[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Applied Food Sciences Inc.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":78},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100649243","a-trial-to-study-the-effects-of-ginseng-and-cordyceps-on-aerobic-capacity-lactate-kinetics-and-nitric-oxide-100649243",false,"NCT07729943","A Trial to Study the Effects of Ginseng and Cordyceps on Aerobic Capacity, Lactate Kinetics, and Nitric Oxide","Comparative Effects of Ginseng, Cordyceps, and Placebo on Aerobic Capacity, Lactate Kinetics, and Nitric Oxide Status: A 30-Day Randomized Trial","Inclusion Criteria:\n\n* Provide voluntary signed and dated informed consent.\n\n  * Be in good health and able to participate in cognitive performance testing as determined by assessment, medical history, and routine blood chemistries.\n  * Between the of 40 and 65 years of age (inclusive).\n  * Body Mass Index of 18.5-34.9 (inclusive).\n  * Body weight of at least 110 pounds.\n  * Normotensive (seated, resting systolic blood pressure \\\u003C140 mm Hg and diastolic blood pressure \\\u003C 90 mm Hg. If the first measurement is slightly elevated above these limits, the subject will be given a brief (5-minute) rest period, and two more measurements will be taken. The average of all three measurements will be used to determine eligibility.\n  * Normal supine, resting heart rate (\\\u003C90 per minute).\n  * Able to provide an adequate blood draw.\n  * If a dietary supplement was initiated within the past month, the participant is willing to discontinue supplement use followed by a 2-week washout prior to participation in the study.\n  * Willing to duplicate their previous 24-hour diet, refrain from caffeine and alcohol for 24 hours, refrain from exercise for 48 hours prior to each trial, and fast for 10 hours prior to each visit.\n  * Recreationally active (≥3 exercise sessions\u002Fwk)\n\nExclusion Criteria:\n\n-Smokers.\n\n* History of malignancy in the previous 5 years except for non-melanoma skin cancer (basal cell cancer or squamous cell cancer of the skin).\n* Prior gastrointestinal bypass surgery (Lapband, etc.).\n* Other known gastrointestinal or metabolic diseases that might impact nutrient absorption or metabolism, e.g. electrolyte abnormalities, diabetes, thyroid disease, adrenal disease, hypogonadism, short bowel syndrome, diarrheal illnesses, history of colon resection, gastric ulcer, reflux disease, gastroparesis, Inborn-Errors-of-Metabolism (such as PKU).\n* Chronic medically diagnosed inflammatory condition or disease (e.g. rheumatoid arthritis, Crohn's disease, ulcerative colitis, Lupus, HIV\u002FAIDS, etc.).\n* Medical history of metabolic, cardiovascular, hepatorenal, musculoskeletal, autoimmune, or neurologic disease.\n* Use of performance enhancing drugs\n* Anti-inflammatory supplement\u002Fmedication use started within 4 weeks\n* Ergogenic supplement use started within 4 weeks. (i.e. beta-alanine, creatine, beet root, citrulline, arginine, )\n* Individuals with excessive caffeine intake (\\>400mg\u002Fday).\n* Known sensitivity to any ingredient in the test formulations as listed in the Certificates- of-Analysis.\n* Women currently pregnant, trying to become pregnant or breastfeeding a child.\n* Any other diseases or conditions that, in the opinion of the medical staff, could confound the primary endpoint or place the subject at increased risk of harm if they were to participate",true,"ALL","40 Years","65 Years",{"count":21,"type":22},75,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study is a double-blind, randomized, parallel group, three-arm, placebo-controlled trial of seventy-five (75) apparently healthy male and female participants to be recruited at a single investigational center in Northeast Ohio (i.e., The Center for Applied Health Sciences). The study will assess the potential benefits of four weeks of supplementation with 300 mg Ginseng or 1 gram Cordyceps Militaris (vs. placebo). Participants will attend 3 study visits. During Visit 1, participants will be screened for participation (i.e., medical history, routine blood work, background baseline diet and familiarization protocol will be completed). During Visit 2 (Day 0) and Visit 3 (Day 30) participants will complete subjective baseline testing including questionnaires that assess recovery, mood, energy, fatigue, and quality of life. They will complete a VO2 max test, a TTE test, isometric mid-thigh pull, and have their handgrip strength assessed. They will also be tested for changes in circulating nitrates\u002Fnitrites (NOx), circulatory efficiency (oxygen pulse), and lactate kinetics (production and clearance).