[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648244":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":26,"responsibleParty":45,"collaborators":26,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":26,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":26,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":26,"overallStatus":69,"whyStopped":26,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":75,"leadSponsor":77,"locationsCount":26},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Zirconia Crown Group- Intervention: Restoration of severely mutilated anterior primary teeth using p","EXPERIMENTAL","Restoration of decayed anterior primary teeth using prefabricated zirconia crowns.",[13],"Procedure: Zirconia Crown",{"label":15,"type":16,"description":17,"interventionNames":18},"Extraction Group - Intervention: Extraction of severely mutilated anterior primary teeth, without an","ACTIVE_COMPARATOR","Extraction of decayed anterior primary teeth, without anterior prosthetic replacement.",[19],"Procedure: Extraction",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Zirconia Crown","Restoration of severely mutilated anterior primary teeth using prefabricated zirconia crowns performed.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Extraction","Extraction of severely mutilated anterior primary teeth, without anterior prosthetic replacement.",[15],[32],{"name":33,"affiliation":5,"role":34},"Cairo University Cairo University","STUDY_CHAIR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Passant Nagi, A. professor","CONTACT","+201120655633","passant.nagi@dentistry.cu.edu.eg",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Ahmed Elkhadem, Professor","+01064440888","Ahmed.elkhadem@dentistry.cu.edu.eg",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Passant Nagy","Associate Professor","100648244","zirconia-crowns-versus-extraction-of-primary-anterior-teeth-100648244",false,"NCT07719478","Zirconia Crowns Versus Extraction of Primary Anterior Teeth","Patient-centred, Developmental and Quality-of-life Outcomes Following Zirconia Crown Restoration Versus Extraction of Severely Mutilated Primary Anterior Teeth: a Pragmatic Comparative Clinical Study","Inclusion Criteria:\n\n* Children aged 3-5 years\n* Presence of one or more decayed primary anterior teeth\n* Written informed consent from parent or legal guardian\n\nExclusion Criteria:\n\n* Craniofacial anomalies or genetic syndromes\n* Diagnosed developmental delay or speech disorders\n* Previous speech therapy\n* Systemic disease contraindicating general anaesthesia",true,"ALL","3 Years","5 Years",{"count":61,"type":62},60,"ESTIMATED","INTERVENTIONAL",[65],"NA","Severely mutilated anterior primary teeth in preschool children are frequently managed by extraction. However, premature loss of anterior primary teeth has been associated with adverse functional, developmental and psychosocial outcomes, including impaired oral health-related quality of life (OHRQoL), speech concerns and negative self-image.\n\nPrefabricated zirconia crowns offer an aesthetic and durable restorative alternative for compromised anterior primary teeth. Despite increasing clinical use, comparative evidence evaluating zirconia crown restoration versus extraction under equivalent conditions using validated patient-centred, developmental and economic outcomes remains limited.\n\nThis pragmatic, prospective, non-randomised controlled clinical study aims to compare zirconia crown restoration and extraction of severely mutilated anterior primary teeth performed under GA in preschool children. Outcomes include OHRQoL, parental satisfaction, child self-image, and speech development.",[68],"Early Childhood Caries (ECC)","NOT_YET_RECRUITING","2026-07-18",{"date":72,"type":73},"2026-07-22","ACTUAL",{"date":70,"type":62},{"date":76,"type":62},"2026-08-01",{"name":47,"class":6}]