[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650080":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":29,"responsibleParty":74,"collaborators":76,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":88,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":10,"studyType":100,"phases":10,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":112,"whyStopped":10,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"University Hospital, Grenoble","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"1 groupe unique",null,"Patients aged 7 to 25 years who underwent surgery for biopsy-confirmed Hirschsprung disease between 2000 and 2018 at one of the five participating university hospitals, regardless of the surgical technique used, and who are evaluated for long-term urinary, sexual, and bowel symptoms, as well as health-related quality of life.",[13],"Procedure: Type of pull-through procedure performed as part of routine clinical care (Swenson, Duhamel, or Soave).",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"PROCEDURE","Type of pull-through procedure performed as part of routine clinical care (Swenson, Duhamel, or Soave).","Swenson, Duhamel, or Soave pull-through procedure, retrospectively collected from the operative report. No intervention or modification of clinical management is performed as part of this study.",[9],[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Amandine MIRKOVIC JUGE, interne en chirurgie","CONTACT","+33669523539","a.juge@icloud.com",{"name":27,"role":23,"phone":10,"phoneExt":10,"email":28},"Pierre-Yves RABATTU, PH CHUGA","PYRabattu@chu-grenoble.fr",[30,41,50,58,66],{"facility":31,"status":10,"city":32,"state":10,"zip":10,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":10},"Chu Clermont Ferrand","Clermont-Ferrand","France","FR",{"type":36,"coordinates":37},"Point",[38,39],3.08682,45.77969,{"lat":39,"lon":38},{"facility":42,"status":10,"city":43,"state":10,"zip":44,"country":33,"countryCode":34,"cosmosGeoPoint":45,"geoPoint":49,"contacts":10},"Chu Grenoble Alpes","Grenoble","38000",{"type":36,"coordinates":46},[47,48],5.71479,45.17869,{"lat":48,"lon":47},{"facility":51,"status":10,"city":52,"state":10,"zip":10,"country":33,"countryCode":34,"cosmosGeoPoint":53,"geoPoint":57,"contacts":10},"Hfme Lyon","Lyon",{"type":36,"coordinates":54},[55,56],4.84789,45.74906,{"lat":56,"lon":55},{"facility":59,"status":10,"city":60,"state":10,"zip":10,"country":33,"countryCode":34,"cosmosGeoPoint":61,"geoPoint":65,"contacts":10},"APHM","Marseille",{"type":36,"coordinates":62},[63,64],5.38107,43.29695,{"lat":64,"lon":63},{"facility":67,"status":10,"city":68,"state":10,"zip":10,"country":33,"countryCode":34,"cosmosGeoPoint":69,"geoPoint":73,"contacts":10},"Chu Saint Etienne","Saint-Etienne",{"type":36,"coordinates":70},[71,72],4.39,45.43389,{"lat":72,"lon":71},{"type":75,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[77,79,81,83],{"name":78,"class":6},"Centre Hospitalier Universitaire de Saint Etienne",{"name":80,"class":6},"Assistance Publique Hopitaux De Marseille",{"name":82,"class":6},"Hospices Civils de Lyon",{"name":84,"class":85},"CHU Gabriel Montpied, Clermont Ferrand, FRANCE","UNKNOWN","100650080","urinary-and-sexual-symptoms-in-patients-with-hirschsprung-disease-100650080",false,"NCT07742436","Urinary and Sexual Symptoms in Patients With Hirschsprung Disease","Medium- and Long-Term Urinary and Sexual Outcomes in Patients Who Underwent Surgery for Hirschsprung Disease in the Auvergne-Rhône-Alpes Region and at Marseille University Hospital Between 2000 and 2018","UroSexH","Inclusion Criteria:\n\n* Biopsy-confirmed Hirschsprung disease treated surgically between 2000 and 2018, regardless of the pull-through technique used.\n* Surgery performed at one of the five participating university hospitals (Grenoble, Lyon, Saint-Étienne, Clermont-Ferrand, or Marseille).\n* Male or female participants.\n* Aged 7 to 25 years at the time of study inclusion.\n* No objection to participation obtained from the participant or, for minors, from the legal representative, in accordance with French regulations.\n* Affiliation with the French national health insurance system.