[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Arizona State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":714},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,33,0,25,[9,54,91,128,156,181,203,229,255,278,298,334,354,380,414,443,468,494,518,548,578,604,630,659,689],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100644875","remote-virtual-inspiration-vitality-and-energy-100644875",false,"NCT07675681","REmote Virtual Inspiration: Vitality and Energy","Improving Cardiometabolic Health With Meditative Movement in Mobility Impaired Women","REVIVE","Inclusion Criteria:\n\n* Self-identify as a woman.\n* Age 35-64 years.\n* Mobility impairment lasting at least 1 year.\n* Regular use of a mobility aid (e.g., wheelchair, scooter, walker, cane, crutches, or other assistive device).\n* Community dwelling.\n* Able to demonstrate sufficient upper-extremity mobility to participate in seated Tai Chi\u002FQigong activities.\n* Access to a smartphone, tablet, or computer with internet access.\n* Willing to wear a study-provided wearable device and complete study assessments.\n* Reside in the United States.\n* Waist circumference ≥ 33 inches (84 cm).\n* Perceived Stress Scale (PSS) score ≥ 15.\n* Insomnia Severity Index (ISI) score ≥ 8.\n* Emotional eating indicated by a score \\\u003C 3 on the Mindful Eating Questionnaire (MEQ) Emotional Response subscale.\n* Able to understand written and spoken English.\n* Able to provide informed consent.\n* Able to provide healthcare provider approval for participation.\n\nExclusion Criteria:\n\n* Medical conditions that would make participation unsafe, as determined during screening.\n* Inability to safely perform seated upper-body movements.\n* Current participation in a structured Tai Chi, Qigong, or similar meditative movement program.\n* Pregnancy, lactation, or plans to become pregnant during the study period.\n* Cognitive, visual, auditory, or other impairments that would preclude completion of study procedures.\n* Implanted cardiac devices or implanted electronic devices that interfere with physiologic measurements.\n* Severe arrhythmia, left ventricular assist device (LVAD), or other conditions that interfere with heart rate variability assessment.\n* Use of sleep medications three or more times per week.\n* Medical conditions or medications that substantially affect autonomic nervous system activity, sleep, or stress-related outcomes.\n* Uncontrolled cardiovascular, neurological, psychiatric, or other serious medical conditions that would preclude safe participation.","FEMALE","35 Years","64 Years",{"count":22,"type":23},280,"ESTIMATED","INTERVENTIONAL",[26],"NA","REVIVE is a randomized controlled trial designed to evaluate the effects of a remotely delivered seated Tai Chi\u002FQigong (TCQ) intervention on cardiometabolic health, stress, sleep, and psychological well-being among women with mobility impairments.\n\nWomen with mobility impairments experience higher rates of obesity, cardiometabolic disease, chronic stress, sleep disturbances, and mental health concerns compared with women without disabilities. Limited access to accessible physical activity programs and barriers to participation in traditional exercise interventions contribute to these health disparities. Tai Chi and Qigong are gentle mind-body practices that may improve physical and psychological health through movement, breathing, and mindfulness techniques and can be adapted for individuals with limited mobility.\n\nParticipants will be randomized to either a seated Tai Chi\u002FQigong intervention or a health education video control condition. During the 12-week intervention phase, participants will receive daily video-based content delivered remotely. Participants assigned to the Tai Chi\u002FQigong group will engage in seated meditative movement practices, while participants assigned to the control group will receive health and wellness education videos unrelated to physical activity or nutrition behavior change.\n\nOutcomes will be assessed remotely at baseline, post-intervention, and follow-up. Primary outcomes include waist circumference and indicators of physiological stress regulation, including heart rate variability and salivary cortisol. Secondary outcomes include perceived stress, emotion regulation, depression, anxiety, emotional eating, sleep quality, and sleep disturbance. Additional measures collected through wearable technology, sleep diaries, questionnaires, and biological samples will be used to examine potential behavioral, psychological, and physiological mechanisms underlying intervention effects.\n\nThe findings from this study will contribute to the development of accessible, scalable, and evidence-based health promotion interventions designed to improve cardiometabolic health and overall well-being among women with mobility impairments.",[29,30,31,32,33],"Implementation Science","Women Health","Disability Physical","Meditation","Tai Chi",[35,36,37,38,39,40],"Mobility Impairment","Tai Chi\u002FQigong","Cardiometabolic Health","Women with Disabilities","Stress Regulation","Sleep Health","RECRUITING","2026-08-04",{"date":44,"type":45},"2026-08-05","ACTUAL",{"date":47,"type":23},"2026-09-01",{"date":49,"type":23},"2030-08-30",{"name":51,"class":52},"Arizona State University","OTHER",1,{"id":55,"slug":56,"hasResults":12,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":24,"phases":68,"briefSummary":69,"conditions":70,"keywords":75,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":53},"100649005","fruit-and-vegetable-study---pilot-100649005","NCT07727746","Fruit and Vegetable Study - Pilot","Amplifying the Impact of the Fresh Fruit and Vegetable Program (FFVP) Beyond Schools: A Multisectoral Approach Pilot","FFVP+ Pilot","Inclusion Criteria:\n\n* Stores: Must be a Food City store located within the Maricopa or Pinal County regions.\n* FFVP Schools: Must 1) be located within 1-mile radius of a Food City store; 2) have 2 years of continuous prior experience in the USDA-funded FFVP program; 3) intend to offer FFVP at least 2 days\u002Fweek over the school year; and 4) are not participating in other FV related research.\n* Non-FFVP School: Must 1) be located within 1-mile radius of a Food City store; 2) eligible for USDA-funding, but not awarded funding for the FFVP program; and 3) are not participating in other FV related research.\n* Children\u002Fstudents: Include 1) boys and girls enrolled in 3rd - 6th grade at participating schools, 2) with parent\u002Fcaregiver consent, 3) regularly participating in the school-lunch program.\n* Parent\u002FCaregiver: Must be 1) an adult aged 18 years or older and 2) a primary caregiver (parent or guardian with at least 50% custody) of the selected child attending a participating school.\n\nExclusion Criteria:\n\n* Schools outside Maricopa and Pinal regions will be excluded. Grocery stores other than Bashas' Food City will be excluded due to the participation of this retail partner in the grant.\n* Students will be excluded if they are not enrolled in grades 3 through 6, do not have parent\u002Fcaregiver consent, do not provide assent, or do not participate in the school lunch program.\n* Parents\u002Fcaregivers will be excluded if they do not provide consent or cannot read or write in English or Spanish.",true,"ALL","7 Years","65 Years",{"count":67,"type":23},880,[26],"Arizona State University is studying how local schools and grocery stores can work together to promote fruits and vegetables and support healthy eating among children and families.\n\nThe goal of this pilot cluster clinical trial is to determine whether FFVP+, a public private partnership between elementary schools and regional Bashas' Food City stores, can used to support fruit and vegetable promotion among children and their caregivers. The study will include elementary school students and caregivers from elementary schools participating in the USDA Fresh Fruit and Vegetable Program.\n\nThe main questions it aims to answer are:\n\nCan schools and Food City stores coordinate promotion of fruits and vegetables through the FFVP+ partnership?\n\nCan we recruit and retain student and caregiver dyads and collect the planned measures across the school year?\n\nDo children and caregivers in the FFVP+ schools consume more fruits and vegetables than schools not receiving this enhanced intervention.\n\nResearchers will compare schools receiving FFVP+ to schools receiving the usual Fresh Fruit and Vegetable Program only. This will help us understand whether the partnership is feasible, whether the recruitment and data collection procedures work, and whether the approach is ready to be tested in a larger trial.