[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648621":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":12,"locations":7,"responsibleParty":22,"collaborators":7,"id":26,"slug":27,"hasResults":28,"nctId":29,"briefTitle":30,"officialTitle":31,"acronym":32,"eligibilityCriteria":33,"healthyVolunteers":28,"sex":34,"minAge":35,"maxAge":7,"enrollmentInfo":36,"targetDuration":7,"studyType":39,"phases":7,"briefSummary":40,"conditions":41,"keywords":43,"overallStatus":49,"whyStopped":7,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":7},{"fullName":5,"class":6},"Sichuan Academy of Medical Sciences","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"No study intervention","No study intervention. This is an observational cohort study using routine hemodynamic monitoring data (Pmsf and CVP) collected during standard clinical care.",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"rongan Liu","CONTACT","+8615928731511","35279240@qq.com",{"name":19,"role":15,"phone":20,"phoneExt":7,"email":21},"chunling Chen","+8618349304972","cclblingk@163.com",{"type":23,"investigatorFullName":24,"investigatorTitle":25,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Rongan Liu","Associate Chief Physician, Intensive Care Unit","100648621","venous-return-pressure-gradient-as-a-predictor-of-acute-kidney-injury-100648621",false,"NCT07722325","Venous Return Pressure Gradient as a Predictor of Acute Kidney Injury","Venous Return Pressure Gradient Predicts Acute Kidney Injury Onset and Progression","VRPG-AKI","Inclusion Criteria:\n\n1. Age ≥18 years\n2. Admitted to the intensive care unit (ICU) within 48 hours\n3. Central venous catheter in place for continuous central venous pressure (CVP) monitoring\n4. Radial artery catheter in place for hemodynamic monitoring including mean systemic filling pressure (Pmsf)\n5. No acute kidney injury (AKI) at ICU admission according to KDIGO criteria\n\nExclusion Criteria:\n\n1. Maintenance hemodialysis or continuous renal replacement therapy (CRRT) prior to ICU admission\n2. Previous kidney transplantation\n3. Pregnancy\n4. Extracorporeal membrane oxygenation (ECMO) support at ICU admission\n5. Incomplete core hemodynamic data precluding calculation of venous return pressure gradient (Pmsf-CVP) or AKI assessment","ALL","18 Years",{"count":37,"type":38},180,"ESTIMATED","OBSERVATIONAL","Acute kidney injury (AKI) is a common and serious complication in the ICU. Current diagnostic indicators (such as creatinine and urine output) exhibit significant lag, and specific hemodynamic predictive markers are lacking. The venous return pressure gradient (Pmsf-CVP), based on Guyton's theory, reflects the driving pressure for venous return; however, its value in the early warning of AKI remains unclear. This study aims to investigate the predictive value of the venous return pressure gradient for the onset and progression of AKI in ICU patients, and to clarify its effectiveness as an AKI risk warning indicator.\n\nPatients admitted to the ICU within 48 hours with risk factors for AKI (including sepsis, shock, major surgery, underlying diseases, etc.) who have radial artery catheterization and can undergo hemodynamic monitoring will be enrolled. Those undergoing maintenance dialysis\u002FCRRT, ECMO support, or with missing core data precluding calculation of Pmsf-CVP or AKI assessment will be excluded.\n\nThe venous return pressure gradient (Pmsf-CVP, mmHg) will be measured within 48 hours of ICU admission using the transient stop-flow arm arterial-venous equilibrium pressure method. The primary outcome is to evaluate the association between the venous return pressure gradient level and AKI occurrence. Secondary outcomes include correlation analyses between the venous return pressure gradient level and serum creatinine and urine output within 48 hours of ICU admission, among others.",[42],"AKI - Acute Kidney Injury",[44,45,46,47,48],"Venous return pressure gradient","Acute kidney injury","Mean systemic filling pressure","Central venous pressure","Intensive care","NOT_YET_RECRUITING","2026-07-22",{"date":52,"type":53},"2026-07-23","ACTUAL",{"date":55,"type":38},"2026-07-05",{"date":57,"type":38},"2027-05-01",{"name":5,"class":6}]