[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ankara Etlik City Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":658},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,71,0,25,[9,50,72,98,124,146,173,198,222,250,281,307,339,368,390,416,444,478,507,528,552,571,592,611,632],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100652634","recto-intercostal-fascial-plane-and-external-oblique-intercostal-blocks-for-pain-in-laparoscopic-cholecystectomyin-laparoscopic-cholecystectomy-100652634",false,"NCT07777172","Recto-Intercostal Fascial Plane and External Oblique Intercostal Blocks for Pain in Laparoscopic Cholecystectomyin Laparoscopic Cholecystectomy","Does the Addition of Recto-Intercostal Fascial Plane Block to External Oblique Intercostal Plane Block Improve the Quality of Postoperative Analgesia in Laparoscopic Cholecystectomy? A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged between 18 and 75 years\n* American Society of Anesthesiologists (ASA) physical status I, II, or III\n* Patients scheduled for elective laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics\n* Infection at the procedure\u002Finjection site\n* Severe coagulopathy or use of anticoagulants\n* Chronic opioid consumption or history of neuropathic pain","ALL","18 Years","75 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"NA","Laparoscopic cholecystectomy is a common surgical procedure that can cause significant postoperative pain, particularly originating from trocar insertion sites. Regional anesthesia techniques are frequently used as part of multimodal analgesia to improve patient comfort.\n\nThis randomized controlled trial aims to evaluate the efficacy of adding a recto-intercostal fascial plane block (RIFPB) to an external oblique intercostal plane block (EOIPB). Patients scheduled for elective laparoscopic cholecystectomy will be randomly assigned to receive either an EOIPB alone or a combination of EOIPB and RIFPB. The primary objective is to determine if the combined block approach provides superior postoperative analgesia, evaluated by compared to the EOIPB alone.",[28,29],"Postoperative Pain","Cholecystectomy, Laparoscopic",[31,32,33,34,35,36],"External Oblique Intercostal Plane Block","Recto-Intercostal Fascial Plane Block","Fascial Plane Block","Regional Anesthesia","Postoperative Analgesia","Multimodal Analgesia","NOT_YET_RECRUITING","2026-08-17",{"date":40,"type":41},"2026-08-20","ACTUAL",{"date":43,"type":22},"2026-08-25",{"date":45,"type":22},"2027-03-15",{"name":47,"class":48},"Ankara Etlik City Hospital","OTHER_GOV",1,{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":49},"100651312","residual-neuromuscular-blockade-and-pacu-admission-100651312","NCT07758868","Residual Neuromuscular Blockade and PACU Admission","Incidence and Clinical Implications of Residual Neuromuscular Blockade in Patients Planned for Post-Anesthesia Care Unit Admission: A Prospective Observational Study","Inclusion Criteria: Patients aged 18-90 years with American Society of Anesthesiologists (ASA) physical status I-III who underwent elective surgery under general anesthesia and received a neuromuscular blocking agent were included in the study.\n\nExclusion Criteria: Patients younger than 18 years or older than 90 years, those requiring postoperative invasive mechanical ventilation and transfer to the intensive care unit while intubated, patients undergoing emergency surgery, and those with a pre-existing neuromuscular disorder were excluded from the study.","90 Years",{"count":59,"type":22},160,"OBSERVATIONAL","Residual neuromuscular blockade (RNMB) remains an underrecognized postoperative safety concern associated with pulmonary complications, prolonged post-anesthesia care unit stay, and reduced patient satisfaction. Because conventional clinical tests are insufficiently sensitive and specific, current guidelines recommend quantitative neuromuscular monitoring to confirm adequate recovery, defined as a train-of-four ratio of ≥0.9.\n\nThis prospective observational study included adult patients aged 18-90 years with ASA physical status I-III who underwent elective surgery under general anesthesia with neuromuscular blocking agents. Demographic, clinical, anesthetic, surgical, and reversal-related variables were recorded. Postoperative neuromuscular recovery was quantitatively assessed at the adductor pollicis muscle using TOFscan® acceleromyography at the 10th postoperative minute. Patients were subsequently followed in either the PACU or surgical ward according to clinical indications, and postoperative adverse events were documented. The study aimed to evaluate the incidence and potential determinants of RNMB in accordance with contemporary neuromuscular monitoring guidelines.",[63],"TOF","2026-08-06",{"date":66,"type":41},"2026-08-11",{"date":68,"type":22},"2026-08-10",{"date":70,"type":22},"2026-10-01",{"name":47,"class":48},{"id":73,"slug":74,"hasResults":12,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":82,"conditions":83,"keywords":88,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":93,"startDateStruct":94,"completionDateStruct":95,"leadSponsor":97,"locationsCount":49},"100650353","perfusion-index-and-spinal-hypotension-in-day-case-knee-arthroscopy-100650353","NCT07747441","Perfusion Index and Spinal Hypotension in Day-Case Knee Arthroscopy","Predictive Value of Baseline Perfusion Index for Spinal Anesthesia-Induced Hypotension in Healthy Patients Undergoing Knee Arthroscopy: A Prospective Observational Trial","Inclusion Criteria:\n\n* Between the ages of 18-65\n* Having an ASA Score of I-II\n* Including data collection of parts that underwent knee arthroscopy\n\nExclusion Criteria:\n\n* Patients under 18 and over 65 years of age\n* Patients with ASA Score III and above","65 Years",{"count":81,"type":22},150,"This prospective observational study aims to investigate the role of the baseline perfusion index (PI) in predicting spinal anesthesia-induced hypotension (SAIH) in ASA I-II patients undergoing day-case knee arthroscopy.\n\nSpinal anesthesia is a widely preferred technique for lower extremity surgeries, including knee arthroscopy. However, sympathetic blockade during spinal anesthesia frequently leads to significant hemodynamic instability, particularly hypotension, which can result in adverse perioperative outcomes. While age and baseline blood pressure are traditional risk factors, they often fail to accurately predict the onset of hypotension in healthy populations. The perfusion index (PI), a non-invasive parameter measured via pulse oximetry, reflects peripheral vascular tone and baseline sympathetic activity. An elevated baseline PI indicates baseline vasodilation and a higher susceptibility to sympathectomy, potentially offering an early and non-invasive prediction of SAIH before the hemodynamic collapse occurs.\n\nThe primary outcome of the study is the incidence of spinal anesthesia-induced hypotension (defined as a mean arterial pressure \\\u003C 65 mmHg or a decrease in systolic blood pressure \\> 25% from baseline). Secondary outcomes include the onset time of sensory block, and intraoperative ephedrine and fluid requirements.",[84,85,86,87],"Hypotension","Spinal Anesthesia Induced Hypotension","Anesthesia, Spinal","Arthroscopy",[89,90,84,91],"Perfusion Index","Spinal Anesthesia","Knee Arthroscopy","RECRUITING",{"date":68,"type":41},{"date":64,"type":41},{"date":96,"type":22},"2026-12-28",{"name":47,"class":48},{"id":99,"slug":100,"hasResults":12,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":105,"targetDuration":4,"studyType":23,"phases":107,"briefSummary":108,"conditions":109,"keywords":115,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":122,"leadSponsor":123,"locationsCount":49},"100649786","anterior-suprascapular-and-axillary-vs-interscalene-block-for-analgesia-and-diaphragmatic-function-in-shoulder-surgery-100649786","NCT07739303","Anterior Suprascapular and Axillary vs. Interscalene Block for Analgesia and Diaphragmatic Function in Shoulder Surgery","Comparison of Anterior Suprascapular and Axillary Nerve Block Versus Interscalene Block for Postoperative Analgesia and Diaphragmatic Function in Shoulder Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I, II, or III\n* Patients scheduled to undergo elective arthroscopic shoulder surgery\n* BMI between 18 and 30 kg\u002Fm2\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to local anesthetics\n* Presence of localized infection at the planned injection site\n* Severe coagulopathy or active use of anticoagulant medications\n* Contralateral phrenic nerve palsy or a diagnosis of severe chronic obstructive pulmonary disease (COPD)\n* History of chronic opioid consumption or neuropathic pain",{"count":106,"type":22},70,[25],"Shoulder surgeries are among the most frequently performed orthopedic interventions and are often associated with moderate to severe postoperative pain. In these procedures, effective pain management is crucial for early rehabilitation and patient comfort.