[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Atlas University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":578},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,41,64,90,120,149,178,214,238,268,315,339,366,392,417,444,467,487,508,534,561],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100649092","efficacy-of-lsvt-loud-therapy-on-voice-speech-and-quality-of-life-in-parkinsons-disease-100649092",false,"NCT07730073","Efficacy of LSVT-LOUD Therapy on Voice, Speech, and Quality of Life in Parkinson's Disease","The Effect of Lee Silverman Voice Therapy-LOUD (LVST-LOUD) Therapy Method on Voice and Speech Skills and Examination of Therapy Experiences in Turkish-Speaking Individuals With Parkinson's Disease","Inclusion Criteria:\n\nDiagnosis: Patients with a confirmed diagnosis of Idiopathic Parkinson's Disease (Hoehn and Yahr stages I-III).\n\nAge: Individuals aged 40-80 years.\n\nLanguage: Native Turkish speakers.\n\nCognitive Status: Sufficient cognitive function to participate in therapy (e.g., Mini-Mental State Examination (MMSE) score ≥ 24).\n\nCommunication: Presence of voice or speech impairment (e.g., hypophonia, reduced intelligibility) as confirmed by a speech-language pathologist.\n\nStability: Stable medication regimen for at least 1 month prior to the study initiation.\n\nExclusion Criteria:\n\nNeurological Comorbidities: Presence of other significant neurological disorders (e.g., stroke, traumatic brain injury, multiple sclerosis) or active voice disorders (e.g., vocal cord nodules, laryngeal cancer).\n\nHearing Impairment: Uncorrected hearing loss that would interfere with speech assessment or therapy.\n\nCognitive Impairment: Diagnosis of dementia or severe cognitive impairment that prevents participation in the intensive LSVT-LOUD protocol.\n\nRecent Surgery: History of laryngeal surgery or deep brain stimulation (DBS) within the last 6 months.\n\nTherapy History: Previous experience with LSVT-LOUD or intensive speech therapy within the past year.","ALL","40 Years","80 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24],"NA","Parkinson's disease often causes speech and voice impairments, such as reduced vocal loudness and decreased speech intelligibility, which significantly impact the quality of life for patients and their families. The Lee Silverman Voice Therapy-LOUD (LSVT-LOUD) is a specialized, evidence-based speech therapy protocol designed to improve vocal function.\n\nThis study investigates the effectiveness of the LSVT-LOUD protocol in Turkish-speaking individuals with Parkinson's disease. The research evaluates objective changes in vocal loudness and speech quality, as well as the subjective therapy experiences of participants. By analyzing both clinical outcomes and patient feedback, this study aims to contribute to the clinical application and adaptation of LSVT-LOUD for the Turkish-speaking population",[27],"Parkinson's Disease (PD)","RECRUITING","2026-07-24",{"date":31,"type":32},"2026-07-28","ACTUAL",{"date":34,"type":32},"2026-02-18",{"date":36,"type":21},"2027-02",{"name":38,"class":39},"Atlas University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":40},"100648921","the-effects-of-menthol-and-cold-spray-applications-on-thirst-and-comfort-in-bariatric-surgery-100648921","NCT07728500","The Effects of Menthol and Cold Spray Applications on Thirst and Comfort in Bariatric Surgery","The Effect of Menthol Spray and Cold Spray Applications on Postoperative Thirst Level and Comfort in Patients Undergoing Bariatric Surgery","Inclusion Criteria:\n\n* • Patients who are 18 years of age or older,\n\n  * who undergo bariatric surgery under general anesthesia,\n  * who do not have oral or nasal diseases, or vision, hearing, speech, or comprehension problems,\n  * who are classified as grade I or II according to the American Society of Anesthesiologists (ASA) Physical Status Classification System,\n  * who are not allergic to menthol,\n  * who do not have severe vomiting, and • whose preoperative fasting and thirst period is 8 hours.\n\nExclusion Criteria:\n\n* Patients with impaired oral and tongue mucosal integrity prior to surgery, Patients with any neurological, kidney, heart or lung disease with cognitive impairment and those using psychoactive drugs will be excluded.","18 Years",{"count":50,"type":21},180,[24],"Bariatric surgery is a widely used surgical treatment method in obesity management that improves quality of life and provides long-term weight loss. Patients often experience thirst in the early postoperative period. Factors that increase thirst include cessation of oral intake, room temperature, intubation, dehydration, hypovolemia, and oxygen therapy in the preoperative period. Furthermore, failure to initiate oral intake early in the postoperative period increases thirst and negatively impacts patient comfort. The aim of this study is to evaluate the effects of menthol spray and cold spray applications on the thirst and comfort levels of patients in the postoperative period. The study aims to contribute to the improvement of nursing practices related to postoperative thirst and comfort management with the findings obtained from this study. This randomized controlled clinical trial is planned to be conducted with patients undergoing bariatric surgery at the General Surgery Clinic of Istanbul Atlas University Hospital. The study population will consist of patients hospitalized in the General Surgery Department of Atlas University Hospital who have undergone bariatric surgery. The sample was determined as 159 patients meeting the inclusion criteria in three groups, calculated using the GPower 3.1.9.7 program with an effect size of f=0.25, a significance level of α=0.05, and a test power of (1-β)=0.80. Considering data loss, the study is planned to be conducted with 180 patients. The \"Patient Information Form,\" \"Visual Analog Scale-Comfort (VAS-A),\" \"Dehydration Visual Analog Scale (VAS),\" and \"Surgical Dehydration Discomfort Scale (CDSBRÖ)\" will be used to collect research data.",[54],"Thirst in Bariatric Surgery Patients","NOT_YET_RECRUITING","2026-07-22",{"date":58,"type":32},"2026-07-27",{"date":60,"type":21},"2026-07-30",{"date":62,"type":21},"2026-10-30",{"name":38,"class":39},{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":16,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":40},"100648161","preliminary-effects-of-the-co-op-approach-in-children-with-autism-spectrum-disorder-100648161","NCT07717853","Preliminary Effects of the CO-OP Approach in Children With Autism Spectrum Disorder","Preliminary Effects of the Cognitive Orientation to Daily Occupational Performance Approach on Occupational Performance in Children With Autism Spectrum Disorder: A Pilot Study","Inclusion Criteria:\n\n* Having a clinical diagnosis of autism spectrum disorder\n* Being of primary school age\n* Having communication and cooperation