[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649143":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":27,"locations":33,"responsibleParty":56,"collaborators":60,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":11,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":11,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":36,"whyStopped":11,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Rigshospitalet, Denmark","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Bilateral LVRS","EXPERIMENTAL",null,[13],"Procedure: Bilateral LVRS",{"label":15,"type":16,"description":11,"interventionNames":17},"Unilateral LVRS","ACTIVE_COMPARATOR",[18],"Procedure: Unilateral LVRS",[20,24],{"type":21,"name":15,"description":22,"armGroupLabels":23,"otherNames":11},"PROCEDURE","Both unilateral and bilateral LVRS are done with a standardized 3 port VATS access. Lower ligament is freed, no graspers on the parenchyma and stapling of the selected areas with a Signia™ powered stapler with Tri-Staple™ technology (Medtronic). The reloads will not be butressed and it will be vascular or parenchymal reloads. Two drains will be placed on the operated side and the same pain management will be applied including perioperative blocs and a pain catheter. The unilateral procedures will be performed with the patient in a side position.\n\nPostoperatively the drains will be removed when there is no sign of air leakage on the digital chest drain system. Chest x-ray will be performed to secure a fully inflated lung before discharge.",[15],{"type":21,"name":9,"description":25,"armGroupLabels":26,"otherNames":11},"Both unilateral and bilateral LVRS are done with a standardized 3 port VATS access. Lower ligament is freed, no graspers on the parenchyma and stapling of the selected areas with a Signia™ powered stapler with Tri-Staple™ technology (Medtronic). The reloads will not be butressed and it will be vascular or parenchymal reloads. Two drains will be placed on the operated side and the same pain management will be applied including perioperative blocs and a pain catheter. In the bilateral procedures the paBent will be positioned on the back and the side to be operated on liked by rotating the table. The surgeon is free to decide which side to deal with first.\n\nPostoperatively the drains will be removed when there is no sign of air leakage on the digital chest drain system. Chest x-ray will be performed to secure a fully inflated lung before discharge.",[9],[28],{"name":29,"role":30,"phone":31,"phoneExt":11,"email":32},"Alberte Lund, MD","CONTACT","+4535458016","alberte.lund@regionh.dk",[34],{"facility":35,"status":36,"city":37,"state":11,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Rigshospitalet","RECRUITING","Copenhagen","2300","Denmark","DK",{"type":42,"coordinates":43},"Point",[44,45],12.56553,55.67594,{"lat":45,"lon":44},[48,49,53],{"name":29,"role":30,"phone":31,"phoneExt":11,"email":32},{"name":50,"role":30,"phone":51,"phoneExt":11,"email":52},"René Horsleben Petersen, MD, Professor","+4535450525","rene.horsleben.petersen@regionh.dk",{"name":54,"role":55,"phone":11,"phoneExt":11,"email":11},"René Horsleben Petersen, MD, professor","SUB_INVESTIGATOR",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Alberte Lund","MD and Phd student",[61],{"name":62,"class":63},"Medtronic","INDUSTRY","100649143","unilateral-vs-bilateral-lung-volume-reduction-surgery-100649143",false,"NCT07731958","Unilateral vs. Bilateral Lung Volume Reduction Surgery","Unilateral Versus Bilateral Lung Volume Reduction Surgery for Patients With Severe COPD","Inclusion Criteria:\n\n* Suitable target areas in both lungs\n* Age ≥ 18 years.\n* Speaks and understands Danish or English\n* Informed consent obtained\n* Usual inclusion criteria in LVRS:\n\nModerate to severe COPD with MRC score \\> 2 \\\u003C 75 years old 17 \\\u003C BMI \\> 30 FEV1 \\> 20% and \\\u003C 45% of predicted RV \\> 200% of predicted as a sign of relevant hyperinflation DLCO \\> 20% of predicted The patient should be in ideal medical treatment and have completed rehabilitation A high-resolution CT \\\u003C 3 months old should follow the referral to MDT Absence of nodules suspicious of malignancy on CT scan Absence of significant comorbidity including severe cardiovascular disease LVEF normal Absence of pulmonary hypertension, TI-gradient \\\u003C 40 mmHg Absence of chronic or frequent lung infections Smoking abstinence six months prior to surgery Assessed as sufficiently physically fit to undergo surgery and rehabilitation\n\nExclusion Criteria:\n\n* Dependent on wheelchair\n* Living in nursery home\n* Dependent on walker device\n* Psychiatric disorder (anxiety, depression, schizophrenia)\n* Simultaneous lung cancer surgery\n* Massive adhesions during surgery assessed by the surgeon indicating problems postoperatively\n* Increased risk of post-operative bleeding assessed perioperatively by the surgeon.\n* Perioperative decision on not doing operation on the other side (medical, surgical or anaesthesiologic problems that favours a fast termination of the surgery, decided by the team in OR).\n* Previous cardiothoracic surgery\n* Increased bleeding risk (e.g., preoperative INR \\>2, overdue discontinuation of anticoagulants according to guidelines by the Danish Society for Thrombosis and Haemostasis, known coagulopathy).","ALL","18 Years","75 Years",{"count":75,"type":76},146,"ESTIMATED","INTERVENTIONAL",[79],"NA","This study compares two surgical approaches for patients with severe Chronic Obstructive Pulmonary Disease (COPD) and severe emphysema: unilateral (operating on one lung) versus bilateral (operating on both lungs) lung volume reduction surgery (LVRS).",[82],"Emphysema, Pulmonary",[84,85,86,87,88,89,90],"Thoracic surgery","VATS","LVRS","Lung volume reduction surgery","Lung function","Mortality","Dyspnea","2026-07-22",{"date":93,"type":94},"2026-07-28","ACTUAL",{"date":96,"type":94},"2025-03-21",{"date":98,"type":76},"2032-07",{"name":5,"class":6},1]