\n\nParticipants will:\n\nComplete study visits at three time points during the school year\n\nComplete surveys about fruit and vegetable intake, preferences, household food availability, and shopping practices\n\nHave fruit and vegetable intake measured using a non-invasive Veggie Meter device\n\nHave height and weight measured\n\nStudents will also have fruit and vegetable intake measured during school lunch using plate waste methods.",[71,72,73,74],"Fruit and Vegetable Consumption in Children","Fruit and Vegetable Consumption","Fruit and Vegetable Selection in the Lunchroom","Caregiver Nutrition",[76,77,78,79,80,81],"Skin carotenoids","Retail food environment","Veggie Meter","Plate waste","School based nutrition intervention","Fruit and vegetable consumption","NOT_YET_RECRUITING","2026-07-21",{"date":85,"type":45},"2026-07-27",{"date":87,"type":23},"2026-07",{"date":89,"type":23},"2027-07",{"name":51,"class":52},{"id":92,"slug":93,"hasResults":12,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":62,"sex":18,"minAge":98,"maxAge":65,"enrollmentInfo":99,"targetDuration":4,"studyType":24,"phases":101,"briefSummary":103,"conditions":104,"keywords":110,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":53},"100542041","phase-2-smart-walk-a-culturally-tailored-smartphone-delivered-physical-activity-intervention-for-african-american-women-100542041","NCT06337708","Smart Walk: A Culturally Tailored Smartphone-Delivered Physical Activity Intervention for African American Women","Smart Walk: An Efficacy Trial of a Culturally Tailored Smartphone-Delivered Physical Activity Intervention for African American Women","Inclusion Criteria:\n\n* Self-reported African American\u002FBlack female\n* Aged of 24-65 years\n* Insufficiently Active (\\\u003C 60 minutes of moderate-to-vigorous physical activity per week as measured by Exercise Vital Sign Questionnaire)\n* BMI \\> 25 kg\u002Fm2\n* English speaking and reading\n* Ownership of a smartphone with the ability to download applications (i.e., apps)\n* Ownership of a smartphone with the ability to receive text messages\n* Willingness to receive a physical activity intervention delivered through their smartphone\n* Willingness to include their first name or create an alias to be used on their profile page on the Smart Walk app\n\nExclusion Criteria:\n\n* Plans to relocate out of Phoenix area in next 12 months\n* Endorsing an item on the Physical Activity Readiness Questionnaire (PAR-Q), unless a doctor's note for study participation in provided\n* Resting systolic blood pressure greater than 180 mmHG and\u002For a diastolic blood pressure greater than 120 mmHG , as assessed at baseline or at any other study assessment\n* Self-reported participation in another diet or weight loss study at screening\n* Pregnant or planning to become pregnant in the next 12 months","24 Years",{"count":100,"type":23},210,[102],"PHASE2","The purpose of this study is to test a culturally tailored, smartphone-delivered intervention designed to increase physical activity and reduce risk for heart disease and type 2 diabetes among African American women.",[105,106,107,108,109],"Physical Activity","Exercise","Heart Diseases","Diabetes Mellitus","Physical Inactivity",[111,112,113,114,115,116,117,118,119],"mHealth","women's health","health equity","African American women","Black women","exercise","physical activity","heart disease","diabetes","2026-07-16",{"date":122,"type":45},"2026-07-17",{"date":124,"type":45},"2024-04-08",{"date":126,"type":23},"2029-03-31",{"name":51,"class":52},{"id":129,"slug":130,"hasResults":12,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":12,"sex":135,"minAge":136,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":24,"phases":140,"briefSummary":141,"conditions":142,"keywords":147,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":150,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":53},"100528293","alcohol--mens-sexual-risk-behaviors-100528293","NCT06158880","Alcohol & Men's Sexual Risk Behaviors","Men's Sexual Risk Behaviors: Alcohol, Sexual Aggression, and Emotional Factors (Extension)","Inclusion Criteria:\n\n* Single\n* Male\n* Ages 21-30\n* Engagement in unprotected intercourse with a woman at least once in the past year\n* Consumed alcohol at least 1 time per week in the past 30 days\n* Had sex with a woman at least 2 times in the past 30 days\n\nExclusion Criteria:\n\n* A history of alcohol problems\n* A medical condition and\u002For medications which contraindicate alcohol consumption\n* In a relationship that is monogamous and has lasted longer than 6 months","MALE","21 Years","30 Years",{"count":139,"type":23},320,[26],"This project extends the investigators' previous research regarding the intersecting risks of alcohol, sexual risk behavior (SRB), and sexual aggression (SA) in male drinkers who have sex with women by examining the mediating and moderating roles of both intrapersonal and interpersonal emotional factors. While independent streams of research consistently document alcohol's role in SRB and SA, the investigators' work has demonstrated that these behaviors are related, and that alcohol exacerbates their likelihood both independently and synergistically. The researchers' investigations focus on a particular type of SRB: men's resistance to condom use with female partners who want to have protected sex. Condom use resistance (CUR) is common and normative among young male drinkers, with up to 80% of men reporting engaging in CUR. Of particular concern, research demonstrates that up to 42% of men report using coercive CUR tactics such as emotional manipulation, deception, condom sabotage, and force to obtain unprotected sex. Investigators will evaluate hypotheses that distal and proximal emotional and alcohol factors influence in-the-moment SRB\u002FCUR intentions as well as daily alcohol use and SRB\u002FCUR. The investigators will also examine whether the relationships among assessed variables are similar across experimental and naturalistic settings. That is, investigate the extent to which men's responses in the lab parallel their real-world drinking and SRB\u002FCUR behaviors, particularly regarding self and partner emotions, empathy, and interpersonal stress.",[143,144,145,146],"Sexual Behavior","Alcohol Drinking","Sexual Aggression","Emotions",[148,149],"Condom use resistance","Emotion dysregulation",{"date":122,"type":45},{"date":152,"type":45},"2024-06-17",{"date":154,"type":23},"2027-12",{"name":51,"class":52},{"id":157,"slug":158,"hasResults":12,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":62,"sex":63,"minAge":163,"maxAge":65,"enrollmentInfo":164,"targetDuration":4,"studyType":24,"phases":166,"briefSummary":167,"conditions":168,"keywords":169,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":175,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":53},"100514557","goal-setting-to-promote-physical-activity-adherence-in-midlife-adults-100514557","NCT05980052","Goal Setting to Promote Physical Activity Adherence in Midlife Adults","Goal Setting to Promote Physical Activity Adherence in Midlife to Reduce Risk of Alzheimer's Disease and Related-Dementias: A Randomized Mechanistic Proof-Of-Concept Trial","Inclusion Criteria:\n\n* Aged 45 to 65 years\n* BMI between 30 kg\u002Fm2 to 50 kg\u002Fm2\n* Participants must weigh a minimum of 110 pounds\n* Engaging in 60 minutes or less of self-reported moderate-to-vigorous physical activity at screening (based on Exercise Vital Sign Questionnaire)\n* Self-reported ownership of a smartphone with an iOS or Android operating system (necessary for participants to track their activity using a Fitbit activity monitor)\n\nExclusion Criteria:\n\n* Endorsing an item on the Physical Activity Readiness Questionnaire (PAR-Q), unless a physician's note is provided\n* Resting blood pressure greater than 200\u002F110 mmHG as assessed at the baseline study assessment (unless a physician's note is provided)\n* Pregnant or planning to become pregnant in next 8-months (Phase 1) or 12 months (Phase 2)\n* Plans to relocate out of metropolitan Phoenix, Arizona area in the next 8-months (Phase 1) or 12 months (Phase 2)\n* Participation in another physical activity, nutrition or weight loss program at time of screening or at any time during the intervention\n* Individuals with mild cognitive impairment (MCI), as determined by either a self-report of receiving a diagnosis of MCI from a health care provider or as assessed by the Montreal Cognitive Assessment (MoCA) at the study orientation session. A score \\\u003C 26 is an exclusion criterion for US born participants. A score of \\\u003C23 is an exclusion for participants born outside of the US who completed their high school education in a country where English is not the primary language.\n* Being previously prescribed one of the 5 approved Alzheimer's medications, including: Donepezil (Aricept), Rivastigmine (Exelon), Galantamine (Razadyne), Memantine (Namenda), Memantine + Donepezil (Namzaric)\n* Score of 16 or higher on the Center for Epidemiological Studies-Depression Scale (CES-D)\n* Self-reported current diagnosis of major depression\n* Currently taking 2 or more ant-depression drugs\n* History of stroke\n* Incarcerated individuals (i.e., Prisoners)","45 Years",{"count":165,"type":23},144,[26],"Engaging in regular physical activity during midlife is a key lifestyle behavior associated with reduced risk for Alzheimer's disease and related dementias (AD\u002FADRD). Yet nearly half of midlife adults (48%) do not meet national physical activity guidelines. The purpose of this mechanistic trial is to identify effective goal setting techniques to enhance psychosocial processes of self-regulation for the successful promotion of PA and adherence to national PA guidelines among midlife adults, with the long-term goal of reducing AD\u002FADRD risk",[105,106],[116,117,170,171,172,173,174],"mild cognitive impairment","Alzheimer's disease","dementia","behavior change","midlife",{"date":122,"type":45},{"date":177,"type":45},"2023-07-17",{"date":179,"type":23},"2027-05-31",{"name":51,"class":52},{"id":182,"slug":183,"hasResults":12,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":62,"sex":63,"minAge":188,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":24,"phases":191,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":53},"100509841","the-brain-processes-underlying-speech-motor-learning-and-speech-production-100509841","NCT05918679","The Brain Processes Underlying Speech