[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"ARQ National Psychotrauma Centre\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":80},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100653897","phase-2-psilocybin-assisted-psychotherapy-for-veterans-with-ptsd-100653897",false,"NCT07792538","Psilocybin-Assisted Psychotherapy for Veterans With PTSD","Psilocybin-Assisted Psychotherapy for Posttraumatic Stress Disorder in Military Veterans: A Pilot Feasibility Study","PsiVet","Inclusion Criteria:\n\n* Are between 18 and 70 years old.\n* Able to provide written informed consent.\n* Fluent in speaking and reading Dutch.\n* Is a veteran of the Dutch Armed Forces.\n* Able to swallow pills.\n* Have a body mass index (kg\u002Fm2) of \\>18.0.\n* Meet DSM-5 criteria for current PTSD.\n* Meet criteria for treatment-refractory PTSD.\n* Agree to have study visits audiovisually recorded.\n* Able to provide a contact (relative, spouse, close friend, or other support person) who is willing and able to be reached by the investigators in the event of the participant becoming unwell or unreachable.\n\nExclusion Criteria:\n\n* Has a history of any medical condition that could make receiving psilocybin harmful because of temporary increases in blood pressure and heart rate.\n* Has a medical or psychiatric condition that could interfere with study participation or pose a risk to the participant's safety or well-being.\n* Has uncontrolled hypertension.\n* Unable or unwilling to safely taper-off prohibited psychiatric medication.\n* Has been exposed to electroconvulsive therapy (ECT) within 12 weeks of enrollment.\n* Has any current problem which, in the opinion of the investigator, might interfere with study participation.","ALL","18 Years","70 Years",{"count":21,"type":22},12,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","This study will evaluate the feasibility, safety and preliminary efficacy of psilocybin-assisted psychotherapy in military veterans with treatment-refractory posttraumatic stress disorder (PTSD).",[28],"Posttraumatic Stress Disorder (PTSD)",[30,31,32,33,34,35],"Psilocybin","PTSD","Veterans","Psilocybin-assisted psychotherapy","Posttraumatic stress disorder","Psychotherapy","NOT_YET_RECRUITING","2026-08-25",{"date":39,"type":40},"2026-08-28","ACTUAL",{"date":42,"type":22},"2026-12",{"date":44,"type":22},"2028-12",{"name":46,"class":47},"ARQ National Psychotrauma Centre","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},"100569926","first-line-intervention-for-ptsd---intensive-treatment-100569926","NCT06700590","First-Line Intervention for PTSD - Intensive Treatment","(Cost)-Effectiveness of Intensive Trauma-Focused Treatment Versus Spaced Trauma-Focused Treatment As First Line Treatment for Post-Traumatic Stress Disorder in Adults with Multiple Trauma Exposure: Randomized Controlled Trial","FLIP-IT","Inclusion Criteria:\n\n* 18 years or older\n* PTSD diagnosis according to DSM-5 (CAPS-5);\n* PTSD diagnosis stemming from 2 or more potentially traumatic events (PTEs)\n* seeking first-time treatment for PTSD (or less than 8 sessions);\n* employed (working or on sick leave for less than two years)\n\nExclusion Criteria:\n\n* Current psychotic disorder, severe alcohol or substance use disorder, high suicidal intent (MINI-S for DSM-5) and a concrete suicide plan, or severe aggressive behavior that poses danger for others\n* insufficient command of the Dutch language to be able to complete the assessments. This will be determined through clinical judgment at intake.",{"count":58,"type":22},186,[60],"NA","The goal of this clinical trial is to learn if an intensive program can treat post-traumatic stress disorder (PTSD) in adults getting treatment for the first time, and whether it has lower societal costs. The main questions it aims to answer are:\n\n* Does an intensive program reduce PTSD symptoms?\n* How expensive is it on a societal level? Researchers will compare the intensive program to the standard weekly treatment to see if the intensive program works to treat PTSD.\n\nParticipants will:\n\n* Get 5 days of intensive treatment in two weeks (with two preparatory and closing sessions), or weekly sessions\n* Get questionnaires and interviews 5 times in 9 months",[63],"PTSD - Post Traumatic Stress Disorder",[65,66,67,68,69],"intensive treatment","massed treatment","randomized controlled trial","RCT","first time treatment","RECRUITING","2025-02-27",{"date":73,"type":40},"2025-03-03",{"date":75,"type":40},"2024-11-21",{"date":77,"type":22},"2028-07-01",{"name":46,"class":47},4,""]