[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Andrew Appleton\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":64},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":5},"100651071","the-basic-s-feasibility-study-for-vascular-risk-reduction-100651071",false,"NCT07755631","The BASIC-S Feasibility Study for Vascular Risk Reduction","Piloting an Integrated Lifestyle Intervention for Vascular Risk Reduction: The BASIC-S Feasibility Study","BASIC-S","Inclusion Criteria:\n\n* Adults aged 18 years and older currently employed at or recently retired from the London Health Sciences Centre (LHSC) or Western University (with an operational focus on pre-retirees aged 50 years and older).\n* The primary applicant (not their partner, if applicable) must be within two years before or after their retirement date.\n* Spouse or cohabitating partner of an enrolled primary participant. Cohabitating partners may include a common-law partner, adult child, close friend, or roommate who lives with the primary participant and shares common health goals. Enrollment of partners is optional but strongly encouraged.\n* Capable of providing informed consent.\n* Has access to a mobile device capable of receiving Short Message Service (SMS) communications and viewing PDF documents.\n* Physically able to safely engage in light-to-moderate intensity physical activity.\n\nExclusion Criteria:\n\n* Medical conditions that preclude safe participation in physical activity (for instance, unstable angina, uncontrolled arrhythmia, severe heart failure) without physician clearance.\n* Active or unstable psychiatric illness, defined as hospitalization for psychiatric care within the preceding 6 months or modifications to antipsychotic or mood-stabilizing pharmacotherapy within the preceding 3 months. Participants with stable, medically managed psychiatric conditions remain eligible.\n* Severe cognitive impairment that compromises the ability to provide informed consent or independently use study-related technology.\n* Inability to read and understand English sufficiently to provide informed consent and complete study procedures.",true,"ALL","18 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"NA","Vascular risk factors drive stroke, heart disease, and dementia, but translating lifestyle guidelines into routine clinical care remains challenging. To address this, we developed the BASIC-S framework, targeting Blood pressure, Activity, Sleep, Interaction (socially), Consumption (nutrition), and Support using partner support and motivational interviewing. This individual-focused approach bypasses the logistical and financial barriers of complex clinical interventions by using sustained behavioral science to support gradual lifestyle changes. This study is a single-center, mixed-methods, cluster-randomized pilot trial evaluating the feasibility of the BASIC-S protocol in an occupational setting. A maximum of 60 households (120 participants) will be randomized 1:1 to either the BASIC-S intervention (motivational coaching, secure video check-ins, automated text messages, and a digital workbook) or standard care. Outcomes will assess feasibility, acceptability, and the validity of new tracking metrics to inform a future full-scale trial.",[28,29,30,31,32,33],"Hypertension (HTN)","Vascular Diseases","Stroke","Dementia","Cardiovascular Risk Factor","Cognitive Decline",[35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51],"Lifestyle Intervention","Motivational Interviewing","Primary Prevention","Behavioral Medicine","Brain Health","Cognition","Mental Health","Social Activity","Social Isolation","Physical Activity","Blood Pressure","Activity","Sleep","Interaction","Consumption","Support","Partnering","NOT_YET_RECRUITING","2026-08-18",{"date":55,"type":56},"2026-08-19","ACTUAL",{"date":58,"type":22},"2026-10-01",{"date":60,"type":22},"2027-10-01",{"name":62,"class":63},"Andrew Appleton","OTHER",""]