[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Allama Iqbal Medical College\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":107},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100651455","comparison-of-functional-recovery-following-medial-parapatellar-and-transpatellar-approaches-for-intramedullary-nailing-of-tibial-shaft-fractures-a-randomized-controlled-trial-100651455",false,"NCT07761780","Comparison of Functional Recovery Following Medial Parapatellar and Transpatellar Approaches for Intramedullary Nailing of Tibial Shaft Fractures","MAPTIN","Inclusion Criteria:\n\n* Adults aged 18 to 60 years, irrespective of sex.\n* Patients with an acute tibial shaft fracture confirmed by radiographic examination.\n* Gustilo-Anderson type I, II, or IIIA open fractures.\n* Patients who are eligible for intramedullary interlocking nailing according to the treating orthopedic surgeon.\n* Patients willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Previous fracture or surgery involving the affected tibia.\n* Osteoporosis or other conditions significantly affecting bone healing.\n* Diabetes mellitus, peripheral vascular disease, autoimmune disorders, or other systemic conditions that may adversely affect bone healing or postoperative recovery.\n* Neurovascular injury involving the affected limb.","ALL","18 Years","60 Years",{"count":20,"type":21},56,"ESTIMATED","INTERVENTIONAL",[24],"NA","Tibial shaft fractures are breaks in the main part of the shin bone and commonly require surgery to restore alignment and allow the patient to return to normal activities. Intramedullary nailing is a commonly used surgical treatment for these fractures. There are different surgical approaches that can be used to insert the nail, including the medial parapatellar approach and the transpatellar approach.\n\nThis study will compare these two surgical approaches to determine whether one is associated with better recovery after surgery. A total of 56 adults with acute tibial shaft fractures will participate in the study. Participants will be randomly assigned to receive intramedullary nailing through either the medial parapatellar approach or the transpatellar approach.\n\nRecovery will be evaluated after surgery using measures of lower-limb function, pain, and knee movement. Lower-limb function will be assessed using the Lower Extremity Functional Scale (LEFS), pain will be assessed using the Numeric Pain Rating Scale (NPRS), and knee range of motion will be measured using a universal goniometer.\n\nParticipants will be assessed at 4 weeks and 8 weeks after surgery. The main outcome of the study will be functional recovery measured by the LEFS. The study will also compare postoperative pain and knee range of motion between the two surgical approaches.\n\nThe purpose of this study is to determine whether the medial parapatellar or transpatellar approach is associated with better early functional recovery following intramedullary nailing of tibial shaft fractures. The results may help orthopedic surgeons select the surgical approach that provides better postoperative recovery for patients with tibial shaft fractures.",[27],"Tibial Shaft Fractures",[29,30,31,32],"Tibial shaft fracture","Intramedullary nailing","Medial parapatellar approach","Transpatellar approach","RECRUITING","2026-08-13",{"date":36,"type":37},"2026-08-14","ACTUAL",{"date":39,"type":21},"2026-08-08",{"date":41,"type":21},"2026-10-10",{"name":43,"class":44},"Allama Iqbal Medical College","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":45},"100648358","management-of-postoperative-complications-after-mandibular-third-molar-extraction-using-submucosal-triamcinolone-injection-kinesiology-taping-and-standard-care-100648358","NCT07719270","Management of Postoperative Complications After Mandibular Third Molar Extraction Using Submucosal Triamcinolone Injection, Kinesiology Taping, and Standard Care","Comparative Analysis of Submucosal Triamcinolone Injection and Kinesiology Taping Along With Standard Care, and Standard Care Alone for the Management of Postoperative Complications in Patients After Surgical Mandibular 3rd Molar Extraction","Inclusion Criteria:\n\n* Patients aged 18-40 years\n* Surgical patients requiring extraction of Impacted mandibular third molars\n\nExclusion Criteria:\n\n* Known allergy to corticosteroids\u002Fadhesive\n* Systemic diseases\n* Active infection\n* Pregnancy and lactation\n* Surgical duration \\> 45 minutes.",true,"40 Years",{"count":56,"type":21},60,[24],"The surgical removal of impacted lower wisdom teeth (mandibular third molars) frequently leads to uncomfortable postoperative symptoms, including pain, facial swelling (edema), and restricted jaw movement (trismus). This study aims to evaluate and compare the effectiveness of two different treatment strategies alongside standard care to reduce these complications.