[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Applied Science & Performance Institute\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":90},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100651252","the-effects-of-tyrosol-and-creatine-on-exercise-performance-and-cognition-in-healthy-adults-100651252",false,"NCT07756658","The Effects of Tyrosol and Creatine on Exercise Performance and Cognition in Healthy Adults","The Effects of Tyrosol and Creatine on Exercise Performance and Cognition in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial","Inclusion Criteria:\n\n* Healthy males aged 20-55\n* Currently active (engaged in moderate to vigorous activity at least 2-days per week as defined by the American College of Sports Medicine Guidelines)\n* Estimated VO2 max greater than the 40th percentile of the population norm for age (assessed via ACSM guidelines, 2014). The VO2 max estimation at screening will be obtained by following a non-exercise regression model validated and described by Bradshaw et al. (2005).\n* Able to read and write in English\n* During the study, agree not to take any other supplements that may increase muscle strength or endurance (e.g. protein formulas, creatine, amino acids, tyrosol or stimulants other than caffeine).\n* During the study, subjects will not deviate from their normal daily routine unless it conflicts with study criteria. This includes maintaining their present workout routine and diet, without substantial changes.\n\nExclusion Criteria:\n\n* Known diagnosis of any cardiovascular, metabolic, endocrine, or renal disease\n* Uncontrolled stage II hypertension or higher\n* Recent musculoskeletal injury (\\\u003C3-months)\n* Recent orthopaedic surgery (\\\u003C12-months)\n* History of or current malignancy\n* Previous gastrointestinal surgery within the past 12 months\n* Regular smoker\n* Regular drinker (\\>14 drinks per week)\n* Current use (within the past 5 weeks) of creatine supplements\n* Current use (within past 3 months) of Tyrosol supplementation\n* Current use of dietary supplements that may enhance mitochondrial function, muscle hypertrophy, or muscle strength (e.g. protein formulas, creatine, amino acids, tyrosol, etc.).\n* Current use of prescription medications that may influence adaptation to exercise (hormone therapies, peptides, etc.)",true,"MALE","20 Years","55 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will be a randomized, double-blind, placebo-controlled trial. It will be conducted over a 8-week intervention investigating the effects of creatine (5g Creatine monohydrate); placebo control (5g resistant dextrin), and a combination group containing both creatine and tyrosol (5g creatine monohydrate + 150mg tyrosol\u002Fday). Endurance, strength, cognition, and fatigue resistance will be examined through repeated strength and endurance testing (described below).\n\nParticipants who pass initial screening will be invited on-site for day one (Visit 1) of testing where the participants will proceed with a series of tests which will include the following: (1) body composition; (2) mood and cognitive testing; (3) full-body strength testing; (4) 5RM (repetition maximum) bench press, leading to multiple sets of bench press (based on the previous weight) completed to failure; (5) finally, a time to exhaustion endurance test will be conducted followed by (6) repeat cognitive testing.\n\nAfter the 8-week supplementation period (\\~56-60 days), all original measures will be repeated as before in the same order (Visit 2). Approximately 24 hours later (Visit 3) participants will complete a questionnaire for muscle soreness remotely, and again at 48 hours post-Visit 2 (visit 4).",[28,29,30,31,32],"Tyrosol","Creatine","Endurance Performance","Cognition","Mood",[34,35,36,37,38,39,40,41],"tyrosol","creatine","muscle strength","muscle endurance","muscle soreness","muscle performance","cognition","mood","NOT_YET_RECRUITING","2026-08-19",{"date":45,"type":46},"2026-08-21","ACTUAL",{"date":48,"type":22},"2026-08-17",{"date":50,"type":22},"2026-12-17",{"name":52,"class":53},"Applied Science & Performance Institute","INDUSTRY",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":16,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":67,"conditions":68,"keywords":74,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":54},"100651481","the-effects-of-quercefit-and-ubiqsome-in-mitigating-inflammation-and-promoting-metabolic-health-100651481","NCT07760506","The Effects of Quercefit® and Ubiqsome™ in Mitigating Inflammation and Promoting Metabolic Health","The Effects of Quercefit® and Ubiqsome™ in Mitigating Inflammation and Promoting Metabolic Health - A Randomized, Double-Blind, Placebo-Controlled Study","Inclusion Criteria:\n\n* Males and females aged 50 to 75 years\n* Participants who meet the requirements of a sedentary lifestyle. Meaning, subjects who do not meet the World Health Organization's (WHO) minimum activity guidelines, of at least 150 minutes of moderate-intensity activity, or, 75 minutes of vigorous-intensity activity a week, plus muscle-strengthening activities at least 2 days per week. Of importance, incidental physical activity (eg, walking to work, household activities) would not meet the standard of being physically active according to WHO guidelines (McKay et al., 2021).