Motor Learning and Speech Production","Improving Speech Motor Learning Processes Using Augmented Behavioral Interventions","Inclusion Criteria:\n\n* 18 years and older\n* native speaker of American English\n* normal (age-appropriate) binaural pure-tone hearing threshold\n* not taking medications affecting sensorimotor functioning\n* no current or history of communication, neurological, or psychological disorders\n\nExclusion Criteria:","18 Years",{"count":190,"type":23},510,[26],"The aim of this research is to develop protocols that selectively target and improve speech-motor learning processes. Participants will be asked to name pictures, read words\u002Fsentences, and listen to sounds while their speech signals will be collected during the study.",[194],"Healthy Adults","2026-07-07",{"date":197,"type":45},"2026-07-08",{"date":199,"type":45},"2023-06-01",{"date":201,"type":23},"2027-08-31",{"name":51,"class":52},{"id":204,"slug":205,"hasResults":12,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":209,"eligibilityCriteria":210,"healthyVolunteers":62,"sex":63,"minAge":211,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":24,"phases":214,"briefSummary":215,"conditions":216,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":53},"100585012","increasing-physical-activity-through-social-support-and-stress-resilience-100585012","NCT06896825","Increasing Physical Activity Through Social Support and Stress Resilience","Increasing Physical Activity Through Social Support and Stress Resilience (I-PASS) Among Older Adults Living Alone With SCD to Lower ADRD Risk","I-PASS","Inclusion Criteria:\n\n* Aged 60 years or older\n* Living alone and community dwelling\n* Engaging in 60 minutes or less per week of self-reported moderate-to-vigorous physical activity at screening (based on Exercise Vital Sign Questionnaire)\n* Self-reported decline in cognitive functioning\n* Self-reported ownership of\u002Fwillingness to use a smartphone with an iOS or Android operating system (necessary for participants to track their activity using a wearable activity monitor).\n* Able to read and speak in English. We hope to offer the intervention in Spanish in the future; however, currently, the study materials are only available in English, and participation will require ability to read and respond to study materials.\n\nExclusion Criteria:\n\n* Endorsing an item on the Physical Activity Readiness Questionnaire (PAR-Q), unless a physician's note is provided\n* Resting blood pressure greater than 200\u002F110 mmHG as assessed at the baseline study assessment (unless a physician's note is provided)\n* Plans to relocate out of metropolitan Phoenix, Arizona area in the next 6 months\n* Participation in another physical activity, nutrition or weight loss program at time of screening or at any time during the intervention\n* Individuals with mild cognitive impairment (MCI), as determined by either a self-report of receiving a diagnosis of MCI from a health care provider or as assessed by the Telephone-Montreal Cognitive Assessment (T-MoCA) at the Baseline Session. A score \\\u003C 18 is an exclusion criterion.\n* Individuals with neurodegenerative (e.g., dementia), developmental (e.g., autism), neurologic (e.g., Parkinson's, epilepsy), or major psychiatric (e.g., bipolar, schizophrenia) diagnoses\n* Being previously prescribed one of the 5 approved Alzheimer's medications, including: Donepezil (Aricept), Rivastigmine (Exelon), Galantamine (Razadyne), Memantine (Namenda), Memantine + Donepezil (Namzaric)\n* Score of 9 or higher on the 15-item Geriatric Depression Scale (GDS) at the Baseline Session \\[scores of 9 and higher are indicative of moderate to severe depression\\]\n* History of stroke\n* Incarcerated individuals (i.e., Prisoners)","60 Years",{"count":213,"type":23},86,[26],"The goal of this clinical trial is to learn the effects of technology enhancements when combined with basic education, goal-setting, and self-monitoring to increase physical activity among older adults living alone, experiencing subjective cognitive decline, and currently engaging minimal physical activity (60 minutes or less of moderate to vigorous physical activity). Further, we will examine key psychosocial mechanisms believed to contribute to successful promotion of physical activity, which include social support and stress resilience.\n\nThe primary questions are to determine whether\n\n* the tech-enhanced condition lead to greater physical activity over time?\n* the tech-enhanced condition lead to social support and stress resilience over time?\n* social support and stress resilience mediate the relationship between the study condition and physical activity?\n\nAll participants will engage in self-monitoring of physical activity, will receive weekly text reminders of their physical activity goals for the week, and will receive basic education about the importance of physical activity, social support, and stress resilience for cognitive, physical, and psychological health. Participants in the tech-enhanced condition will also receive access to a study-specific website and virtual coaching to reinforce the information presented. Researchers will then compare the tech-enhanced condition to the basic education condition to determine the benefits of technology to deliver the intervention materials in order to increase physical activity, social support, and stress resilience.\n\nParticipants will:\n\n* Use a Garmin wearable device to monitor their physical activity\n* Be randomly assigned to a basic education condition or tech-enhanced condition\n* Set achievable goals for weekly physical activity, with incremental increases to achieve 7000 average daily steps by the end of the study\n* Respond to surveys to monitor their social support, stress resilience, quality of life, and depression.\n\nThe sample has several risk factors for Alzheimer's disease and related dementias: low physical activity, social isolation risk via living alone, and subjective cognitive impairment. Therefore, a long-term goal includes the determination of the intervention's effectiveness at increasing physical activity, social support, and stress resilience to reduce risk for developing dementia.",[217,218,219,220],"Healthy","Subjective Cognitive Decline (SCD)","Sedentary Behavior","Social Isolation in Older Adults","2026-06-25",{"date":223,"type":45},"2026-06-29",{"date":225,"type":45},"2025-06-23",{"date":227,"type":23},"2027-04",{"name":51,"class":52},{"id":230,"slug":231,"hasResults":12,"nctId":232,"briefTitle":233,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":62,"sex":63,"minAge":188,"maxAge":236,"enrollmentInfo":237,"targetDuration":4,"studyType":24,"phases":239,"briefSummary":240,"conditions":241,"keywords":245,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":252,"leadSponsor":254,"locationsCount":53},"100642275","the-role-of-carbohydrate-blends-and-electrolytes-on-physical-and-mental-performance-during-cycling-in-the-heat-100642275","NCT07658820","The Role of Carbohydrate Blends and Electrolytes on Physical and Mental Performance During Cycling in the Heat","CARB-HEAT","Inclusion Criteria:\n\n* Healthy and injury free (muscle, skeletal) for greater than 2 months\n* Active cyclists who train at least 3 times per week\n* Body mass index (BMI) range of 18.5-30 kg\u002Fm2\n* VO₂max ≥ 51 mL\u002Fkg\u002Fmin for male participants\n* VO₂max ≥ 45 mL\u002Fkg\u002Fmin for female participants\n\nExclusion Criteria:\n\n* Taking medicine influences the cardiovascular system\n* non-steroidal anti-inflammatory drugs during the last week\n* Cancer Diagnosis during the last 5 years\n* Current Pregnancy\n* History of renal disease, hypertension, obstructive gastrointestinal tract disease, disorders or impairment of the gag reflex, previous gastrointestinal surgery\n* History of heat stroke\n* Use of testosterone therapy\n* Adults who are unable to consent (impaired decision-making capacity)\n* Adults having Felinization of the esophagus\n* Adults who will undergo Nuclear Magnetic Resonance (NMR) or MRI scanning within 3 days of swallowing a temperature sensitive pills","55 Years",{"count":238,"type":23},14,[26],"The aim of the present study is to evaluate the effectiveness of a milk permeate-based sports drink on hydration, carbohydrate oxidation, exercise performance, vigilance, and reaction time in the heat. We anticipate that the milk permeate, with 44 g per liter and high sodium and potassium, will lead to better hydration, energy delivery, and physical and cognitive performance.",[242,243,244],"Hydration","Dehydration (Physiology)","Performance",[246,247],"exercise in the heat","cognitive performance","2026-06-17",{"date":250,"type":45},"2026-06-22",{"date":250,"type":23},{"date":253,"type":23},"2027-12-31",{"name":51,"class":52},{"id":256,"slug":257,"hasResults":12,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":62,"sex":18,"minAge":188,"maxAge":137,"enrollmentInfo":262,"targetDuration":4,"studyType":24,"phases":264,"briefSummary":265,"conditions":266,"keywords":268,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":4},"100641706","the-effect-of-water-temperature-on-heart-rate-variability-and-cognition-100641706","NCT07654270","The Effect of Water Temperature on Heart Rate Variability and Cognition","Effects of Water Temperature on Heart Rate Variability During Cognitive Testing in Healthy Adult Women: A Randomized Crossover Trial","Inclusion Criteria:\n\n* Healthy women free of chronic disease (by self-report)\n* 18-30 years of age\n\nExclusion Criteria:\n\n* medication\u002Fdrug use that has not been