[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647478":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":18,"locations":18,"responsibleParty":25,"collaborators":18,"id":27,"slug":28,"hasResults":29,"nctId":30,"briefTitle":31,"officialTitle":32,"acronym":33,"eligibilityCriteria":34,"healthyVolunteers":35,"sex":36,"minAge":37,"maxAge":38,"enrollmentInfo":39,"targetDuration":18,"studyType":42,"phases":43,"briefSummary":45,"conditions":46,"keywords":48,"overallStatus":57,"whyStopped":18,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":18},{"fullName":5,"class":6},"Psychiatric University Hospital, Zurich","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Personalized VR exposure therapy in addition to treatment as usual","EXPERIMENTAL","Participants receive individualized therapist-guided virtual reality exposure sessions in addition to treatment as usual (TAU) during their inpatient stay. VR scenarios are selected and adapted according to each participant's individual emotional and environmental triggers using standardized 360° environments. Therapists gradually increase the intensity and complexity of exposure across sessions while applying cognitive behavioral therapy principles. Participants also complete all scheduled study assessments before the intervention, after completion of the intervention, and at follow-up.",[13],"Device: Virtual Reality Exposure Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Treatment as Usual","NO_INTERVENTION","Participants receive treatment as usual (TAU) provided as part of routine inpatient psychiatric care. TAU may include individual psychotherapy, group therapy, pharmacological treatment, occupational and recreational therapy, psychoeducation, and other clinical services according to individual treatment needs. Participants complete the same study assessments as the experimental group at baseline, post-intervention, and follow-up but do not receive the study-specific VR intervention.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DEVICE","Virtual Reality Exposure Therapy","The intervention consists of therapist-guided, individualized virtual reality (VR) exposure sessions delivered as an adjunct to treatment as usual during inpatient psychiatric care. Personalized VR scenarios are created using standardized 360° environments based on each participant's individual emotional and environmental triggers. Sessions include graded exposure, with therapists adapting the intensity and complexity of the scenarios according to treatment progress and individual needs. The intervention is delivered several times a week throughout the inpatient stay by trained therapists. The VR intervention is intended to improve emotion regulation by providing repeated, controlled exposure to clinically relevant situations within a safe and structured therapeutic environment.",[9],{"type":26,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100647478","virtual-reality-exposure-therapy-for-emotion-regulation-difficulties-in-adolescent-inpatients-100647478",false,"NCT07709468","Virtual Reality Exposure Therapy for Emotion Regulation Difficulties in Adolescent Inpatients","Investigating the Efficacy of a Virtual Reality Exposure Therapy Intervention Targeting Emotion Regulation Difficulties in Adolescent Inpatients","VRsafe","Inclusion Criteria:\n\n* Written informed consent\u002Fassent.\n* Age 11-18 years.\n* Intelligence Quotient (IQ) ≥ 85.\n* Ability and willingness to participate in VR procedures, behavioral tasks, and questionnaires.\n\nExclusion Criteria:\n\n* Major somatic or cardiovascular conditions.\n* Aggressive behavior posing a risk to self or others.\n* Participation in another clinical investigation within the previous 30 days.\n* Severe motion sickness or vestibular disorders.\n* Inability to comply with study procedures.\n* Discharge from the inpatient setting before completing the minimum intervention duration.",true,"ALL","11 Years","18 Years",{"count":40,"type":41},90,"ESTIMATED","INTERVENTIONAL",[44],"NA","The goal of this clinical trial is to evaluate whether a therapist-guided virtual reality (VR)-based intervention can improve emotion regulation in adolescents receiving inpatient psychiatric treatment. The study will also assess the feasibility, acceptability, and safety of the intervention, as well as explore factors that may predict treatment response.\n\nThe main questions it aims to answer are:\n\nDoes the VR-based intervention improve emotion regulation compared with a VR relaxation control intervention? Does the intervention reduce sensory sensitivities, anxiety, and related psychological symptoms? Which behavioral, physiological, and speech-based measures are associated with treatment response?\n\nResearchers will compare a personalized VR exposure intervention with a VR relaxation control intervention. Both groups will receive treatment as usual during their inpatient stay.\n\nParticipants will:\n\nBe randomly assigned to either the VR exposure or the VR relaxation group. Complete questionnaires, behavioral tasks, and clinical assessments before and after the intervention, with a follow-up assessment approximately three months later.\n\nParticipate in weekly therapist-guided VR sessions throughout their inpatient treatment.\n\nComplete additional assessments including speech recordings and standardized behavioral tasks to investigate predictors and mechanisms of treatment response.\n\nThroughout the study, participants will be monitored for adverse events and tolerability of the VR intervention.",[47],"Emotion Regulation Disorders",[49,22,50,51,52,53,54,55,56],"Virtual Reality","Emotion Regulation","Adolescents","Child and Adolescent Psychiatry","Inpatient Psychiatry","Anxiety Disorders","Social Anxiety","Sensory Sensitivity \u002F Sensory Over-Responsivity","NOT_YET_RECRUITING","2026-07-13",{"date":60,"type":61},"2026-07-16","ACTUAL",{"date":63,"type":41},"2026-08-04",{"date":65,"type":41},"2030-10",{"name":5,"class":6}]