[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Association of Migraine Disorders\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":97},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100651799","phase-2-visual-instillation-of-sphenopalatine-block-intervention-for-ongoing-migraine-100651799",false,"NCT07764783","Visual Instillation of Sphenopalatine-block Intervention for ONgoing Migraine","VISION","Inclusion criteria:\n\n* Aged 18 years or older\n* Any race\n* Any gender\n* At least 2 of 3 positives (a, b, c) below on the ID Migraine Screener from the American Headache Society:\n\n  1. Photophobia\n  2. Inability to function\n  3. Nausea\n* At least 3 months of patient-reported episodic or persistent discomfort, pain, or pressure in the anatomic distribution of the paranasal sinuses, orbits, or nasal cavities.\n* The patient experiences at least 10 days of headaches and\u002For FPP within a 30-day period, during the run-in phase.\n* No evidence of abnormal sinus findings on imaging \\[paranasal sinus CT, including cone beam imaging, or MRI (MRI images must include all paranasal sinuses) obtained when symptomatic in the last 12 months prior to presentation. Normal imaging findings included isolated mucus retention cysts 2 cm or less in size and minimal non-circumferential (isolated areas) mucosal thickening (3mm or less).\n* Normal endoscopy if performed prior to enrollment, defined as the absence of purulent (opaque - white or other discolored - secretions) at the middle meatus or sphenoethmoid recess or nasal polyp disease.\n* Daily access to a cell phone that can function with the study mobile application\n* For women of child bearing potential: not pregnant and using a method of contraception during the duration of the study.\n* The patient can be taking interventional and preventive medications and other treatments before and during the study period, including new medications which will be tracked. The clinical coordinator will ask the patient to refrain from taking any abortive medication, cannabis, and psilocybin 24 hours prior to the procedure visit.\n\nExclusion criteria:\n\n* Prior endoscopic sinus surgery within the 3 months prior to enrollment.\n* Nasal endoscopy if performed prior to enrollment shows severe signs of mucosal infection, (mucopurulent drainage) or nasal polyposis.\n* A history of anterior skull base neoplasia.\n* Nasal endoscopy if performed prior to enrollment does not allow visualization of the middle turbinate on endoscopy bilaterally after application of a topical decongestant.\n* Signs of active or chronic sinusitis on CT (\\>3mm mucosal thickening or air fluid level in any paranasal sinus.)\n* The patient cannot tolerate the use of topical anesthetics or intranasal endoscopy without sedation or general anesthesia\n* Unable to see the middle meatus with either a nasal speculum or an endoscope\n* Allergy to lidocaine or other local anesthetics (tertiary amine class 1b).\n* Is currently using a schedule II narcotic for migraine pain.\n* Current cocaine use or cocaine use within the last 30 days.\n* Currently immunocompromised\n* History or evidence of any other unstable or clinically significant medical condition that in the opinion of the sponsor-investigator\u002F Principal Investigator, would pose a risk to subject safety or interfere with the study evaluation, procedures or completion.\n* Has received any investigational agent within 30 days of enrollment.\n* Plans to participate in a concurrent clinical trial.","ALL","18 Years",{"count":19,"type":20},74,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","The goal of this double-blinded, randomized placebo controlled clinical trial is to to see if using a numbing medicine (lidocaine) on certain areas inside the nose can help with headaches, neck pain, facial pain and pressure, and other symptoms. It also aims to understand the pathophysiology that causes these symptoms.\n\nThe main questions it aims to answer are:\n\n1. Is applying numbing medication directly to the sphenopalatine ganglion (SPG) area, while watching through the scope to make sure it's in the right place, a workable and effective way to treat migraine headaches immediately and 24 hours?\n2. Is applying numbing medication directly to the sphenopalatine ganglion (SPG) area, while watching through the scope to make sure it's in the right place, a workable and effective way to improve patient-reported outcomes?