consistent for the previous 3 months or will be discontinued during the trial\n* any acute illness\n* regular use of cigarettes or marijuana\n* pregnant or lactating women\n* not fluent in English\n* not willing to attend two in-person lab visits in downtown Phoenix and follow study protocol (including abstaining from caffeine in the 12 hours prior to testing)\n* not currently competing in sports or unusually high-intensity exercise protocols (e.g., high-intensity exercise greater than 30 minutes most days of the week)",{"count":263,"type":23},30,[26],"Heart rate variability (HRV) is a key indicator of fitness, and stress resilience. Previous research has shown that HRV decreases under mental workload, including during tasks that require strict attention. Studies also show that temperature exposure affects attention: cold increases the stress response while warm water has a calming effect. Very few studies combine thermal exposure with cognitive testing, and no controlled trials have investigated whether water temperature modulates HRV responses specifically during cognitive demand.",[267],"Mental Acuity",[269,270,247],"heart rate variability","water temperature","2026-06-12",{"date":248,"type":45},{"date":274,"type":23},"2026-07-13",{"date":276,"type":23},"2027-06-15",{"name":51,"class":52},{"id":279,"slug":280,"hasResults":12,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":62,"sex":63,"minAge":188,"maxAge":137,"enrollmentInfo":285,"targetDuration":4,"studyType":24,"phases":286,"briefSummary":287,"conditions":288,"keywords":289,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":296,"leadSponsor":297,"locationsCount":4},"100641622","effects-of-red-panax-ginseng-supplementation-on-cognitive-performance-and-emotional-well-being-in-young-healthy-adults-100641622","NCT07648316","Effects of Red Panax Ginseng Supplementation on Cognitive Performance and Emotional Well-Being in Young Healthy Adults","Effects of Red Panax Ginseng Supplementation on Cognitive Performance and Emotional Well-Being in Young Healthy Adults, a Randomized Controlled Trial","Inclusion Criteria:\n\n* Healthy young adults\n* 18-30 years of age\n\nExclusion Criteria:\n\n* medication\u002Fdrug use that has not been consistent for the previous 3 months or will be discontinued during the trial\n* unresolved chronic medical conditions (e.g., presence of persistent symptomology)\n* diagnosed clinical depression\n* acute illness\n* regular use of cigarettes or marijuana\n* pregnant or lactating women\n* not fluent in English\n* currently competing in sports or unusually high-intensity exercise protocols (e.g., high-intensity exercise greater than 30 minutes most days of the week)\n* current use of ginseng or adaptogenic supplements, or allergy to ginseng\n* any significant food allergies\n* not willing to attend two in-person lab visits in downtown Phoenix and follow study protocol (including abstaining from caffeine in the 12 hours prior to testing)",{"count":263,"type":23},[26],"College students face substantial and persistent mental health challenges that directly affect cognitive performance, stress regulation, and emotional well-being. Neurological functions such as working memory, attention regulation, executive control, and emotional processing are highly sensitive to stressors, leaving young adults vulnerable to daily fluctuations in cognitive efficiency. Recent findings from the Healthy Minds Network (2025) indicate that although rates of moderate to severe depression among college students declined from 44% in 2022 to 37% in 2025, and anxiety symptoms fell from 37% to 32%, levels of psychological flourishing also dropped, falling to 36% despite these improvements.\n\nGinseng contains bioactive compounds known as ginsenosides that favorably influence brain function and inflammatory cascades. Studies in stressed and moderately stressed adults demonstrated reduced perceived stress, improved emotional processing, enhanced cognitive performance, and beneficial changes to biomarkers with ginseng supplementation. In addition, randomized controlled trials reported improvements in mood regulation, fatigue resistance, and aspects of working memory and attention following short-term ginseng supplementation. This study will examine the effects of daily red panax ginseng supplementation (3000 mg\u002Fday; two 1500 mg Red Panax gummies) on cognitive performance and emotional well-being in healthy young adults.",[267],[290,291,292],"ginseng","mental health","cognitive performancd",{"date":294,"type":45},"2026-06-16",{"date":250,"type":23},{"date":276,"type":23},{"name":51,"class":52},{"id":299,"slug":300,"hasResults":12,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":4,"eligibilityCriteria":304,"healthyVolunteers":62,"sex":63,"minAge":188,"maxAge":305,"enrollmentInfo":306,"targetDuration":4,"studyType":24,"phases":308,"briefSummary":309,"conditions":310,"keywords":313,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":327,"startDateStruct":329,"completionDateStruct":331,"leadSponsor":333,"locationsCount":53},"100588793","effect-of-a-fermented-dairy-protein-with-prebiotic-fiber-on-gi-complaints-100588793","NCT06946017","Effect of a Fermented Dairy Protein With Prebiotic Fiber on GI Complaints","Effect of a Fermented Whey and Fiber Supplement on Digestive Comfort of Recreational Athletes With and Without GI Complaints","Aside from having participants fitting the inclusion and exclusion criteria below, potential participants will be screened using the gastrointestinal symptom rating scale (GSRS). Based on the outcome they will be assigned to the Part I (i.e. no self-reported GI tract issues (GSRS questionnaire score GI complaints, based on GSRS screening with all items scored \\\u003C4 (severe) and a total GSRS score ≤25), or Part II (i.e. Severe self-reported GI tract issues (GSRS questionnaire score GI complaints, based on GSRS screening with at least one item scored ≥4 (severe) and a total GSRS score ≥30). If they don't fit these criteria (i.e., having a GSRS score ranging from 26-29) they will be excluded from participation.\n\nInclusion Criteria:\n\n* Healthy subjects living in the Phoenix area in AZ, USA during the study\n* Women\u002FMen aged between 18-50 years (50-50%)\n* Recreational competitive and non-competitive athletes (exercise at least 2x per week with a minimal total duration of 2 hours\u002Fweek)\n* BMI value between ≥18.5 and ≤ 30 kg\u002Fm2\n* No physical limitations due to an injury (i.e., able to perform all activities associated with daily living and exercise in an independent manner).\n* Willing to slightly increase their energy intake via a supplement during the study period on daily basis in the morning before breakfast.\n* Willing and comfortable to perform multiple physical (stress) tests on a treadmill during the study.\n* Participants without any contraindications when scoring the Physical Activity Readiness Questionnaire (PAR-Q+).\n* Written informed consent\n* For part I: Self-perceived lactose intolerance, and\u002For omission of dairy products, and\u002For identifying as Hispanic\u002FLatino or Asian\n* For part I: Determined to be lactase non-persistent (LNP) CC genotype by qPCR, and\u002For positive lactose intolerance test (\\>20ppm increase from baseline when 25g of lactose administered)\n\nExclusion Criteria:\n\n* Users of (sport) supplements containing probiotics and\u002For prebiotics and those unwilling to temporarily stop use of these supplements at least 3 weeks prior to start of the intervention\n* Women who plan to start or stop the use of contraceptives before or during study period\n* Women that have additional or worse GI symptoms during their period that can be classified as severe\n* Smoking\n* Clinical lactose intolerance\n* Clinical or self-perceived milk protein allergy\n* Diagnosed GI tract disorders or diseases\n* Musculoskeletal disorders\n* Diagnosed metabolic disorders (such as diabetes)\n* Use of any medications known to affect protein metabolism (i.e., corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications).\n* Chronic use of gastric acid suppressing medication or anti-coagulants\n* Chronic use of anti-inflammatory medication\n* Use of antibiotics the past 0-6 months\n* Blood donation in the past 2 months\n* (Intending to become) Pregnant\u002Flactating women\n* Significant changes in body weight during the past 4 weeks (i.e., due to reduction of body weight through limiting caloric intake, illness,)\n* Athletes should not aim to lose bodyweight by reducing energy intake during the study\n* For Part I: A hydrogen breath peak of less than 20 ppm over baseline during a lactose tolerance test","50 Years",{"count":307,"type":23},114,[26],"A positive impact of a fermented dairy protein with prebiotic fiber supplement on self-reported GI complaints and wellbeing has been suggested (Wardenaar et al. 2024). The following project aims to further investigate the impact of this supplements in athletes with and without GI complaints in two separate data collections.\n\nPart I of the data collection aims to investigate the impact of this supplement vs. a placebo on carbohydrate malabsorption (as a potential cause for GI distress) in athletes that normally don't identify as having GI complaints (randomized double-blind cross over study design covering a total of 9 weeks, including a 3-week washout period).