\n\nPeripheral nerve blockade is widely used for postoperative analgesia in shoulder surgery. While the interscalene brachial plexus block is considered the gold standard for pain control, it is frequently associated with unintended phrenic nerve blockade, leading to hemidiaphragmatic paresis. To minimize respiratory complications while maintaining effective analgesia, alternative diaphragm-sparing regional anesthesia techniques, such as the combination of suprascapular and axillary nerve blocks, have been introduced.\n\nThe aim of this study is to compare the analgesic efficacy and respiratory functions preservation of the ultrasound-guided anterior approach suprascapular combined with axillary nerve block versus interscalene block in patients undergoing shoulder surgery",[110,111,112,113,114],"Peripheral Nerve Block","Pain Management","Diaphragm Protective Block","Upper Extremity","Interscalene Block",[116,114,117,118,111],"Shoulder Arthroscopy","Anterior Suprascapular Block","Axillary Block",{"date":120,"type":41},"2026-08-07",{"date":64,"type":41},{"date":96,"type":22},{"name":47,"class":48},{"id":125,"slug":126,"hasResults":12,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":131,"targetDuration":4,"studyType":23,"phases":132,"briefSummary":133,"conditions":134,"keywords":139,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":141,"startDateStruct":142,"completionDateStruct":143,"leadSponsor":145,"locationsCount":49},"100649779","transverse-vs-longitudinal-serratus-anterior-plane-block-in-breast-surgery-100649779","NCT07739277","Transverse vs. Longitudinal Serratus Anterior Plane Block in Breast Surgery","Efficacy of Transverse Versus Longitudinal Ultrasound Probe Orientation for Serratus Anterior Plane Block on Postoperative Pain in Breast Surgery: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I, II, or III\n* BMI between 18 - 30 kg\u002Fm2\n* Patients scheduled for elective breast surgery\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics\n* Infection at the injection site\n* Severe coagulopathy or use of anticoagulants\n* Chronic opioid use or history of neuropathic pain",{"count":106,"type":22},[25],"The aim of this prospective, randomized controlled trial is to compare the analgesic efficacy of transverse versus longitudinal ultrasound probe orientations during Serratus Anterior Plane (SAP) block in patients undergoing breast surgery. The study hypothesizes that the longitudinal approach (probe parallel to the ribs) may provide better craniocaudal spread of the local anesthetic, thereby resulting in lower postoperative Visual Analog Scale (VAS) scores and reduced opioid consumption compared to the standard transverse approach.",[33,135,136,137,138],"Pain, Postoperative","Breast Surgery","Acute Pain","Mastectomy",[140,34,35,136],"Serratus Anterior Plane Block",{"date":120,"type":41},{"date":64,"type":41},{"date":144,"type":22},"2027-02-19",{"name":47,"class":48},{"id":147,"slug":148,"hasResults":12,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":23,"phases":157,"briefSummary":158,"conditions":159,"keywords":161,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":49},"100650618","hilt-in-greater-trochanteric-pain-syndrome-100650618","NCT07749066","HILT in Greater Trochanteric Pain Syndrome","Efficacy of High-Intensity Laser Therapy in Greater Trochanteric Pain Syndrome: A Randomized Controlled Trial","HILT-GTPS","Inclusion Criteria:\n\n* Adults aged 18 to 80 years\n* Patients diagnosed with Greater Trochanteric Pain Syndrome (GTPS) based on clinical examination\n* Presence of symptoms for at least 3 months\n* Pain intensity ≥4 on the Visual Analog Scale (VAS)\n* No corticosteroid injection or other conservative treatment within the last 3 months\n\nExclusion Criteria:\n\n* Hip fracture, tumor, infection, or advanced osteoarthritis\n* Contraindications to high-intensity laser therapy (e.g., pacemaker, pregnancy, coagulation disorders, anticoagulant therapy, neoplasia, history of epilepsy)\n* Contraindications to physical activity (e.g., ischemic heart disease, arrhythmia, uncontrolled hypertension, heart failure, severe respiratory insufficiency)\n* Peripheral vascular disorders (e.g., thrombophlebitis, thrombosis, lymphedema)\n* History of trauma within the last 3 months or prior surgery involving the lower extremity or lumbar spine\n* Neurological disorders or chronic inflammatory diseases","80 Years",{"count":156,"type":22},64,[25],"Greater Trochanteric Pain Syndrome (GTPS) is a common cause of lateral hip pain that can significantly impair daily activities and quality of life. Conservative treatments, including physical therapy modalities and injections, are considered first-line management.\n\nHigh-Intensity Laser Therapy (HILT) is a non-invasive modality with greater tissue penetration compared to low-level laser therapy and has shown promising results in musculoskeletal disorders; however, evidence in GTPS is limited.\n\nThis study aims to evaluate the efficacy of HILT compared with a sham intervention in patients with GTPS, focusing on pain intensity, functional status, and quality of life.",[160],"Greater Trochanteric Pain Syndrome",[160,162,163,164,165],"GTPS","High-Intensity Laser Therapy","HILT","Lateral Hip Pain","2026-08-01",{"date":64,"type":41},{"date":169,"type":41},"2026-06-01",{"date":171,"type":22},"2027-07-30",{"name":47,"class":48},{"id":174,"slug":175,"hasResults":12,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":154,"enrollmentInfo":180,"targetDuration":4,"studyType":23,"phases":182,"briefSummary":183,"conditions":184,"keywords":186,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":197,"locationsCount":49},"100650195","crps-hand-contrast--compression-vs-whirlpool-100650195","NCT07744269","CRPS-Hand: Contrast + Compression vs Whirlpool","Combined Contrast Therapy and Intermittent Compression vs Whirlpool Therapy in Post-Traumatic Hand and Wrist CRPS: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients diagnosed with Complex Regional Pain Syndrome Type 1 (CRPS-I) according to the Budapest Criteria\n* Age between 18 and 80 years\n* CRPS developed following upper extremity trauma (e.g., hand or wrist fracture, soft tissue injury)\n* Symptom duration less than 3 months (subacute stage)\n* Ability and willingness to provide written informed consent and voluntarily participate in the study\n\nExclusion Criteria:\n\n* Patients diagnosed with Complex Regional Pain Syndrome Type 2 (CRPS-II) or with evidence of peripheral nerve injury\n* History of peripheral neuropathy, Raynaud's phenomenon, or vascular circulation disorders\n* Presence of impaired skin integrity, open wounds, infection, or dermatological disease in the affected area\n* History of cold or heat intolerance, cold urticaria, or hypersensitivity to thermal modalities\n* Active infection or severe edema in the affected extremity\n* Presence of serious systemic diseases (cardiovascular, pulmonary, renal, or neurological)\n* Receipt of similar physical therapy or modality-based treatment within the past 3 months",{"count":181,"type":22},50,[25],"This randomized controlled trial aims to evaluate and compare the effectiveness of combined contrast therapy with intermittent compression and whirlpool therapy in patients with post-traumatic CRPS-I of the hand and wrist, using objective outcome measures of pain, edema, and functional status.",[185],"Complex Regional Pain Syndrome I (CRPS I)",[187,188,189,190,191],"Contrast Therapy","Intermittent Pneumatic Compression","Whirlpool Therapy","Complex Regional Pain Syndrome","Hand Rehabilitation",{"date":193,"type":41},"2026-08-04",{"date":195,"type":41},"2026-05-01",{"date":171,"type":22},{"name":47,"class":48},{"id":199,"slug":200,"hasResults":12,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":205,"targetDuration":4,"studyType":23,"phases":207,"briefSummary":208,"conditions":209,"keywords":211,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":218,"completionDateStruct":219,"leadSponsor":221,"locationsCount":49},"100650229","45-v-vs-60-v-pulsed-radiofrequency-of-the-cervical-dorsal-root-ganglion-for-cervical-radicular-pain-100650229","NCT07744438","45 V vs 60 V Pulsed Radiofrequency of the Cervical Dorsal Root Ganglion for Cervical Radicular Pain","Does Higher Voltage Improve Outcomes in Cervical Radicular Pain? A Comparison of 45 V and 60 V Pulsed Radiofrequency of the Cervical Dorsal Root Ganglion","Inclusion Criteria:\n\n* Unilateral cervical radicular pain consistent with cervical disc herniation.