[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648716":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":58,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":25,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":25,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Augusta University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Augusta Way","EXPERIMENTAL","Modified programming of VNS that provides rapid titration",[13],"Device: Rapid Titration VNS programming",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","ACTIVE_COMPARATOR","Standard of care VNS programming",[19],"Device: Standard VNS programming",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"DEVICE","Rapid Titration VNS programming",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Standard VNS programming","Standard of Care VNS programming",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Brandy Quarles, MPH","CONTACT","706-721-0390","bquarles@augusta.edu",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Wellstar MCG Hospital","RECRUITING","Augusta","Georgia","30912","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-81.97484,33.47097,{"lat":49,"lon":48},[52],{"name":32,"role":33,"phone":53,"phoneExt":25,"email":35},"7067210390",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Fernando Vale","Allen Distinguished Chair in Neurosurgery",[59],{"name":5,"class":6},"100648716","vns-algorithm-for-advanced-dosing-100648716",false,"NCT07725601","VNS Algorithm for Advanced Dosing","VNS Algorithm for Advanced Dosing: Example Guided Mode Titrations \"The Augusta Way\"","Inclusion Criteria:\n\n* Subjects who are clinically determined to be candidates for VNS implantation for seizure control\n* Subject\u002Flegally authorized representative able to provide informed consent.\n\nExclusion Criteria:\n\n* Subjects with VNS system treating pathologies other than drug refractory epilepsy or medical co-morbidities that prevent any surgical intervention","ALL","18 Years","75 Years",{"count":71,"type":72},80,"ESTIMATED","INTERVENTIONAL",[75],"NA","The goal of this clinical trial is to compare the standard programming of the VNS device (Control) to a modified programming (Augusta Way) in adults with epilepsy. The main question it aims to answer is:\n\nDoes the modified programming of the VNS reduce seizures faster than the standard programming?\n\nParticipants in both groups will:\n\n1. Attend up to 3 study visits every 3 months for 2 years\n2. Answer questionnaires to assess quality of life and cognitive function\n3. Maintain a diary of seizure activity",[78],"Epilepsies",[80,81],"Vagal Nerve Stimulation","Drug-Resistant Epilepsy","2026-07-23",{"date":84,"type":85},"2026-07-24","ACTUAL",{"date":87,"type":85},"2025-08-01",{"date":89,"type":72},"2030-12-30",{"name":56,"class":6},1]