[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Biruni University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":658},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,37,0,25,[9,44,75,100,130,165,191,214,236,269,296,323,350,372,393,411,433,458,485,513,537,568,591,611,634],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100652847","video-based-facial-movement-analysis-in-facial-paralysis-100652847",false,"NCT07780370","Video-Based Facial Movement Analysis in Facial Paralysis","Investigation of the Relationship Between Video-Based Objective Facial Movement Analysis and Clinical Assessment Scales in Patients With Facial Paralysis","Inclusion Criteria:\n\n* Diagnosis of facial paralysis (e.g., Bell's palsy)\n* Age 18 years and older\n* Willing and able to provide informed consent\n\nExclusion Criteria:\n\n* Presence of other neurological or craniofacial conditions affecting facial movement\n* Prior facial surgery affecting facial musculature\n* Inability to cooperate with video recording or clinical assessment procedures","ALL","18 Years",{"count":20,"type":21},49,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate facial movements in patients with facial paralysis using video-based objective analysis and to examine the relationship between these video-based measurements and standard clinical assessment scales. Participants will be asked to perform simple facial movements, such as raising the eyebrows, closing the eyes tightly, smiling, showing the teeth, pursing the lips, and puffing the cheeks, while a video recording is taken. Researchers will also evaluate participants' facial function using established clinical rating scales and questionnaires. No medication will be given, no invasive procedures will be performed, and no changes will be made to participants' current treatment. The goal is to contribute to the development of more detailed, objective, and standardized methods for evaluating facial function in patients with facial paralysis.",[25],"Facial Paralysis",[25,27,28,29,30],"Video-Based Analysis","Facial Movement Analysis","Objective Facial Assessment","Clinical Assessment Scales","NOT_YET_RECRUITING","2026-08-19",{"date":34,"type":35},"2026-08-21","ACTUAL",{"date":37,"type":21},"2026-09-01",{"date":39,"type":21},"2027-06-20",{"name":41,"class":42},"Biruni University","OTHER",1,{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":57,"studyType":22,"phases":4,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":43},"100651735","menstruel-cycle-knowledge-questionnaite-100651735","NCT07766577","Menstruel Cycle Knowledge Questionnaite","Turkish Validity and Reliability of the Menstrual Cycle Knowledge Questionnaire in Female Athletes","Inclusion Criteria:\n\n* Being between 16 and 35 years of age\n* Being willing to participate in the study\n* Being able to read and write in Turkish and having sufficient language proficiency to understand the questionnaires used in the study\n* Participating in sports for at least 5 hours per week\n* Being a licensed athlete who participates in competitive sports\n\nExclusion Criteria:\n\n* Having a history of psychiatric disorders that may affect cognitive functioning (e.g., schizophrenia, bipolar disorder, severe depression, or attention-deficit\u002Fhyperactivity disorder)\n* Having insufficient proficiency in reading and understanding Turkish",true,"FEMALE","16 Years","35 Years",{"count":56,"type":21},120,"15 Days","Menstrual health is an important component of women's physical, mental, and social well-being. Adequate knowledge of the menstrual cycle is essential for distinguishing between normal and abnormal menstrual patterns, facilitating the early recognition of potential health problems, and promoting appropriate health behaviors. This is particularly important for female athletes, given the high prevalence of menstrual disturbances and the potential influence of the menstrual cycle on physical symptoms, mood, and athletic performance. However, validated and standardized tools for assessing menstrual cycle knowledge are limited in the Turkish literature. The Menstrual Cycle Knowledge Questionnaire (MCKQ) is a 12-item instrument specifically developed to assess knowledge of the menstrual cycle. This study aims to culturally adapt the MCKQ into Turkish and evaluate the validity and reliability of the Turkish version among both sedentary and physically active women, thereby providing a standardized assessment tool for use in the Turkish population.",[60,61],"Menstrual Cycle","Athletes",[63,64,65,66],"reliability","validity","turkish","menstrual health knowledge questionnaire","2026-08-14",{"date":69,"type":35},"2026-08-17",{"date":71,"type":21},"2026-08-15",{"date":73,"type":21},"2026-09-12",{"name":41,"class":42},{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":43},"100649419","psychological-readiness-and-return-to-sport-after-acl-reconstruction-100649419","NCT07733895","Psychological Readiness and Return to Sport After ACL Reconstruction","Evaluation of Psychological Readiness, Kinesiophobia, Subjective Knee Function, and Return-to-Sport Status Across Different Postoperative Periods Following Primary Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Age ≥18 years.