\n* Pain intensity of ≥6 on the Numerical Rating Scale (NRS).\n* Radicular pain persisting for at least 3 months.\n* MRI evidence of lower cervical nerve root compression consistent with clinical findings.\n* Inadequate response to conservative treatment, including analgesic medications and physical therapy.\n* Completion of cervical dorsal root ganglion pulsed radiofrequency (PRF) treatment.\n\nExclusion Criteria:\n\n* Bilateral upper extremity pain or predominant axial neck pain.\n* Cervical spinal stenosis, spondylolisthesis, cervical myelopathy, or other structural spinal disorders causing radicular pain.\n* Previous cervical spine surgery at the target level.\n* Cognitive impairment preventing reliable outcome assessment.\n* Active local or systemic infection.\n* Coagulopathy or inability to discontinue anticoagulant\u002Fantiplatelet therapy for the procedure.\n* Severe hepatic or renal failure.\n* Pregnancy.\n* Unstable psychiatric disorders.\n* Any condition that could interfere with completion of follow-up evaluations.",{"count":206,"type":22},58,[25],"This study aims to compare the clinical outcomes of 45 V and 60 V pulsed radiofrequency (PRF) applied to the cervical dorsal root ganglion (DRG) in patients with cervical radicular pain. Treatment efficacy will be evaluated using the Numerical Rating Scale (NRS) for pain intensity and the Neck Disability Index (NDI) for functional disability. Procedure-related adverse events will also be compared to assess the safety of both voltage settings.",[210],"Cervical Radicular Pain",[212,213,214,215],"Pulsed Radiofrequency Treatment","Dorsal Root Ganglion","Voltage","Neck Disability Index","2026-07-29",{"date":193,"type":41},{"date":216,"type":41},{"date":220,"type":22},"2027-03-01",{"name":47,"class":48},{"id":223,"slug":224,"hasResults":12,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":229,"enrollmentInfo":230,"targetDuration":4,"studyType":23,"phases":231,"briefSummary":232,"conditions":233,"keywords":236,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":247,"leadSponsor":249,"locationsCount":49},"100648883","laparoscopic-appendectomy-outcomes-of-10-mmhg-versus-15-mmhg-intra-abdominal-pressure-100648883","NCT07727499","Laparoscopic Appendectomy: Outcomes of 10 mmHg Versus 15 mmHg Intra-abdominal Pressure","Comparison of Standard Pneumoperitoneum Pressures in Laparoscopic Appendectomy: Clinical Outcomes of 10 mmHg Versus 15 mmHg Intra-abdominal Pressure","Inclusion Criteria:\n\n* Age 18-60 years.\n* Clinical and\u002For radiological diagnosis of acute appendicitis.\n* Planned laparoscopic appendectomy(Uncomplicated acute appendicitis considered suitable for laparoscopic management).\n* ASA physical status I-III.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years and \\>60 years\n* Pregnancy\n* Appendiceal mass or suspected appendiceal malignancy\n* Diffuse peritonitis requiring planned open surgery\n* Severe cardiopulmonary disease in whom pneumoperitoneum pressure cannot be standardized\n* Previous extensive abdominal surgery causing expected severe adhesions\n* Patients requiring additional major abdominal procedure\n* Missing consent\n* Incomplete postoperative follow-up\n* Patients managed non-operatively without surgery","60 Years",{"count":81,"type":22},[25],"This prospective, randomized controlled trial aims to compare the clinical outcomes of laparoscopic appendectomy performed under two standard pneumoperitoneum pressures (10 mmHg and 15 mmHg). The primary objective is to evaluate postoperative pain, while secondary outcomes include operative time, conversion rate, time to first flatus and bowel movement, length of hospital stay, postoperative ileus, and intra-abdominal abscess formation. The study will determine whether lower-pressure pneumoperitoneum provides comparable surgical conditions while improving postoperative recovery.",[234,235],"Appendectomy, Laparoscopic","Intra Abdominal Pressure",[237,238,239,240,241,242],"pain","vas","flatus","pressure","appendicitis","intra-abdominal pressure","2026-07-21",{"date":245,"type":41},"2026-07-27",{"date":245,"type":22},{"date":248,"type":22},"2027-10-27",{"name":47,"class":48},{"id":251,"slug":252,"hasResults":12,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":256,"eligibilityCriteria":257,"healthyVolunteers":12,"sex":258,"minAge":259,"maxAge":19,"enrollmentInfo":260,"targetDuration":4,"studyType":23,"phases":262,"briefSummary":263,"conditions":264,"keywords":268,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":278,"leadSponsor":280,"locationsCount":49},"100647530","transperineal-versus-transrectal-cognitive-fusion-prostate-biopsy-100647530","NCT07710807","Transperineal Versus Transrectal Cognitive Fusion Prostate Biopsy","Comparison of Transperineal and Transrectal Cognitive Fusion Prostate Biopsy for the Detection of Clinically Significant Prostate Cancer in Patients With mpMRI-Detected Suspicious Lesions: A Prospective Randomized Controlled Trial","PROCOG","Inclusion Criteria:\n\n* Male patients aged 50-75 years.\n* Patients with PI-RADS 3, 4, or 5 lesions detected on multiparametric prostate magnetic resonance imaging (mpMRI).\n* Patients with an indication for prostate biopsy.\n* Patients who are willing to participate and provide informed consent.\n\nExclusion Criteria:\n\n* Previous diagnosis of prostate cancer.\n* Active urinary tract infection.\n* Coagulopathy or bleeding disorders preventing prostate biopsy.\n* Absence of multiparametric prostate MRI evaluation.\n* No indication for prostate biopsy.","MALE","50 Years",{"count":261,"type":22},280,[25],"This prospective randomized controlled trial aims to compare transperineal and transrectal cognitive fusion prostate biopsy techniques in patients with suspicious prostate lesions detected by multiparametric magnetic resonance imaging (mpMRI).\n\nPatients aged 50-75 years with PI-RADS 3-5 lesions on mpMRI and an indication for prostate biopsy will be randomly assigned in a 1:1 ratio to undergo either transperineal cognitive fusion prostate biopsy or transrectal cognitive fusion prostate biopsy.\n\nThe primary objective of this study is to evaluate whether transperineal cognitive fusion biopsy is non-inferior to transrectal cognitive fusion biopsy in detecting clinically significant prostate cancer (csPCa). Secondary objectives include comparison of overall prostate cancer detection rates, detection of Gleason Grade Group ≥2 prostate cancer, biopsy-related infectious complications, other procedure-related complications, pain scores, and procedure duration.\n\nA total of 280 participants will be enrolled. Pathological evaluation will be performed after biopsy, and clinical outcomes and complications will be assessed during follow-up.",[265,266,267],"Prostate Cancer","Clinically Significant Prostate Cancer","Cognitive Fusion",[269,270,271,272,273],"prostate biopsy","Transperineal biopsy","Transrectal biopsy","Multiparametric magnetic resonance imaging","Prostate cancer detection","2026-07-14",{"date":276,"type":41},"2026-07-17",{"date":169,"type":41},{"date":279,"type":22},"2027-03-31",{"name":47,"class":48},{"id":282,"slug":283,"hasResults":12,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":12,"sex":288,"minAge":18,"maxAge":79,"enrollmentInfo":289,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":291,"conditions":292,"keywords":294,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":49},"100628020","menstrual-status-anesthetic-consumption-and-ponv-100628020","NCT07456202","Menstrual Status, Anesthetic Consumption, and PONV","Impact of Menstrual Phases and Menopause on Intraoperative Anesthetic Consumption and Postoperative Nausea and Vomiting: A Prospective Observational Study","Inclusion Criteria:\n\n* Female patients aged 18 to 65 years\n* American Society of Anesthesiologists (ASA) physical status I-II-III\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n* Willing and able to provide written informed consent\n\nExclusion Criteria:\n\n* Age outside the specified range (younger than 18 or older than 65 years)\n* Male patients\n* American Society of Anesthesiologists (ASA) physical status ≥ IV\n* Severe systemic comorbidities (e.g., significant cardiovascular, hepatic, renal, or pulmonary disease)\n* Conversion from laparoscopic to open cholecystectomy\n* History of alcohol, drug, or substance abuse\n* Visual or hearing impairment interfering with