[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654859":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":33,"studyPopulation":34,"armGroups":35,"interventions":41,"overallOfficials":47,"centralContacts":51,"locations":57,"responsibleParty":70,"collaborators":29,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":29,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":82,"maxAge":29,"enrollmentInfo":83,"targetDuration":29,"studyType":86,"phases":29,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":59,"whyStopped":29,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Istanbul Training and Research Hospital","OTHER_GOV",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":29},[9,13],{"measure":10,"description":11,"timeFrame":12},"Association Between Baseline UV-Trichoscopic Red Fluorescence Intensity and Timing of First Visible Hair Regrowth","Baseline UV-trichoscopic red fluorescence intensity will be quantified from standardized digital images using red-channel intensity measurements. Participants will be evaluated for the first appearance of visible hair regrowth at follow-up visits at weeks 4, 8, and 12. The association between baseline red fluorescence intensity and the timing of first visible hair regrowth will be assessed.","Baseline through week 12",{"measure":14,"description":15,"timeFrame":16},"Association Between Baseline UV-Trichoscopic Red Fluorescence Intensity and Degree of Hair Regrowth","The degree of hair regrowth will be assessed at follow-up visits using standardized clinical photographs and trichoscopic images of the alopecic plaque. Hair regrowth will be evaluated according to the proportion of the baseline alopecic area showing visible regrowth, with trichoscopic examination used to identify early or fine regrowing hairs that may not be clearly visible in clinical photographs. The association between baseline UV-trichoscopic red fluorescence intensity and the degree of hair regrowth will be evaluated.","Weeks 4, 8, and 12",[18,22,25],{"measure":19,"description":20,"timeFrame":21},"Change in UV-Trichoscopic Red Fluorescence Intensity During Follow-up","UV-trichoscopic red fluorescence intensity will be quantified from standardized digital images using red-channel intensity measurements. Changes in red fluorescence intensity from baseline through follow-up visits will be evaluated","Baseline and weeks 4, 8, and 12",{"measure":23,"description":24,"timeFrame":21},"Change in Area-Normalized Counts of Selected Trichoscopic Findings During Follow-up","Yellow dots, black dots, exclamation mark hairs, and broken hairs will be counted individually on standardized trichoscopic images. Counts will be normalized to the area of the alopecic plaque and expressed as the number of each finding per square centimeter (findings\u002Fcm²). Each trichoscopic finding will be analyzed separately rather than combined into a composite severity score. Higher values indicate a greater density of the corresponding finding. For activity-associated findings, including black dots, broken hairs, and exclamation mark hairs, a decrease during follow-up will be interpreted as a reduction in trichoscopic disease activity. Yellow dots will be evaluated separately and will not be interpreted as a direct measure of disease activity.",{"measure":26,"description":27,"timeFrame":28},"Association Between Baseline UV-Trichoscopic Red Fluorescence Intensity and Trichoscopic Findings","The association between baseline UV-trichoscopic red fluorescence intensity and baseline trichoscopic findings, including yellow dots, black dots, exclamation mark hairs, and broken hairs, will be evaluated.","Baseline",null,{"allocation":29,"interventionModel":29,"interventionModelDescription":29,"primaryPurpose":29,"observationalModel":31,"timePerspective":32,"maskingInfo":29},"COHORT","PROSPECTIVE","This is a prospective observational cohort study involving adults with limited plaque-type alopecia areata who are receiving intralesional corticosteroid treatment as part of routine clinical care. Participation in the study does not determine whether a patient receives intralesional corticosteroid treatment.\n\nAt baseline, the affected scalp area will be evaluated using conventional polarized trichoscopy and UV-trichoscopy. Follow-up assessments will be performed at weeks 4, 8, and 12 using the same imaging approach. Trichoscopic findings of interest will include yellow dots, black dots, exclamation mark hairs, and broken hairs.\n\nUV-trichoscopic red fluorescence will be assessed quantitatively by measuring red-channel intensity on standardized digital images. Imaging and image analysis procedures will be performed using a standardized acquisition protocol to improve comparability between visits.