\n\nPart II of the data collection aims to confirm the earlier found results in the previous study (Wardenaar et al. 2024) in a group athletes self-reporting GI complaints that will be randomized into an intervention group or a placebo group (randomized double-blind parallel study design covering a total of 3 weeks).",[311,312],"Digestive Health","Quality of Life",[314,315,316,317,318,319,320,321,322,323,324,325,106],"Participants","Healthy subjects","Athlete","Women","Men","Fermented Dairy","Prebiotics","Gut microbiota","Self-reported","GI-tract","Diet","Immune markers","2026-05-06",{"date":328,"type":45},"2026-05-08",{"date":330,"type":45},"2025-03-31",{"date":332,"type":23},"2027-06-30",{"name":51,"class":52},{"id":335,"slug":336,"hasResults":12,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":4,"eligibilityCriteria":340,"healthyVolunteers":62,"sex":63,"minAge":188,"maxAge":4,"enrollmentInfo":341,"targetDuration":4,"studyType":24,"phases":343,"briefSummary":344,"conditions":345,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":350,"completionDateStruct":352,"leadSponsor":353,"locationsCount":53},"100541048","brain-mechanisms-of-reducing-polysubstance-use-100541048","NCT06324786","Brain Mechanisms of Reducing Polysubstance Use","Brain Mechanisms of Reducing Polysubstance Use Following a Novel Body-mind Intervention 2","Inclusion Criteria:\n\n* At least 18 years old\n* Free of any psychiatric diagnoses or medication (besides a substance use disorder (SUD) to alcohol, tobacco, or cannabis)\n* In the past month, at least 4 episodes of heavy episodic drinking; at least 3 occasions of cannabis use; and daily cigarette use for at least the past month\n* Normal or corrected-to-normal vision\n* Written informed consent\n* No previous meditation or NF experiences\n\nExclusion Criteria:\n\n* Any psychiatric diagnoses other than an SUD\n* Medical disorder(s) that may affect the central nervous system; medications that affect the central and autonomic nervous system; or a positive pregnancy test result (females)\n* Excluding cannabis, evidence of recent (past month) illicit drug use",{"count":342,"type":23},35,[26],"The proposed study will test whether neurofeedback (NF) could optimize integrative body-mind training (IBMT) practice.",[346],"Multiple Drug Use","2026-05-01",{"date":349,"type":45},"2026-05-04",{"date":351,"type":45},"2023-09-01",{"date":201,"type":23},{"name":51,"class":52},{"id":355,"slug":356,"hasResults":12,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":360,"eligibilityCriteria":361,"healthyVolunteers":62,"sex":63,"minAge":65,"maxAge":4,"enrollmentInfo":362,"targetDuration":4,"studyType":24,"phases":364,"briefSummary":365,"conditions":366,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":53},"100506654","a-smart-trial-of-adaptive-exercises-to-optimize-aerobic-fitness-responses-100506654","NCT05877196","A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses","Precision Medicine in Alzheimer's Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-Fitness Responses (The FIT-AD SMART Trial)","SMART","Inclusion Criteria:\n\nParticipants:\n\n* Clinical diagnosis of MCI or probable and possible mild AD dementia according to 2011 Alzheimer's association-NIA criteria.\n* Community-dwelling, e.g., homes and assisted living\n* Age 65 years and older\n* Medical clearance from PCP or cardiovascular provider\n* Have a qualified study partner\n* Agree to the blood draws\n* Verified MRI safety\n\nStudy Partner:\n\n* Age 18 or older\n* Contact with participant ≥ 2 times per week for ≥ 6 months\n* Know the participant's memory status and ability to perform activities of daily living\n* Consent to participant\n\nExclusion Criteria:\n\nParticipants\n\n* Resting HR ≤ 50 or ≥ 100 beats\u002Fmin after 5-minutes of quiet resting\n* American College of Sports Medicine contraindications to exercise\n* New, unevaluated symptoms or diseases a healthcare provider has not evaluated\n* Abnormal cardiac condition uncovered during VO2peak testing\n* Enrollment in another intervention that aims at improving cognition\n* Moderate to strenuous exercise ≥150 minutes a week in the previous 6 months\n* ≥ 2 anti-depression medications, or poorly managed or unstable depression\n* Poorly managed or unstable anxiety\n\nStudy partners:\n\n* none",{"count":363,"type":23},216,[26],"The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable\u002Fpossible mild Alzheimer's Disease. The main questions it aims to answer are:\n\n* test the effects of aerobic exercise on aerobic fitness, white matter hyperintensity (WMH) volume, and patient-centered outcomes;\n* identify the best exercise to improve aerobic fitness and reduce non-responses over 6 months; and\n* examines the mechanisms of aerobic exercise's action on memory in older adults with early AD.\n\nParticipants will receive 6 months of supervised exercise, undergo cognitive data collection and exercise testing 5 times over a year span, have an MRI brain scan 3 times over a one-year span, and have monthly follow-up discussions on health and wellness.",[367,368,369,370,371,372],"Mild Cognitive Impairment","Alzheimer Disease","Cognitive Impairment","Cognitive Decline","Memory Loss","Memory Impairment",{"date":374,"type":45},"2026-05-05",{"date":376,"type":45},"2023-06-22",{"date":378,"type":23},"2028-06-30",{"name":51,"class":52},{"id":381,"slug":382,"hasResults":12,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":386,"eligibilityCriteria":387,"healthyVolunteers":12,"sex":63,"minAge":188,"maxAge":4,"enrollmentInfo":388,"targetDuration":4,"studyType":24,"phases":390,"briefSummary":391,"conditions":392,"keywords":396,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":53},"100588219","the-role-of-prolonged-nightly-fasting-to-improve-sleep-and-cognition-in-breast-cancer-survivors-100588219","NCT06938555","The RolE of Prolonged Nightly faSTing to Improve Sleep and cOgnition in bREast Cancer Survivors","The RolE of Prolonged Nightly faSTing to Improve Sleep and cOgnition in bREast Cancer Survivors (RESTORE)","RESTORE","Inclusion Criteria:\n\n1. ≥18 years old\n2. diagnosed with breast cancer (all stages included)\n3. ≥3 months post neoadjuvant or adjuvant chemotherapy (maintenance or palliative systemic therapy is included)\n4. score ≤30 or lower on the Patient Reported Outcome Measurement Information System Cognitive Function Short Form 8a (sr-CRCI)\n5. able to speak\u002Funderstand English\n6. have access to a computer and Wi-Fi\n7. live within the United States\n8. Identifies as female\n9. willing and able to fully participate in the study\n\nExclusion Criteria:\n\n1. type 1 diabetes\n2. actively enrolled in formal diet\u002Fweight loss program\n3. previous bariatric surgery\n4. eating disorder history\n5. night shift work\n6. pregnant, breast feeding, or trying to get pregnant\n7. dementia, psychological, psychiatric, or neurological diagnoses\n8. active brain or central nervous system disease\n9. prior or current use of memory enhancing medications\n10. history or current brain radiation\n11. frequently fasting for 12+ hours every night\n\n13\\) history of hypoglycemia 14) depression screening on PHQ9 with a score of 20 or greater across all 9 questions OR anything other than 0 on question 9",{"count":389,"type":23},60,[26],"The investigators are interested in finding out how Prolonged Nightly Fasting (PNF) and\u002For health education may impact health and cancer recovery for breast cancer patients and survivors.",[393,394,395,312],"Breast Cancer Survivor","Cancer Related Cognitive Difficulties","Sleep",[397,398,399,400,401,402,403,404,405,406],"breast cancer","breast cancer survivor","brain fog","prolonged nightly fasting","nationwide","remote","non-invasive","health education","sleep","quality of life","2026-04-27",{"date":347,"type":45},{"date":410,"type":45},"2025-03-18",{"date":412,"type":23},"2026-12-31",{"name":51,"class":52},{"id":415,"slug":416,"hasResults":12,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":420,"eligibilityCriteria":421,"healthyVolunteers":62,"sex":63,"minAge":422,"maxAge":4,"enrollmentInfo":423,"targetDuration":4,"studyType":24,"phases":425,"briefSummary":426,"conditions":427,"keywords":432,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":442},"100541012","phase-2-parenting-in-2-worlds-multisite-trial-100541012","NCT06324318","Parenting in 2 Worlds Multisite Trial","A Multiregional RCT of Parenting in 2 Worlds for Urban American Indian Families","(P2W)","Inclusion Criteria:\n\nAdult participants:\n\n* Must be American Indian parents or guardians of American Indian children aged 12 to 17 who attend urban schools\n* Must reside in the service areas of the four urban Indian centers who are participating in this study\n* Self-identifies as American Indian\n* Must be primary caregiver responsible for day-to-day decisions for an American Indian child ages 12 to 17\n\nChild Participants:\n\n* Aged 12 - 17\n* Identified by their parent\u002Fguardian as American Indian\n* Attends an urban school\n\nExclusion Criteria:\n\n* Not applicable","12 Years",{"count":424,"type":23},1440,[102],"This research study will test the effectiveness of a culturally grounded parenting intervention called Parenting in 2 Worlds (P2W). This intervention is designed for American Indian \u002F Alaska Native (AI) parents\u002Fguardians of adolescents who reside in urban areas. This will be a multi-regional effectiveness trial across four regions: Northeast (Buffalo\u002FNiagara), Midwest (St. Paul\u002FMinneapolis), Mountain (Denver), and Southwest (Phoenix). There are four specific aims. First, this study will test the effectiveness of Parenting in Two Worlds (P2W) as compared to an informational family health intervention, Healthy Families in 2 Worlds (HF2W), in improving parenting and family functioning. Second, this