[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Africa Health Research Institute\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":104},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100650052","community-popular-opinion-leader-intervention-for-hiv-prevention-uptake-in-rural-south-africa-100650052",false,"NCT07741474","Community Popular Opinion Leader Intervention for HIV Prevention Uptake in Rural South Africa","Adapting and Piloting a Community Popular Opinion Leader Intervention to Increase Uptake of HIV Prevention Interventions in Rural South Africa","Izinkanyezi","Inclusion Criteria:\n\n* Resident in Sixhumene study area household\n\nExclusion Criteria:\n\n* Unable to provide informed consent",true,"ALL","18 Years","28 Years",{"count":22,"type":23},60,"ESTIMATED","INTERVENTIONAL",[26],"NA","The Community Popular Opinion Leader (CPOL) is an intervention dveloped in the United States which identifies, trains, and enlists key opinion leaders within communities to deliver messages to peers and help link them to services. This project involves testing the feasibility and acceptability of such a localized version of the CPOL intervention in rural South Africa. This will be achieved through a pilot intervention in three purposively selected communities in the Hlabisa sub-district of uMkhanyakude district, KwaZulu-Natal. The investigators will select potential peer leaders in three ways (at random; based on nominations by peers; based on statistical analysis of previously collected social network data). Peer leaders will be invited to attend four weekly training sessions to learn about HIV prevention and persuasive communication. They will then be coached to start HIV prevention conversations with peers, including provision of HIV self-test kits and linkage to healthcare services. The investigators will evaluate this pilot using group discussions, in-depth interviews and brief pre\u002Fpost questionnaires with session facilitators, peer leaders, contacted peers and healthcare providers. The investigators will analyse the data collected with the Practical, Robust Implementation and Sustainability Model (PRISM) dissemination and implementation framework, identifying factors likely to affect Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM).",[29,30],"HIV","Sexually Transmitted Infections (STI)",[32,33,34,35,36,37],"pilot","HIV prevention","behavior change","risk communication","HIV self-testing","social networks","NOT_YET_RECRUITING","2026-07-30",{"date":41,"type":42},"2026-08-03","ACTUAL",{"date":44,"type":23},"2026-08",{"date":46,"type":23},"2026-10",{"name":48,"class":49},"Africa Health Research Institute","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":17,"sex":18,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":24,"phases":63,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":75,"locationsCount":50},"100535336","phase-3-long-acting-hiv-pre-exposure-prophylaxis-integrated-with-sexual-and-reproductive-health---crct-100535336","NCT06250504","Long-Acting HIV Pre-Exposure Prophylaxis Integrated With Sexual and Reproductive Health - cRCT","Long-acting HIV Pre-Exposure Prophylaxis Integrated With Community-based Sexual and Reproductive Health in South Africa (LAPIS): A Hybrid (1a) Cluster Randomised Controlled Phase 3B Trial of Effectiveness and Implementation","LAPIS","Inclusion Criteria:\n\nAll young men and women aged 15-30 who are residing in the 40 administrative clusters in the study district and attend any integrated SRH\u002FHIV service\n\nDocumented HIV negative test\n\nSuitable for PrEP and\u002For already on PrEP\n\nWeight \\> 35 kg\n\nUnderstand the required dosing schedule and HIV testing.\n\nAware that details can be shared with a peer navigator to support their follow-up\n\nIf pregnant or breast feeding and\u002For planning to become pregnant participant can be offered CAB LA, if risk of acquiring HIV out weighs unknown risk of CAB LA, but must understand that safety in pregnancy or breast feeding for CAB LA has not been established and oral daily PrEP is a safe alternative.\n\nExclusion Criteria:\n\nHistory or presence of allergy to the study drugs or their components\n\nInvestigator assessment find them not suitable\n\nAdditional exclusion criteria for specific products:\n\nCAB LA: Taking medication that is contraindicated (Carbamazepine, oxcarbazepine, phenobarbital, phenytoin, Rifampin, rifapentine) and Severe mental health disorder, Hep B surface antigen positive, living with hepatitis C and not yet treated, or abnormal liver function tests (ALT more than two times the upper limit of normal)\n\nDapiRing: Pregnancy.","15 Years","30 Years",{"count":62,"type":23},2052,[64],"PHASE3","The goal of this hybrid (1a) Cluster Randomised Controlled Trial phase 3B trial is to evaluate the effectiveness and implementation of offering a choice of HIV Pre-Exposure Products (PrEP) through community-based sexual and reproductive health services, on PrEP uptake and retention, and population prevalence of sexually transmissible HIV amongst adolescents and young adults living in rural South Africa.\n\nResearchers will compare adding the choice of long-acting PrEP, i.e. two monthly injectable cabotegravir (CAB LA) or dapiravine vaginal ring and HIV post exposure prophylaxis packs to daily oral PrEP integrated with community-based SRH in the 20 intervention clusters with standard of care (SoC), daily oral PrEP integrated with community-based SRH in the 20 control clusters, on uptake and retention on PrEP. We hypothesise that offering a choice of long-acting or oral PrEP and PEP within the community-based delivery of SRH services will overcome the challenges and barriers to effective use of oral daily PrEP and lead to a population-level effect on uptake and retention on PrEP and thus the prevalence of sexually transmissible HIV amongst 15-30 year olds living in rural KwaZulu-Natal, South Africa.",[67],"HIV Infections","RECRUITING","2026-07-07",{"date":71,"type":42},"2026-07-09",{"date":73,"type":42},"2024-02-27",{"date":46,"type":23},{"name":48,"class":49},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":17,"sex":18,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":24,"phases":87,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},"100571501","evaluation-of-long-acting-injectable-lai-and-teen-clubs-in-adolescents-attune-100571501","NCT06721078","Evaluation of Long-Acting Injectable (LAI) and Teen Clubs in Adolescents (ATTUNE).","ATTUNE","Inclusion Criteria:\n\n* Aged between 12 - \\\u003C19, at enrolment\n* Living with HIV\n* Aware of their HIV status\n* Receiving ART for at least six months\n* Able to read and\u002For speak English, isiZulu, Sepedi, Afrikaans, Xhosa, or Sesotho\n* Willing and able to consent to study activities\n* Willing and able to get parental consent for study activities\n* (Stage 1, objective 2 only) Age ≥ 18 years and Caregiver of an adolescent with HIV\n* (Stage 1, objective 2 only) Age ≥ 18 years and provides clinical services or is a policy maker involved in adolescents with HIV\n\nExclusion Criteria:\n\n* Inability to read and\u002For speak English, isiZulu, Sepedi, Afrikaans, Xhosa, or Sesotho\n* Severe mental or physical illness preventing participation in informed consent activities.","12 Years","19 Years",{"count":86,"type":23},720,[26],"This is a 2-stage study assessing the effect of peer navigation (support from peers) and long-acting injectable antiretroviral therapy (ART) on viral suppression and retention in care among adolescents living with HIV and receiving care in South Africa.",[90],"Hiv",[92,93,94],"peer navigation","long acting injectables","antiretroviral therapy","2026-03-30",{"date":97,"type":42},"2026-04-03",{"date":99,"type":42},"2026-02-09",{"date":101,"type":23},"2029-06-30",{"name":48,"class":49},12,""]