[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646351":3},{"organization":4,"armGroups":7,"interventions":77,"overallOfficials":101,"centralContacts":105,"locations":111,"responsibleParty":128,"collaborators":130,"id":134,"slug":135,"hasResults":136,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":83,"eligibilityCriteria":140,"healthyVolunteers":141,"sex":142,"minAge":143,"maxAge":83,"enrollmentInfo":144,"targetDuration":83,"studyType":147,"phases":148,"briefSummary":150,"conditions":151,"keywords":153,"overallStatus":164,"whyStopped":83,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":174},{"fullName":5,"class":6},"University of Virginia","OTHER",[8,17,21,26,30,34,37,41,45,49,53,57,61,65,69,73],{"label":9,"type":10,"description":11,"interventionNames":12},"VergeRx + SmokefreeTXT + 16-wk Patch + Lozenge","EXPERIMENTAL","VergeRx; SmokefreeTXT; Extended NRT Patch (16 wk); NRT Lozenge",[13,14,15,16],"Behavioral: VergeRx","Behavioral: SmokefreeTXT","Drug: NRT Lozenge (Combination)","Drug: Extended NRT Patch (16 weeks)",{"label":18,"type":10,"description":19,"interventionNames":20},"VergeRx + SmokefreeTXT + 16-wk Patch","VergeRx; SmokefreeTXT; Extended NRT Patch (16 wk)",[13,14,16],{"label":22,"type":10,"description":23,"interventionNames":24},"VergeRx + SmokefreeTXT + 8-wk Patch + Lozenge","VergeRx; SmokefreeTXT; Standard NRT Patch (8 wk); NRT Lozenge",[13,14,15,25],"Drug: Standard NRT Patch (8 weeks)",{"label":27,"type":10,"description":28,"interventionNames":29},"VergeRx + SmokefreeTXT + 8-wk Patch","VergeRx; SmokefreeTXT; Standard NRT Patch (8 wk)",[13,14,25],{"label":31,"type":10,"description":32,"interventionNames":33},"VergeRx + 16-wk Patch + Lozenge","VergeRx; Extended NRT Patch (16 wk); NRT Lozenge",[13,15,16],{"label":35,"type":10,"description":35,"interventionNames":36},"VergeRx + 16-wk Patch",[13,16],{"label":38,"type":10,"description":39,"interventionNames":40},"VergeRx + 8-wk Patch + Lozenge","VergeRx; Standard NRT Patch (8 wk); NRT Lozenge",[13,15,25],{"label":42,"type":10,"description":43,"interventionNames":44},"VergeRx + 8-wk Patch","VergeRx; Standard NRT Patch (8 wk)",[13,25],{"label":46,"type":10,"description":47,"interventionNames":48},"SmokefreeTXT + 16-wk Patch + Lozenge","SmokefreeTXT; Extended NRT Patch (16 wk); NRT Lozenge",[14,15,16],{"label":50,"type":10,"description":51,"interventionNames":52},"SmokefreeTXT + 16-wk Patch","SmokefreeTXT; Extended NRT Patch (16 wk)",[14,16],{"label":54,"type":10,"description":55,"interventionNames":56},"SmokefreeTXT + 8-wk Patch + Lozenge","SmokefreeTXT; Standard NRT Patch (8 wk); NRT Lozenge",[14,15,25],{"label":58,"type":10,"description":59,"interventionNames":60},"SmokefreeTXT + 8-wk Patch","SmokefreeTXT; Standard NRT Patch (8 wk)",[14,25],{"label":62,"type":10,"description":63,"interventionNames":64},"16-wk Patch + Lozenge","Extended NRT Patch (16 wk); NRT Lozenge",[16],{"label":66,"type":10,"description":67,"interventionNames":68},"16-wk Patch","Extended NRT Patch (16 wk)",[16],{"label":70,"type":10,"description":71,"interventionNames":72},"8-wk Patch + Lozenge","Standard NRT Patch (8 wk); NRT Lozenge",[25],{"label":74,"type":10,"description":75,"interventionNames":76},"8-wk Patch (reference)","Standard NRT Patch (8 wk)",[25],[78,84,88,93,97],{"type":79,"name":80,"description":81,"armGroupLabels":82,"otherNames":83},"BEHAVIORAL","VergeRx","Up to three pre-quit modules delivered by a local pharmacist\u002Ftechnician to promote NRT adherence; upon reported readiness to quit (assessed at weekly REDCap check-ins), participants advance to six treatment sessions over four weeks. Component ends if readiness is not reported after four weekly check-ins.",[35,31,42,38,18,9,27,22],null,{"type":79,"name":85,"description":86,"armGroupLabels":87,"otherNames":83},"SmokefreeTXT","Up to three 7-day pre-quit \"Daily Challenges\" text modules; upon