[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Alma Mater Europaea - Slovenia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":78},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100651562","effectiveness-and-clinical-optimization-of-a-standardized-physiotherapy-exercise-program-targeting-balance-posture-interaction-and-fall-risk-in-osteoporosis-a-randomized-controlled-trial-100651562",false,"NCT07763717","EFFECTIVENESS AND CLINICAL OPTIMIZATION OF A STANDARDIZED PHYSIOTHERAPY EXERCISE PROGRAM TARGETING BALANCE-POSTURE INTERACTION AND FALL RISK IN OSTEOPOROSIS: A RANDOMIZED CONTROLLED TRIAL","Effectiveness and Clinical Optimization of a Standardized Physiotherapy Exercise Program Targeting Balance-Posture Interaction and Fall Risk in Osteoporosis: A Randomized Controlled Trial","EFFECTIVENESS","Inclusion Criteria:o Confirmed clinical diagnosis of osteoporosis, established through standard diagnostic procedures such as bone mineral density (BMD) assessment (e.g., T-score ≤ -2.5 at the lumbar spine, femoral neck, or total hip) or a physician's diagnosis based on clinical history and fracture risk assessment.\n\n* Aged 50 years or older.\n* Ability to understand and follow verbal and written instructions in Albanian.\n* Ability to ambulate independently, with or without an assistive device, for at least 10 meters.\n* Willingness to provide informed consent and commit to the full 12-week intervention period and follow-up assessments.\n\nExclusion Criteria:\n\n* o Presence of any neurological disorder (e.g., Parkinson's disease, stroke) that significantly affects balance or mobility.\n\n  * Acute fractures or recent (within the last 6 months) osteoporotic fractures that would preclude participation in an exercise program.\n  * Severe cardiovascular or respiratory conditions that would contraindicate moderate-intensity exercise.\n  * Uncontrolled systemic diseases (diabetes, hypertension).\n  * Cognitive impairment that would interfere with understanding or adhering to the study protocol.\n  * Participation in another balance or strength training program within the last 3 months.\n  * Any other medical condition or medication use that, in the opinion of the primary investigator, would compromise participant safety or the integrity of the study results.","ALL","50 Years",{"count":20,"type":21},88,"ESTIMATED","INTERVENTIONAL",[24],"NA","Osteoporosis is a systemic disorder of the skeletal system characterized by decreased Bone Mass and deterioration of the Microarchitecture, making it significantly easier to fracture the bones. In addition to the increased risk of fracture due to reduced Bone Strength, other common impairments in the balance, postural control and coordination of muscles may increase the risk of falling, as well. Recent research has increasingly begun to conceptually link fall risk to be a multi-factorial issue, due to the interaction of the biomechanical, neuromuscular and functional deficits that an older person most likely experiences in conjunction with the effects of ageing (Papalia et al., 2020). As such, physiotherapy techniques for treating persons at risk of falling have progressed away from providing isolated (and consequently limited) gains in strength or mobility, towards providing a more multi-faceted and thus comprehensive, integrated method of enhancing overall physical performance through exercise.\n\nPhysical activity interventions are being used to treat the condition of osteoporosis and have been identified as an essential component of preventing osteoporosis. Many recent statements have indicated that through the incorporation of organized physical activity into each individual's physical activity routine, as opposed to the previous recommendation for just resistance training and balance activities, the ability for individuals to experience a change in their physical abilities and thereby decrease their risk of falling is significantly improved (Brooke-Wavell et al., 2022; Bae et al., 2023). Among the many types of exercise-based interventions for treating osteoporosis, those that focus on improving balance have been shown to be effective in improving stability of the body postural position as well as decreasing the fear of falling (which can contribute to decreased mobility and increase the risk of falling) (Wei et al., 2023). A systematic review and analysis of the available literature indicates that targeted balance training is effective for improving both static and dynamic postural stability among older adults and persons with osteoporosis; moderate effects were found with regard to the risk of falling as a result of balance training (Zhou et al., 2018; Papalia et al., 2020).