[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623986":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":35,"locations":41,"responsibleParty":59,"collaborators":11,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":11,"enrollmentInfo":71,"targetDuration":11,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":44,"whyStopped":11,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Beijing Anzhen Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Catheter Ablation Group","EXPERIMENTAL",null,[13],"Procedure: Catheter Ablation",{"label":15,"type":16,"description":11,"interventionNames":17},"Sham Control Group","SHAM_COMPARATOR",[18],"Procedure: Sham Control",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","Catheter Ablation","Patients undergo PVI (for paroxysmal AF) or PVI +linear ablation+EI-VOM(for persistent AF). All patients will wear eye masks and headphones with music during the procedure.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Sham Control","Patients undergo femoral vein puncture and catheter placement. Phrenic nerve stimulation is performed to mimic procedural sensations. No ablation energy is delivered. All patients will wear eye masks and headphones with music during the procedure. Patients remain in the lab for at least 60 minutes (for paroxysmal AF) or 90 minutes (for persistent AF).",[15],[30,33],{"name":31,"affiliation":5,"role":32},"Changsheng Ma, Prof.","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":5,"role":32},"Ning Zhou, Prof.",[36],{"name":37,"role":38,"phone":39,"phoneExt":11,"email":40},"Liu He, PhD","CONTACT","+86 13810720787","theliu@139.com",[42],{"facility":43,"status":44,"city":45,"state":11,"zip":11,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Beijing Anzhen Hospital, Capital Medical University, Beijing, China","RECRUITING","Beijing","China","CN",{"type":49,"coordinates":50},"Point",[51,52],116.39723,39.9075,{"lat":52,"lon":51},[55,57,58],{"name":56,"role":38,"phone":39,"phoneExt":11,"email":40},"Liu He, PhD.",{"name":31,"role":32,"phone":11,"phoneExt":11,"email":11},{"name":34,"role":32,"phone":11,"phoneExt":11,"email":11},{"type":60,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100623986","wellbeing-and-survival-improvement-with-event-reduction-by-ablation-for-atrial-fibrillation-in-the-very-elderly-100623986",false,"NCT07403760","Wellbeing and Survival Improvement With Event Reduction by Ablation for Atrial Fibrillation in the Very Elderly","Wellbeing and Survival Improvement With Event Reduction by Ablation for Atrial Fibrillation in the Very Elderly (WISER-AF)","WISER-AF","Inclusion Criteria:\n\n1. Age ≥ 80 years.\n2. Documented paroxysmal or persistent atrial fibrillation by ECG or Holter within 6 months prior to enrollment.\n3. Symptomatic AF (including palpitations, chest tightness, fatigue, dizziness, blackouts, dyspnea).\n4. Voluntary participation and signed informed consent.\n\nExclusion Criteria:\n\n1. NYHA Class IV heart failure.\n2. Acute myocardial infarction, cardiac surgery, or PCI within the past 1 year.\n3. Long-standing persistent AF (duration \\> 1 year).\n4. Left atrial anteroposterior diameter \\> 6 cm.\n5. History of prior AF ablation.\n6. AF secondary to reversible causes (e.g., post-surgery, infection, hyperthyroidism).\n7. Severe mitral stenosis.\n8. Moderate to severe hepatic failure (Child-Pugh B-C).\n9. Renal failure stage 4-5 (eGFR \\\u003C30 ml\u002Fmin\u002F1.73m2) or continuous dialysis.\n10. Inability to cooperate due to dementia or severe mental disorder.\n11. Presence of left atrial thrombus.\n12. Prior Left Atrial Appendage Occlusion (LAAO).\n13. Contraindication to anticoagulation.\n14. Life expectancy \\\u003C 1 year.","ALL","80 Years",{"count":72,"type":73},136,"ESTIMATED","INTERVENTIONAL",[76],"NA","The WISER-AF trial is a multicenter, double-blind, sham-controlled, randomized controlled trial. It aims to evaluate the efficacy and safety of catheter ablation compared to a sham procedure in improving the quality of life (SF-36 score) in very elderly patients (aged ≥80 years) with symptomatic atrial fibrillation over a 6-month follow-up period.",[79],"Atrial Fibrillation (AF)",[81,82,83],"catheter ablation","very elderly","quality of life","2026-07-01",{"date":86,"type":87},"2026-07-06","ACTUAL",{"date":84,"type":73},{"date":90,"type":73},"2028-12-30",{"name":5,"class":6},1]