study assessments\n* Current hormone replacement therapy\n* Use of oral contraceptives\n* Preoperative nausea or vomiting\n* History of severe postoperative nausea and vomiting\n* Neurological or psychiatric disorders affecting assessment reliability\n* Hemodynamic instability during surgery\n* Postoperative admission to intensive care unit\n* Acute cholecystitis at the time of surgery\n* Refusal to participate or inability to provide informed consent","FEMALE",{"count":290,"type":22},120,"This prospective observational cohort study aims to evaluate the association between menstrual phase (determined by postoperative serum progesterone levels), intraoperative anesthetic consumption, and the incidence and severity of postoperative nausea and vomiting (PONV) in female patients undergoing cholecystectomy. Intraoperative anesthetic requirements will be recorded, and postoperative nausea and vomiting will be assessed using standardized scoring systems.",[293],"Menstrual Cycle",[295,296,297,298],"Anesthetic Consumption","Luteal Phase","Follicular Phase","Postoperative Nausea and Vomiting","2026-07-10",{"date":301,"type":41},"2026-07-13",{"date":303,"type":41},"2026-03-07",{"date":305,"type":22},"2026-08-16",{"name":47,"class":48},{"id":308,"slug":309,"hasResults":12,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":4,"eligibilityCriteria":313,"healthyVolunteers":12,"sex":17,"minAge":314,"maxAge":18,"enrollmentInfo":315,"targetDuration":4,"studyType":23,"phases":317,"briefSummary":318,"conditions":319,"keywords":324,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":338,"locationsCount":49},"100645133","effect-of-endotracheal-tube-cuff-pressure-management-on-postoperative-sore-throat-in-pediatric-laparoscopic-appendectomy-100645133","NCT07678086","Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy","The Effect of Intraoperative Endotracheal Tube Cuff Pressure on Postoperative Sore Throat in Pediatric Patients Undergoing Laparoscopic Appendectomy: A Prospective Randomized Controlled Trial.","Inclusion Criteria:\n\n* Pediatric patients aged 6-18 years\n* Patients with ASA physical status classification I-III\n* Patients scheduled for laparoscopic appendectomy\n* Voluntary written informed consent from the patient's legal guardian\u002Fparent after being informed in detail about the purpose and method of the study..\n\nExclusion Criteria:\n\n* Patients under 6 years of age\n* Patients with ASA IV or higher\n* Patients with preoperative sore throat\n* Patients who have not completed the preoperative fasting period\n* Patients who received intraoperative nasogastric tube\n* Patients who received intraoperative N₂O\n* Patients with complicated appendicitis diagnosis\n* Patients who underwent two or more intubation attempts\n* Patients with surgery duration longer than 2 hours\n* Patients with predicted or likely airway difficulties\n* Patients who underwent conversion from intraoperative laparoscopy to laparotomy\n* Presence of tracheal pathology\n* Congenital anomalies affecting the airway\n* Presence of known upper\u002Flower respiratory tract disease\n* Patients requiring planned postoperative mechanical ventilation\n* Patients in shock\n* Patients with decompensated heart failure or respiratory failure\n* Patient or legal representative's refusal to participate in the study\n* Patients with a history of smoking","6 Years",{"count":316,"type":22},60,[25],"Abstract Objective:\n\nThe aim of this study is to compare two different ways of adjusting the air-filled cushion (cuff) of the breathing tube used during general anesthesia in children undergoing laparoscopic appendectomy (closed surgery for appendicitis). The goal is to see if maintaining the pressure in this cushion within a safe, specific range (15-18 mmHg) helps prevent or reduce sore throat, hoarseness, and discomfort, which are common postoperative complications in children.\n\nStudy Design:\n\nThis is a prospective, randomized, controlled study. Sixty children aged 6 to 18 years scheduled for laparoscopic appendectomy will be included. Participants will be randomly assigned to two equal groups: Group A (Control Group): Breathing tube cuff pressure is adjusted using the standard \"feeling\" (finger palpation) method common in routine practice. Group B (Intervention Group): Breathing tube cuff pressure is measured throughout the surgery using a medical pressure sensor (manometer) and maintained within a safe range (15-18 mmHg). Research Questions: Does actively monitoring airway pressure reduce the number of children experiencing postoperative sore throat? Does this method reduce the severity of sore throat, cough, hoarseness, or other respiratory discomfort compared to the standard method? What will happen?\n\nDuring surgery, respiratory and heart rate measurements will be recorded every 15 minutes for all participants. After surgery, researchers will visit participants (and their parents) at 2, 6, and 24 hours postoperatively to assess the presence of sore throat, discomfort, or hoarseness. No additional medications or invasive procedures will be used for this study; only how we manage airway pressure will be compared.",[320,321,322,323],"Appendicitis Acute","Postoperative Sore Throat, Cough, Hoarseness","Airway Complications","Respiratory Complications",[325,326,327,328,329,330,331],"Endotracheal tube cuff pressure","Post-anesthetic complications","Pressure transducer","Laparoscopic appendectomy","Pediatric anesthesia","Airway management","postoperative sore throat","2026-07-04",{"date":334,"type":41},"2026-07-07",{"date":336,"type":22},"2026-06-30",{"date":43,"type":22},{"name":47,"class":48},{"id":340,"slug":341,"hasResults":12,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":4,"eligibilityCriteria":345,"healthyVolunteers":12,"sex":288,"minAge":18,"maxAge":346,"enrollmentInfo":347,"targetDuration":4,"studyType":23,"phases":349,"briefSummary":350,"conditions":351,"keywords":353,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":49},"100630498","effectiveness-of-video-based-or-written-pelvic-floor-education-in-postpartum-women-100630498","NCT07488455","Effectiveness of Video-Based or Written Pelvic Floor Education in Postpartum Women","An Evaluation of the Effectiveness of Video-Based or Written Pelvic Floor Education on Knowledge Levels and Pelvic Floor Function in Postpartum Women","Inclusion Criteria:\n\n1. Be between the ages of 18 and 45\n2. Single pregnancy\n3. Full-term delivery\n4. Be willing to participate in the study\n5. Be literate in Turkish\n\nExclusion Criteria:\n\n1. Presence of fecal or urinary incontinence prior to pregnancy\n2. Presence of neurological or orthopedic problems that could cause pelvic floor dysfunction\n3. Presence of psychiatric illness or cognitive impairment that makes it difficult to answer questions\n4. History of pelvic surgery\n5. History of high-risk pregnancy (preeclampsia, eclampsia, multiple pregnancy, etc.)","45 Years",{"count":348,"type":22},141,[25],"The aim of this study is to evaluate the effect of written or visual information provided outside of routine postpartum follow-up on pelvic floor knowledge and pelvic floor function in women during the postpartum period.",[352],"Postpartum Pelvic Floor Function and Symptoms",[354,355,356,357,358,359],"postpartum","knowledge","pelvic floor dysfunction","education","video-based","written","2026-06-16",{"date":362,"type":41},"2026-06-17",{"date":364,"type":41},"2026-03-30",{"date":366,"type":22},"2026-09-30",{"name":47,"class":48},{"id":369,"slug":370,"hasResults":12,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":4,"eligibilityCriteria":374,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":375,"enrollmentInfo":376,"targetDuration":4,"studyType":23,"phases":378,"briefSummary":379,"conditions":380,"keywords":382,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":386,"startDateStruct":387,"completionDateStruct":388,"leadSponsor":389,"locationsCount":49},"100630497","efficacy-of-cognitive-behavioral-therapy-administered-in-patients-with-dyssynergic-defecation-100630497","NCT07488442","Efficacy of Cognitive Behavioral Therapy Administered in Patients With Dyssynergic Defecation","An Evaluation of the Efficacy of Cognitive Behavioral Therapy Administered in Conjunction With Pelvic Floor Exercises in Patients With Dyssynergic Defecation","Inclusion Criteria:\n\n1. A history of constipation lasting longer than one year\n2. Chronic constipation as defined by the Rome IV criteria\n3. Being between the ages of 18 and 55\n4. Findings consistent with dyssynergic defecation on anorectal manometry and balloon defecography\n5. Exclusion of