skills sufficient to participate in the - Cognitive Orientation to Daily Occupational Performance intervention\n* Having at least one daily occupational performance goal identified by the child and\u002For family\n* Being able to attend the assessment and intervention sessions regularly\n* Provision of written informed consent by a parent or legal guardian\n\nExclusion Criteria:\n\n* Having a severe neurological, orthopedic, or psychiatric condition that may substantially affect the assessment or intervention process\n* Having severe behavioral difficulties that prevent safe and consistent participation in the intervention sessions\n* Having participated in an intensive, structured cognitive strategy-based intervention program within the previous 6 months\n* Withdrawal of the child or parent\u002Flegal guardian from the study","7 Years","10 Years",{"count":74,"type":21},10,[24],"Autism spectrum disorder may affect children's participation in daily occupations through difficulties related to motor planning, problem-solving, attention, behavioral regulation, and sensory processing. The Cognitive Orientation to Daily Occupational Performance approach is a goal-oriented intervention that supports children in identifying and using cognitive strategies to improve the performance of personally meaningful activities.\n\nThis pilot study aims to examine the preliminary effects of a 10-session Cognitive Orientation to Daily Occupational Performance intervention on occupational performance, satisfaction with performance, observed performance quality, and individualized goal attainment in primary school-aged children with autism spectrum disorder. Possible changes in autism-related behavioral characteristics and sensory processing patterns will also be examined.",[78],"Autism Spectrum Disorder",[78,80,81],"Cognitive Orientation to Daily Occupational Performance","Occupational Therapy","2026-07-16",{"date":84,"type":32},"2026-07-21",{"date":86,"type":32},"2026-07-10",{"date":88,"type":21},"2026-09-30",{"name":38,"class":39},{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":101,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":117,"leadSponsor":119,"locationsCount":40},"100647054","extracorporeal-shock-wave-therapy-in-patients-with-lipedema-100647054","NCT07683559","Extracorporeal Shock Wave Therapy in Patients With Lipedema","Evaluation of the Effects of Extracorporeal Shock Wave Therapy on Pain, Quality of Life, and Ultrasonographic Findings in Patients With Lipedema","LIPO-ESWT","Inclusion Criteria:\n\n* Male or female participants aged 18 to 75 years\n* Clinical diagnosis of lipedema\n* Willingness to participate and provide written informed consent\n* Ability to comply with study procedures and follow-up assessments\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Active infection in the treatment area\n* Malignancy\n* Severe cardiovascular disease\n* Coagulation disorders or current anticoagulant therapy\n* Previous ESWT treatment within the last 6 months\n* Severe psychiatric or cognitive disorders interfering with study participation\n* Any condition deemed by the investigator to make participation unsafe","75 Years",{"count":100,"type":21},40,[24],"Lipedema is a chronic adipose tissue disorder characterized by pain, tenderness, disproportionate fat accumulation, and impaired quality of life. Extracorporeal shock wave therapy (ESWT) has been proposed as a non-invasive treatment option that may improve pain and tissue characteristics in patients with lipedema.\n\nThe aim of this prospective interventional study is to evaluate the effects of ESWT on pain intensity, quality of life, functional outcomes, and ultrasonographic findings in patients diagnosed with lipedema. Participants will receive a standardized ESWT protocol consisting of six treatment sessions over a two-week period. Clinical assessments and ultrasonographic examinations will be performed before and after treatment.",[104],"Lipedema",[106,107,104,108,109,110,111,112],"Extracorporeal Shock Wave Therapy","ESWT","Pain","Ultrasonography","Quality of Life","PROMIS","Patient-Reported Outcomes","2026-07-01",{"date":115,"type":32},"2026-07-06",{"date":113,"type":21},{"date":118,"type":21},"2027-01-01",{"name":38,"class":39},{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":127,"sex":16,"minAge":128,"maxAge":129,"enrollmentInfo":130,"targetDuration":4,"studyType":22,"phases":132,"briefSummary":133,"conditions":134,"keywords":136,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":40},"100619754","non-pharmacological-methods-in-heel-lance-100619754","NCT07348731","Non-Pharmacological Methods in Heel Lance","Comparison of the Effects of Foot Bath, ShotBlocker®, and Buzzy® on Neonatal Vital Signs During Heel Lance","Inclusion Criteria:\n\n* Newborns with a gestational age of ≥37 weeks\n* Newborns in the neonatal period (0-28 days)\n* Stable vital signs\n* Obtained informed consent from the parents\n* No use of analgesics or sedatives within the 24 hours before the procedure\n* Absence of any respiratory problems\n* First-time heel lance procedure\n* No condition that would interfere with pain assessment\n\nExclusion Criteria:\n\n* Preterm or low birth weight infants (\\\u003C 2500 g)\n* Infants with congenital anomalies or requiring respiratory support\n* Infants receiving sedative or analgesic treatment",true,"4 Days","1 Month",{"count":131,"type":21},90,[24],"This randomized controlled study was designed to compare the effects of Warm Foot Bath, ShotBlocker®, and Buzzy®-applied prior to heel lance-on the vital signs of newborns. Heel lance is one of the most frequently performed invasive procedures during the neonatal period, and the pain and stress experienced during the procedure may lead to alterations in vital parameters such as heart rate, respiratory rate, and oxygen saturation. Therefore, identifying non-pharmacological, safe, and feasible pain management methods is essential for enhancing the quality of nursing care.\n\nData will be collected at three time points: before, during, and after the procedure, and changes in heart rate, respiratory rate, and SpO₂ will be recorded. With parental consent, the procedure will be video-recorded before, during, and after heel lance; the recordings will be anonymized and shared with experts for pain assessment. Additionally, the infant's crying duration and time to bleeding cessation will also be evaluated.",[135],"Heel Lance Procedures",[137,138,139,140],"Foot Bath","Buzzy","Shotblocker","heel lance","2026-05-31",{"date":143,"type":32},"2026-06-02",{"date":145,"type":32},"2026-02-25",{"date":147,"type":21},"2026-06-15",{"name":38,"class":39},{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":4,"eligibilityCriteria":155,"healthyVolunteers":127,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":156,"targetDuration":4,"studyType":22,"phases":157,"briefSummary":158,"conditions":159,"keywords":164,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":40},"100637086","three-teaching-strategies-in-nursing-education-effects-on-learning-and-knowledge-retention-100637086","NCT07598500","Three Teaching Strategies in Nursing Education: Effects on Learning and Knowledge Retention","The Effect of Three Different Instructional Strategies on Learning Outcomes and Knowledge Retention in Nursing Education: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Being a second- or third-year undergraduate nursing student.