[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"18-years-and-older\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:18-years-and-older":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100648978","preoperative-genicular-radiofrequency-and-functional-outcomes-after-total-knee-arthroplasty-100648978",false,"NCT07727551","Preoperative Genicular Radiofrequency and Functional Outcomes After Total Knee Arthroplasty","Enhancing Functional Outcomes in Total Knee Arthroplasty: the Role of Preoperative Genicular Radiofrequency","Inclusion Criteria:\n\n* Age between 18 and 60\n* Elective total knee arthroplasty\n* 2 to 6 weeks before the procedure\n\nAND either of:\n\n* BMI \\> 35\n* Diabetes under insulin\n* Anxiety disorder\n* Treated depressive disorder\n* Widespread pain disorder or central sensitisation disorder\n* Chronic pain at a different site\n* Catastrophising\n* Sleep disorder\n* preoperative EVA 7 or more\n* OKS 25 or less\n* WOMAC 50 or more\n* Previous total knee arthroplasty (contralateral)\n* Knee CRPS\n\nExclusion Criteria:\n\n* Previous prosthetic surgery on the same knee (i.e. redo surgery, open reduction internal fixation, knee hemiarthroplasty)\n* Major psychiatric disorder (i.e. major depression, schizophrenia)\n* Patient refusal\n* Inability to communicate with the patient and obtain informed consent","ALL","18 Years","60 Years",{"count":20,"type":21},44,"ESTIMATED","INTERVENTIONAL",[24],"NA","Knee osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage wear, leading to pain, stiffness, and joint swelling. It is highly prevalent in aging populations and is strongly associated with obesity and previous joint injury. OA affects millions of individuals worldwide, with incidence and prevalence increasing markedly with age and resulting in significant functional disability\n\nThe primary therapeutic goals in the management of knee osteoarthritis are pain reduction and improvement of joint mobility.\n\nTotal knee arthroplasty is considered one of the most effective surgical interventions for relieving pain and restoring function in patients with severe knee osteoarthritis. Nevertheless, residual pain and limited functional improvement remain the most frequent causes of patient dissatisfaction following TKA\n\nGenicular nerve radiofrequency ablation (GNRFA) has emerged as an innovative treatment option for symptomatic knee osteoarthritis. This technique has been shown to reduce pain and improve function, with clinical benefits often observed as early as one week after treatment. GNRFA consistently provides short-term pain relief (3 to 6 months) and, in some cases, longer-lasting benefits.\n\nThe hypothesis tested in this study is whether GNRFA performed at least two weeks preoperatively can reduce postoperative pain and improve postoperative function.",[27,28],"Total Knee Arthroplasty Secondary to Osteoarthritis","18 Years and Older",[30,31],"Radiofrequency ablation","Genicular nerve","RECRUITING","2026-07-22",{"date":35,"type":36},"2026-07-27","ACTUAL",{"date":38,"type":36},"2026-06-01",{"date":40,"type":21},"2027-06",{"name":42,"class":43},"Anesthesiology department Iris South Hospitals","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":17,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":72,"leadSponsor":74,"locationsCount":5},"100627673","the-effect-of-the-world-health-organisation-based-intrapartum-care-model-on-labour-pain-comfort-satisfaction-and-postpartum-depression-100627673","NCT07451691","The Effect of the World Health Organisation-Based Intrapartum Care Model on Labour Pain, Comfort, Satisfaction and Postpartum Depression","The Effect of the World Health Organisation-Based Intrapartum Care Model on Labour Pain, Comfort, Satisfaction and Postpartum Depression: A Randomised Controlled Trial","WHO-ICARE Tria","Inclusion Criteria:\n\n* Age: 18 years and older\n\nGestational status: Term pregnancy\n\nExclusion Criteria:\n\n* those with psychological problems",true,"FEMALE","49 Years",{"count":57,"type":21},108,[24],"This randomized controlled trial aims to evaluate the effects of the World Health Organization-based intrapartum care model on labour pain, labour comfort, childbirth satisfaction, and postpartum depression. The intrapartum care model emphasizes woman-centred, respectful, and supportive care throughout labour, promoting continuous support, effective communication, and active involvement of women in decision-making processes. Although this approach has been associated with improved labour experiences, including reduced pain, increased comfort and satisfaction, evidence from randomized controlled trials evaluating these outcomes together with postpartum depression in a comprehensive framework remains limited. This study seeks to provide high-quality evidence on the impact of the intrapartum care model on maternal childbirth experience and postpartum mental health.",[28,61],"Term Pregnancy",[63,64,65,66],"Labor Pain","Childbirth","Normal Vaginal","Maternal Comfort","NOT_YET_RECRUITING","2026-03-02",{"date":70,"type":36},"2026-03-05",{"date":70,"type":21},{"date":73,"type":21},"2026-03-15",{"name":75,"class":43},"Kahramanmaras Sutcu Imam University"]