organic and metabolic causes of chronic constipation\n\nExclusion Criteria:\n\n1. Active bowel disease\n2. Presence of an active anal fissure\n3. History of major abdominal surgery\n4. Presence of a neurological disorder\n5. Presence of a serious psychiatric disorder\n6. Use of medications that cause constipation","55 Years",{"count":377,"type":22},26,[25],"The aim of this study is to evaluate the effectiveness of cognitive-behavioral therapy when used in conjunction with lifestyle modifications and pelvic floor rehabilitation.",[381],"Dyssynergic Defaecation",[383,384,385],"Dyssynergic Defecation","Cognitive Behavioral Therapy","Pelvic Floor Rehabilitation",{"date":362,"type":41},{"date":364,"type":41},{"date":366,"type":22},{"name":47,"class":48},{"id":391,"slug":392,"hasResults":12,"nctId":393,"briefTitle":394,"officialTitle":395,"acronym":4,"eligibilityCriteria":396,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":397,"targetDuration":4,"studyType":23,"phases":399,"briefSummary":400,"conditions":401,"keywords":403,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":410,"startDateStruct":411,"completionDateStruct":413,"leadSponsor":415,"locationsCount":49},"100608566","comparison-of-effectiveness-of-low-dose-laser-and-transcutaneous-electrical-stimulation-in-hemiplegic-shoulder-100608566","NCT07203222","Comparison of Effectiveness of Low Dose Laser and Transcutaneous Electrical Stimulation in Hemiplegic Shoulder","Comparison of the Efficacy of Low-Dose Laser and Transcutaneous Electrical Nerve Stimulation in Subacute Hemiplegic Shoulder Pain, and the Effect of Treatments on Upper Extremity Function and Quality of Life","Inclusion Criteria:\n\n* Patients aged 18-75 years\n* Patients with shoulder pain on the hemiplegic side \\*Mini mental state examination ≥ 25\n* History of stroke within the last 2 weeks to 6 months\n* Patients with shoulder pain scoring 40-100 points on the visual analogue scale (moderate to severe) will be included.\n\nExclusion Criteria:\n\n* Patients who refuse to provide written consent or attend follow-up visits\n* Being under 18 years of age\n* Patients with motor aphasia\n* Patients who have had a shoulder injection within the last 3 months\n* Patients who have undergone upper extremity botulinum toxin application within the last 6 months\n\n  \\*Pregnant women or those planning to become pregnant\n* Inflammatory rheumatic disease\n* Patients who have undergone shoulder injury and surgery prior to stroke\n* Patients with other conditions that could explain shoulder pain\n* Patients with complex regional pain syndrome\n* Patients with a history of epilepsy, pacemaker, or arrhythmia diagnosis\n* Malignancy\n* Diseases such as Alzheimer's or dementia that cause cognitive impairment -History of psychiatric disorders such as major depression or personality disorders\n* Alcohol and drug addiction",{"count":398,"type":22},45,[25],"The primary aim of this study is to compare the efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) and Low Level Laser Therapy (LLLT), which are analgesic modalities that play an important role in the treatment of this frequently encountered complication. The secondary aim of the study is to evaluate its effectiveness on upper extremity function, quality of life, sleep, and fatigue.",[402],"Hemiplegic Shoulder Pain",[404,405,406,407,408,409],"Hemiplegic shoulder pain","Low Dose Laser","TENS","Ultrasonographic evaluation","Upper extremity function","stroke",{"date":362,"type":41},{"date":412,"type":41},"2025-09-24",{"date":414,"type":22},"2026-08-31",{"name":47,"class":48},{"id":417,"slug":418,"hasResults":12,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":4,"eligibilityCriteria":422,"healthyVolunteers":12,"sex":258,"minAge":18,"maxAge":154,"enrollmentInfo":423,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":425,"conditions":426,"keywords":432,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":436,"lastUpdatePostDateStruct":437,"startDateStruct":439,"completionDateStruct":441,"leadSponsor":443,"locationsCount":49},"100643495","intraoperative-driving-pressure-and-postoperative-lung-ultrasound-score-in-robot-assisted-radical-prostatectomy-100643495","NCT07610824","Intraoperative Driving Pressure and Postoperative Lung Ultrasound Score in Robot-Assisted Radical Prostatectomy","Evaluation of the Relationship Between Intraoperative Driving Pressure and Postoperative Lung Ultrasound Score in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy","Inclusion Criteria:\n\n* Male patients aged between 18 and 80 years.\n\nScheduled for elective robot-assisted laparoscopic radical prostatectomy.\n\nAmerican Society of Anesthesiologists (ASA) physical status I, II, or III.\n\nWillingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Patient refusal to participate.\n\nSevere obstructive or restrictive pulmonary disease (e.g., severe COPD, uncontrolled asthma).\n\nBody Mass Index (BMI) \\> 35 kg\u002Fm\\^2.\n\nPre-existing severe lung pathology or active pulmonary infection.\n\nHemodynamic instability or severe cardiovascular disease (e.g., severe heart failure, recent myocardial infarction).\n\nRequirement for postoperative mechanical ventilation.\n\nEmergency surgery.",{"count":424,"type":22},76,"The primary objective of this study is to evaluate the relationship between intraoperative driving pressure and postoperative lung ultrasound scores in patients undergoing robot-assisted laparoscopic radical prostatectomy. During this specific surgery, factors such as pneumoperitoneum and patient positioning can significantly affect respiratory mechanics. Postoperative lung condition will be objectively assessed using the lung ultrasound score (LUS). The findings may provide valuable insights for optimizing intraoperative mechanical ventilation strategies.",[427,428,429,430,431],"Mechanical Ventilation","Postoperative Pulmonary Complications (PPCs)","Prostatic Neoplams","Driving Pressure","Lung Ultrasonography Score",[433,434,435],"driving pressure","lung ultrasonography score","postoperative pulmonary comlications","2026-06-09",{"date":438,"type":41},"2026-06-11",{"date":440,"type":22},"2026-05-30",{"date":442,"type":22},"2026-09-15",{"name":47,"class":48},{"id":445,"slug":446,"hasResults":12,"nctId":447,"briefTitle":448,"officialTitle":449,"acronym":4,"eligibilityCriteria":450,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":154,"enrollmentInfo":451,"targetDuration":4,"studyType":23,"phases":453,"briefSummary":454,"conditions":455,"keywords":459,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":477,"locationsCount":49},"100643654","comparison-of-iv-analgesia-protocols-after-the-regional-blocks-effect-diminishes-in-thoracic-surgery-100643654","NCT07610408","Comparison of IV Analgesia Protocols After the Regional Block's Effect Diminishes in Thoracic Surgery","Comparison of the Effectiveness of Intravenous Analgesia Protocols Used After the Duration of Block Action for Postoperative Pain Control in Thoracic Surgery","Inclusion Criteria:\n\n1. \\- Patients aged 18 to 80 years.\n2. \\- ASA (American Society of Anesthesiologists) Physical Status Score of I-III.\n3. \\- Body Mass Index (BMI) between 18 and 35 kg\u002Fm².\n4. \\- Undergoing elective thoracic surgery via Video-Assisted Thoracoscopic Surgery (VATS).\n5. \\- Voluntary participation confirmed by signing the written Informed Consent Form.\n\nExclusion Criteria:\n\n1. \\- Age below 18 or above 80 years.\n2. \\- Advanced organ failure (e.g., severe hepatic or renal impairment).\n3. \\- ASA physical status \\> III.\n4. \\- History of chronic pain treatment or long-term opioid use.\n5. \\- BMI \\\u003C 18 kg\u002Fm² or \\> 35 kg\u002Fm².\n6. \\- Pregnancy or breastfeeding.\n7. \\- Limited cooperation due to dementia or uncontrolled psychiatric disorders.\n8. \\- Communication barriers (inability to communicate in the native language).\n9. \\- History of substance or drug abuse.\n10. \\- Known allergy or contraindication to the study drugs (Fentanyl, Tramadol, or Ibuprofen).