study will test if the relative effectiveness of P2W, compared to HF2W, varies by parent's\u002Fguardian's level of socioeconomic vulnerability, experiences of historical loss, or AI cultural identity. Third, this study will examine if P2W can reduce adolescent (ages 12 - 17) risky health behaviors including substance use, depressive symptoms, suicidality, and risky sexual behaviors. Fourth, this study will examine whether positive changes in parenting and family functioning that result from P2W lead to positive changes in adolescent's health behaviors.",[428,429,430,431],"Parenting","Mental Health Wellness 1","Substance Use","Risky Health Behavior",[433,434],"family functioning","risky sexual behavior",{"date":436,"type":45},"2026-04-29",{"date":438,"type":45},"2023-09-14",{"date":440,"type":23},"2028-06-01",{"name":51,"class":52},4,{"id":444,"slug":445,"hasResults":12,"nctId":446,"briefTitle":447,"officialTitle":448,"acronym":4,"eligibilityCriteria":449,"healthyVolunteers":12,"sex":63,"minAge":188,"maxAge":4,"enrollmentInfo":450,"targetDuration":4,"studyType":24,"phases":452,"briefSummary":453,"conditions":454,"keywords":457,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":463,"completionDateStruct":465,"leadSponsor":467,"locationsCount":53},"100629544","light-exposure-migraine-outcomes-and-sleep-quality-100629544","NCT07476053","Light Exposure, Migraine Outcomes, and Sleep Quality","Daily Light Exposure Patterns and Their Associations With Migraine Outcomes and Sleep Quality","Inclusion Criteria:\n\n* Meet the International Classification of Headache Disorders, 3rd edition (2018) criteria for migraine, with or without aura or photosensitivity\n* Report experiencing more than 4 headache days per month and at least three migraine attacks per month\n* No other major health issues based on self-reported data\n* Able to read and communicate in English\n* Work in a private office space for at least six hours per day, four days per week\n\nExclusion Criteria:\n\n* Light therapy\n* Use light-altering devices (e.g., blue-blocking contact lenses or glasses)\n* Traveling out of town during the participation",{"count":451,"type":23},20,[26],"The purpose of this study is to examine the relationship between daily light exposure patterns, sleep quality, and migraine characteristics in adults with migraine, with and without photophobia, across an 8-week study period.",[455,395,456],"Migraine Headache","Photophobia",[458,395,459,456],"Migraine","Lighting","2026-04-23",{"date":462,"type":45},"2026-04-28",{"date":464,"type":45},"2026-03-24",{"date":466,"type":23},"2027-03",{"name":51,"class":52},{"id":469,"slug":470,"hasResults":12,"nctId":471,"briefTitle":472,"officialTitle":473,"acronym":4,"eligibilityCriteria":474,"healthyVolunteers":12,"sex":63,"minAge":188,"maxAge":4,"enrollmentInfo":475,"targetDuration":4,"studyType":24,"phases":477,"briefSummary":478,"conditions":479,"keywords":482,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":487,"startDateStruct":488,"completionDateStruct":490,"leadSponsor":492,"locationsCount":493},"100588877","mindfulness-based-ecological-momentary-intervention-for-opioid-use-disorder-and-chronic-pain-100588877","NCT06947122","Mindfulness-Based Ecological Momentary Intervention for Opioid Use Disorder and Chronic Pain","Mindfulness-Based Ecological Momentary Intervention for Co-Occurring Opioid Use Disorder and Chronic Pain: A Pilot Study","Inclusion Criteria:\n\n* 18 years of age or older\n* fluent in English\n* enrollment in medication-assisted treatment for opioid use disorder\n* report at least bothersome chronic pain, as indicated by Graded Chronic Pain Scale-Revised\n* has a smartphone.\n\nExclusion Criteria:\n\n* self-reporting of chronic malignant pain (e.g., cancer) or systemic inflammatory disease (e.g., rheumatoid arthritis, ankylosing spondylitis, lupus, and sarcoidosis)\n* self-reporting of psychotic disorder symptoms\n* participated in the previous phase of the study in which participants provided feedback to inform the development of the Mindful Journey app.",{"count":476,"type":23},10,[26],"The goal of this clinical trial is to evaluate whether a smartphone app-based ecological momentary intervention called Mindful Journey, which teaches mindfulness skills, can support adults in recovery from both opioid use disorder and chronic pain. The primary objective of this pilot study is to assess the feasibility and acceptability of Mindful Journey in this population.",[480,481],"Chronic Pain","Opioid Use Disorder",[483,484,485,111,486],"mindfulness","opioid use disorder","chronic pain","ecological momentary intervention",{"date":407,"type":45},{"date":489,"type":45},"2026-02-10",{"date":491,"type":23},"2026-08",{"name":51,"class":52},2,{"id":495,"slug":496,"hasResults":12,"nctId":497,"briefTitle":498,"officialTitle":499,"acronym":4,"eligibilityCriteria":500,"healthyVolunteers":62,"sex":63,"minAge":188,"maxAge":305,"enrollmentInfo":501,"targetDuration":4,"studyType":24,"phases":502,"briefSummary":503,"conditions":504,"keywords":506,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":510,"lastUpdatePostDateStruct":511,"startDateStruct":513,"completionDateStruct":515,"leadSponsor":517,"locationsCount":4},"100632878","acute-kidney-injury-and-ultra-endurance-running-100632878","NCT07519408","Acute Kidney Injury and Ultra-endurance Running","The Incidence and Severity of Acute Kidney Injury in Ultrarunners Competing in the Western States Endurance Run","Inclusion Criteria:\n\n* Running in the Western States Endurance Run in either 2026, 2027 or 2028\n* No contraindications to exercise as indicated by the Physical Activity Readiness Questionnaire (PAR-Q+) as prepared by the American College of Sports Medicine (ACSM)\n* Not currently taking medicine or experiencing illness that may influence the cardiovascular or neuromuscular system\n* Age ≥18 and ≤ 50 years old and injury free (skeletal muscle) for \\> 3 months\n\nExclusion Criteria:\n\n* Minors (under 18)\n* Adults who are unable to consent (impaired decision-making capacity)\n* Prisoners\n* Pregnant Women\n* Individuals with known kidney disease, or are on any medication that specifically effects kidney function (e.g., diuretics)",{"count":263,"type":23},[26],"This study aims to understand how participating in the Western States Endurance Run (WSER), a 100-mile ultramarathon, affects kidney health. Long, strenuous exercise in hot conditions can temporarily strain the kidneys, especially when combined with dehydration, muscle breakdown, and the use of common pain-relief medications such as ibuprofen. Although kidney stress has been reported in endurance sports, no study has examined it directly in runners during the WSER using newer, more sensitive urine markers of kidney injury. Runners who volunteer will complete brief assessments before and after the race. These include providing a urine sample, a small finger-prick blood sample, a body-weight measurement, and answering a short questionnaire about pain-medication use. During the race, participants will wear a global positioning system (GPS) watch and heart-rate strap to monitor effort. Each assessment takes about 15 minutes, and no follow-up is required. Findings from this study will help determine how often kidney stress occurs in this event and what factors may contribute to it, ultimately supporting safer training and medical practices for ultramarathon athletes.",[505],"AKI (Acute Kidney Injury) Due to Trauma",[507,508,509],"ultra-endurance","bicarbonate","AKI","2026-04-07",{"date":512,"type":45},"2026-04-09",{"date":514,"type":23},"2026-06-27",{"date":516,"type":23},"2028-12-01",{"name":51,"class":52},{"id":519,"slug":520,"hasResults":12,"nctId":521,"briefTitle":522,"officialTitle":523,"acronym":524,"eligibilityCriteria":525,"healthyVolunteers":12,"sex":63,"minAge":211,"maxAge":4,"enrollmentInfo":526,"targetDuration":4,"studyType":24,"phases":528,"briefSummary":529,"conditions":530,"keywords":533,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":541,"lastUpdatePostDateStruct":542,"startDateStruct":544,"completionDateStruct":546,"leadSponsor":547,"locationsCount":53},"100590030","early-stage-partner-in-care-living-alone-plus-100590030","NCT06962111","Early-Stage Partner in Care Living Alone Plus","Early-Stage Partner in Care-Living Alone (EPIC-LA)","EPICLA+","Early-stage inclusion criteria\n\n1. Must be at least 60 years of age\n2. Must be able to participate in English or Spanish\n3. Must be a US resident\n4. Must be able to provide consent verbally and in writing (electronically or via mail)\n5. Must exhibit at least 2 of 8 changes caused by thinking and memory problems on the AD8 (a reliable and valid 8-item dementia screening tool).\n6. The Early-stage individual must have a diagnosis of early-stage ADRD or have a Mini-Mental State Exam (MMSE) score:\n\n   1. between 20-26 for those who have completed high school, or\n   2. between 17-26\\*, for those who have not completed high school, or\n   3. 27 or higher with a confirmed diagnosis of early-stage dementia or MCI.\n7. Able to participate in EPIC-LA workshops via zoom\n\n   Exclusion Criteria:\n8. Inability to participate via telephone or online video conferencing service.