\n\nExclusion Criteria:\n\n* Syndromic Hirschsprung disease (e.g., Down syndrome, Waardenburg syndrome, or Multiple Endocrine Neoplasia type 2).\n* Total colonic aganglionosis.\n* Small-bowel aganglionosis.\n* Major congenital urogenital malformation unrelated to Hirschsprung disease (e.g., bladder exstrophy or posterior urethral valves).\n* Deceased before study inclusion.\n* Unable to be contacted despite repeated attempts.\n* Individuals not eligible for biomedical research under Articles L1121-5 to L1121-8 of the French Public Health Code.","ALL","7 Years","25 Years",{"count":98,"type":99},556,"ESTIMATED","OBSERVATIONAL","Hirschsprung disease is a rare congenital disorder affecting the gastrointestinal tract of newborns. It is caused by the absence of enteric ganglion cells in a segment of the large intestine, preventing normal bowel function and leading to intestinal obstruction. The only effective treatment is surgical, usually performed during the first months or years of life, and consists of resecting the affected bowel segment and reconnecting the healthy intestine.\n\nAdvances in surgical techniques have enabled most children with Hirschsprung disease to achieve normal growth and development. However, surgery is performed in an anatomical region containing nerves and structures that are essential for normal bladder and sexual function. Although previous studies have demonstrated that some patients continue to experience long-term bowel dysfunction after surgery, the potential long-term effects on urinary function and sexual health during childhood, adolescence, and adulthood remain insufficiently investigated.\n\nThe primary objective of this study is to determine the prevalence and characteristics of long-term urinary symptoms in patients who underwent surgery for Hirschsprung disease during early childhood. Secondary objectives are to assess sexual function, overall quality of life, and long-term bowel function. In addition, the investigators aim to compare these outcomes according to the surgical technique used, as several operative approaches are currently available and none has yet been shown to be superior in preventing long-term sequelae.\n\nthe investigators hypothesize that a clinically relevant proportion of patients-approximately 10%-experience persistent urinary symptoms years after surgery, despite these symptoms being infrequently assessed and rarely included in routine long-term follow-up.\n\nThis study is intended for individuals aged 7 to 25 years who underwent surgery for Hirschsprung disease between 2000 and 2018 at one of the five participating university hospitals: Grenoble, Lyon, Saint-Étienne, Clermont-Ferrand, and Marseille. Eligible participants will be contacted by telephone and invited to participate. Those who provide informed consent (and assent\u002Fparental consent when applicable) will receive a secure email link to complete online questionnaires assessing urinary symptoms, sexual function (when age-appropriate), quality of life, and bowel function. These validated questionnaires have been widely used in previous studies and require approximately 15-20 minutes to complete. No study visits, medical examinations, or additional follow-up are planned as part of this research; participation consists solely of completing the questionnaires.\n\nThe findings of this study will improve our understanding of the long-term urinary and sexual sequelae associated with Hirschsprung disease surgery. Ultimately, they may contribute to the development of more systematic long-term postoperative follow-up strategies, enabling earlier identification and improved management of urinary and sexual dysfunction in children as they progress through adolescence and into adulthood.",[103],"Hirschsprung Disease",[103,105,106,107,108,109,110,111],"Lower Urinary Tract Symptoms","Sexual Dysfunction","Quality of Life","Pediatric Surgery","Long-Term Outcome","Multicenter Study","Bowel Function","NOT_YET_RECRUITING","2026-07-28",{"date":115,"type":116},"2026-08-03","ACTUAL",{"date":118,"type":99},"2026-08",{"date":120,"type":99},"2027-02",{"name":5,"class":6},5]