"label":15,"type":10,"description":16,"interventionNames":17},"Internet-delivered Cognitive Behavioural Therapy (iCBT)","The iCBT program (clinician follow-up with the therapist and 4 online modules) will be administered for 8 weeks. The four modules: \"1) psychoeducation about emotions, including a functional nature of emotions; 2) alteration of antecedent cognitive misappraisals; 3) prevention of emotional avoidance; and 4) modification of emotion-driven \\[behaviours\\] (EDBs)\", are adapted from The Unified Protocol (UP) for transdiagnostic treatment of emotional disorders. UP is a CBT consisting of four overarching themes- \"increasing emotional awareness, facilitating flexibility in appraisals, identifying and preventing \\[behavioural\\] and emotional awareness, and situational and interoceptive exposure to emotion cues\".",[18],"Behavioral: Internet-delivered Cognitive Behavioural Therapy (iCBT)",{"label":20,"type":10,"description":21,"interventionNames":22},"Group CBT","The group CBT program (for e.g. PsychUp) will be conducted over 8 weeks, with weekly 2-hour sessions. Each group consists of 4-8 patients and are facilitated by two practicing clinical psychologists and one clinical psychologist in training. Sessions are structured such that each session, except the first, begins with a brief review of previous session material and a collaborative review of homework. This is followed by introduction of new material and completion of any in-session exercises, with sessions concluding with homework assignment. Specific treatment content is similarly adapted from UP. Session 1 begins by covering psychoeducation on the CBT model of pathological depression and anxiety and the role of avoidance in maintenance of symptoms. Sessions 2 to 7 covers goal-setting, cognitive reappraisal and development of adaptive emotional coping strategies through situational emotion-focused exposures. Session 8 ends with a discussion on relapse prevention.",[23],"Behavioral: Group Cognitive Behavioural Therapy (group CBT)",{"label":25,"type":26,"description":27,"interventionNames":28},"Delayed Waitlist","NO_INTERVENTION","Participants in the Waitlist group will be recruited from those referred for psychotherapy and who are not assigned to either group or iCBT and not planned for psychotherapy at IMH for 8 weeks or more from the point of consent.",null,{"label":30,"type":26,"description":31,"interventionNames":28},"Treatment as Usual (TAU)","Participants in the Treatment as Usual (TAU) group are individuals who are not assigned to psychotherapy at IMH. They will be recruited from outpatient services and emergency services at IMH.",[33,37,39],{"type":34,"name":35,"description":11,"armGroupLabels":36,"otherNames":28},"BEHAVIORAL","Individual Psychotherapy",[9],{"type":34,"name":15,"description":16,"armGroupLabels":38,"otherNames":28},[15],{"type":34,"name":40,"description":21,"armGroupLabels":41,"otherNames":28},"Group Cognitive Behavioural Therapy (group CBT)",[20],[43],{"name":44,"affiliation":5,"role":45},"Geoffrey CY Tan","PRINCIPAL_INVESTIGATOR",[47],{"name":44,"role":48,"phone":49,"phoneExt":28,"email":50},"CONTACT","+65 63891923","geoffrey_tan@imh.com.sg",[52],{"facility":5,"status":53,"city":54,"state":54,"zip":55,"country":54,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"RECRUITING","Singapore","539747","SG",{"type":58,"coordinates":59},"Point",[60,61],103.85007,1.28967,{"lat":61,"lon":60},[64],{"name":44,"role":48,"phone":49,"phoneExt":28,"email":50},{"type":66,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR","100370696","understanding-the-person-exploring-change-across-psychotherapies-100370696",false,"NCT04106713","Understanding the Person, Exploring Change Across Psychotherapies","Xchange","Inclusion Criteria:\n\n1. For patients:\n\n   1. 18-99 years old;\n   2. have current or past symptoms of anxiety and\u002For depression;\n   3. able to communicate and read in English;\n   4. able to provide informed consent.\n   5. Waitlist arm:\n\n      \\- Referred for psychotherapy but given a waiting time of 8 weeks or more to the first visit or not assigned to therapy at IMH.\n   6. Treatment as usual:\n\n      \\- Not assigned to any psychotherapeutic interventions.\n   7. iCBT: - Referred for iCBT;\n\n      \\- Identified as a 'P2' patient\u002Fappropriate for iCBT by triage.\n   8. Group therapy:\n\n      \\- Referred for group therapy;\n\n      \\- Identified as a 'P2' patient\u002Fappropriate for group therapy by triage.\n   9. Individual psychotherapy:\n\n      * Referred for individual therapy;\n      * Patient and therapist committed to frequent therapy (ideally fortnightly).\n2. For therapists:\n\n   1. Therapists who will see OR have been assigned to clients in the waitlist arm, iCBT, group therapy (e.g. PsychUp), and individual psychotherapy group.\n\nExclusion Criteria:\n\n1\\. For patients:\n\n1. current active suicidal intention or plan;\n2. cognitively-impaired\u002Fare unable to consent\u002Flack capacity to consent.","ALL","18 Years","99 Years",{"count":78,"type":79},250,"ESTIMATED","INTERVENTIONAL",[82],"NA","Identifying predictors and understanding mechanisms of change will inform referral to psychotherapy, triage and right-siting by helping clinicians to understand how their patients are likely to benefit from clinical interventions. This study will be the first of its kind conducted in an Asian hospital setting to identify the predictors of response to individual, group and internet-delivered CBT for the treatment of depressed and anxious patients in the Institute of Mental Health (IMH), Singapore. With increasing challenges with hospital workload, there is an increasing emphasis on group and online interventions. Understanding of the factors that may predict outcome from these therapies can improve right-siting by identifying who will get better without therapy or who may not benefit from a given form of therapy and guide personalisation of care. An important biological predictor of outcome is likely to be genetic risk as it has been demonstrated that patients with greater melancholia and a family history may not be sufficiently treated with brief courses of therapy. Identifying psychological factors underlying psychological distress and determining the extent to which these factors are addressed by these interventions will help to improve and individualise existing psychotherapy and motivate new psychotherapeutic interventions.",[85,86],"Depression","Anxiety Disorders",[88,89,90,91],"Psychotherapy","Cognitive behavioural therapy","Group psychotherapy","Internet-based psychotherapy","2026-08-05",{"date":94,"type":95},"2026-08-06","ACTUAL",{"date":97,"type":95},"2019-10-04",{"date":99,"type":79},"2026-09-30",{"name":5,"class":6},1]