\n9. The participant expresses feelings of not wanting to participate\n10. The participant do not have enough time to attend the training,\n11. The participant demonstrates lack of skills with using a computer that precludes participation\n12. The participant does not have a stable internet connection to connect to the video platform\n13. The participant has difficulty hearing or a visual impairment that precludes participation.",{"count":527,"type":23},70,[26],"EPICLA+ (Early-Stage Partners in Care Living Alone Plus) is a research project designed to assist people with early-stage memory loss who live alone in the community by providing early-stage related education and skill-training sessions, held via Zoom, designed to reduce stress, enhance well-being, manage challenges, and plan for the future. Researchers will gather feedback from individuals about their experience to continue to improve programs for early-stage memory loss.",[531,532,368],"Dementia","Mild Cognitive Impairment (MCI)",[534,535,536,537,538,539,540],"Living Alone","Memory Disorders","Older adults (60 years and older)","Alzheimer Disease and Related Dementias","Early Stage Alzheimer disease","Intervention","Skill-building","2026-03-25",{"date":543,"type":45},"2026-03-27",{"date":545,"type":45},"2025-03-26",{"date":466,"type":23},{"name":51,"class":52},{"id":549,"slug":550,"hasResults":12,"nctId":551,"briefTitle":552,"officialTitle":552,"acronym":4,"eligibilityCriteria":553,"healthyVolunteers":62,"sex":63,"minAge":554,"maxAge":4,"enrollmentInfo":555,"targetDuration":4,"studyType":24,"phases":556,"briefSummary":557,"conditions":558,"keywords":563,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":570,"lastUpdatePostDateStruct":571,"startDateStruct":573,"completionDateStruct":575,"leadSponsor":577,"locationsCount":53},"100590155","watchwell-simple-and-practical-strategies-to-reduce-the-negative-health-impact-of-sedentary-screen-time-100590155","NCT06963736","WatchWell: Simple and Practical Strategies to Reduce the Negative Health Impact of Sedentary Screen Time","Inclusion Criteria\n\n* ≥26 years of age\n* BMI ≥ 27 kg\u002Fm2\\*; ≥25 kg\u002Fm2, if Asian (full or multiple race)\\*\\*\n* Insufficiently active (per US National Guidelines for Physical Activity of 150 minutes of MVPA\u002FWeek)\n* Reporting an average of ≥3 hours of recreational sedentary screen time (rSST) per day, that usually extends at least until 9:00pm.\n* On a typical night, consumes calories (food and\u002For drink) after 8:00pm.\n* Meet at least 2 criteria for metabolic syndrome\n\n  * Central adiposity: waist circumference \\>40 inches (men); \\>35 inches (women)\n  * Elevated blood pressure: SBP \\>130 mmHg and\u002For DBP \\>85 mmHg OR controlled with medication\n  * Low high density lipoprotein (HDL) cholesterol: \\\u003C40 mg\u002FdL (men); \\\u003C50 mg\u002FdL (women)\n  * Elevated triglycerides: \\>150 mg\u002FdL OR controlled with medication\n  * Elevated fasting glucose: ≥100 mg\u002FdL OR controlled with medication\n\nExclusion Criteria\n\n* Conditions related to sleep disruption, including lactation, pregnancy, mid-night care providers, sleep disorders, severe sleep apnea\n* History of hypoglycemia\n* Pacemaker\n* Caffeine consumption in excess and\u002For after 5pm (excess equals \\>4 cups of coffee per day or equivalent)\n* Involvement in other physical activity, diet, or weight loss programs\u002Fstudies\n* Weight change of 5% up or down in the last three months.\n* Drug abuse\n* THC use (smoking, edibles)\n* Excessive alcohol use (for women, 8 or more drinks per week; for men, 15 or more drinks per week)\n* Current smoker or user of any nicotine source - any amount or form (vapor\u002Fe-cig\u002Ftobacco\u002Fpatch, gum, etc.)\n* Medications that markedly impact glucose metabolism and sleep (insulin, corticosteroids, growth hormone, melatonin)\n* Previous or current diagnosis of a clinical eating disorder (e.g., night eating syndrome, anorexia, bulimia, binge eating disorder); or self-report eating disorder behaviors\n* Unstable or poorly controlled blood glucose (e.g., hypoglycemia, fasting glucose greater than 125 mg\u002FdL)\n* Chronic illness that may be associated with weight change (HIV\u002FAIDS, active cancer, or uncontrolled thyroid disease)\n* Shift work\n* Recent or upcoming jetlag (travel 3 months prior and during study that is \\>1 time zone away from Arizona)\n* Current practice of evening and nighttime blue light blocking.\n* Poorly controlled hypertension (SBP ≥165 or DBP ≥100)\n* Any condition or circumstance that would prevent compliance to the protocol\n* Use non-android phone as their primary\u002Fpersonal phone","26 Years",{"count":263,"type":23},[26],"The purpose of this study is to determine the feasibility, acceptability, efficacy, and participant adherence in using home-based technologies and wearable devices and simple, practical strategies to reduce the negative impact that evening screen time may have on your health.",[559,560,561,562],"Sedentary Time","Cardiovascular Diseases","Prediabetes","Obesity",[564,565,566,567,568,569],"sedentary screen time","blue light","sedentary behavior","standing","crossover design","glucose metabolism","2026-02-24",{"date":572,"type":45},"2026-02-25",{"date":574,"type":45},"2025-08-07",{"date":576,"type":23},"2026-07-31",{"name":51,"class":52},{"id":579,"slug":580,"hasResults":12,"nctId":581,"briefTitle":582,"officialTitle":583,"acronym":584,"eligibilityCriteria":585,"healthyVolunteers":12,"sex":135,"minAge":188,"maxAge":4,"enrollmentInfo":586,"targetDuration":4,"studyType":24,"phases":587,"briefSummary":588,"conditions":589,"keywords":593,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":597,"lastUpdatePostDateStruct":598,"startDateStruct":600,"completionDateStruct":602,"leadSponsor":603,"locationsCount":4},"100499531","methamphetamine-prep-and-intersectional-stigma-study-100499531","NCT05784467","Methamphetamine, PrEP, and Intersectional Stigma Study","Addressing Intersectional Stigma Through Coping, Resistance, and Resilience to Improve Methamphetamine Use and Factors Influencing PrEP Uptake Among Latino MSM: a Step Towards Ending HIV by 2030","eMPrISe","Inclusion Criteria:\n\n* 18+ years of age\n* cisgender male\n* self-identify as Latino or Hispanic\n* fluent in English or Spanish\n* any sexual activity with men in the past 12 months\n* HIV-negative\n* moderate methamphetamine use risk (as determined by the the ASSIST assessment)\n* experience of intersectional stigma within their social network in the past 12 months\n* willing to provide written informed consent\n\nExclusion Criteria:\n\n* N\u002FA",{"count":451,"type":23},[26],"The goal of this clinical trail is to test the developed eMPrISe study in HIV-negative, adult, Latino men who have sex with men (MSM) who use non-injection substances. The main questions it aims to answer are:\n\n* Can participation in the developed eMPrISe study reduce methamphetamine ('meth') use risk?\n* Can participation in the developed eMPrISe study improve preexposure prophylaxis (PrEP) cascade progression? Participants will participate in 12 weekly modules that: (1) build critical thinking skills, (2) identify and discuss the link between oppression and harmful behaviors, (3) take action, (4) voice and validate feelings and experiences, and (5) share knowledge and resources.",[590,591,592],"Methamphetamine Abuse","Hiv","Social Stigma",[594,595,596],"Methamphetamine","Preexposure prophylaxis","Intersectional Stigma","2026-02-17",{"date":599,"type":45},"2026-02-19",{"date":601,"type":23},"2026-04-15",{"date":201,"type":23},{"name":51,"class":52},{"id":605,"slug":606,"hasResults":12,"nctId":607,"briefTitle":608,"officialTitle":609,"acronym":4,"eligibilityCriteria":610,"healthyVolunteers":62,"sex":63,"minAge":422,"maxAge":611,"enrollmentInfo":612,"targetDuration":4,"studyType":24,"phases":613,"briefSummary":614,"conditions":615,"keywords":619,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":625,"startDateStruct":626,"completionDateStruct":628,"leadSponsor":629,"locationsCount":493},"100576439","native-spirit-significant-aim-3-intervention-100576439","NCT06785311","Native Spirit: Significant Aim 3: Intervention","Native Spirit: Culturally-grounded Substance Use Prevention for Indigenous Adolescents","Inclusion:\n\n* English-speaking\n* Currently in grade 7-12 at time of enrollment\n* Member of the Salt River Pima Maricopa Indian Community (SRPMIC) OR member of the Pascua Yaqui Tribe (PYT)\n* Engaged in after school programs.\n\nExclusion:\n\n• Non-American Indians will be excluded from statistical analysis","17 Years",{"count":389,"type":23},[26],"The proposed research will used community-based participatory research methods in an urban-based American Indian (AI) community to adapt, implement, and evaluate an after-school program, called Native Spirit (NS), that seeks to improve cultural identity, self-esteem, resilience, and prevent substance use by increasing cultural engagement. Prior research suggests that AI youth that are culturally engaged experience better health outcomes. Additionally, the use of culturally-specific after-school programs has been shown to increase feasibility and sustainability of prevention programs. In order to achieve the goals of this proposed study, the Principal Investigator (PI) will work with local community members and existing tribal partners to implement the 10-session culturally-grounded after-school program and evaluate the program with the following aims:\n\nSpecific Aim 3 (R00): Examine the effectiveness of NS (increases exposure to local cultural values and activities), a program that seeks to prevent or decrease substance use by strengthening self-esteem, resilience, and cultural identity with 2 Indigenous communities in Arizona using a wait-list control design with 3 data collection timepoints and participant interviews.",[430,616,617,618],"Self Esteem","Youth Drinking","Prevention, Suicide",[620,621,622,623],"American Indian","Adolescent Health","Prevention","After-School Programs","2026-02-13",{"date":597,"type":45},{"date":627,"type":45},"2025-01-09",{"date":201,"type":23},{"name":51,"class":52},{"id":631,"slug":632,"hasResults":12,"nctId":633,"briefTitle":634,"officialTitle":634,"acronym":635,"eligibilityCriteria":636,"healthyVolunteers":62,"sex":63,"minAge":637,"maxAge":65,"enrollmentInfo":638,"targetDuration":4,"studyType":24,"phases":639,"briefSummary":640,"conditions":641,"keywords":645,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":651,"lastUpdatePostDateStruct":652,"startDateStruct":654,"completionDateStruct":656,"leadSponsor":658,"locationsCount":493},"100606711","adequate-hydration-and-health-outcomes-100606711","NCT07179107","Adequate Hydration and Health Outcomes","HYDRATE","Inclusion Criteria:\n\n* BMI 18.5-24.9 or 30.0-39.9 kg\u002Fm2\n* HbA1c ≤7%\n* Age 20-65 y\n* available for 8 consecutive weeks same day and time\n\nExclusion Criteria:\n\n* Diabetes\n* HbA1c \\>7% BMI ≤18.5, BMI of 25 to \\\u003C30, or ≥ 40 kg\u002Fm2\n* night shifting work\n* losing or gaining weight during the last 2 months (\\>5 lbs. fluctuation)\n* thyroid medication\n* bariatric surgery\n* Habitual strenuous exercise (\\>120 min\u002Fweek) Strenuous exercise is defined as activities that take hard physical effort and make you breathe much harder than normal.