\n* Being enrolled in the relevant nursing course during the study period.\n* Being scheduled to participate in the educational intervention on peritoneal dialysis catheter care.\n* Voluntarily agreeing to participate in the study.\n* Providing informed consent.\n* Being able to complete the pre-test, immediate post-test, and 4-week follow-up assessments.\n\nExclusion Criteria:\n\n* Not providing informed consent.\n* Not attending the educational intervention.\n* Being unable to complete the study assessment forms.\n* Participating in another educational activity or training program specifically related to peritoneal dialysis catheter care during the study period.",{"count":131,"type":21},[24],"The goal of this clinical trial is to learn whether three different instructional strategies improve learning outcomes and knowledge retention in nursing students receiving education on peritoneal dialysis catheter care. The main questions it aims to answer are:\n\nDoes Pecha Kucha-based education improve students' knowledge of peritoneal dialysis catheter care compared with concept map-based education and traditional education? Do the three instructional strategies differ in terms of knowledge retention, learning satisfaction, learning experience, and perceived cognitive load? Researchers will compare Pecha Kucha-based education, concept map-based education, and traditional education to see which instructional strategy is more effective in improving students' knowledge, supporting knowledge retention, and providing a positive learning experience.\n\nParticipants will:\n\nComplete a pre-test before the education. Receive one of three educational interventions on peritoneal dialysis catheter care: Pecha Kucha-based education, concept map-based education, or traditional education.\n\nComplete a post-test after the education. Complete forms evaluating learning satisfaction, learning experience, and perceived cognitive load.\n\nComplete a follow-up knowledge test to assess knowledge retention.",[160,161,162,163],"Nursing Education","Peritoneal Dialysis Catheter Care","Knowledge Retention","Instructional Strategies",[165,166,167,168,169],"Nursing education","Peritoneal dialysis catheter care","Pecha Kucha","Educational intervention","Concept map","2026-05-13",{"date":172,"type":32},"2026-05-20",{"date":174,"type":21},"2026-05-25",{"date":176,"type":21},"2026-08-30",{"name":38,"class":39},{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":184,"eligibilityCriteria":185,"healthyVolunteers":127,"sex":186,"minAge":48,"maxAge":187,"enrollmentInfo":188,"targetDuration":4,"studyType":22,"phases":190,"briefSummary":191,"conditions":192,"keywords":196,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":40},"100638112","midwife-led-antenatal-perineal-massage-education-in-primiparous-pregnant-women-100638112","NCT07593326","Midwife-Led Antenatal Perineal Massage Education in Primiparous Pregnant Women","The Effect of Midwife-Led Antenatal Perineal Massage Education on Pregnancy Empowerment, Self-Efficacy for Normal Birth, and Fear of Childbirth","APM-EDU","Inclusion Criteria:\n\n* Women aged 18 to 35 years\n* At least primary school graduates\n* Able to communicate in Turkish\n* Between 28 and 34 weeks of gestation\n* Primiparous pregnant women\n* Singleton pregnancy\n* Planning vaginal birth\n* Able to use a smartphone\n* Having internet access\n* Willing to participate in the study and providing informed consent\n\nExclusion Criteria:\n\n* Having an indication for planned cesarean section\n* History of perineal surgery\n* Presence of active genital infection or genital lesion\n* Cognitive, communication-related, or psychiatric condition that may prevent completion of the study forms\n* Refusal to participate in the study\n* Withdrawal from the study during the study process\n* Failure to complete the educational intervention\n* Missing pre-test or post-test data","FEMALE","35 Years",{"count":189,"type":21},152,[24],"This study aims to evaluate the effect of midwife-led antenatal perineal massage education on pregnancy empowerment, self-efficacy for normal birth, and fear of childbirth among primiparous pregnant women. The study is designed as a controlled quasi-experimental study and will be conducted at the Obstetrics and Gynecology Outpatient Clinic of Silifke State Hospital in Mersin, Turkey.\n\nEligible participants will be primiparous pregnant women aged 18-35 years, between 28 and 34 weeks of gestation, with a singleton pregnancy and a plan for vaginal birth. Participants in the intervention group will receive structured antenatal perineal massage education led by a midwife, in addition to routine antenatal care. Participants in the control group will receive routine antenatal care.\n\nThe primary outcome will be pregnancy empowerment. Secondary outcomes will include self-efficacy for normal birth, fear of childbirth, knowledge and preferences regarding antenatal perineal massage, and adherence to antenatal perineal massage practice.",[193,194,195],"Pregnancy","Fear of Childbirth","Antenatal Education",[197,198,199,200,201,202,203,204,205],"Antenatal perineal massage","Midwife-led education","Primiparous pregnant women","Pregnancy empowerment","Self-efficacy for normal birth","Fear of childbirth","Vaginal birth","Pelvic health","Routine antenatal care","2026-05-12",{"date":208,"type":32},"2026-05-18",{"date":210,"type":21},"2026-05-15",{"date":212,"type":21},"2026-12-31",{"name":38,"class":39},{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":127,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":222,"targetDuration":4,"studyType":22,"phases":224,"briefSummary":225,"conditions":226,"keywords":228,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":235,"leadSponsor":237,"locationsCount":4},"100635392","guided-imagery-exercise-for-surgical-fear-and-perioperative-comfort-in-turp-patients-100635392","NCT07552090","Guided Imagery Exercise for Surgical Fear and Perioperative Comfort in TURP Patients","The Effect of Guided Imagery Exercises on Surgical Anxiety and Perioperative Comfort in Patients Undergoing Transurethral Prostate Resection:","Guided Imagery","Inclusion Criteria:\n\n* TUR-T surgery performed on Patients over 18 years of age\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery Patients under 8 years of age",{"count":223,"type":21},70,[24],"Objective: This randomized controlled trial aims to evaluate the impact of guided imagery exercises on surgical fear and perioperative comfort in patients undergoing Transurethral Resection of the Prostate (TURP).