\n\nComprehensive side effect profile\u002F adverse event monitoring will take place throughout thevstudy duration. The study will be conducted following ICH-GCP guidelines to ensure subject safety and scientific integrity of the data.",[28],"Healthy Subjects With Low Energy Levels",[30,31,32,33,34],"Cordyceps (Cordyceps Militaris)","Panax Ginseng","VO2Max","NOx","Circulatory efficiency","RECRUITING","2026-07-22",{"date":38,"type":39},"2026-07-28","ACTUAL",{"date":41,"type":39},"2026-03-15",{"date":43,"type":22},"2027-02-01",{"name":45,"class":46},"Applied Food Sciences Inc.","INDUSTRY",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":47},"100632463","examining-olive-oil-extract-on-knee-comfort-and-function-100632463","NCT07514013","Examining Olive Oil Extract on Knee Comfort and Function","A 6-Week, Randomized, Double-Blind, Placebo-Controlled Virtual Study Evaluating an Olive Oil Extract on Knee Comfort and Function","Inclusion Criteria:\n\nParticipants must meet all of the following criteria to be eligible for participation:\n\n* Adults aged 40 to 75 years\n* Self-reported knee discomfort for at least 3 months\n* Willing and able to take one study capsule daily for the duration of the study\n* Willing and able to complete digital questionnaires, functional movement tasks, and other study activities using the Alethios platform\n* Willing and able to wear a compatible activity-tracking device throughout the study\n* Willing and able to collect saliva samples at home using a provided kit, if applicable\n* Able to read and understand English\n* Willing to provide informed consent electronically\n\nExclusion Criteria:\n\nParticipants will be excluded if any of the following apply:\n\n* Diagnosis of inflammatory joint disease (e.g., rheumatoid arthritis) or other systemic inflammatory conditions affecting the knee\n* Any current or prior diagnosis from a licensed medical provider of knee disease\n* Knee surgery or significant knee injury within the past 6 months\n* Planned knee surgery during the study period\n* Known allergy or sensitivity to olive-derived products or any component of the study product\n* Current use of investigational drugs or participation in another research study during the study period\n* Any medical condition or circumstance that, in the opinion of the investigator, would make participation unsafe or interfere with study participation or data quality","75 Years",{"count":57,"type":22},168,[25],"The goal of this study is to learn if an olive oil extract works to improve knee pain and discomfort in adults. The main questions it aims to answer are: 1) Does the olive oil extract improve the perceptions of knee pain and discomfort, and 2) Does the olive oil extract improve knee function in adults?\n\nThe main procedures in the study include:\n\n* Screening and informed consent\n* Take one assigned study capsule (supplement or placebo) daily with food for 6 weeks\n* Complete digital questionnaires about your knee pain, stiffness, and function at scheduled times\n* Complete a Day 1 acute assessment and two simple functional movement tests at home as described below\n* If possible, connect a compatible wearable device to allow collection of sleep and physical activity data as detailed below.\n* Collect saliva samples at home using a provided kit at designated timepoints\n* Record any pain medications taken during the study or any side effects",[61,62,63],"Healthy Adult Male","Healthy Adult Females","Joint Discomfort",[65,66,67,68,69],"olive oil extract","randomized","double-blind","placebo","joint discomfort","2026-04-10",{"date":72,"type":39},"2026-04-15",{"date":74,"type":22},"2026-04",{"date":76,"type":22},"2026-11-01",{"name":45,"class":46},""]