[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Autonomous University of Morelos\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":47},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100653036","effect-of-tocopherol-and-ascorbic-acid-on-neuroinflammation-markers-associated-with-neuropeptide-expression-in-the-agrpnpy-and-pomc-pathways-in-mexican-population-with-obesity-100653036",false,"NCT07782411","Effect of Tocopherol and Ascorbic Acid on Neuroinflammation Markers Associated With Neuropeptide Expression in the AgRP\u002FNPY and POMC Pathways in Mexican Population With Obesity","Inclusion Criteria:\n\n1. Adults aged 40 to 59 years, Mexican men and women.\n2. Obese group: Body mass index (BMI) \\> 30 kg\u002Fm²; body fat percentage \\> 25% in men and \\> 35% in women; waist circumference \\> 90 cm in men and \\> 80 cm in women.\n3. Non-obese group: BMI \\\u003C 24.9 kg\u002Fm²; body fat percentage \\\u003C 25% in men and \\\u003C 35% in women; waist circumference \\\u003C 90 cm in men and \\\u003C 80 cm in women.\n4. Willingness to sign the informed consent form.\n\nExclusion Criteria:\n\n1. Individuals with renal diseases, hepatic diseases, or those under pharmacological treatment for any condition associated with acute inflammation.\n2. Individuals currently undergoing treatment for obesity (pharmacological, nutritional, or physical activity programs).\n3. Individuals taking dietary supplements or multivitamins.",true,"ALL","40 Years","59 Years",{"count":20,"type":21},192,"ESTIMATED","INTERVENTIONAL",[24],"NA","This clinical trial will determine whether taking ascorbic acid (vitamin C), α-tocopherol (vitamin E), or both together can lower markers of brain inflammation and change the expression of neuropeptides in Mexican adults with obesity.\n\nMain Questions\n\nThe study aims to answer:\n\n1. Does vitamin C, vitamin E, or both reduce neuroinflammation?\n2. Do these supplements change the expression of neuropeptides linked to obesity? Comparison Groups Researchers will compare the effects of vitamin C alone, vitamin E alone, and the combination of both to see if they improve brain health in people with obesity.\n\nWhat Participants Will Do\n\nParticipants will:\n\n1. Take vitamin C, vitamin E, or both daily, depending on their assigned group\n2. Attend clinic visits once every 2 weeks for and tests for checkups and tests for record and report supplement intake so that researchers can monitor and evaluate treatment adherence\n3. Provide samples and health information to measure inflammation and neuropeptides , at the beginning of the intervention and at 12 weeks, when the intervention ends.",[27,28],"Obesity (BMI>30)","Neuroinflammation",[30,31,32,33,34],"neuroinflammation","obesity","neuropeptides","a-tocoferol","ascorbic acid","NOT_YET_RECRUITING","2026-08-20",{"date":38,"type":39},"2026-08-24","ACTUAL",{"date":41,"type":21},"2026-08-10",{"date":43,"type":21},"2027-08-30",{"name":45,"class":46},"Autonomous University of Morelos","OTHER",""]