\n\nBackground: Transurethral Resection of the Prostate (TURP) remains the gold standard surgical treatment for Benign Prostatic Hyperplasia (BPH). Despite its efficacy, a significant majority of patients (60-80%) experience substantial surgical fear, which can negatively affect their recovery and perioperative comfort. Guided imagery is a non-pharmacological, cognitive-behavioral technique that utilizes mental visualization to activate the mind-body connection, reduce sympathetic activity, and promote relaxation.\n\nMethods: Grounded in Kolcaba's Comfort Theory, this study investigates the relationship between guided imagery and the multi-dimensional aspects of patient comfort (physical, psycho-spiritual, environmental, and socio-cultural). The intervention group will receive structured guided imagery sessions designed to reduce physiological stress responses and enhance emotional regulation, while the control group will receive standard care.",[227],"Guided Imagery Exercise",[227,229,230],"Transurethral Prostate Resection","surgical fear","2026-04-20",{"date":233,"type":32},"2026-04-27",{"date":231,"type":21},{"date":236,"type":21},"2026-06-30",{"name":38,"class":39},{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":244,"eligibilityCriteria":245,"healthyVolunteers":11,"sex":186,"minAge":48,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":247,"phases":4,"briefSummary":248,"conditions":249,"keywords":252,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":40},"100632664","patient-derived-organoids-to-functionally-characterize-chemotherapy-resistance-in-breast-cancer-100632664","NCT07516626","Patient-Derived Organoids to Functionally Characterize Chemotherapy Resistance in Breast Cancer","Functional Characterization of Neoadjuvant Chemotherapy Resistance in Breast Cancer Using Patient-Derived Organoid Models and Development of Drug Repurposing Strategies With Next-Generation Small Molecules","BC-PDO","Inclusion Criteria:\n\n* Female patients aged 18 years or older\n* Histologically confirmed locally advanced breast cancer\n* Planned to receive neoadjuvant chemotherapy\n* Availability of tumor tissue obtained during routine diagnostic or therapeutic procedures\n* Availability of clinical and pathological treatment data\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Age under 18 years\n* Metastatic breast cancer\n* Prior systemic chemotherapy or targeted therapy for the current diagnosis\n* Presence of another active malignancy\n* Severe comorbid conditions that may interfere with study participation\n* Insufficient biological sample for organoid generation or analysis\n* Inability or unwillingness to provide informed consent",{"count":100,"type":21},"OBSERVATIONAL","This prospective observational study aims to functionally characterize chemotherapy resistance in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy. Despite standard molecular classification, significant heterogeneity in treatment response exists, and the biological mechanisms underlying chemoresistance remain incompletely understood.\n\nIn this study, patient-derived organoid (PDO) models will be established from tumor tissues obtained during routine clinical care. These three-dimensional models preserve the biological characteristics of individual tumors and enable ex vivo functional assessment of drug response. Chemotherapy sensitivity and resistance will be evaluated using quantitative parameters including Half-Maximal Inhibitory Concentration (IC50) values, cell viability, and apoptotic response.\n\nFunctional data obtained from PDO models will be correlated with clinical and pathological treatment outcomes, particularly pathological complete response (pCR), to assess the predictive value of PDO-based assays. In addition, apoptotic biomarkers such as Caspase-3\u002F7 will be measured in serum samples collected during routine clinical evaluation and analyzed in relation to treatment response.\n\nFurthermore, selected Food and Drug Administration (FDA) and European Medicines Agency (EMA) approved small molecules will be tested in PDO models to evaluate their potential to reverse chemotherapy resistance, supporting drug repurposing strategies. This study aims to establish a functional, patient-specific platform for assessing chemoresistance and to contribute to the development of personalized therapeutic approaches in breast cancer.",[250,251],"Breast Cancer","Locally Advanced Breast Cancer (LABC)",[253,254,255,256,257,258,259],"Neoadjuvant Chemotherapy","Chemotherapy Resistance","Patient-Derived Organoids","Drug Repurposing","Pathological Complete Response","Ex Vivo Drug Testing","Locally Advanced Breast Cancer","2026-04-07",{"date":262,"type":32},"2026-04-13",{"date":264,"type":21},"2026-06",{"date":266,"type":21},"2029-06",{"name":38,"class":39},{"id":269,"slug":270,"hasResults":11,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":274,"eligibilityCriteria":275,"healthyVolunteers":127,"sex":16,"minAge":276,"maxAge":277,"enrollmentInfo":278,"targetDuration":4,"studyType":247,"phases":4,"briefSummary":280,"conditions":281,"keywords":291,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":40},"100632676","neck-musculoskeletal-symptoms-among-turkish-endodontists-100632676","NCT07516782","Neck Musculoskeletal Symptoms Among Turkish Endodontists","Analysis of Neck Musculoskeletal Symptoms, Functional Parameters, and Associated Factors in Turkish Endodontists","ENDO-NECK","Inclusion Criteria:\n\n* Aged 25 to 65 years\n* Actively practicing as an endodontist in Turkey in public institutions, university hospitals, or the private sector\n* Willing and able to provide informed consent\n* Endodontists with or without neck pain\n\nExclusion Criteria:\n\n* History of cervical spine surgery within the last 3 months\n* History of cervical spine infection within the last 3 months (e.g., spondylodiscitis)\n* History of malignancy involving the cervical region\n* Spinal cord compression due to tumor or another cause\n* Presence of neurological deficit\n* Inflammatory disease involving the cervical region, such as rheumatoid arthritis\n* Use of muscle relaxant medication within the last 1 week","25 Years","65 Years",{"count":279,"type":21},120,"This observational study aims to evaluate the prevalence, severity, and characteristics of neck musculoskeletal symptoms among Turkish endodontists. Endodontists are exposed to prolonged static postures and repetitive movements during clinical procedures, which may increase the risk of neck-related disorders.\n\nParticipants will be asked to complete questionnaires regarding demographic characteristics, occupational factors, ergonomic conditions, and neck pain. In addition, physical assessments including cervical range of motion, muscle strength, endurance, posture, and proprioception will be performed using validated measurement tools.