reported readiness to quit, the SmokefreeTXT program delivers 3-5 messages\u002Fday for seven weeks. Component ends if readiness is not reported after four weekly check-ins.",[50,46,58,54,18,9,27,22],{"type":89,"name":90,"description":91,"armGroupLabels":92,"otherNames":83},"DRUG","NRT Lozenge (Combination)","Nicotine lozenge provided in addition to the NRT patch (combination NRT vs. patch monotherapy).",[46,54,31,38,9,22],{"type":89,"name":94,"description":95,"armGroupLabels":96,"otherNames":83},"Extended NRT Patch (16 weeks)","Nicotine patch provided for 16 weeks.",[66,62,50,46,35,31,18,9],{"type":89,"name":98,"description":99,"armGroupLabels":100,"otherNames":83},"Standard NRT Patch (8 weeks)","Nicotine patch provided for 8 weeks (all participants receive at least 8 weeks of patch beginning Week 1).",[74,70,58,54,42,38,27,22],[102],{"name":103,"affiliation":5,"role":104},"Melissa Little, PhD, MPH","PRINCIPAL_INVESTIGATOR",[106],{"name":107,"role":108,"phone":109,"phoneExt":83,"email":110},"Melissa A Little","CONTACT","4349241935","mal7uj@virginia.edu",[112],{"facility":5,"status":83,"city":113,"state":114,"zip":115,"country":116,"countryCode":117,"cosmosGeoPoint":118,"geoPoint":123,"contacts":124},"Charlottesville","Virginia","22904","United States","US",{"type":119,"coordinates":120},"Point",[121,122],-78.47668,38.02931,{"lat":122,"lon":121},[125],{"name":126,"role":108,"phone":127,"phoneExt":83,"email":110},"Melissa Little","434-924-1935",{"type":104,"investigatorFullName":103,"investigatorTitle":129,"investigatorAffiliation":5,"oldNameTitle":83,"oldOrganization":83},"Associate Professor",[131],{"name":132,"class":133},"National Cancer Institute (NCI)","NIH","100646351","vergerx-for-smokers-not-ready-to-quit-100646351",false,"NCT07693660","VergeRx for Smokers Not Ready to Quit","Optimizing Pharmacist-Led Tobacco Treatment for Individuals Who Smoke and Are Not Ready to Make a Quit Attempt in Federally-Qualified Health Centers","Inclusion Criteria:\n\n* Not ready to quit smoking in the next 30 days\n* Age ≥ 18 years\n* Able to read, speak, and understand English\n* Report smoking ≥ 5 cigarettes per day for the past 6 months\n* Own a cell phone\n* Willing and able to use nicotine replacement therapy (NRT) in the form of patch and lozenge\n\nExclusion Criteria:\n\n* Currently pregnant, or planning to become pregnant in the next 6 months",true,"ALL","18 Years",{"count":145,"type":146},592,"ESTIMATED","INTERVENTIONAL",[149],"NA","This study uses a factorial optimization experiment to identify which treatment components help adults who smoke and are not ready to quit in the next 30 days (smokers not ready to quit, or SNRTQ) achieve smoking cessation. Participants are recruited through Federally Qualified Health Centers (FQHCs) in Virginia and West Virginia. All participants receive at least 8 weeks of nicotine replacement therapy (NRT) patch. Using a 2×2×2×2 factorial design, the study independently tests four components: a pharmacist-delivered behavioral program (VergeRx), a text-message support program (SmokefreeTXT), the addition of an NRT lozenge to the patch, and an extended 16-week course of the NRT patch versus the standard 8 weeks. The goal is to estimate the effect of each component on biochemically confirmed smoking abstinence so that an optimized treatment package can be assembled. The primary outcome is abstinence at 26 weeks; a secondary outcome is abstinence at 52 weeks.",[152],"Tobacco Use Cessation",[154,155,156,157,158,159,160,161,162,163],"federally qualified health center","rural","urban","appalachia","smoking cessation","readiness to quit","smokers not ready to quit","pharmacists","low income","medicaid","NOT_YET_RECRUITING","2026-07-02",{"date":167,"type":168},"2026-07-09","ACTUAL",{"date":170,"type":146},"2027-12-01",{"date":172,"type":146},"2032-11-01",{"name":5,"class":6},1]