[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650293":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":17,"locations":27,"responsibleParty":43,"collaborators":45,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":7,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":77,"whyStopped":7,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"BIOLOGICAL","Serum","Neurofilament light chain NfL, brain-derived tau, GFAP, UCHL1, p-tau217, s100B, neurone specific enolase NSE, sTREM2, YKL-40",[14],{"name":15,"affiliation":5,"role":16},"Sarah BENGHANEM, Dr","PRINCIPAL_INVESTIGATOR",[18,23],{"name":15,"role":19,"phone":20,"phoneExt":21,"email":22},"CONTACT","01 58 41 25 25","+33","sarah.benghanem@aphp.fr",{"name":24,"role":19,"phone":25,"phoneExt":21,"email":26},"Adèle BELLINO","01 71 76 07 57","adele.bellino@aphp.fr",[28],{"facility":29,"status":7,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Hôpital Cochin - APHP Centre","Paris","Île-de-France Region","75014","France","FR",{"type":36,"coordinates":37},"Point",[38,39],2.3488,48.85341,{"lat":39,"lon":38},[42],{"name":15,"role":19,"phone":20,"phoneExt":21,"email":22},{"type":44,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[46,48],{"name":47,"class":6},"URC-CIC Paris Descartes Necker Cochin",{"name":49,"class":50},"ANR and Ministry of Health","UNKNOWN","100650293","value-of-biomarkers-of-brain-injury-for-predicting-psycho-cognitive-sequelae-secondary-to-sepsis-a-prospective-multicenter-study-100650293",false,"NCT07746050","Value of Biomarkers of Brain Injury for Predicting Psycho-cognitive Sequelae Secondary to Sepsis: a Prospective Multicenter Study","SEPSYM","Inclusion Criteria:\n\n* Adults aged 18-80 years.\n* Admission to a medical or mixed ICU.\n* Sepsis or septic shock according to Sepsis-3 criteria.\n* ICU admission for less than 24 hours.\n* Need for invasive or non-invasive mechanical ventilation and\u002For vasopressor support.\n* Informed consent obtained from the patient or legal representative.\n\nExclusion Criteria:\n\n* Moribund patients.\n* Age \\>80 years.\n* Patients under legal guardianship.\n* History of schizophrenia or bipolar disorder.\n* Pregnancy.\n* No health insurance coverage.\n* Previous inclusion in the study.\n* Refusal to participate.","ALL","18 Years","80 Years",{"count":62,"type":63},210,"ESTIMATED","INTERVENTIONAL",[66],"NA","To evaluate the value of biomarkers of neuronal and glial injury for predicting cognitive impairment (memory impairment assessed by a MoCA score \\\u003C 26\u002F30) at 3 months in patient admitted in the intensive care unit for a sepsis or a septic shock.",[69,70],"Sepsis","Septic Shock",[69,72,73,74,75,76],"Delirium","Post intensive care syndrome","Biomarkers","NSE","NFL","NOT_YET_RECRUITING","2026-08-03",{"date":80,"type":81},"2026-08-04","ACTUAL",{"date":83,"type":63},"2026-09",{"date":85,"type":63},"2028-08",{"name":5,"class":6},1]