\n\nThe study also aims to identify factors associated with neck pain, such as working conditions, posture, and clinical experience. The findings may help improve preventive strategies, ergonomic recommendations, and rehabilitation approaches for dental professionals.",[282,283,284,285,286,287,288,289,290],"Neck Pain","Neck Pain Musculoskeletal","Musculoskeletal Assessment","Musculoskeletal Disorder of the Neck","Musculoskeletal Disorders (MSDs)","Occupational Musculoskeletal Disorders","Occupational Diseases","Endodontics","Dentistry",[292,293,282,294,295,296,297,298,299,300,301,302,303,304,305,306],"Endodontists","Dentists","Musculoskeletal Pain","Cervical Spine","Ergonomics","Occupational Health","Neck Disability Index","Posture","Work-Related Musculoskeletal Disorders","Cervical Range of Motion","Musculoskeletal Symptoms","Cervical Isometric Muscle Strength","Neck Muscle Endurance","Cervical Muscle Strength","Forward Head Posture","2026-04-01",{"date":309,"type":32},"2026-04-08",{"date":311,"type":21},"2026-05",{"date":313,"type":21},"2027-08",{"name":38,"class":39},{"id":316,"slug":317,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":320,"acronym":321,"eligibilityCriteria":322,"healthyVolunteers":127,"sex":16,"minAge":48,"maxAge":276,"enrollmentInfo":323,"targetDuration":4,"studyType":22,"phases":324,"briefSummary":325,"conditions":326,"keywords":329,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":338,"locationsCount":40},"100632133","moulage-technique-in-child-abuse-recognition-100632133","NCT07509723","Moulage Technique in Child Abuse Recognition","The Role of Moulage Technique in Identifying Physical Abuse in Children: A Randomized Controlled Study With Nursing Students","Moulage","Inclusion Criteria:\n\n* Agreeing to participate in the study voluntarily\n* Having completed the Child Health and Diseases course\n\nExclusion Criteria:\n\n* Having received any education or training related to child abuse and neglect other than the Child Health and Diseases course",{"count":223,"type":21},[24],"Early recognition of physical abuse in children is essential for ensuring child safety and preventing further harm. However, distinguishing abuse-related injuries from accidental findings can be challenging, especially for nursing students who have limited clinical experience. Simulation-based educational methods may provide safe and effective environments for developing these skills.\n\nThis study aims to evaluate the effectiveness of moulage-based simulation training in improving nursing students' ability to recognize signs of physical abuse in children. The study will use a randomized controlled design in which students will be assigned to either a moulage-based simulation group or a control group receiving standard theoretical education.\n\nAfter a lecture on child physical abuse within the Child Health and Pediatric Nursing course, students will participate in laboratory practice sessions. The intervention group will assess a pediatric mannequin prepared with simulated abuse findings using moulage techniques. Students' knowledge and recognition of physical abuse indicators will be evaluated before and after the intervention.\n\nThe study seeks to determine whether moulage-based education improves nursing students' recognition of physical abuse findings and supports the development of clinical assessment skills.",[160,327,328],"Simulation of Physical Illness","Child Physical Abuse, Suspected, Sequela",[330,331,165],"Child Physical Abuse","Moulage Technique","2026-03-31",{"date":334,"type":32},"2026-04-03",{"date":336,"type":21},"2026-04-10",{"date":236,"type":21},{"name":38,"class":39},{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":345,"eligibilityCriteria":346,"healthyVolunteers":11,"sex":186,"minAge":48,"maxAge":4,"enrollmentInfo":347,"targetDuration":4,"studyType":247,"phases":4,"briefSummary":349,"conditions":350,"keywords":355,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":40},"100615182","circulating-micrornas-and-response-to-neoadjuvant-chemotherapy-in-breast-cancer-100615182","NCT07289282","Circulating microRNAs and Response to Neoadjuvant Chemotherapy in Breast Cancer","The Relationship Between microRNAs in Breast Cancer Subtypes and Response to Neoadjuvant Chemotherapy and Pathological Response","miRNA-NAC","Inclusion Criteria:\n\n* Histologically confirmed breast cancer\n* Planned to receive neoadjuvant chemotherapy\n* Biologically female\n* Age ≥ 18 years\n* Ability to provide informed consent\n* Adequate organ function to receive standard NAC (based on routine clinical evaluation)\n\nExclusion Criteria:\n\n* Presence of metastatic disease at diagnosis\n* Prior systemic chemotherapy for breast cancer\n* Pregnancy or breastfeeding\n* Active infection or uncontrolled comorbid conditions interfering with study participation\n* Any condition preventing collection of blood samples",{"count":348,"type":21},80,"This prospective observational study aims to investigate subtype-specific circulating microRNAs (miRNAs) and their association with response to neoadjuvant chemotherapy (NAC) in patients with breast cancer. Serum samples will be collected before NAC and prior to surgery, and changes in miRNA expression levels will be evaluated. Pathological complete response (pCR) and Miller-Payne scoring will be used to assess treatment response after NAC. The study also explores whether changes in circulating miRNA profiles can predict treatment response across different breast cancer subtypes. The findings may help identify biomarkers that support treatment planning and personalized therapy strategies.",[250,351,352,353,354],"Neoadjuvant Therapy","Pathological Response","Invasive Breast Carcinoma","MicroRNAs",[356,357,253,257,358],"microRNA","Circulating microRNAs","Predictive Biomarkers","2026-03-30",{"date":332,"type":32},{"date":362,"type":32},"2025-12-15",{"date":364,"type":21},"2026-12",{"name":38,"class":39},{"id":367,"slug":368,"hasResults":11,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":372,"eligibilityCriteria":373,"healthyVolunteers":127,"sex":186,"minAge":48,"maxAge":4,"enrollmentInfo":374,"targetDuration":4,"studyType":247,"phases":4,"briefSummary":376,"conditions":377,"keywords":380,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":391,"locationsCount":4},"100631396","tissue--and-serum-derived-exosomal-micrornas-as-predictors-of-neoadjuvant-chemotherapy-response-in-breast-cancer-100631396","NCT07500129","Tissue- and Serum-Derived Exosomal microRNAs as Predictors of Neoadjuvant Chemotherapy Response in Breast Cancer","Clinical and Mechanistic Validation of a Tumor-Derived Extracellular Vesicle-Associated miRNA Signature Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer","ExoTSS-BC","Inclusion Criteria:\n\n* Female patients aged 18 years or older\n* Histologically confirmed locally advanced breast cancer scheduled to receive neoadjuvant chemotherapy\n* Availability of residual tumor tissue and\u002For serum samples obtained during routine clinical care\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Male sex\n* Age under 18 years\n* Prior systemic chemotherapy or radiotherapy administered for the current breast disease before enrollment.