\n* Construction and other workers that spend signifant portion of their work day outdoors\n* Commuting by bicycle\n* Eating disorders\n* Use of aspirin during the duration of the study\n* Cancer\n* Renal disease (including kidney stones or recurrent urinary track infections\n* Hepatic disease\n* Cardiac conditions\n* Current infection requiring medication\n* Chronic, contagious, infectious diseases such as tuberculosis, Hepatitis A, B, C, or HIV\n* Medication that could affect appetite or body weight regulation\n* GLP1-RA medication\n* Anti-depressent SSRI medication\n* Testosterone replacement therapy\n* Participating in another study at the same time\n* Unable to abstain from alcohol during the study\n* Unable to limit caffeinated beverage intake to 1 cup per day\n* Donated blood during the past two months\n* Uneasibly acessable veins\n* Does not have smart phone","20 Years",{"count":165,"type":23},[26],"Cardiovascular diseases (CVD) are the leading cause of death in middle- and high-income countries, according to data from the World Health Organization (WHO). Epidemiological studies have associated low water intake and underhydration with diabetes, chronic kidney disease, and an increased risk of CVD. Similarly, the prevalence of chronic metabolic dysfunction is increasing dramatically worldwide, becoming both a significant public health concern and a global economic burden. Reports from the WHO indicate that the number of people with diabetes worldwide has risen from 108 million in 1980 to 422 million in 2014, representing 8.5% of adults. Therefore, there is an urgent need to identify modifiable risk factors that could help prevent metabolic dysfunction and mitigate the epidemic of type 2 diabetes (T2D). Evidence suggests that the hormone arginine vasopressin (AVP) may play a key role. AVP is the primary hormone responsible for regulating body fluid balance; however, increased AVP secretion, such as under conditions of low water intake, appears to be a risk factor for developing diabetes.\n\nIncreasing water intake may represent a simple and cost-effective way to improve glucose regulation and cardiovascular health. However, many individuals do not prefer drinking plain water, and although beverages with high sugar content may promote greater fluid intake, they also contribute additional calories that can negatively impact body weight and overall health. Thus, the central research question of this study is whether improving hydration with non-sugar-sweetened beverages can provide equivalent benefits for hydration and health outcomes in adults.\n\nAim 1: To explore the association between habitual fluid intake and fluid preferences (water and non-sugar-sweetened beverages), hydration biomarkers, and health outcomes in normal-weight and obese adults.\n\nAim 2: To compare the impact of increased total water intake, provided as plain water or non-sugar-sweetened beverages, on hydration, cardiovascular health, and glucose regulation in normal-weight and obese adults.",[642,243,643,644],"Dehydration","Glucose Abnormalities","Cardiovascular",[646,647,648,649,650],"hydration","dehydration","underhydration","fluid intake","non caloric sweeteners","2026-01-26",{"date":653,"type":45},"2026-01-27",{"date":655,"type":45},"2025-09-29",{"date":657,"type":23},"2028-12-31",{"name":51,"class":52},{"id":660,"slug":661,"hasResults":12,"nctId":662,"briefTitle":663,"officialTitle":663,"acronym":664,"eligibilityCriteria":665,"healthyVolunteers":62,"sex":63,"minAge":188,"maxAge":4,"enrollmentInfo":666,"targetDuration":4,"studyType":24,"phases":668,"briefSummary":669,"conditions":670,"keywords":671,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":681,"lastUpdatePostDateStruct":682,"startDateStruct":684,"completionDateStruct":686,"leadSponsor":688,"locationsCount":53},"100476572","stand--move-at-work-ii-effectiveness-and-implementation-of-a-worksite-wellness-program-100476572","NCT05485675","Stand & Move at Work II: Effectiveness and Implementation of a Worksite Wellness Program","SMWII","Worksite-Level Inclusion Criteria:\n\n* More than 80% of employees work full time (30+ hours per week).\n* At least 45 employees in the worksite with sit-stand workstations working at least three days per week\n* Occupations require primarily desk-based work (e.g., computer- and telephone-based)\n* Willing to allow the researchers to distribute online research surveys to all employees in order to allow the program to be evaluated.\n* Allow 30 randomly selected individuals to wear an activity monitor in several 7-day intervals across two years.\n* Willing to be randomized to either intervention.\n* Willing to identify one or more worksite champions to implement the Stand \\& Move at Work™ program.\n\nWorksite-level exclusion criteria:\n\n* Involved in previous interventions to reduce sitting and increase standing and moving at work in the last 24 months.\n* Involved in the Stand and Move I intervention.\n* Another worksite within the same organization is participating in the program and contamination across those worksites cannot be avoided.\n\nEmployee-level inclusion criteria:\n\n* 18 years or older\n* Willing to provide informed consent",{"count":667,"type":23},4800,[26],"This is a 2-arm group-randomized hybrid effectiveness-implementation (HEI type 2) study to test an evidence-based intervention (EBI) known as Stand \\& Move at Work(SMW) to reduce sedentary time in the workplace, and to test the role of expert facilitation (SMW+) for improving intervention fidelity.",[219],[672,673,674,675,676,677,678,566,679,680],"worksite health","sit-stand workstations","multilevel intervention","implementation science","fidelity","facilitation","effectiveness","posture","Light physical activity","2026-01-13",{"date":683,"type":45},"2026-01-14",{"date":685,"type":45},"2022-10-07",{"date":687,"type":23},"2027-02-28",{"name":51,"class":52},{"id":690,"slug":691,"hasResults":12,"nctId":692,"briefTitle":693,"officialTitle":694,"acronym":4,"eligibilityCriteria":695,"healthyVolunteers":62,"sex":63,"minAge":236,"maxAge":4,"enrollmentInfo":696,"targetDuration":4,"studyType":24,"phases":698,"briefSummary":699,"conditions":700,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":706,"lastUpdatePostDateStruct":707,"startDateStruct":709,"completionDateStruct":711,"leadSponsor":713,"locationsCount":53},"100608955","cognitive-vitality-pilot-study-100608955","NCT07208279","Cognitive Vitality Pilot Study","Effects of Dietary Supplement Intervention on Cognitive Function and Psychological Well-Being","Inclusion Criteria:\n\n* Adults aged 55 years and older\n* Live independently,\n* Self-report as healthy\n* Adequate vision\n* Fluent in English\n* No history of mild cognitive impairment\n* Currently not taking dietary supplements with the same active ingredients in Axolt or naturally flavored water\n* A Montreal Cognitive Assessment \\[12\\] (MOCA) score ≥ 24\n* Able to provide written informed consent, and medical clearance to participate.\n\nExclusion Criteria:\n\n* Previous participation in a cognitive dietary supplement study in the last 12 months\n* A score of \\\u003C 24 on the Montreal Cognitive Assessment (MoCA) as a potential risk for obtaining informed consent\n* History of seizures\n* Epilepsy\n* Parkinson's disease\n* History of severe head trauma\n* Uncontrolled hypertension\n* On psychoactive medications\n* Substance abuse\n* Unwilling or unable to discontinue current dietary supplements with similar ingredients\n* Planned surgery during the study period\n* Medications known to interact with active ingredients with Axolt\n* Minors and prisoners will be excluded.",{"count":697,"type":23},16,[26],"This study's purpose is to evaluate the effects of a dietary supplement on cognitive function and psychological well-being in community-dwelling older adults aged 55+. The study involves taking a commercially available dietary supplement daily for 45 days. A 45-minute assessment will be conducted at the beginning and again at the end of the study.",[701,702,703,704,705],"Aging","Healthy Aging","Cognition","Memory","Brain","2025-10-27",{"date":708,"type":45},"2025-10-28",{"date":710,"type":45},"2025-09-01",{"date":712,"type":23},"2026-08-11",{"name":51,"class":52},""]