[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651358":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":25,"locations":39,"responsibleParty":133,"collaborators":25,"id":135,"slug":136,"hasResults":137,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":137,"sex":143,"minAge":144,"maxAge":145,"enrollmentInfo":146,"targetDuration":25,"studyType":149,"phases":150,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":166,"whyStopped":25,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":176},{"fullName":5,"class":6},"Beijing University of Chinese Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Yanlishuang Buccal Dropping Pills","EXPERIMENTAL","Participants allow 4 Yanlishuang Buccal Dropping Pills to dissolve in the mouth per dose, 4 to 6 times daily, with at least 2 hours between doses, for up to 5 days. Each pill weighs 0.025 g.",[13],"Drug: Yanlishuang Buccal Dropping Pills",{"label":15,"type":16,"description":17,"interventionNames":18},"Matching Placebo","PLACEBO_COMPARATOR","Participants allow 4 matching placebo buccal dropping pills to dissolve in the mouth per dose, 4 to 6 times daily, with at least 2 hours between doses, for up to 5 days. Each placebo pill weighs 0.025 g.",[19],"Drug: Yanlishuang Buccal Dropping Pills Placebo",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Miao medicine buccal dropping pills supplied by the sponsor. The protocol lists Aipian\u002Fnatural borneol, Blumea balsamifera oil, peppermint oil, menthol, and monoammonium glycyrrhizinate, with polyethylene glycol 6000 as excipient. Dose: 4 pills buccally per administration, 4 to 6 administrations per day, at intervals of at least 2 hours, for up to 5 days.",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Yanlishuang Buccal Dropping Pills Placebo","Matching placebo with identical dosage form, weight, packaging, schedule, and administration: 4 pills buccally per administration, 4 to 6 administrations per day, at intervals of at least 2 hours, for up to 5 days.",[15],[31,35,37],{"name":32,"affiliation":33,"role":34},"Chunjiang Huang","Yunnan Provincial Hospital of Traditional Chinese Medicine \u002F The First Affiliated Hospital of Yunnan University of Chinese Medicine","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":33,"role":34},"Jianping Liu",{"name":38,"affiliation":33,"role":34},"Jianchang He",[40,52,61,70,79,88,97,106,115,124],{"facility":41,"status":25,"city":42,"state":43,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":25},"First Affiliated Hospital of Guangzhou University of Chinese Medicine","Guangzhou","Guangdong","China","CN",{"type":47,"coordinates":48},"Point",[49,50],113.25,23.11667,{"lat":50,"lon":49},{"facility":53,"status":25,"city":54,"state":55,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":56,"geoPoint":60,"contacts":25},"Affiliated Hospital of Guizhou Medical University","Guiyang","Guizhou",{"type":47,"coordinates":57},[58,59],106.71667,26.58333,{"lat":59,"lon":58},{"facility":62,"status":25,"city":63,"state":64,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":65,"geoPoint":69,"contacts":25},"First Affiliated Hospital of Heilongjiang University of Chinese Medicine","Harbin","Heilongjiang",{"type":47,"coordinates":66},[67,68],126.65,45.75,{"lat":68,"lon":67},{"facility":71,"status":25,"city":72,"state":73,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":74,"geoPoint":78,"contacts":25},"Jiangsu Province Hospital of Chinese Medicine","Nanjing","Jiangsu",{"type":47,"coordinates":75},[76,77],118.77778,32.06167,{"lat":77,"lon":76},{"facility":80,"status":25,"city":81,"state":82,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":83,"geoPoint":87,"contacts":25},"Jiangxi Provincial Hospital of Traditional Chinese Medicine","Nanchang","Jiangxi",{"type":47,"coordinates":84},[85,86],115.85306,28.68396,{"lat":86,"lon":85},{"facility":89,"status":25,"city":90,"state":91,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":92,"geoPoint":96,"contacts":25},"First Affiliated Hospital of Shandong University of Traditional Chinese Medicine \u002F Shandong Provincial Hospital of Traditional Chinese Medicine","Jinan","Shandong",{"type":47,"coordinates":93},[94,95],116.99722,36.66833,{"lat":95,"lon":94},{"facility":98,"status":25,"city":99,"state":100,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":101,"geoPoint":105,"contacts":25},"Shanghai Municipal Hospital of Traditional Chinese Medicine","Shanghai","Shanghai Municipality",{"type":47,"coordinates":102},[103,104],121.45806,31.22222,{"lat":104,"lon":103},{"facility":107,"status":25,"city":108,"state":109,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":110,"geoPoint":114,"contacts":25},"Affiliated Hospital of Chengdu University of Traditional Chinese Medicine \u002F Sichuan Provincial Hospital of Traditional Chinese Medicine","Chengdu","Sichuan",{"type":47,"coordinates":111},[112,113],104.06667,30.66667,{"lat":113,"lon":112},{"facility":116,"status":25,"city":117,"state":118,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":119,"geoPoint":123,"contacts":25},"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","Tianjin","Tianjin