\n\nRandomized controlled trials provide additional evidence of the positive impact of physiotherapy programs on their clinical use. For Osteoporotic women, having balance training interventions leads to the to the outcome of significantly reducing falls and enhancing stability (Mikó et al., 2017). On the same note, Multicomponent programs that combine resistance and balance training have resulted in increased muscle strength, physical performance and health-related quality of life for patients with vertebral fractures, along with reduced fear of falling. (Stanghelle et al., 2020). Newer developments in this area such as virtual reality exercise programs have provided additional improvements in Balance performance and increased patient engagement in rehabilitation (Yilmaz \\& Kösehasanoğulları, 2024).",[27,28,29],"Osteoporosis","Risk of Falls","Rehabilitation",[31],"Physiotherapy, osteoporosis, balance, posture, risk of falls, exercise program, rehabilitation","NOT_YET_RECRUITING","2026-08-10",{"date":35,"type":36},"2026-08-13","ACTUAL",{"date":38,"type":21},"2026-09-01",{"date":40,"type":21},"2027-06-30",{"name":42,"class":43},"Alma Mater Europaea - Slovenia","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":44},"100648477","manual-traction-and-rehabilitation-after-knee-replacement-surgery-100648477","NCT07722559","Manual Traction and Rehabilitation After Knee Replacement Surgery","The Short-Term Impact of Manual Traction Combined With Standard Rehabilitation Protocol on Pain, Function, and Quality of Life After Total Knee Arthroplasty","SMART-TKA","Inclusion Criteria:\n\n* Female patients aged between 50 and 75 years.\n* Patients who will undergo primary total knee arthroplasty due to osteoarthritis, classified as Kellgren-Lawrence grades 3 to 4.\n* Patients willing to participate in the study and able to provide informed consent.\n\nExclusion Criteria:\n\n* Morbid obesity, defined as a body mass index (BMI) greater than 40 kg\u002Fm².\n* Revision arthroplasty procedures.\n* Presence of severe cardiac, vascular, renal, neurological, psychiatric, or other orthopedic conditions affecting the lower limb and limiting functional abilities.\n* Active infections or contraindications to physical therapy.\n* Inability to comply with the prescribed rehabilitation protocol.","FEMALE","75 Years",{"count":56,"type":21},48,[24],"The goal of this clinical trial is to determine whether the addition of manual traction to a standard rehabilitation protocol improves early recovery after primary total knee arthroplasty (TKA) in women aged 50-75 years with knee osteoarthritis.\n\nThe main questions it aims to answer are:\n\n* Does the addition of manual traction reduce postoperative pain during the first four weeks after TKA?\n* Does manual traction improve physical function, knee range of motion, patient-reported knee function, and health-related quality of life compared with standard rehabilitation alone?\n* Does manual traction reduce the need for analgesic medication during the early postoperative rehabilitation period?\n\nResearchers will compare participants receiving manual traction plus standard rehabilitation with participants receiving sham traction plus the same standard rehabilitation protocol to determine whether manual traction provides additional clinical benefits during early rehabilitation after TKA.\n\nParticipants will:\n\n* Be randomly assigned to either the manual traction group or the sham traction (control) group.\n* Receive a standardized rehabilitation program for four weeks after surgery, with the intervention group receiving manual traction and the control group receiving sham traction.\n* Attend supervised rehabilitation sessions five times per week throughout the four-week intervention period.\n* Complete validated questionnaires assessing pain, knee function, joint awareness, and health-related quality of life at predefined assessment time points.\n* Undergo standardized clinical assessments of knee range of motion and physical function before surgery, before rehabilitation, during follow-up, and one month after surgery.\n* Have their analgesic medication use recorded throughout the rehabilitation period.",[60,61],"Knee Osteoarthritis (OA)","Total Knee Arthroplasty (TKA)",[63,64,65,66,67,68,69],"Manual Traction","Quality of life","Early rehabilitation","Standard Rehabilitation protocol","Total Knee Arthroplasty","Pain","Function","2026-07-21",{"date":72,"type":36},"2026-07-23",{"date":74,"type":21},"2026-07-22",{"date":76,"type":21},"2026-11-12",{"name":42,"class":43},""]