[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650885":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":23,"centralContacts":33,"locations":39,"responsibleParty":56,"collaborators":23,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":23,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":23,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":42,"whyStopped":23,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Hacettepe University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Unilateral Resistance Training Group","EXPERIMENTAL","Participants will receive a supervised unilateral resistance training program twice weekly for 12 weeks. Training intensity will be set at 60-70% of one-repetition maximum (1RM). Exercises will include leg press, knee extension, leg curl, seated row, and chest press, performed separately with the right and left limbs. Each session will consist of 2-3 sets of 8-12 repetitions with at least 1 minute of rest between sets. Training load will be progressively increased according to participants' performance and perceived exertion.",[13],"Other: Unilateral Resistance Training",{"label":15,"type":10,"description":16,"interventionNames":17},"Bilateral Resistance Training Group","Participants will receive a supervised bilateral resistance training program twice weekly for 12 weeks. Exercise intensity will be prescribed at 60-70% of one-repetition maximum (1RM). The training program will include leg press, knee extension, leg curl, seated row, and chest press performed simultaneously with both limbs. Each exercise will be completed for 2-3 sets of 8-12 repetitions with at least 1 minute of rest between sets. Training intensity will be progressively increased according to participants' performance and perceived exertion.",[18],"Other: Bilateral Resistance Training",{"label":20,"type":21,"description":22,"interventionNames":23},"Control Group","NO_INTERVENTION","Participants assigned to the control group will not receive supervised resistance training during the 12-week study period. They will receive standardized education regarding the health benefits of regular physical activity. After study completion, participants will be offered the exercise program if the intervention is shown to be beneficial.",null,[25,29],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":23},"Unilateral Resistance Training","Participants will complete a supervised unilateral resistance training program twice weekly for 12 weeks. Exercise intensity will be prescribed at 60-70% of one-repetition maximum (1RM). Exercises include leg press, knee extension, leg curl, seated row, and chest press performed separately with the right and left limbs. Each session consists of 2-3 sets of 8-12 repetitions with at least 1 minute of rest between sets. Training loads will be progressively increased based on participants' performance and perceived exertion using the Modified Borg Scale.",[9],{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":23},"Bilateral Resistance Training","Participants will complete a supervised bilateral resistance training program twice weekly for 12 weeks. Exercise intensity will be prescribed at 60-70% of one-repetition maximum (1RM). Exercises include leg press, knee extension, leg curl, seated row, and chest press performed simultaneously with both limbs. Each session consists of 2-3 sets of 8-12 repetitions with at least 1 minute of rest between sets. Training loads will be progressively increased according to participants' performance and perceived exertion using the Modified Borg Scale.",[15],[34],{"name":35,"role":36,"phone":37,"phoneExt":23,"email":38},"Ceyhun TOPCUOGLU, Dr.","CONTACT","+90 535 653 51 37","ceyhuntopcuoglu1@gmail.com",[40],{"facility":41,"status":42,"city":43,"state":23,"zip":23,"country":44,"countryCode":23,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Munzur University Faculty of Health Sciences","RECRUITING","Tunceli","Turkey (Türkiye)",{"type":46,"coordinates":47},"Point",[48,49],39.54351,39.09921,{"lat":49,"lon":48},[52],{"name":53,"role":36,"phone":54,"phoneExt":23,"email":55},"Ulku OZBEY, Prof. Dr.","+90 531 435 88 94","ulkuozbey@munzur.edu.tr",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":60,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Ceyhun Topcuoglu","Dr.","Munzur University","100650885","unilateral-and-bilateral-resistance-training-in-hypertension-100650885",false,"NCT07751445","Unilateral and Bilateral Resistance Training in Hypertension","Comparison of the Effects of Unilateral and Bilateral Resistance Training on Heart Rate Variability, Muscle Strength, and Functional Capacity in Individuals With Hypertension: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 40 to 75 years.\n* Physician-confirmed diagnosis of hypertension.\n* Medically stable and able to safely participate in a supervised resistance training program.\n* Able to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Presence of cardiovascular diseases other than hypertension.\n* Neurological disorders.\n* Psychiatric disorders.\n* Orthopedic conditions limiting participation in resistance exercise.\n* Any other systemic disease that may interfere with study participation.\n* Cognitive impairment or psychological conditions preventing completion of the assessments.\n* History of recent surgery or medical conditions contraindicating exercise.\n* Inability or unwillingness to comply with the study protocol.",true,"ALL","40 Years","75 Years",{"count":73,"type":74},54,"ESTIMATED","INTERVENTIONAL",[77],"NA","Hypertension is associated with autonomic nervous system dysfunction, reduced muscle strength, and impaired functional capacity, all of which contribute to increased cardiovascular risk and decreased quality of life. Resistance training is recommended as a non-pharmacological intervention for hypertension; however, it remains unclear whether unilateral and bilateral resistance training produce different physiological adaptations, particularly regarding cardiac autonomic function.\n\nThis randomized controlled trial aims to compare the effects of unilateral and bilateral resistance training on heart rate variability (HRV), muscle strength, and functional capacity in adults with hypertension. Eligible participants aged 40-75 years with a confirmed diagnosis of hypertension will be randomly allocated to one of three groups: a unilateral resistance training group, a bilateral resistance training group, or a control group. Randomization will be performed using a computer-generated block randomization procedure with sex stratification to ensure balanced group allocation.\n\nParticipants in the two intervention groups will complete a supervised 12-week resistance training program, performed twice weekly at an intensity of 60-70% of one-repetition maximum (1RM). The unilateral training group will perform exercises using one limb at a time, whereas the bilateral training group will perform the same exercises simultaneously with both limbs. The control group will receive no structured exercise intervention during the study period but will receive general information regarding the benefits of physical activity.\n\nAssessments will be conducted at baseline and after the 12-week intervention. The primary outcome will be heart rate variability measured using a Polar H10 heart rate sensor and Elite HRV software. Secondary outcomes will include peripheral muscle strength assessed by one-repetition maximum testing, functional capacity assessed using the Six-Minute Walk Test and the Glittre Activities of Daily Living Test, and blood pressure measured using a sphygmomanometer.\n\nThe findings of this study are expected to provide evidence regarding the optimal resistance training strategy for improving autonomic function and physical performance in individuals with hypertension, thereby supporting the development of safer and more individualized exercise prescriptions.",[80],"Hypertension",[80,82,83,84,85],"Resistance Training","Heart Rate Variability","Muscle Strength","Functional Capacity","2026-08-05",{"date":88,"type":89},"2026-08-07","ACTUAL",{"date":91,"type":89},"2026-06-22",{"date":93,"type":74},"2026-10-01",{"name":5,"class":6},1]