[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Affiliated 2 Hospital of Nantong University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":99},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100648050","phase-4-ciprofol-and-remimazolam-for-intraoperative-neurophysiological-monitoring-during-spine-surgery-100648050",false,"NCT07718152","Ciprofol and Remimazolam for Intraoperative Neurophysiological Monitoring During Spine Surgery","Effects of Alternating Ciprofol and Remimazolam on Intraoperative Motor and Somatosensory Evoked Potentials During Spine Surgery: A Randomized Crossover Trial","CIRIONM","Inclusion Criteria:\n\n1. Age 18 to 75 years.\n2. Scheduled to undergo elective spine surgery.\n3. Planned intraoperative monitoring with MEP and SEP\u002FSSEP.\n4. Expected surgical duration sufficient to complete two study drug periods and intraoperative monitoring windows, preferably at least 3.5 to 4 hours.\n5. American Society of Anesthesiologists physical status I to III.\n6. Able to provide written informed consent, or consent provided by a legally authorized representative where applicable.\n\nExclusion Criteria:\n\n1. Known allergy or contraindication to ciprofol, remimazolam, benzodiazepines, propofol-related formulations, opioids, or relevant excipients.\n2. Severe preoperative motor or sensory deficit preventing interpretable target MEP or SEP baseline recordings.\n3. Implanted cardiac pacemaker, skull defect, or other condition considered unsuitable for transcranial electrical stimulation.\n4. Severe neuromuscular disease, poorly controlled epilepsy, severe cognitive impairment, or inability to complete postoperative neurological assessment.\n5. Severe hepatic or renal dysfunction, severe hemodynamic instability, shock, or requirement for high-dose vasoactive medications before enrollment.\n6. Long-term benzodiazepine, sedative-hypnotic, antiepileptic drug use, or drug\u002Falcohol dependence that may substantially alter anesthetic response.\n7. Expected need for continuous deep neuromuscular blockade during surgery, preventing valid MEP monitoring.\n8. Any other condition judged by the investigators to make participation unsuitable or unsafe.","ALL","18 Years","75 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","Intraoperative neurophysiological monitoring, including motor evoked potentials and somatosensory evoked potentials, is commonly used during spine surgery to help detect impending neurological injury. The quality of these signals can be affected by anesthetic agents. Ciprofol and remimazolam are newer intravenous hypnotic agents that may be suitable for total intravenous anesthesia during procedures requiring neurophysiological monitoring, but direct within-patient comparisons between the two agents are lacking. This single-center, prospective, randomized, two-sequence crossover trial will compare the effects of ciprofol and remimazolam, administered with remifentanil, on intraoperative MEP and SEP signal quality during spine surgery. Eligible participants will be randomized to receive either ciprofol followed by remimazolam or remimazolam followed by ciprofol during predefined stable intraoperative monitoring windows. The primary outcome is the within-participant difference in lower-extremity MEP peak-to-peak amplitude between the ciprofol and remimazolam periods. Secondary outcomes include SEP amplitude and latency, MEP latency, warning-threshold events, hemodynamic variables, rescue medication requirements, recovery characteristics, and postoperative neurological status.",[28,29,30],"Intraoperative Neurophysiological Monitoring","Spine Surgery","Anesthesia",[32,33,34,35,36,37,38,39],"Ciprofol","Remimazolam","Motor evoked potential","Somatosensory evoked potential","Intraoperative neurophysiological monitoring","Spine surgery","Total intravenous anesthesia","Crossover trial","NOT_YET_RECRUITING","2026-07-17",{"date":43,"type":44},"2026-07-21","ACTUAL",{"date":46,"type":22},"2026-08",{"date":48,"type":22},"2027-01",{"name":50,"class":51},"Affiliated 2 Hospital of Nantong University","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},"100552853","laminoplasty-for-multilevel-cervical-spondylotic-myelopathy-guided-by-modified-k-line-and-modified-sc-line-in-mri-100552853","NCT06478485","Laminoplasty for Multilevel Cervical Spondylotic Myelopathy Guided by Modified K-line and Modified SC-line in MRI","Feasibility and Clinical Applicability of Surgical Segments Choice for Laminoplasty in Multilevel Cervical Spondylotic Myelopathy Guided by Modified K-line and Modified SC-line in MRI","Inclusion Criteria:\n\n(1) Diagnosis of MCSM confirmed by two spine surgeons with MRI examination and clinic signs; (2) More than 2 level lesions and\u002For spinal stenosis in MRI, underwent LAMP surgery; (3) Available for both preoperative and follow-up imaging data and clinical data, including sex, age, clinical symptoms, Japanese Orthopedic Association (JOA) score, Visual Analog Scale (VAS) score, Neck Disability Index(NDI) score and MRI data.\n\nExclusion Criteria:\n\n(1) Previous cervical spine surgery; (2) Diagnosis of tumor, central cord syndrome, infection or other acute traumatic injuries; (3) Diagnosed neurological disorders Parkinson's disease, polio, multiple sclerosis, or other central and peripheral nervous system diseases).",{"count":60,"type":22},300,"OBSERVATIONAL","This study intended to investigate the combined Impact of mK-line and mSC-line on the selection of the surgical approach and whether could be used to predict sufficient decompression of cervical spinal cord and clinical outcome in patients after LAMP.",[64],"Modified K-line and Modified SC-line in MRI",[66,67,68],"mK-line","mSC-line","Multilevel Cervical Spondylotic Myelopathy","RECRUITING","2024-06-28",{"date":72,"type":44},"2024-07-01",{"date":74,"type":44},"2020-01-01",{"date":76,"type":22},"2027-12-30",{"name":50,"class":51},1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":78},"100549644","artificial-intelligence-model-for-traumatic-cervical-spinal-cord-injury-based-on-radiomics-and-genomics-100549644","NCT06436716","Artificial Intelligence Model for Traumatic Cervical Spinal Cord Injury Based on Radiomics and Genomics","The Second Affiliated Hospital of Nantong University, Nantong First People's Hospital, Nantong University","Inclusion Criteria:\n\n1. MRI Diagnosis of TCSCI\n2. Clinic Diagnosis of TCSCI\n3. The injury site must be in cervical spinal cord\n4. MRI images of T2WI must be collected within 48 hours after injury\n5. Complete and available imaging data, clinical data, including MRI, sex, age\n\nExclusion Criteria:\n\n1. Spinal cord concussion and MRI scans have no obvious positive performance of spinal cord\n2. The quality of MRI images is insufficient or there are serious motion artifacts",true,{"count":60,"type":22},"Collect standardized, structured, and comprehensive disease-specific information, produce high-quality and accurate clinical data, provide a sample basis for the analysis and mining of spinal cord injury clinical big data, and establish a spinal cord injury-specific disease data platform to serve clinical work. Promote multi-center cooperation in spinal cord injury research: Establish a unified, standardized, queryable, and sharable efficient spinal cord clinical research data platform to promote multi-center cooperation in spinal cord injury clinical research and enhance the international competitiveness of this research field. Help the region to prepare for the establishment of a spinal cord injury-specific disease data platform for various hospitals in the region, forming a spinal cord injury-specific disease network center to achieve data sharing.",[90],"Spinal Cord Injuries","2024-05-24",{"date":93,"type":44},"2024-05-31",{"date":95,"type":44},"2016-01",{"date":97,"type":22},"2027-12",{"name":50,"class":51},""]