\n11. \\- Contraindication to regional block placement (e.g., infection at the injection site).",{"count":452,"type":22},135,[25],"The purpose of this study is to compare the effectiveness of three different intravenous (IV) patient-controlled analgesia (PCA) regimens-Fentanyl, Tramadol, and Ibuprofen-in managing postoperative pain and respiratory performance in patients undergoing Video-Assisted Thoracoscopic Surgery (VATS). While regional blocks like Erector Spinae Plane (ESP) block provide effective early analgesia, their effect typically diminishes after 8-12 hours, leading to potential 'rebound pain.' This study specifically investigates the period following the duration of the regional block's action. The primary goal is to evaluate which IV PCA protocol better controls pain (Visual Analog Scale scores) and supports better respiratory performance (measured by incentive spirometry) during the first 72 hours post-surgery",[456,28,457,458,137],"Postoperative Pain After Thoracic Surgery","Thoracic Surgery, Video Assisted","Patient Controlled Analgesia",[460,461,462,463,464,465,466,467,468,469,470],"Video-Assisted Thoracoscopic Surgery","VATS","Erector Spinae Plane Block","ESP","Patient-Controlled Analgesia","PCA","IV analgesia","Incentive spirometry","Opioid-sparing","Postoperative pain after thoracic surgery","Rebound Pain","2026-06-06",{"date":436,"type":41},{"date":474,"type":41},"2026-06-02",{"date":476,"type":22},"2026-10-15",{"name":47,"class":48},{"id":479,"slug":480,"hasResults":12,"nctId":481,"briefTitle":482,"officialTitle":483,"acronym":484,"eligibilityCriteria":485,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":154,"enrollmentInfo":486,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":488,"conditions":489,"keywords":492,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":501,"startDateStruct":502,"completionDateStruct":504,"leadSponsor":506,"locationsCount":49},"100643633","comparison-of-m-tapa-and-external-oblique-intercostal-block-for-intraoperative-opioid-consumption-in-laparoscopic-cholecystectomy-100643633","NCT07595679","Comparison of M-TAPA and External Oblique Intercostal Block for Intraoperative Opioid Consumption in Laparoscopic Cholecystectomy","Comparison of M-TAPA and External Oblique Intercostal Plane Block on Intraoperative Analgesia and Opioid Consumption Guided by Skin Conductance Algesimeter in Laparoscopic Cholecystectomy","MTAPA-EOI","Inclusion Criteria:\n\n* Patients aged 18-80 years\n* ASA physical status I-III\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Patient refusal\n* Known allergy to local anesthetics\n* Chronic opioid use or opioid dependence\n* Neurological or psychiatric disorders affecting pain perception\n* Use of medications affecting autonomic nervous system activity, such as beta-blockers\n* Infection at the injection site\n* Coagulopathy or anticoagulant therapy\n* Pregnancy",{"count":487,"type":22},80,"This prospective observational study is designed to evaluate the effects of modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) and external oblique intercostal (EOI) plane block on intraoperative analgesia and opioid consumption in patients undergoing elective laparoscopic cholecystectomy. Abdominal wall blocks are widely used to improve perioperative analgesia; however, their impact on intraoperative opioid requirements when guided by objective nociception monitoring remains unclear.\n\nAll patients will receive standardized general anesthesia. Intraoperative analgesia will be guided using the Skin Conductance Algesimeter (SCA), which reflects sympathetic nervous system activity by measuring fluctuations in skin conductance. The SCA parameter \"peaks per second (PPS)\" will be used to assess nociceptive responses. Remifentanil infusion will be titrated according to SCA values to maintain adequate analgesia. Dose adjustments will be performed at predefined intervals, and changes will be considered valid only if sustained for a minimum duration.\n\nPatients will receive either M-TAPA or EOI block as part of routine clinical practice. The choice of block will not be influenced by the investigators, in accordance with the observational design of the study. Data will be collected prospectively during the intraoperative period and postoperative follow-up.\n\nThe primary outcome of the study is the time-weighted average intraoperative remifentanil infusion rate (µg\u002Fkg\u002Fmin). Secondary outcomes include total intraoperative remifentanil consumption (µg\u002Fkg), intraoperative hemodynamic parameters (heart rate and mean arterial pressure), frequency of deviations in SCA values from the target range, postoperative pain scores assessed using a numeric rating scale (NRS), time to first analgesic requirement, and total rescue analgesic consumption.\n\nPerioperative analgesia will be standardized. All patients will receive intravenous dexketoprofen toward the end of surgery as part of routine clinical practice. Rescue analgesia will be provided with intravenous dexketoprofen when clinically indicated. Additional outcomes include postoperative nausea and vomiting and perioperative complications.\n\nThis study aims to provide objective data on the opioid-sparing effects of different abdominal wall block techniques when intraoperative analgesia is guided by nociception monitoring. The findings may contribute to optimizing analgesic strategies and improving perioperative pain management in laparoscopic surgery.",[490,491],"Laparoscopic Cholecystectomy Surgery","Perioperative Analgesia",[493,494,495,496,497,498,499,500],"M-TAPA","External Oblique Intercostal Block","Abdominal Wall Block","Skin Conductance Algesimeter","Remifentanil","Opioid Consumption","Laparoscopic Cholecystectomy","Intraoperative Analgesia",{"date":436,"type":41},{"date":503,"type":41},"2026-05-15",{"date":505,"type":22},"2026-09",{"name":47,"class":48},{"id":508,"slug":509,"hasResults":12,"nctId":510,"briefTitle":511,"officialTitle":512,"acronym":513,"eligibilityCriteria":514,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":154,"enrollmentInfo":515,"targetDuration":4,"studyType":23,"phases":517,"briefSummary":518,"conditions":519,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":523,"startDateStruct":524,"completionDateStruct":525,"leadSponsor":527,"locationsCount":4},"100643126","comparison-of-90-and-120-arm-positions-in-costoclavicular-block-100643126","NCT07586670","Comparison of 90° and 120° Arm Positions in Costoclavicular Block","Effect of Arm Abduction Degree ( 90° vs. 120° ) on Block Onset Time and Block Success in Costoclavicular Brachial Plexus Block in Patients Undergoing Hand, Wrist and Forearm Surgery: A Prospective Randomized Controlled Trial","COSTO-RCT","Inclusion Criteria:\n\n* Patients aged between 18 and 80 years.\n* Patients scheduled for elective upper extremity surgery (hand, wrist, forearm).\n* Patients classified as ASA I-III.\n* Patients who provide informed consent after being informed about the study.\n\nExclusion Criteria:\n\n* History of previous surgery, scar tissue, tumor, or trauma that may alter brachial plexus anatomy.\n* Presence of infection, hematoma, severe edema, burn, or open wound at the block application site.\n* Known allergy to local anesthetics or other medications used in the study.\n* Coagulopathy, use of anticoagulants, or platelet count \\\u003C 100,000\u002Fmm³.\n* History of peripheral neuropathy, neurological deficit, cervical radiculopathy, or CRPS.\n* Pregnancy or breastfeeding.\n* Patients with BMI \\\u003C 18 kg\u002Fm².\n* Patients with BMI \\> 35 kg\u002Fm².\n* Severe cardiac, pulmonary, renal, or hepatic failure.\n* Mental retardation, communication difficulties, or lack of cooperation.\n* Deformity, amputation, or large mass in the surgical extremity that may interfere with sensorimotor assessment.\n* Preoperative significant sensory loss, motor weakness, or signs of neurological disease.\n* Severe anemia (Hb \\\u003C 9 g\u002FdL) or polycythemia (Hb \\> 18 g\u002FdL).\n* Psychiatric disorders, substance abuse, or any condition that may interfere with study compliance.",{"count":516,"type":22},106,[25],"The costoclavicular approach of the infraclavicular brachial plexus block is widely used for upper extremity surgeries due to its reliable anatomy and high success rates. Patient positioning, particularly the degree of arm abduction, may influence the spread of local anesthetic and the characteristics of the block. However, the optimal arm abduction angle during this procedure remains unclear.\n\nThis prospective randomized controlled trial aims to investigate the effect of two different arm abduction angles (90° and 120°) on block onset time and block success in patients undergoing hand, wrist, and forearm surgery under ultrasound-guided costoclavicular brachial plexus block.\n\nPatients will be randomly assigned to one of two groups according to the degree of arm abduction. The primary outcome is block onset time. Secondary outcomes include block success, sensory and motor block characteristics, perfusion index changes, hemodynamic parameters, readiness for surgery at 15 and 20 minutes, block performance time, need for additional anesthesia, postoperative neurological evaluation at 4 and 24 hours, complications, and patient satisfaction.