[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604933":3},{"organization":4,"outcomesModule":7,"designInfo":28,"detailedDescription":31,"studyPopulation":32,"armGroups":33,"interventions":43,"overallOfficials":49,"centralContacts":53,"locations":59,"responsibleParty":76,"collaborators":11,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":11,"eligibilityCriteria":84,"healthyVolunteers":80,"sex":85,"minAge":86,"maxAge":11,"enrollmentInfo":87,"targetDuration":11,"studyType":90,"phases":11,"briefSummary":91,"conditions":92,"keywords":11,"overallStatus":61,"whyStopped":11,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Peking University Third Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"benign or malignant pathology results from biopsy or surgery",null,"within 1 month after SRUS imaging",[14,17,20,23,25],{"measure":15,"description":11,"timeFrame":16},"The expression level of various immuno-histochemical indicators of lymph nodes","within 2 months after SRUS imaging",{"measure":18,"description":11,"timeFrame":19},"Microvascular Quantitative Indices between benign and malignant lymph nodes by SRUS","within 2 months after the SRUS",{"measure":21,"description":11,"timeFrame":22},"Microvascular Quantitative Indices between lymph node metastasis and lymphoma","within 2 months after the SRUS imaging",{"measure":24,"description":11,"timeFrame":22},"Blood supply mode of CEUS between benign and malignant lymph nodes",{"measure":26,"description":27,"timeFrame":16},"Quantitative analysis parameters of CEUS between benign and malignant lymph nodes","Quantitative analysis parameters of CEUS including AT, TTP, PKI, MTT, and AUC between benign and malignant lymph nodes",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":29,"timePerspective":30,"maskingInfo":11},"COHORT","PROSPECTIVE","The study aim to evaluate the feasibility of SRUS technology in distinguishing between benign and malignant lymph nodes, and compare the differences in blood flow distribution, perfusion index, CEUS parameters, blood supply mode between benign and malignant lymph nodes under SRUS imaging.","Patients with abnormal lymph nodes and who are scheduled for lymph nodes puncture or fine needle aspiration or surgery",[34,39],{"label":35,"type":11,"description":36,"interventionNames":37},"benign lymph nodes","the lymph nodes are benign disease proved by pathology",[38],"Diagnostic Test: SRUS imaging of the lymph nodes before surgery or biopsy",{"label":40,"type":11,"description":41,"interventionNames":42},"malignant lymph nodes","lymph nodes are metastatic lymph nodes or lymphoma proved by pathology",[38],[44],{"type":45,"name":46,"description":47,"armGroupLabels":48,"otherNames":11},"DIAGNOSTIC_TEST","SRUS imaging of the lymph nodes before surgery or biopsy","Ultrasound contrast agent (Sonovue\u002FSonazoid) is administered to the patients through a peripheral vein. When the micro-bubbles enter the lymph nodes, super-resolution ultrasonography imaging will initiate immediately, to capture the trajectory of the micro-bubbles, thus construct a map of the microvascular distribution.",[35,40],[50],{"name":51,"affiliation":5,"role":52},"li g cui, Chief Physician","STUDY_CHAIR",[54],{"name":55,"role":56,"phone":57,"phoneExt":11,"email":58},"li g cui","CONTACT","+86 13910627163","cuijuegang@126.com",[60],{"facility":5,"status":61,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"RECRUITING","Beijing","Beijing Municipality","100049","China","CN",{"type":68,"coordinates":69},"Point",[70,71],116.39723,39.9075,{"lat":71,"lon":70},[74],{"name":75,"role":56,"phone":57,"phoneExt":11,"email":58},"li gang cui",{"type":77,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100604933","value-of-super-resolution-ultrasonography-in-differentiating-benign-and-malignant-lymph-nodes-100604933",false,"NCT07155954","Value of Super-resolution Ultrasonography in Differentiating Benign and Malignant Lymph Nodes","Value of Super-resolution Ultrasound Microvascular Imaging in Distinguishing Benign and Malignant Superficial Lymph Nodes: a Prospective Multi-center Study","Inclusion Criteria:\n\n* (1)suggested abnormal lymph nodes indicated by ultrasonography; (2) Patients scheduled for lymph nodes puncture or fine needle aspiration or surgery; (3) Age greater than or equal to 18 years old.\n\nExclusion Criteria:\n\n* (1) Pregnant and lactating women; (2)pathological results not indicating benign or malignant lymph nodes; (3) history of chemotherapy or radiotherapy ; (4) History of allergies to eggs, milk, and ultrasound contrast agents; (5) Patients with acute coronary syndrome, severe pulmonary hypertension, or acute respiratory distress syndrome.","ALL","18 Years",{"count":88,"type":89},779,"ESTIMATED","OBSERVATIONAL","Lymph nodes are one of the most important components of the human immune system, and superficial lymph node enlargement lacks specificity.\n\nUltrasound examination has been widely used in the diagnosis of lymph node lesions and is of great significance in distinguishing between benign and malignant. However, the two-dimensional and Doppler ultrasound features of different types of lymph node lesions overlap and intersect, and the blood flow perfusion information of lymph nodes can provide more information for differentiation.\n\nAt present, the widely used contrast-enhanced ultrasound is easier to evaluate blood flow perfusion and can display small blood vessels smaller than 100 microns. The diagnostic accuracy of cervical lymph nodes using contrast-enhanced ultrasound is 80-90%.\n\nHowever, current contrast-enhanced ultrasound is limited by physical diffraction, with a resolution ranging from sub-millimeter to millimeter. This limitation hinders the visualization of small blood vessels or microcirculation by ultrasound, and parameters such as vascular size, spatial vascular pattern, and velocity of microcirculation are crucial for disease diagnosis and prognosis evaluation. Super resolution ultrasound (SRUS) is a new blood flow imaging technique. By tracking the movement trajectory of micro-bubbles instead of imaging the micro-bubbles themselves, the ultrasound diffraction limit can be exceeded to improve the sensitivity and image resolution of blood flow.\n\nThus the study aim to evaluate the feasibility of SRUS technology in distinguishing between benign and malignant lymph nodes, and compare the differences in blood flow distribution and perfusion index between benign and malignant lymph nodes under SRUS imaging.",[93,94,95,96],"Lymphadenopathy","Lymphnode Metastasis","Lymphoma","Lymphatic Tuberculosis","2025-08-27",{"date":99,"type":100},"2025-09-04","ACTUAL",{"date":102,"type":100},"2024-10-23",{"date":104,"type":89},"2027-10-22",{"name":5,"class":6},1]