[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655121":3},{"organization":4,"outcomesModule":7,"designInfo":34,"detailedDescription":33,"studyPopulation":37,"armGroups":33,"interventions":38,"overallOfficials":33,"centralContacts":33,"locations":33,"responsibleParty":46,"collaborators":48,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":33,"enrollmentInfo":62,"targetDuration":33,"studyType":65,"phases":33,"briefSummary":66,"conditions":67,"keywords":33,"overallStatus":71,"whyStopped":33,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":33},{"fullName":5,"class":6},"Royal Free Hospital NHS Foundation Trust","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":20,"otherOutcomes":33},[9,13,17],{"measure":10,"description":11,"timeFrame":12},"Technical success or failure of POCUS readings","The number of POCUS scans attempted that resulted in a recorded measurement","From enrollment until the end of the POCUS readings period at 7 days",{"measure":14,"description":15,"timeFrame":16},"Duration of POCUS readings","Time taken to perform each episode of POCUS during the study period, defined by the start and end times recorded in the case report form","From enrolment until the end of the POCUS readings period at 7 days",{"measure":18,"description":19,"timeFrame":12},"Patient acceptability","Structured feedback from participants on the acceptability of the POCUS readings via a questionnaire",[21,25,29],{"measure":22,"description":23,"timeFrame":24},"Changes in POCUS measurements in response to fluid management interventions","The delta of POCUS readings before and after fluid management interventions (intravenous fluid or albumin, diuretics, terlipressin or large volume paracentesis)","From enrolment until the end of POCUS readings period at 7 days",{"measure":26,"description":27,"timeFrame":28},"Correlation of POCUS readings with clinical assessment","A descriptive analysis of how frequently baseline clinical assessments agreed with POCUS findings suggestive of hypovolaemia or hypervolaemia","From enrolment until end of POCUS readings period (7 days)",{"measure":30,"description":31,"timeFrame":32},"Correlation of POCUS readings with clinical outcomes","A descriptive analysis of POCUS parameters and predefined clinical outcomes (emergency readmission to hospital, renal dysfunction, fluid overload\u002Fpulmonary oedema, variceal bleeding, hepatic encephalopathy, other organ dysfunction\u002FACLF grade, ICU admission and death)","From enrolment until 90 days",null,{"allocation":33,"interventionModel":33,"interventionModelDescription":33,"primaryPurpose":33,"observationalModel":35,"timePerspective":36,"maskingInfo":33},"COHORT","PROSPECTIVE","Participants under the care of the hepatology team at the Royal Free Hospital will be recruited from the emergency department, wards or ambulatory care.",[39,43],{"type":40,"name":41,"description":42,"armGroupLabels":33,"otherNames":33},"DIAGNOSTIC_TEST","Ultrasound measurement","Point-of-care ultrasound measurements of the IJV, IVC, thorax and abdomen performed at least once following recruitments and on up to three separate occasions in total during the first seven days of admission, with up to five measurements in total on each occasion.",{"type":40,"name":44,"description":45,"armGroupLabels":33,"otherNames":33},"Blood draw for the laboratory assessment","A blood sample for research analysis may be taken at the same time as standard of care blood tests during the study.",{"type":47,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR",[49],{"name":50,"class":51},"Royal Free Charity","UNKNOWN","100655121","using-bedside-ultrasound-to-understand-fluid-management-in-patients-with-chronic-liver-disease-100655121",false,"NCT07810855","Using Bedside Ultrasound to Understand Fluid Management in Patients With Chronic Liver Disease","POCUS Guided Fluid Resuscitation in Cirrhosis","POCUS-C","Inclusion Criteria:\n\n* Participants must be capable of giving informed consent\n* Hospitalized patients with liver cirrhosis (of any cause) and clinically significant ascites\n* \\> 18 years of age\n\nExclusion Criteria:\n\n* patients receiving end of life care","ALL","18 Years",{"count":63,"type":64},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to see if repeated bedside ultrasound measurements of the lungs and abdomen as well as a blood vessel in the neck can be done in patients with advanced liver disease and ascites (fluid in the abdomen) on hospital wards and day case units. We will also learn about how patients view this test.\n\nThe main questions it will answer are:\n\nHow long does it take to do the measurements? How often are we able to get all the measurements we are trying to do? How do patients feel about having this test done?\n\nFor patients in the study this will involve:\n\nUndergoing ultrasound scans of the neck, chest and abdomen on at least one occasion during hospital admission, and up to a maximum of five times in a day.\n\nAn extra blood test may be taken at the same time as usual blood tests taken during the hospital stay.\n\nA brief questionnaire about their experience of having the test.",[68,69,70],"Cirrhosis","Ascites Hepatic","Fluid Balance","NOT_YET_RECRUITING","2026-09-02",{"date":74,"type":75},"2026-09-09","ACTUAL",{"date":77,"type":64},"2026-09-01",{"date":79,"type":64},"2027-04",{"name":5,"class":6}]