[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658162":3},{"organization":4,"outcomesModule":7,"designInfo":28,"detailedDescription":30,"studyPopulation":31,"armGroups":32,"interventions":27,"overallOfficials":27,"centralContacts":35,"locations":44,"responsibleParty":60,"collaborators":27,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":27,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":77,"studyType":78,"phases":27,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":90,"whyStopped":27,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"National and Kapodistrian University of Athens","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":27},[9],{"measure":10,"description":11,"timeFrame":12},"Greek Version of the Work Productivity and Activity Impairment Questionnaire for Migraine (WPAI:Migraine)","The validity and reliability of the Greek version of the WPAI:Migraine will be evaluated in patients with migraine. The questionnaire assesses work productivity and activity impairment over the previous 7 days, including absenteeism, presenteeism, overall work impairment, and activity impairment. Higher percentage scores indicate greater impairment.","Baseline and 7-14 days after baseline for test-retest reliability.",[14,18,21,24],{"measure":15,"description":16,"timeFrame":17},"Migraine-Related Disability","igraine-related disability will be assessed using the MIDAS questionnaire, which evaluates disability over the previous 3 months. The total score is calculated from five items, with higher scores indicating greater migraine-related disability.","Baseline",{"measure":19,"description":20,"timeFrame":17},"Headache Impact","The impact of headache on daily functioning and quality of life will be assessed using the HIT-6. Total scores range from 36 to 78, with higher scores indicating greater headache impact.",{"measure":22,"description":23,"timeFrame":17},"Migraine-Specific Quality of Life","Migraine-specific quality of life over the previous 4 weeks will be assessed using the MSQv2.1, which includes Role Function-Restrictive, Role Function-Preventive, and Emotional Function domains. Scores are transformed to a 0-100 scale, with higher scores indicating better migraine-specific quality of life.",{"measure":25,"description":26,"timeFrame":17},"Headache Pain Intensity","Headache pain intensity will be assessed using the Visual Analog Scale, ranging from 0 (no pain) to 10 (worst imaginable pain), with higher scores indicating greater pain intensity.",null,{"allocation":27,"interventionModel":27,"interventionModelDescription":27,"primaryPurpose":27,"observationalModel":6,"timePerspective":29,"maskingInfo":27},"PROSPECTIVE","Migraine is one of the most common neurological disorders among working-age individuals worldwide and a major cause of lost work productivity. Migraine attacks not only cause pain and associated symptoms but also lead to work absenteeism, reduced productivity, and limitations in daily activities. A study including 31 countries showed that 52% of individuals with at least 4 migraine days per month experienced an overall reduction in work performance due to migraine, and that this was attributable more to presenteeism than absenteeism. The American Migraine Prevalence and Prevention Study reported that the cost of presenteeism was nearly three times that of absenteeism in patients with episodic migraine.\n\nThe Work Productivity and Activity Impairment Questionnaire (WPAI) is a brief and widely used patient-reported outcome measure that assesses the impact of chronic diseases on work performance. WPAI:Migraine, a migraine-specific version, has been found to be valid and reliable in American and Arabic populations of patients with episodic and chronic migraine. International Headache Society (IHS) guidelines for preventive treatment trials in episodic and chronic migraine recommend the use of the WPAI. Therefore, it is important to evaluate the impact of migraine not only through clinical parameters but also in terms of productivity and functioning.\n\nIn Greece, migraine studies have been conducted at the population level using pharmacological treatments and assessments. However, with regard to daily life and work productivity, there is currently no validated Greek WPAI:Migraine questionnaire available to assess migraine-related productivity loss. Availability of such a scale for the Greek migraine population is important for clinical applications, health-economics research, and evaluation of treatment outcomes.\n\nAim of the study - Hypotheses to be tested The aim of the present study is to investigate the validity and reliability of the Greek version of the WPAI:Migraine questionnaire in individuals with migraine and to determine whether it can be used as a valid and reliable tool for assessing work productivity and functioning in the Greek population.\n\nHypotheses:\n\nHypotheses:\n\n* H0: The Greek version of the WPAI:Migraine is not valid and reliable for patients with migraine in the Greek population.\n* H1: The Greek version of the WPAI:Migraine is valid and reliable for patients with migraine in the Greek population.","Adults aged 18-70 years with a diagnosis of episodic or chronic migraine according to the International Classification of Headache Disorders, 3rd edition (ICHD-3), confirmed by a specialist neurologist. Participants will be recruited from the Specialized Headache Clinic of Aeginition Hospital in Greece.",[33],{"label":34,"type":27,"description":27,"interventionNames":27},"Patients with Migraine",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":27,"email":40},"Michalis Kodounis, Neurologist, PhD","CONTACT","+30 697 3600069","kodounis@gmail.com",{"name":42,"role":38,"phone":27,"phoneExt":27,"email":43},"Dimos Mitsikostas, Neurologist, PhD","dimosmitsikostas@me.com",[45],{"facility":46,"status":27,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"National Kapodistrian University of Athens, Aeginition Hospital, Headache Clinic","Athens","Attica","11528","Greece","GR",{"type":53,"coordinates":54},"Point",[55,56],23.72784,37.98376,{"lat":56,"lon":55},[59],{"name":37,"role":38,"phone":39,"phoneExt":27,"email":40},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Michalis Kodounis","PhD, Neurologist, Medical Doctor","100658162","validity-and-reliability-of-the-greek-wpaimigraine-100658162",false,"NCT07847554","Validity and Reliability of the Greek WPAI:Migraine","Assessment of Work Productivity and Activities in Patients With Migraine Using the \"WPAI (Work Productivity and Activity Impairment)\" Questionnaire: Validity and Reliability Study of the Greek Version","Inclusion Criteria:\n\n* Diagnosis of migraine\n* Age 18-70 years\n* Ability to understand, read, write, and speak the Greek language\n\nExclusion Criteria:\n\n* Presence of a headache disorder other than migraine\n* History of systemic diseases (malignant, inflammatory, acute traumatic, infectious, surgical, neurological, psychiatric, or rheumatological conditions)","ALL","18 Years","70 Years",{"count":75,"type":76},60,"ESTIMATED","1 Week","OBSERVATIONAL","Migraine is a common neurological disorder that can substantially impair work productivity and daily functioning through both absenteeism and presenteeism. The Work Productivity and Activity Impairment Questionnaire for Migraine (WPAI:Migraine) is a brief patient-reported measure designed to assess migraine-related impairment in work and daily activities. Although the questionnaire has demonstrated validity and reliability in other populations, a validated Greek version is currently unavailable. This study aims to evaluate the validity and reliability of the Greek version of the WPAI:Migraine in individuals with episodic or chronic migraine, thereby providing an appropriate tool for assessing migraine-related work productivity and functional impairment in the Greek population.",[81],"Migraine",[83,84,85,86,87,88,89],"migraine","headache","work productivity","absenteeism","presenteeism","disability","quality of life","NOT_YET_RECRUITING","2026-10-04",{"date":93,"type":94},"2026-10-08","ACTUAL",{"date":96,"type":76},"2026-11-01",{"date":98,"type":76},"2027-07-01",{"name":5,"class":6},1]