[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649641":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":19,"collaborators":10,"id":23,"slug":24,"hasResults":25,"nctId":26,"briefTitle":27,"officialTitle":28,"acronym":10,"eligibilityCriteria":29,"healthyVolunteers":25,"sex":30,"minAge":31,"maxAge":10,"enrollmentInfo":32,"targetDuration":10,"studyType":35,"phases":10,"briefSummary":36,"conditions":37,"keywords":39,"overallStatus":46,"whyStopped":10,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":10},{"fullName":5,"class":6},"Hospital H+ Queretaro","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Mechanically ventilated adult patients",null,[12],"Diagnostic Test: Observational measurement of Cough Peak Flow and Tidal Volume",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"DIAGNOSTIC_TEST","Observational measurement of Cough Peak Flow and Tidal Volume","Patients undergo standardized CPF and pre-cough tidal volume (VT) measurements prior to extubation. Measurements are stratified by cooperation level (Voluntary vs. Reflex).",[9],{"type":20,"investigatorFullName":21,"investigatorTitle":22,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Jose J Zaragoza, MD MSc","Dr","100649641","validation-of-an-effort-based-cough-peak-flow-algorithm-to-predict-extubation-outcomes-100649641",false,"NCT07737483","Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes","Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes in the ICU: A Prospective Blinded Cohort Study","Inclusion Criteria:\n\n* Adult patients (≥18 years) admitted to the ICU who received invasive mechanical ventilation for \\>24 hours and successfully completed a Spontaneous Breathing Trial (SBT).\n\nExclusion Criteria:\n\n* Prior indication for tracheostomy (e.g., severe maxillofacial trauma, upper airway obstruction).\n\n  * Self-extubation or accidental extubation.\n  * Decision to withhold or withdraw life-sustaining treatments.\n  * Severe primary neuromuscular diseases.","ALL","18 Years",{"count":33,"type":34},150,"ESTIMATED","OBSERVATIONAL","This study aims to prospectively validate the diagnostic accuracy of an effort-stratified Cough Peak Flow (CPF) decision algorithm for predicting extubation failure, maintaining strict blinding of the clinical team. The model classifies patients by neurological status and uses an effort-based approach, including a \"Gray Zone\" (40-59 L\u002Fmin) managed by tidal volume evaluation.",[38],"Extubation Failure",[40,41,42,43,44,45],"Cough Peak Flow","Mechanical Ventilation","Intensive Care Unit","Airway Protection","Tidal Volume","Respiratory Weaning","NOT_YET_RECRUITING","2026-07-27",{"date":49,"type":50},"2026-07-30","ACTUAL",{"date":52,"type":34},"2026-07-01",{"date":54,"type":34},"2026-11-30",{"name":5,"class":6}]