\n* BMI of \\> or equal to 25.00kg\u002Fm²\n* Individuals with \\> or equal to 5 score relative to high risk for prediabetes as defined by the CDC (https:\u002F\u002Fwww.cdc.gov\u002Fprediabetes\u002Ftakethetest)\n* Free of all other chronic diseases.\n* Not currently using glucose-lowering agents or insulin.\n* Able to read and write in English\n* Willing to maintain a habitual diet, supplement routine, and avoid other lifestyle changes during the study period.\n* During the study, participants agree not to take any other supplement that can impact glucose or insulin regulation.\n* During the study, participants agree not to take any other supplement that can impact cardiovascular health, inflammatory status, or anti-aging supplements\n* Willing to have blood drawn\n* Must have access to a reliable internet connection and a computer to complete remote assessments\n\nExclusion Criteria:\n\n* Unwilling to have blood drawn\n* Unwilling to swallow pills\n* Pregnancy or has breast fed within 3 months prior to enrollment\n* Current use of prescription medication or drug that impacts Glucose or Insulin metabolism (including direct insulin treatment) within the past 6-months\n* Current use of Quercetine or CoQ10 supplements within the past 4-weeks\n* History or current alcohol or drug abuse\n* Known diagnosis of any chronic cardiovascular, metabolic, endocrine, or renal disease outside of prediabetes as listed above.\n* Has significant concurrent illnesses (controlled or uncontrolled), such as lupus, hepatitis B\u002FC, HIV, serious mental health illness such as dementia or schizophrenia; psychiatric hospitalization in the past two years, or other conditions, which in the opinion of the investigator, such condition might be aggravated as a result of treatment\n* Developmental disability or cognitive impairment that would preclude adequate comprehension of the informed consent form and\u002For ability to follow study subject requirements and\u002For record the necessary study measurements.\n* History of cardiovascular disease (i.e., myocardial infarction, hypertension, hypercholesterolemia, peripheral vascular disease, other)\n* History of neurological disorders (Parkinson's, Amyotrophic lateral sclerosis, epilepsy, spinal cord injury resulting in inability to use upper extremities, other.)\n* History of gastrointestinal disorders that could lead to uncertain absorption of the study supplements (i.e., inflammatory bowel disease, ulcerative colitis, -Crohn's disease, colostomy, or eating disorder)\n* History of kidney or liver disease\n* History of metabolic disorders (diabetes, metabolic syndrome, other)\n* History of current malignancy\u002Fcancer\n* Receiving chemotherapy agents or radiation treatments\n* Diagnosis of a terminal illness\n* The investigator feels that, for any reason, the subject is not eligible to participate in the study","ALL","50 Years","75 Years",{"count":21,"type":22},[25],"The goal of this clinical trial is to learn if Quercefit® or Ubiqsome™ can improve markers of healthy aging, blood sugar control, and heart health in older adults. It will also learn about the safety of these supplements.\n\nThe main questions it aims to answer are:\n\n1. Do Quercefit® or Ubiqsome™ improve blood sugar, cholesterol, and markers of aging compared to a placebo?\n2. What side effects, if any, do participants have while taking these supplements?\n\nResearchers will compare Quercefit® (500 mg\u002Fday), Ubiqsome™ (300 mg\u002Fday), and a placebo (a look-alike capsule with no active ingredient).\n\nParticipants will:\n\n1. Take their assigned capsules (Quercefit®, Ubiqsome™, or placebo) twice daily for 12 weeks\n2. Go to a preferred clinic at the start and end of the study for a fasting blood draw\n\n   Complete at-home tests:\n3. Grip strength testing (using a device mailed to them)\n4. Online surveys about fatigue and quality of life\n5. Report any side effects and keep track of supplement use",[69,70,71,72,73],"Healthy Aging","Inflammaging","Metabolic Health","Quercetin","Coenzyme Q10",[69,70,71,75,76,77,78,79,80,81],"Blood testing","Pre-Diabetic","Composite Inflammaging Metric","Blood Glucose Regulation","Neuromuscular Function","Fatigue Impact Scale","Quality of life","2026-08-10",{"date":84,"type":46},"2026-08-12",{"date":86,"type":22},"2026-08",{"date":88,"type":22},"2028-08",{"name":52,"class":53},""]