\n* Evidence of metastatic disease at diagnosis (for breast cancer cohort)\n* Pregnancy or breastfeeding\n* Any condition that precludes the availability or adequate quality of tissue or blood samples for research purposes",{"count":375,"type":21},60,"This prospective observational study aims to evaluate whether exosomal microRNA profiles derived from tumor tissue and blood serum are associated with pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in patients with breast cancer.\n\nBreast cancer patients with similar clinical and pathological features may respond differently to treatment, underscoring the need for reliable biomarkers that can help predict therapeutic outcomes. Exosomes are small extracellular vesicles released by tumor cells that carry molecular signals, including microRNAs, which may reflect tumor behavior and treatment sensitivity.\n\nIn this study, patients with breast cancer receiving standard NAC as part of routine clinical care will be followed prospectively. Exosomal microRNA profiles obtained from tumor tissue and blood samples collected during routine diagnostic and treatment procedures will be analyzed and compared with pathological complete response (pCR) assessed after completion of neoadjuvant chemotherapy.\n\nA group of patients with benign breast disease will be included as a reference control for comparative analyses.\n\nThe results of this study may contribute to the identification of minimally invasive biomarkers that support personalized treatment strategies in breast cancer.",[250,353,378,379,257],"Exosomal microRNA","Neoadjuvant Chemotherapy Response",[250,381,378,382,383,384,257],"Breast Cancer Biomarkers","Circulating microRNA","Tissue-derived exosomes","Serum-derived exosomes","2026-03-24",{"date":359,"type":32},{"date":388,"type":21},"2026-04-12",{"date":390,"type":21},"2027-04-22",{"name":38,"class":39},{"id":393,"slug":394,"hasResults":11,"nctId":395,"briefTitle":396,"officialTitle":397,"acronym":398,"eligibilityCriteria":399,"healthyVolunteers":127,"sex":186,"minAge":48,"maxAge":4,"enrollmentInfo":400,"targetDuration":4,"studyType":247,"phases":4,"briefSummary":402,"conditions":403,"keywords":407,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":410,"lastUpdatePostDateStruct":411,"startDateStruct":413,"completionDateStruct":415,"leadSponsor":416,"locationsCount":40},"100615786","pten-and-organ-specific-micrornas-in-metastatic-breast-cancer-100615786","NCT07297134","PTEN and Organ-Specific microRNAs in Metastatic Breast Cancer","Serum PTEN Levels and Organ-Specific microRNA Signatures as Predictors of Metastatic Patterns in Breast Cancer: A Prospective Observational Study","PTEN-miR-MBC","Inclusion Criteria:\n\n* Female individuals aged ≥18 years\n* Ability to provide written informed consent\n* Group I (Metastatic BC): Histopathologically confirmed breast cancer and radiologically or clinically proven distant organ metastasis at the time of enrollment\n* Group II (Non-Metastatic BC): Histopathologically confirmed breast cancer with no evidence of distant metastasis\n* Group III (Healthy Controls): Women ≥18 years with no known breast disease and no personal history of malignancy\n\nExclusion Criteria:\n\n* History of any other primary malignancy\n* Known breast disease or breast cancer diagnosis in Group III\n* Immunosuppressive therapy that may alter immune or biomarker profiles\n* Active infection or inflammatory condition that may alter biomarker levels\n* Inability or unwillingness to provide informed consent\n* Severe hepatic, renal, or hematologic dysfunction\n* Current pregnancy or lactation",{"count":401,"type":21},160,"This prospective observational study aims to evaluate serum levels of PTEN, a tumor suppressor gene, and organ-specific microRNAs (miRNAs) associated with metastatic patterns in breast cancer. Serum samples will be analyzed using quantitative reverse transcription polymerase chain reaction (qRT-PCR)-based miRNA profiling and enzyme-linked immunosorbent assay (ELISA)-based PTEN quantification. Three groups will be included: patients with metastatic breast cancer (n=80), patients with non-metastatic early-stage breast cancer (n=40), and healthy controls (n=40).\n\nThe primary objective is to identify serum biomarkers that differentiate metastatic from non-metastatic disease. Secondary analyses will evaluate correlations between biomarker levels and organ-specific metastatic involvement, including bone, lung, liver, and brain metastases. Findings from this study may support the development of a noninvasive serum-based tool for predicting metastatic patterns in breast cancer.",[250,404,405,406],"Metastatic Breast Cancer","miRNAs","PTEN",[250,404,405,406,381,408,409],"Organ Specific Metastasis","miRNA Profiling","2026-01-26",{"date":412,"type":32},"2026-01-27",{"date":414,"type":32},"2025-12-01",{"date":364,"type":21},{"name":38,"class":39},{"id":418,"slug":419,"hasResults":11,"nctId":420,"briefTitle":421,"officialTitle":422,"acronym":4,"eligibilityCriteria":423,"healthyVolunteers":11,"sex":186,"minAge":48,"maxAge":424,"enrollmentInfo":425,"targetDuration":4,"studyType":22,"phases":427,"briefSummary":428,"conditions":429,"keywords":431,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":436,"lastUpdatePostDateStruct":437,"startDateStruct":439,"completionDateStruct":441,"leadSponsor":443,"locationsCount":4},"100619309","the-effects-of-the-mediterranean-diet-and-synbiotics-in-polycystic-ovary-syndrome-100619309","NCT07342946","The Effects of the Mediterranean Diet and Synbiotics in Polycystic Ovary Syndrome","Effects of a Mediterranean Diet and Synbiotic Supplementation on Anthropometric and Biochemical Parameters and Quality of Life in Obese Women With Polycystic Ovary Syndrome","Inclusion Criteria:\n\n* Premenopausal women who are overweight or obese, with a body mass index (BMI) between 25 and 35 kg\u002Fm²\n* Aged 18 to 45 years (reproductive age)\n* Diagnosed with polycystic ovary syndrome (PCOS)\n\nNo underlying metabolic diseases, including type 2 diabetes mellitus, hypertension, diagnosed anemia, or any other metabolic condition requiring a special diet\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding within the past 6 months\n* Presence of comorbid conditions, including kidney, liver, or cardiovascular disease, gout, hyperuricemia, or other related disorders\n* Use of oral contraceptives\n* Following a special dietary treatment or a hypocaloric diet within the last 3 