Municipality",{"type":47,"coordinates":120},[121,122],117.17667,39.14222,{"lat":122,"lon":121},{"facility":125,"status":25,"city":126,"state":127,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":128,"geoPoint":132,"contacts":25},"First Affiliated Hospital of Yunnan University of Chinese Medicine \u002F Yunnan Provincial Hospital of Traditional Chinese Medicine","Kunming","Yunnan",{"type":47,"coordinates":129},[130,131],102.71833,25.03889,{"lat":131,"lon":130},{"type":34,"investigatorFullName":134,"investigatorTitle":5,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Mei Han","100651358","yanlishuang-buccal-dropping-pills-for-acute-pharyngitis-100651358",false,"NCT07761013","Yanlishuang Buccal Dropping Pills for Acute Pharyngitis","A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial to Evaluate the Efficacy and Safety of Miao Medicine Yanlishuang Buccal Dropping Pills in Adults With Acute Pharyngitis","YLS-AP-RCT","Inclusion Criteria:\n\n* Age 18 to 65 years, inclusive, of any sex.\n* Baseline throat-pain visual analog scale score of at least 4.\n* Meets the protocol-defined Western medicine diagnostic criteria for acute pharyngitis.\n* Acute onset with disease duration of 48 hours or less.\n* Provides written informed consent and is able to follow the study protocol.\n\nExclusion Criteria:\n\n* Prior use of Yanlishuang Buccal Dropping Pills before enrollment, or use before enrollment of any other Chinese or Western medicine for the target disease that, in the investigator's judgment, may affect efficacy evaluation.\n* Prodromal or accompanying throat symptoms of an acute infectious disease, such as measles, scarlet fever, or infectious mononucleosis; suppurative tonsillitis; peritonsillar abscess; retropharyngeal abscess; acute epiglottitis; or throat symptoms caused by another disease.\n* Modified Centor score of at least 2, with white blood cell count, absolute neutrophil count, and C-reactive protein all above the upper limit of normal, when the investigator considers bacterial infection or antibiotic treatment necessary.\n* Concurrent bacterial otitis media, sinusitis, laryngitis, bronchitis, pneumonia, acute nephritis, rheumatic fever, sepsis, or a similar complication.\n* Severe primary disease of the central nervous, hematopoietic, endocrine, cardiovascular\u002Fcerebrovascular, digestive, or other system, or a psychiatric disorder, that the investigator considers may affect participant safety or materially affect clinical evaluation.\n* Abnormal hepatic or renal function: alanine aminotransferase or aspartate aminotransferase greater than 1.5 times the upper limit of normal and\u002For serum creatinine above the upper limit of normal.\n* Suspected or confirmed history of alcohol or drug abuse.\n* Pregnancy, breastfeeding, preparation for pregnancy, or a recent childbearing plan.\n* Known allergy to any component of the study medication.\n* Participation in another clinical trial and use of an investigational product within the previous 1 month.\n* Constitutional spleen-stomach deficiency-cold or a condition considered unsuitable for study medication, including but not limited to acute or chronic gastritis, erosive gastritis, or gastroesophageal reflux disease.\n* Any other condition that the investigator considers makes the individual unsuitable for participation.","ALL","18 Years","65 Years",{"count":147,"type":148},400,"ESTIMATED","INTERVENTIONAL",[151],"NA","Acute pharyngitis commonly causes sore throat and pain on swallowing. This multicenter trial will compare Yanlishuang Buccal Dropping Pills with a matching placebo in 400 adults aged 18 to 65 years whose acute pharyngitis began within 48 hours and whose baseline throat-pain visual analog scale score is at least 4. Participants will be randomized 1:1 and treated under double-blind conditions. Each group will use four buccal dropping pills 4 to 6 times daily at intervals of at least 2 hours for up to 5 days. Participants whose sore throat resolves after at least 72 hours and remains absent for at least 24 hours may stop treatment early. The primary outcome is time to complete sore throat resolution. Secondary outcomes assess immediate pain relief, onset and resolution of pain, symptom and physical-sign response, complications, and work absence. Safety will be assessed using physical examinations, vital signs, laboratory tests, electrocardiograms, and adverse events.",[154],"Acute Pharyngitis",[156,157,158,159,160,161,162,163,164,165],"acute pharyngitis","sore throat","swallowing pain","resting throat pain","visual analog scale","Miao medicine","Traditional Chinese Medicine","Yanlishuang","buccal dropping pills","placebo-controlled trial","NOT_YET_RECRUITING","2026-08-07",{"date":169,"type":170},"2026-08-12","ACTUAL",{"date":172,"type":148},"2026-08-01",{"date":174,"type":148},"2027-06-29",{"name":5,"class":6},10]