\n\nThe findings of this study are expected to provide evidence on optimal patient positioning to improve the effectiveness and reliability of ultrasound-guided costoclavicular brachial plexus block.",[89,520,521,522],"Upper Extremity Surgery","Brachial Plexus Block","Regional Anaesthesia",{"date":436,"type":41},{"date":503,"type":22},{"date":526,"type":22},"2026-08-27",{"name":47,"class":48},{"id":529,"slug":530,"hasResults":12,"nctId":531,"briefTitle":532,"officialTitle":533,"acronym":4,"eligibilityCriteria":534,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":154,"enrollmentInfo":535,"targetDuration":4,"studyType":23,"phases":536,"briefSummary":537,"conditions":538,"keywords":541,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":474,"lastUpdatePostDateStruct":546,"startDateStruct":548,"completionDateStruct":549,"leadSponsor":551,"locationsCount":49},"100640161","map--versus-cardiac-index-guided-hemodynamic-management-in-colorectal-surgery-100640161","NCT07609680","MAP- Versus Cardiac Index-Guided Hemodynamic Management in Colorectal Surgery","Comparison of the Effects of Mean Arterial Pressure-Based and Cardiac Index-Based Intraoperative Hemodynamic Management on Postoperative Renal Function in Patients Undergoing Colorectal Surgery: A Prospective Randomized Study","Inclusion Criteria:\n\n* Patients aged 18 to 80 years\n* Patients with American Society of Anesthesiologists physical status II-III\n* Patients with estimated glomerular filtration rate ≥60 mL\u002Fmin\u002F1.73 m²\n* Patients scheduled for colorectal surgery\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 80 years\n* Patients with estimated glomerular filtration rate \\\u003C60 mL\u002Fmin\u002F1.73 m²\n* Patients with American Society of Anesthesiologists physical status other than II-III\n* Patients who refuse to participate in the study\n* Patients who withdraw consent at any stage of the study",{"count":316,"type":22},[25],"This prospective randomized trial aims to compare the effects of two intraoperative hemodynamic management strategies on early postoperative renal function in patients undergoing colorectal surgery. Patients will be randomly assigned to receive either mean arterial pressure-guided or cardiac index-guided intraoperative hemodynamic management.\n\nColorectal surgery is a major abdominal procedure associated with prolonged operative times, significant fluid shifts, blood loss, and hemodynamic instability. These factors can contribute to impaired renal perfusion and subsequent postoperative renal dysfunction. Although mean arterial pressure is widely used to guide intraoperative hemodynamic management, blood pressure alone may not adequately reflect systemic blood flow or regional tissue perfusion. Cardiac index-guided management may provide a more direct assessment of global circulatory adequacy.\n\nThe primary outcome of the study is the change in serum creatinine levels from the preoperative baseline to 72 hours postoperatively. Secondary outcomes include intraoperative hemodynamic variables, fluid and vasopressor requirements, urine output, postoperative renal function parameters, intensive care unit (ICU) and hospital length of stay, and 30-day mortality.",[539,540],"Colorectal Cancer","Intraoperative Hemodynamic Management",[542,543,544,545],"Colorectal surgery","Cardiac index","Mean arterial pressure","Hemodynamic management",{"date":547,"type":41},"2026-06-03",{"date":474,"type":41},{"date":550,"type":22},"2027-12-28",{"name":47,"class":48},{"id":553,"slug":554,"hasResults":12,"nctId":555,"briefTitle":556,"officialTitle":556,"acronym":4,"eligibilityCriteria":557,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":558,"targetDuration":4,"studyType":23,"phases":559,"briefSummary":560,"conditions":561,"keywords":563,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":474,"lastUpdatePostDateStruct":566,"startDateStruct":567,"completionDateStruct":568,"leadSponsor":570,"locationsCount":49},"100626942","comparison-of-postoperative-analgesic-effects-of-quadro-iliac-plane-block-and-transversus-abdominis-plane-blocks-in-inguinal-hernia-surgery-100626942","NCT07442188","Comparison of Postoperative Analgesic Effects of Quadro-iliac Plane Block and Transversus Abdominis Plane Blocks in Inguinal Hernia Surgery","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* Patients with an American Society of Anesthesiologists (ASA) physical status classification of I-III.\n* Patients with a body mass index (BMI) between 18 and 30 kg\u002Fm².\n* Patients scheduled to undergo unilateral inguinal hernia repair under general anesthesia in the operating room.\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 65 years.\n* Patients with an ASA physical status classification of IV or higher.\n* Patients with advanced comorbidities.\n* Patients with a history of bleeding diathesis.\n* Patients with infection at the site of the planned procedure.\n* Patients with a BMI below 18 kg\u002Fm² or above 30 kg\u002Fm².",{"count":316,"type":22},[25],"Inguinal hernia repair is one of the most commonly performed surgical procedures worldwide. Despite being classified as a minor surgical intervention, moderate to severe postoperative pain is reported in approximately 60% of patients. In a subset of these patients, acute postoperative pain may persist and evolve into chronic post-surgical inguinal pain, significantly affecting quality of life.\n\nIn recent years, beyond the use of systemic intravenous analgesics, ultrasound-guided fascial plane blocks have been increasingly incorporated into multimodal analgesia protocols with the aim of reducing postoperative opioid consumption and improving pain control. However, the current literature does not provide definitive evidence regarding the superiority of one block technique over another in this surgical population.\n\nThe primary objective of the present study is to compare the analgesic efficacy of the Quadro-iliac Plane Block (QIPB) and the transversus abdominis plane block (TAPB) in patients undergoing inguinal hernia repair.",[110,111,562],"Hernia, Inguinal",[564,565],"Quadro Iliac Plane Block","Transversus Abdominis Plane Block",{"date":547,"type":41},{"date":474,"type":41},{"date":569,"type":22},"2026-10-19",{"name":47,"class":48},{"id":572,"slug":573,"hasResults":12,"nctId":574,"briefTitle":575,"officialTitle":576,"acronym":4,"eligibilityCriteria":577,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":578,"targetDuration":4,"studyType":23,"phases":579,"briefSummary":580,"conditions":581,"keywords":583,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":586,"lastUpdatePostDateStruct":587,"startDateStruct":588,"completionDateStruct":589,"leadSponsor":591,"locationsCount":49},"100639262","flow-controlled-versus-volume-controlled-ventilation-in-lumbar-disc-herniation-surgery-100639262","NCT07614555","Flow-Controlled Versus Volume-Controlled Ventilation in Lumbar Disc Herniation Surgery","Comparison of Flow-Controlled and Volume-Controlled Ventilation During Lumbar Disc Herniation Surgery: A Prospective Randomized Trial","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* ASA physical status I-III\n* Body Mass Index between 18 and 30 kg\u002Fm²\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years or \\> 65 years\n* Known or previously diagnosed pulmonary disease\n* Patients with severe preoperative pulmonary function impairment (e.g., FEV₁ \\\u003C 50% predicted, severe restrictive or obstructive pathology)\n* Patients with markedly altered lung anatomy or function due to prior major thoracic surgery\n* Patients who were dependent on supplemental oxygen therapy in the preoperative period\n* ASA physical status IV or higher\n* Refusal or inability to provide informed consent",{"count":487,"type":22},[25],"This prospective randomized trial aims to compare the effects of flow-controlled ventilation (FCV) and volume-controlled ventilation (VCV) on intraoperative airway pressures and oxygenation in patients undergoing lumbar disc herniation surgery under general anesthesia.\n\nAdult patients aged 18-65 years, with ASA physical status I-III and a body mass index of 18-30 kg\u002Fm², will be allocated to receive either FCV or VCV during routine intraoperative mechanical ventilation. Ventilatory parameters, including peak airway pressure, plateau pressure, pulmonary compliance, EtCO₂, SpO₂, and arterial blood gas variables, will be recorded at predefined time points after intubation.\n\nThe primary endpoint is the PaO₂ value measured after 20 minutes in the prone position.