\n\nTreatment response will be evaluated according to the appearance and extent of visible hair regrowth and the change in trichoscopic activity findings during follow-up. The main analysis will examine whether baseline red fluorescence intensity is associated with the timing and magnitude of response to intralesional corticosteroid treatment. Associations between red fluorescence intensity and baseline trichoscopic findings, as well as changes in fluorescence intensity and trichoscopic findings over time, will also be evaluated.","Adults with limited plaque-type alopecia areata of the scalp who are receiving intralesional corticosteroid treatment as part of routine clinical care at the dermatology outpatient clinic will be prospectively enrolled. Participants will undergo standardized conventional trichoscopic and UV-trichoscopic assessments and will be followed for 12 weeks to evaluate red fluorescence intensity, trichoscopic findings, and hair regrowth.",[36],{"label":37,"type":29,"description":38,"interventionNames":39},"Limited Plaque-Type Alopecia Areata","Adults with limited plaque-type alopecia areata who are receiving intralesional corticosteroid treatment as part of routine clinical care. Participants will undergo conventional trichoscopic and UV-trichoscopic assessments at baseline and during follow-up at weeks 4, 8, and 12. Hair regrowth, trichoscopic findings, and UV-trichoscopic red fluorescence intensity will be evaluated over time.",[40],"Drug: Triamcinolone Acetonide",[42],{"type":43,"name":44,"description":45,"armGroupLabels":46,"otherNames":29},"DRUG","Triamcinolone Acetonide","Intralesional triamcinolone acetonide is administered for limited plaque-type alopecia areata as part of routine clinical care. The decision to administer treatment is made independently of participation in this observational study. The study prospectively evaluates trichoscopic and UV-trichoscopic findings and hair regrowth during routine treatment follow-up.",[37],[48],{"name":49,"affiliation":5,"role":50},"Vildan Manav","STUDY_CHAIR",[52],{"name":53,"role":54,"phone":55,"phoneExt":29,"email":56},"Sevgi Nazli Apucu, Dermatology Resident Physician","CONTACT","+905374048180","snapucu@gmail.com",[58],{"facility":5,"status":59,"city":60,"state":29,"zip":29,"country":61,"countryCode":29,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"RECRUITING","Istanbul","Turkey (Türkiye)",{"type":63,"coordinates":64},"Point",[65,66],28.94966,41.01384,{"lat":66,"lon":65},[69],{"name":53,"role":54,"phone":55,"phoneExt":29,"email":56},{"type":71,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Sevgi Nazli Apucu","Dermatology Resident Physician","100654859","uv-trichoscopic-red-fluorescence-in-alopecia-areata-100654859",false,"NCT07803874","UV-Trichoscopic Red Fluorescence in Alopecia Areata","Evaluation of UV-Trichoscopic Red Fluorescence Intensity in Relation to Trichoscopic Findings and Response to Intralesional Corticosteroid Treatment in Limited Plaque-Type Alopecia Areata","Inclusion Criteria:\n\n* Age 18 years or older\n* Limited plaque-type alopecia areata of the scalp\n* Active hair loss\n* Symptom onset within the previous 6 months\n* No topical, intramuscular, or oral treatment for alopecia areata within the previous 1 month\n* No intralesional corticosteroid treatment within the previous 6 weeks\n* Provision of informed consent\n\nExclusion Criteria:\n\n* Beard alopecia areata\n* Very extensive alopecia areata or multiple large plaques\n* Tinea capitis or active infection\n* Current phototherapy\n* Systemic immunosuppressive treatment within the washout period specified in the study protocol\n* Pregnancy or breastfeeding\n* Contraindication to UV imaging","ALL","18 Years",{"count":84,"type":85},40,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn whether red fluorescence seen with ultraviolet (UV) trichoscopy is related to disease findings and treatment response in adults with limited plaque-type alopecia areata. Trichoscopy is a close-up imaging method used to examine the hair and scalp. The study will investigate whether the amount of red fluorescence at the beginning of the study is related to how soon hair starts to grow back, how much hair regrows, and how trichoscopic findings change during follow-up. Participants for whom intralesional corticosteroid treatment has been planned as part of their regular medical care will have standard trichoscopic and UV-trichoscopic images taken of the affected scalp area. They will be followed at weeks 4, 8, and 12, when hair regrowth and changes in scalp and hair findings will be evaluated. Researchers will measure red fluorescence in the images and examine whether it is related to treatment response over time.",[89],"Alopecia Areata",[91,92,93,94,95],"UV Trichoscopy","Red Fluorescence","Trichoscopy","Intralesional Corticosteroid","Hair Regrowth","2026-09-08",{"date":98,"type":99},"2026-09-11","ACTUAL",{"date":101,"type":99},"2026-07-01",{"date":103,"type":85},"2026-12",{"name":5,"class":6},1]