[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651374":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":55,"collaborators":57,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":26,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":26,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":26,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Nanfang Hospital, Southern Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"UEMR group","EXPERIMENTAL","In UEMR group, enrolled patients will receive UEMR to remove small rectal NET.",[13],"Procedure: UEMR procedure",{"label":15,"type":16,"description":17,"interventionNames":18},"ESD group","ACTIVE_COMPARATOR","In ESD group, enrolled patients will receive the standard treatment modality of ESD to remove small rectal NET",[19],"Procedure: ESD procedure",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","UEMR procedure","Small rectal NET will be removed by underwater endoscopic mucosal resection. The UEMR procedure included the following: (1) complete deflation of the colorectal lumen; (2) total immersion of the lesion in normal saline using a mechanical water pump; (3)needle injection of normal saline into the submucosa; (4) snaring the lesion and the surrounding mucosa; and (5) resection using electrocautery.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"ESD procedure","Small rectal NET will be removed by endoscopic submucosal dissection. The ESD procedure included the following: (1) dots were marked approximately 5 mm from the periphery of the lesion using coagulation; (2) a diluted sodium hyaluronate solution with indigo carmine dye was injected submucosally. (3) mucosal incision and submucosal dissection were performed using a T-Type ESD Knife (Micro-Tech, Nanjing, China) or Dual-knife (Olympus Medical, Tokyo, Japan); (4)after resection was completed, all visible vessels on the artificial wound were thoroughly coagulated to prevent postoperative bleeding.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Zelong Han, MD","CONTACT","+86 20-6278-7385","hanzelong2025@163.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Bitao Lin, MD","+86 137-2532-1385","linbitao1996@163.com",[42],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":26},"RECRUITING","Guangzhou","Guangdong","510515","China","CN",{"type":50,"coordinates":51},"Point",[52,53],113.25,23.11667,{"lat":53,"lon":52},{"type":56,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[58,60,63,65,67,69,71,73,75],{"name":59,"class":6},"Guangdong Provincial Hospital of Traditional Chinese Medicine",{"name":61,"class":62},"The Eighth Affiliated Hospital of Southern Medical University","UNKNOWN",{"name":64,"class":6},"ZhuHai Hospital",{"name":66,"class":62},"Shenzhen Longgang District People's Hospital",{"name":68,"class":6},"Jiangmen Central Hospital",{"name":70,"class":6},"Yangjiang People's Hospital",{"name":72,"class":6},"The Third People's Hospital of Huizhou",{"name":74,"class":62},"the Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai)",{"name":76,"class":6},"Ganzhou City People's Hospital","100651374","underwater-endoscopic-mucosal-resection-versus-endoscopic-submucosal-dissection-for-the-treatment-of-small-rectal-neuroendocrine-tumors-100651374",false,"NCT07759960","Underwater Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Small Rectal Neuroendocrine Tumors","Underwater Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Small Rectal Neuroendocrine Tumors: A Prospective, Multicenter, Non-inferiority Trial","Inclusion Criteria:\n\n1. Age from 18 to 75 years;\n2. With a high suspicion or evidence of rectal NET assessed using EUS, CT scan or colonoscopy;\n3. With tumor size ≤10 mm assessed by colonoscopy or EUS;\n4. Plan to receive UEMR or ESD treatment and provide written informed consent.\n\nExclusion Criteria:\n\n1. Unable to tolerate ESD or UEMR as assessed by the research team;\n2. Complicated with serious diseases such as malignant tumor, which may lead to shorter life expectancy, the research team considers that it is not suitable for inclusion in the study after comprehensive evaluation;\n3. Rectal NET with lymph node metastasis or distant metastasis;\n4. Received resection of rectal neuroendocrine tumor by other surgical procedures;\n5. Multiple rectal neuroendocrine tumors;\n6. Vulnerable groups such as pregnant women or patients with mental disorders;\n7. Poor compliance, unable to cooperate with treatment.","ALL","18 Years","75 Years",{"count":88,"type":89},174,"ESTIMATED","INTERVENTIONAL",[92],"NA","Underwater endoscopic mucosal resection (UEMR) and endoscopic submucosal dissection (ESD) have both been reported to be two effective treatment methods for small rectal neuroendocrine tumor (NET). However, there is no consensus on the best method for the endoscopic resection of rectal NET. Therefore, we aimed to compare the efficacy and safety of UEMR and ESD for the treatment of small rectal NET.",[95],"Rectal Neuroendocrine Tumor","2026-08-09",{"date":98,"type":99},"2026-08-12","ACTUAL",{"date":101,"type":99},"2026-04-14",{"date":103,"type":89},"2029-12",{"name":5,"class":6},1]