months\n* Occasional or current use of medications that may affect fluid balance, including diuretics and laxatives\n* Participants will be withdrawn from the study in case of abnormal biochemical parameters, non-adherence to the prescribed diet, or failure to comply with the supplementation protoco","45 Years",{"count":426,"type":21},32,[24],"This study will look at whether a reduced-calorie Mediterranean-style eating plan, together with a synbiotic supplement, can improve health measures and quality of life in women who have polycystic ovary syndrome (PCOS) and are overweight or have obesity. Participants will be assigned by chance (like flipping a coin) to receive either the synbiotic supplement or a placebo (a look-alike product with no active ingredients). All participants will follow the same reduced-calorie Mediterranean diet for 8 weeks. The study team will measure body composition and weight-related measurements, and will collect blood samples to evaluate selected laboratory markers before and after the 8-week period. Participants will also complete the PCOSQ-50 quality-of-life questionnaire before and after the intervention. The goal is to better understand the possible role of synbiotic supplementation alongside dietary treatment in PCOS.",[430],"PCOS (Polycystic Ovary Syndrome)",[432,433,434,435],"synbiotics","pcos","diet","nutrition","2026-01-06",{"date":438,"type":32},"2026-01-15",{"date":440,"type":21},"2025-12-20",{"date":442,"type":21},"2027-08-01",{"name":38,"class":39},{"id":445,"slug":446,"hasResults":11,"nctId":447,"briefTitle":448,"officialTitle":449,"acronym":4,"eligibilityCriteria":450,"healthyVolunteers":127,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":451,"targetDuration":4,"studyType":22,"phases":453,"briefSummary":454,"conditions":455,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":40},"100618987","the-acute-effects-of-core-stabilization-exercises-on-balance-and-upper-extremity-functional-performance-in-archers-100618987","NCT07338760","The Acute Effects of Core Stabilization Exercises on Balance and Upper Extremity Functional Performance in Archers","Acute Effect of Core Stabilization Exercises Among Archers","Inclusion Criteria:\n\n* Have been involved in licensed archery for at least 1 year\n\n  * Be willing to participate in the program (both the athlete and their parent\u002Fguardian)\n  * Be an athlete without any illness or disability that prevents participation in sports (as determined by a current medical report submitted to the club for licensing purposes)\n  * Be able to read and write\n\nExclusion Criteria:\n\n* ● Those with diagnosed mental or cognitive problems\n\n  * Those who have undergone orthopedic surgery or received intra-articular steroid treatment within the last 6 months\n  * Those with a diagnosed medical condition that could affect balance and shooting performance\n  * Those with instability issues and associated joint movement restrictions\n  * Those with acute muscle spasms and pain complaints\n  * Those using painkillers, sedatives, alcohol, etc., or any other medication or substance that may affect shooting performance\n  * Those with any diagnosis of injury related to the musculoskeletal system\n  * Those actively involved in another sport besides archery",{"count":452,"type":21},30,[24],"This randomized controlled study aims to investigate the acute effects of a single session of core stabilization exercises on balance and upper extremity functional performance in competitive archers. Core stability is essential for postural control, neuromuscular coordination, and efficient force transfer during archery shooting. Understanding the immediate effects of core stabilization exercises may support their use as an effective warm-up and performance-enhancing strategy in archery athletes.",[456,457,458],"Archery","Core Stability","Balance","2026-01-04",{"date":461,"type":32},"2026-01-14",{"date":463,"type":32},"2025-06-03",{"date":465,"type":21},"2026-02-01",{"name":38,"class":39},{"id":468,"slug":469,"hasResults":11,"nctId":470,"briefTitle":471,"officialTitle":471,"acronym":4,"eligibilityCriteria":472,"healthyVolunteers":127,"sex":16,"minAge":71,"maxAge":48,"enrollmentInfo":473,"targetDuration":4,"studyType":22,"phases":474,"briefSummary":475,"conditions":476,"keywords":478,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":481,"lastUpdatePostDateStruct":482,"startDateStruct":483,"completionDateStruct":485,"leadSponsor":486,"locationsCount":40},"100585084","development-of-an-interactive-digital-respiratory-game-and-device-and-investigation-of-its-effectiveness-in-children-with-bronchiectasis-100585084","NCT06897761","Development of an Interactive Digital Respiratory Game and Device and Investigation of Its Effectiveness in Children With Bronchiectasis","Inclusion Criteria:\n\n* Aged between 7-18 years\n* Clinically stable\n* No exacerbations or infections\n* Possesses a computer, tablet, or mobile phone\n\nExclusion Criteria:\n\n* Participation in a supervised physiotherapy and rehabilitation program within the last 6 months\n* History of lung or liver transplant\n* Presence of any cognitive impairment that would hinder the use of the system\n* Changes in medical treatment during the study\n* Presence of concurrent cardiac, orthopedic, or neurological diseases",{"count":100,"type":21},[24],"Our study aims to develop a personalized interactive digital breathing game and device that can be produced in our country and to provide daily airway cleaning treatment at home via mobile phone or computer without the need for a physiotherapist or healthcare professional with the use of an interactive digital breathing game.",[477],"Bronchiectasis",[479,480],"respiratory game, Active Cycle of Breathing Techniques","bronchiectasis","2026-01-02",{"date":436,"type":32},{"date":484,"type":32},"2025-10-07",{"date":438,"type":21},{"name":38,"class":39},{"id":488,"slug":489,"hasResults":11,"nctId":490,"briefTitle":491,"officialTitle":491,"acronym":4,"eligibilityCriteria":492,"healthyVolunteers":11,"sex":186,"minAge":48,"maxAge":493,"enrollmentInfo":494,"targetDuration":4,"studyType":247,"phases":4,"briefSummary":496,"conditions":497,"keywords":498,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":507,"locationsCount":40},"100602447","the-effect-of-couples-participation-in-childbirth-preparation-education-on-pregnant-womens-perceived-spousal-support-fear-of-childbirth-and-self-efficacy-100602447","NCT07123623","The Effect of Couples' Participation in Childbirth Preparation Education on Pregnant Women's Perceived Spousal Support, Fear of Childbirth, and Self-Efficacy","Inclusion Criteria:\n\n* Having applied to the specified institution within the study period\n* Willingness to participate in the study\n* Having at least a primary school education\n* Pregnant women over the age of 18\n* Being over the 20th week of pregnancy\n* Having given birth