\n\nA total of 60 patients undergoing surgical extraction will be randomly assigned to one of three groups: Group A will receive a local submucosal injection of 10mg Triamcinolone (a corticosteroid), Group B will have Kinesiology Tape applied to the face to enhance fluid drainage, and Group C will receive standard postoperative care alone. Patient recovery outcomes, including pain levels, facial swelling, and jaw mobility, will be monitored and measured at 24 hours, 3 days, and 7 days after the surgery. The study's primary objective is to determine if adding either a pharmacological injection or a mechanical tape significantly improves patient recovery compared to standard postoperative care alone.",[60,61,62],"Trismus","Edema","Pain",[64,65,66,67],"Triamcinolone Acetonide","Kinesiology Taping","Third Molar Extraction","Maxillofacial Surgery","NOT_YET_RECRUITING","2026-07-18",{"date":71,"type":37},"2026-07-22",{"date":73,"type":21},"2027-01-01",{"date":75,"type":21},"2029-01-01",{"name":43,"class":44},{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":85,"minAge":17,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":45},"100625478","phase-3-tranexamic-acid-vs-vasopressin-in-placenta-previa-trial-100625478","NCT07423156","Tranexamic Acid vs Vasopressin in Placenta Previa Trial","Comparison of Efficacy of Tranexamic Acid Versus Vasopressin in Blood Loss Among Placenta Previa Patients Undergoing Cesarean Section","TXA-VASO-PP","Inclusion Criteria:\n\nWomen of reproductive age\n\nAge 18-45 years\n\nDiagnosed placenta previa in current pregnancy\n\nScheduled for elective cesarean section\n\nSingleton pregnancy\n\nExclusion Criteria:\n\nEmergency cesarean section\n\nPlatelet or coagulation disorder\n\nUse of anti-platelet or anti-coagulant drugs\n\nPrevious history of postpartum hemorrhage\n\nChronic liver disease\n\nChronic kidney disease\n\nGestational diabetes\n\nPregnancy-related hypertensive disorders\n\n\\-","FEMALE","45 Years",{"count":88,"type":21},58,[90],"PHASE3","Placenta previa is a major obstetric condition associated with increased risk of excessive blood loss during cesarean section, leading to maternal morbidity and mortality. Different pharmacological agents have been used to minimize intraoperative hemorrhage. Tranexamic acid is an antifibrinolytic agent, while vasopressin reduces blood loss by causing vasoconstriction and myometrial contraction at the injection site. Both drugs have been used separately in placenta previa cases, however direct comparison between tranexamic acid and vasopressin is limited.\n\nThis randomized controlled trial will be conducted at the Department of Obstetrics \\& Gynecology, AIMC\u002FJinnah Hospital Lahore. A total of 58 women (29 in each group), aged 18-45 years, with singleton pregnancy and diagnosed placenta previa undergoing elective cesarean section will be included. Participants will be randomly allocated into two groups. Group A will receive 1 gram tranexamic acid diluted in 20 ml of 5% dextrose intravenously 15 minutes before cesarean section. Group B will receive 4 units vasopressin diluted in 20 ml normal saline injected at placental implantation site after delivery of placenta.\n\nThe primary outcome will be intraoperative blood loss measured by gauze saturation assessment and suction drain measurement. The study will help determine which drug is more effective in reducing blood loss in placenta previa patients undergoing cesarean section.",[93],"Placenta Previa",[95,96,97,98],"Obstetric Hemorrhage","Cesarean Section","Tranexamic Acid","Vasopressin","2026-02-13",{"date":101,"type":37},"2026-02-20",{"date":103,"type":21},"2026-03-01",{"date":105,"type":21},"2026-08-31",{"name":43,"class":44},""]