\n\nThe 2-month study requires:\n\n* One virtual visit (on the computer)\n* One visit to the office for placement of the numbing medicine under direct vision\n* Daily headache diary entries that take less than two minutes to complete",[26,27,28],"Migraine","Facial Pain or Pressure","Headache","NOT_YET_RECRUITING","2026-08-10",{"date":32,"type":33},"2026-08-14","ACTUAL",{"date":35,"type":20},"2026-09",{"date":37,"type":20},"2028-09",{"name":39,"class":40},"Association of Migraine Disorders","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":52,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":63,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":41},"100651108","headache-ear-auditory-dizziness-sinus-heads-registry-100651108","NCT07754266","Headache Ear Auditory Dizziness Sinus (HEADS) Registry","HEADS","Inclusion Criteria:\n\n* Resident of the United States of America\n* Age of Majority (18+ in 47 states and Washington, D.C., 19+ in Alabama and Nebraska, 21+ in Puerto Rico and Mississippi)\n* Fluent in English OR Spanish.\n* Experience sinus, vestibular auditory, and\u002For headache symptoms, with and without diagnosis of migraine.\n\nExclusion Criteria:\n\n* Under 18 years of age, under age of Majority. Minors are not the population of interest for the study at this time.",true,{"count":51,"type":20},10000,"10 Years","OBSERVATIONAL","The Headache, Ear, Auditory, Dizziness, Sinus (HEADS) Registry is a study over time of individuals living in the United States who experience sinus, vestibular, auditory, and headache symptoms. Through an online portal, participants are asked questions about their symptoms, how they have affected their lives, and how effectively they have managed them. This information is then used to better understand these symptoms and to improve patient diagnosis and treatment.\n\nSome potential research benefits of the HEADS Registry include:\n\n* Improving healthcare professionals' understanding of the causes of specific head and neck symptoms.\n* Reducing delays in diagnosis and the use of inappropriate tests, medications, and surgeries.\n* Finding the most effective treatments for sinus, vestibular, and auditory disorders.\n* Providing participants the opportunity to be contacted for additional important research related to sinus, vestibular, and auditory disorders.\n\nAll U.S. residents over the age of majority who experience sinus, vestibular, and auditory symptoms, with or without migraine, are eligible to participate. Enrollment is voluntary, confidential, and free of charge.",[56,57,58,59,60,61,28,26,62],"Headache Disorders","Dizziness","Vestibular Diseases","Sinus Disease","Vestibular Disorder","Migraine Disorders","Facial Pain",[64,61,65,66,62,28],"Registries","Ear Diseases","Paranasal Sinus Diseases","RECRUITING","2026-08-04",{"date":30,"type":33},{"date":71,"type":33},"2023-07-06",{"date":73,"type":20},"2033-12-31",{"name":39,"class":40},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":41},"100636915","topical-intranasal-anesthetic-block-for-reducing-the-pain-of-botulinum-toxin-injections-for-chronic-migraine-100636915","NCT07571889","Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine","Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine: A Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Study","Inclusion Criteria:\n\n* Aged ≥18 years\n* Any gender\n* Able to provide informed consent\n* Meets clinical criteria for onabotulinumtoxinA for chronic migraine (minimum of 2 days of disability per month due to facial or headache pain, or 8 headache days per month, or more than 15 headaches per month)\n* Scheduled for modified PREEMPT injections at the clinical site\n\nExclusion Criteria:\n\n* Aged \\\u003C 18 years\n* Trigeminal neuralgia, cluster headache, or other primary headache disorders as dominant diagnosis\n* Not able to provide informed consent\n* Known allergy\u002Fhypersensitivity to lidocaine or amide anesthetics\n* Pregnancy\u002Flactation\n* Inability to tolerate intranasal nasal cotton pledgets\n* Significant nasal pathology at placement site",{"count":83,"type":20},18,[85],"NA","People find the injections used in onabotulinumtoxinA (Botox®) uncomfortable. This study will test whether putting a small piece of cotton soaked with 4% lidocaine (a numbing medicine) inside the front of each nostril for 5 minutes before the injections reduces injection pain compared with cotton soaked in saline (salt water).",[88],"Pain From onabotulinumtoxinA Injections","2026-05-04",{"date":91,"type":33},"2026-05-06",{"date":93,"type":33},"2026-03-03",{"date":95,"type":20},"2027-01",{"name":39,"class":40},""]