\n\nBy comparing respiratory mechanics and oxygenation between the two ventilation modes, this study aims to contribute to the optimization of intraoperative ventilatory management in lumbar disc herniation surgery.",[582,427],"Lumbar Disc Herniation Surgery",[584,585,582],"Flow-Controlled Ventilation","Volume-Controlled Ventilation","2026-05-28",{"date":169,"type":41},{"date":586,"type":41},{"date":590,"type":22},"2026-11-26",{"name":47,"class":48},{"id":593,"slug":594,"hasResults":12,"nctId":595,"briefTitle":596,"officialTitle":597,"acronym":4,"eligibilityCriteria":598,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":154,"enrollmentInfo":599,"targetDuration":4,"studyType":23,"phases":600,"briefSummary":601,"conditions":602,"keywords":604,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":606,"lastUpdatePostDateStruct":607,"startDateStruct":608,"completionDateStruct":609,"leadSponsor":610,"locationsCount":49},"100638458","map--versus-cardiac-index-guided-hemodynamic-management-in-whipple-surgery-100638458","NCT07603336","MAP- Versus Cardiac Index-Guided Hemodynamic Management in Whipple Surgery","Comparison of the Effects of Mean Arterial Pressure-Based and Cardiac Index-Based Intraoperative Hemodynamic Management on Postoperative Renal Function in Patients Undergoing Pancreaticoduodenectomy: A Prospective Randomized Study","Inclusion Criteria:\n\n* Patients aged 18 to 80 years\n* Patients with American Society of Anesthesiologists physical status II-III\n* Patients with estimated glomerular filtration rate ≥60 mL\u002Fmin\u002F1.73 m²\n* Patients scheduled for pancreaticoduodenectomy \u002F Whipple procedure\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 80 years\n* Patients with estimated glomerular filtration rate \\\u003C60 mL\u002Fmin\u002F1.73 m²\n* Patients with American Society of Anesthesiologists physical status other than II-III\n* Patients who refuse to participate in the study\n* Patients who withdraw consent at any stage of the study",{"count":316,"type":22},[25],"This prospective randomized study aims to compare the effects of two intraoperative hemodynamic management strategies on early postoperative renal function in patients undergoing pancreaticoduodenectomy. Patients will be allocated to either mean arterial pressure-guided hemodynamic management or cardiac index-guided hemodynamic management during surgery.\n\nPancreaticoduodenectomy is a major abdominal surgical procedure associated with prolonged operative duration, considerable fluid shifts, blood loss, and hemodynamic instability. These factors may contribute to impaired renal perfusion and postoperative renal dysfunction. Although mean arterial pressure is commonly used to guide intraoperative hemodynamic management, blood pressure alone may not fully reflect systemic blood flow or tissue perfusion. Cardiac index-guided management may provide a more direct assessment of global circulatory adequacy.\n\nThe primary outcome of the study is the change in serum creatinine level from the preoperative baseline value to the postoperative 72nd hour. Secondary outcomes include intraoperative hemodynamic variables, fluid and vasopressor requirements, urine output, postoperative renal function parameters, length of intensive care unit and hospital stay, and 30-day mortality.",[603,540],"Whipple Procedure",[605,543,544,545],"Whipple procedure","2026-05-27",{"date":586,"type":41},{"date":606,"type":41},{"date":550,"type":22},{"name":47,"class":48},{"id":612,"slug":613,"hasResults":12,"nctId":614,"briefTitle":615,"officialTitle":616,"acronym":4,"eligibilityCriteria":617,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":618,"targetDuration":4,"studyType":23,"phases":619,"briefSummary":620,"conditions":621,"keywords":623,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":606,"lastUpdatePostDateStruct":626,"startDateStruct":628,"completionDateStruct":629,"leadSponsor":631,"locationsCount":49},"100638017","comparison-of-analgesic-effects-of-acb-versus-acb-combined-with-bifes-block-in-meniscopathy-surgery-100638017","NCT07603323","Comparison of Analgesic Effects of ACB Versus ACB Combined With BiFeS Block in Meniscopathy Surgery","Comparison of Analgesic Effects of Adductor Canal Block Versus Adductor Canal Block Combined With BiFeS (Biceps Femoris Short Head) Block in Meniscopathy Surgery","Inclusion Criteria:\n\n* Patients aged 18-65 years\n* American Society of Anesthesiologists (ASA) score I-II-III\n* Body Mass Index (BMI) between 18-30 kg\u002Fm2\n\nExclusion Criteria:\n\n* Patients under 18 and over 65 years of age\n* ASA score IV and above\n* Patients with a history of bleeding diathesis\n* BMI below 18 or above 30 kg\u002Fm2",{"count":452,"type":22},[25],"Meniscopathy surgeries are commonly associated with moderate postoperative pain, particularly during early mobilization and rehabilitation. Inadequate postoperative analgesia may negatively affect functional recovery, delay ambulation, increase opioid consumption, and contribute to opioid-related adverse effects. Therefore, effective multimodal analgesic strategies are of considerable importance in patients undergoing arthroscopic knee procedures.\n\nAdductor canal block (ACB) is a widely used regional anesthesia technique that provides effective analgesia while largely preserving quadriceps muscle strength. However, its limited effect on posterior knee capsule innervation may result in insufficient control of posterior knee pain. Recently, the biceps femoris short head (BiFeS) block has been described as a novel motor-sparing fascial plane block targeting the posterolateral knee capsule and may provide additional analgesic benefit when combined with ACB.\n\nIn this study, it was aimed to compare the postoperative analgesic efficacy of adductor canal block alone and adductor canal block combined with BiFeS block in patients undergoing surgery for meniscopathy.",[622,110,111],"Meniscopathy Surgery",[622,624,625],"Adductor Canal Block","Biceps Femoris Short Head Block",{"date":627,"type":41},"2026-05-29",{"date":606,"type":41},{"date":630,"type":22},"2027-05-21",{"name":47,"class":48},{"id":633,"slug":634,"hasResults":12,"nctId":635,"briefTitle":636,"officialTitle":637,"acronym":4,"eligibilityCriteria":638,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":639,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":641,"conditions":642,"keywords":645,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":651,"lastUpdatePostDateStruct":652,"startDateStruct":654,"completionDateStruct":655,"leadSponsor":657,"locationsCount":49},"100638126","cortisol-levels-and-mortality-in-septic-shock-icu-patients-100638126","NCT07582926","Cortisol Levels and Mortality in Septic Shock ICU Patients","Prognostic Value of Cortisol Levels in Critically Ill Patients With Sepsis and Septic Shock: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Age 18 years or older\n* Admission to the intensive care unit for more than 24 hours\n* Presence of a clinically or microbiologically confirmed source of infection\n* Diagnosis of sepsis or septic shock during ICU stay\n\nExclusion Criteria:\n\n* Pregnancy\n* Known disorders of the hypothalamic-pituitary-adrenal (HPA) axis\n* Known disorders affecting cortisol secretion 4.Long-term systemic glucocorticoid use (≥3 months)",{"count":640,"type":22},183,"This prospective observational study aims to evaluate the prognostic value of cortisol levels and their dynamic changes in critically ill patients with sepsis and septic shock admitted to the intensive care unit. Cortisol plays a crucial role in maintaining hemodynamic stability and modulating the inflammatory response during critical illness, and relative adrenal insufficiency has been associated with worse clinical outcomes.\n\nAdult patients admitted to the intensive care unit with sepsis or septic shock will be enrolled and followed prospectively. Serum cortisol levels will be measured, and their association with clinical outcomes, including intensive care unit mortality, 28-day mortality, and 90-day mortality, will be analyzed. In addition, the relationship between cortisol levels and disease severity scores such as SOFA and APACHE, as well as laboratory parameters including inflammatory biomarkers, will be evaluated.\n\nThe findings of this study are expected to contribute to the early identification of high-risk patients and improve prognostic assessment in critically ill patients with sepsis and septic shock.",[643,644],"Sepsis","Septic Shock",[646,647,648,649,650],"sepsis","septic shock","cortisol","mortality","intensive care unit","2026-05-14",{"date":653,"type":41},"2026-05-18",{"date":195,"type":22},{"date":656,"type":22},"2026-12-01",{"name":47,"class":48},""]