vaginally at least once (for the multiparous group)\n* Having a singleton pregnancy\n\nExclusion Criteria:\n\n* Those who do not consent to participate in the study\n* Pregnant women with a gestational age of less than 20 weeks\n* Individuals with communication impairments\n* Individuals with sensory-perceptual disorders\n* Individuals with any psychiatric illness\n* Pregnant women under the age of 18\n* Pregnant women who have not completed at least primary school education.","50 Years",{"count":495,"type":21},102,"Fear of childbirth can be defined as approaching the process of giving birth with fear and anxiety. The aim of prenatal education is to help expectant mothers develop positive feelings towards childbirth and to foster a sense of security.",[491],[499],"Childbirth Preparation Training, Father Involvement, Fear of Childbirth, Partner Support, Childbirth Self-Efficacy.","2025-08-13",{"date":502,"type":32},"2025-08-14",{"date":504,"type":32},"2024-09-09",{"date":506,"type":21},"2025-09-25",{"name":38,"class":39},{"id":509,"slug":510,"hasResults":11,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":4,"eligibilityCriteria":514,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":18,"enrollmentInfo":515,"targetDuration":4,"studyType":22,"phases":516,"briefSummary":517,"conditions":518,"keywords":521,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":525,"lastUpdatePostDateStruct":526,"startDateStruct":528,"completionDateStruct":530,"leadSponsor":532,"locationsCount":533},"100592730","effects-of-triflow-and-deep-breathing-and-cough-exercises-on-respiration-in-patients-undergoing-mitral-valve-replacement-100592730","NCT06997224","Effects of Triflow and Deep Breathing and Cough Exercises on Respiration in Patients Undergoing Mitral Valve Replacement","Comparison of the Effects of Triflow and Deep Breathing and Cough Exercises on Postoperative Respiratory Functions in Patients Undergoing Mitral Valve Replacement: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Volunteering to participate in the study Literate and knowing the native language\n\nExclusion Criteria:\n\n* Hemodynamically unstable patients, Patients who develop postoperative respiratory complications, Lip or palate anomalies",{"count":375,"type":21},[24],"The purpose of breathing exercises or the use of assistive devices is to provide deep breathing after surgery and to obtain a normal breathing pattern. The purpose of choosing the method to be applied is to obtain the best result. The results of the few studies conducted on this subject are contradictory and insufficient. In this context, the purpose of this study is to compare the effects of using only triflow and using triflow together with deep breathing and cough exercises on postoperative respiratory functions in patients who underwent simultaneous tricuspid valve surgery for mitral valve.",[519,520],"Mitral Valve Failure","Surgery",[522,523,524],"triflow","respiratory functions","cough exercise","2025-05-21",{"date":527,"type":32},"2025-05-30",{"date":529,"type":32},"2025-05-15",{"date":531,"type":21},"2025-08-01",{"name":38,"class":39},2,{"id":535,"slug":536,"hasResults":11,"nctId":537,"briefTitle":538,"officialTitle":539,"acronym":4,"eligibilityCriteria":540,"healthyVolunteers":127,"sex":16,"minAge":48,"maxAge":541,"enrollmentInfo":542,"targetDuration":4,"studyType":22,"phases":543,"briefSummary":544,"conditions":545,"keywords":549,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":556,"completionDateStruct":558,"leadSponsor":560,"locationsCount":40},"100589478","periorbital-massage-for-nausea-and-vomiting-after-laparoscopic-surgery-100589478","NCT06954935","Periorbital Massage for Nausea and Vomiting After Laparoscopic Surgery","Effectiveness of Periorbital Massage in the Management of Nausea and Vomiting After Laparoscopic Cholecystectomy","Inclusion Criteria:\n\nThose who have laparoscopic cholecystectomy surgery under general anesthesia,\n\n* Those between the ages of 18-70,\n* Those who do not have a psychiatric disease,\n* Those who understand what they read and volunteer patients,\n* Those who do not have a hearing or speech problem,\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery,\n\n  * Patients with psychiatric disorders\n  * Patients who have taken another antiemetic drug within 24 hours before surgery","70 Years",{"count":533,"type":21},[24],"Laparoscopic cholecystectomy is one of the commonly used surgical treatment methods for gallbladder diseases. However, many patients experience significant nausea and vomiting after laparoscopic cholecystectomy. It is observed that approximately 20% to 30% of patients experience postoperative nausea and vomiting as the most common complaint after laparoscopic cholecystectomy. This study aims to investigate the effectiveness of periorbital massage in postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.",[546,547,548],"Nausea","Vomiting","Laparoscopic Cholecystectomy",[550,551,552],"nausea","voming","periorbital massage","2025-04-30",{"date":555,"type":32},"2025-05-02",{"date":557,"type":32},"2025-04-23",{"date":559,"type":21},"2025-09-10",{"name":38,"class":39},{"id":562,"slug":563,"hasResults":11,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":4,"eligibilityCriteria":567,"healthyVolunteers":11,"sex":186,"minAge":48,"maxAge":4,"enrollmentInfo":568,"targetDuration":4,"studyType":247,"phases":4,"briefSummary":569,"conditions":570,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":572,"startDateStruct":574,"completionDateStruct":576,"leadSponsor":577,"locationsCount":40},"100562813","reborn-lifestyle-adjustment-program-100562813","NCT06608043","Reborn Lifestyle Adjustment Program","Reborn Lifestyle Adjustment Program for Breast Cancer Patients","Inclusion Criteria:\n\n* Being a female individual aged 18 or older\n* Have been diagnosed with Stage I, II, or III breast cancer\n* At least 6 months have passed since the completion of chemotherapy\n* Approval by an oncologist to participate in the study\n* Having internet access and the ability to connect online\n* Scoring above 23 on a standardized Mini Mental Status Examination Test\n* Being in the contemplation stage according to the Transtheoretical Model\n\nExclusion Criteria:\n\n* Having a neurological or systemic disease that could significantly affect the course of the intervention\n* Having metastasis that could impact the sustainability of the study\n* Suffering from neuropathic pain\n* Having participated in a healthy lifestyle program within the last 3 months",{"count":375,"type":21},"The aim of this study is to investigate the effects of the reborn lifestyle regulation program on physical activity, fatigue level, pain, mental health burden and quality of life in breast cancer patients.",[250,110],"2024-09-19",{"date":573,"type":32},"2024-09-23",{"date":575,"type":32},"2024-08-01",{"date":531,"type":21},{"name":38,"class":39},""]