[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Argentinian Intensive Care Society\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":70},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100659335","high-flow-tracheal-oxygen-during-spontaneous-breathing-trial-100659335",false,"NCT07864415","High-Flow Tracheal Oxygen During Spontaneous Breathing Trial","Effect of High-flow Tracheal Oxygen on End-expiratory Lung Impedance and Work of Breathing in Intubated Patients During a Spontaneous Breathing Trial.","HFTO-SBT","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Invasive mechanical ventilation ≥ 24 hours\n* Presence of esophageal balloon catheter\n* Meets criteria to start an SBT\n* Signed informed consent by patient or responsible family member\n\nExclusion Criteria:\n\n* Neuromuscular or neurodegenerative disease\n* contraindication to electrical impedance tomography (e.g., implantable defibrillator)\n* Impossible to place EIT electrode belt (e.g., wound dressings or chest drains)\n\nElimination Criteria:\n\n* Flow intolerance\n* Behavioral\u002Fcognitive alterations that interrupt measurements in two consecutive attempts.","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to find out whether high-flow tracheal oxygen (HFTO) delivered at flows greater than 60 L\u002Fmin can increase end-expiratory lung volume (EELV) in intubated patients during a spontaneous breathing trial (SBT).\n\nWeaning from mechanical ventilation can be difficult, especially in patients at higher risk of failure. During an SBT, losing positive end-expiratory pressure (PEEP) can cause the lungs to lose volume and make breathing harder by increasing the work of breathing (WOB). HFTO may help reduce the work of breathing, but previous studies using flows of 30-60 L\u002Fmin did not consistently show an increase in EELV. Higher flows may create more airway pressure.\n\nTherefore, the main question this study is trying to answer is: In intubated patients during an SBT, does HFTO at flows greater than 60 L\u002Fmin increase EELV? The hypothesis is that HFTO at flows above 60 L\u002Fmin will increase EELV during the SBT.",[27,28,29],"Mechanical Ventilation Weaning","Spontaneous Breathing Trial","High Flow Oxygen Therapy",[31,32,28,33,29],"Mechanical Ventilation","Weaning","High Flow Tracheal Oxygen","NOT_YET_RECRUITING","2026-10-02",{"date":37,"type":38},"2026-10-07","ACTUAL",{"date":40,"type":21},"2026-10-01",{"date":42,"type":21},"2027-03-31",{"name":44,"class":45},"Argentinian Intensive Care Society","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},"100594266","microaspiration-and-endotracheal-tubes-100594266","NCT07017205","Microaspiration and Endotracheal Tubes","Automated Versus Manual Cuff Pressure Control for Preventing Microaspiration With TaperGuard Endotracheal Tubes in Elective Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients (\\>18 years old) scheduled for surgery lasting at least one hour.\n* ASA I-III classification.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Pre-existing airway pathology (e.g., tracheomalacia, granulomas, stenosis, tumors).\n* Anticipated difficult intubation (Macocha Score \\> 3 points).\n* Selective lung ventilation \u002F one-lung ventilation.\n* Current participation in another clinical trial.\n\nElimination Criteria:\n\n* Accidental extubation.\n* Cardiorespiratory arrest or death.",{"count":54,"type":21},72,[24],"The goal of this clinical trial is to learn if a new method for managing breathing tube pressure is better at preventing fluid from leaking into patients' lungs during surgery. It will also check if it causes fewer side effects like a sore throat.\n\nThe main questions it aims to answer are:\n\nDoes using a continuous pressure controller reduce fluid leakage past the breathing tube cuff compared to the standard manual method? Does the continuous pressure controller lead to fewer and less severe sore throats and voice changes after surgery?\n\nResearchers will compare two groups:\n\nGroup 1: Patients whose breathing tube cuff pressure is managed with a continuous automatic controller.\n\nGroup 2: Patients whose breathing tube cuff pressure is managed with the standard manual method.\n\nParticipants will:\n\nBe randomly assigned to one of the two groups before their surgery. Receive a small, safe amount of blue dye in their mouth during the procedure to help measure leakage.\n\nHave two small secretion samples collected from their breathing tube during surgery.\n\nBe asked about sore throat and voice changes at 1, 2, 3, and 24 hours after the breathing tube is removed.",[58,59,60],"Endotracheal Tube Cuff","Microaspiration","Endotracheal Tube Cuff Pressure","2025-12-05",{"date":63,"type":38},"2025-12-15",{"date":65,"type":21},"2026-02-01",{"date":67,"type":21},"2026-05-31",{"name":44,"class":45},1,""]