\n* History of unilateral primary anterior cruciate ligament (ACL) reconstruction.\n* Between 3 and 24 months after ACL reconstruction at the time of assessment.\n* Regular participation in sports before ACL injury with a preinjury Tegner Activity Scale score of ≥4.\n* Ability to read and understand Turkish and independently complete the study questionnaires.\n* Willingness to participate in the study.\n* Provision of written informed consent.\n\nExclusion Criteria:\n\n* Revision ACL reconstruction.\n* Reinjury or graft rupture of the reconstructed ACL.\n* Bilateral ACL injury.\n* History of ACL reconstruction in the contralateral knee.\n* Concomitant major ligament, cartilage, bone, or extensor mechanism surgery that is expected to substantially affect rehabilitation, weight-bearing status, return-to-sport timing, or knee function following primary ACL reconstruction.\n* Other lower-extremity injuries or surgical conditions unrelated to ACL reconstruction that limit sports participation at the time of assessment.\n* Neurological, rheumatologic, cardiopulmonary, or other severe systemic diseases that substantially limit sports participation.\n* Cognitive, psychiatric, or communication disorders that preclude reliable completion of the study questionnaires.",{"count":83,"type":21},200,"The goal of this observational study is to evaluate psychological readiness, kinesiophobia, subjective knee function, sport activity level, and return-to-sport status in athletes who have undergone primary anterior cruciate ligament (ACL) reconstruction between 3 and 24 months after surgery.\n\nThe main questions it aims to answer are:\n\nDo these outcomes differ across different postoperative time periods? Are they associated with return-to-sport status? Participants will complete questionnaires assessing psychological readiness (ACL-RSI), kinesiophobia (TSK), subjective knee function (IKDC), and sport activity level (Tegner), and will provide information about their return-to-sport status.",[86],"Anterior Cruciate Ligament Injury",[88,89,90,91,92],"Anterior cruciate ligament reconstruction","Psychological readiness","Return to sport","Kinesiophobia","Subjective knee function","2026-08-13",{"date":69,"type":35},{"date":96,"type":21},"2026-08-01",{"date":98,"type":21},"2027-08-01",{"name":41,"class":42},{"id":101,"slug":102,"hasResults":12,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":43},"100650689","spinal-mobilization-and-manipulation-for-nonspecific-low-back-pain-100650689","NCT07749898","Spinal Mobilization and Manipulation for Nonspecific Low Back Pain","Effects of Spinal Mobilization and Manipulation Added to Conventional Physiotherapy on Pain Intensity, Functional Disability, Fear-Avoidance Beliefs, and Lumbar Range of Motion in Individuals With Non-Specific Low Back Pain: A Randomized Controlled Trial","SMM-LBP","Inclusion Criteria:\n\n* Adults aged 18 to 60 years.\n* Diagnosis of non-specific low back pain.\n* Symptoms persisting for more than 12 weeks.\n* Able to understand the study procedures and provide written informed consent.\n* Willing to participate in the study and comply with the intervention protocol\n\nExclusion Criteria:\n\n* Structural spinal abnormalities.\n* Spinal infection or tumor.\n* Inflammatory spinal diseases.\n* Neurological disorders or neurological deficits.\n* Psychiatric disorders.\n* Pregnancy.\n* History of recent spinal surgery.\n* Chronic or systemic diseases that could affect participation.\n* Conditions that could interfere with adherence to the treatment protocol","65 Years",{"count":110,"type":21},30,"INTERVENTIONAL",[113],"NA","Low back pain is one of the most common musculoskeletal disorders worldwide and is a major cause of pain and disability. Manual therapy techniques such as spinal mobilization and spinal manipulation are frequently used together with conventional physiotherapy; however, their additional benefits remain unclear.\n\nThis randomized controlled trial aims to investigate whether adding spinal mobilization and spinal manipulation to conventional physiotherapy improves pain intensity, functional disability, fear-avoidance beliefs, and lumbar range of motion in individuals with non-specific low back pain. Participants will be randomly assigned to receive either conventional physiotherapy alone or conventional physiotherapy combined with spinal mobilization and manipulation. Outcome measures will be assessed before and after the six-week intervention. The findings of this study may provide evidence regarding the effectiveness of combining manual therapy with conventional physiotherapy for the management of non-specific low back pain.",[116],"Non-Specific Low Back Pain",[118,119,120,116,121],"Spinal Mobilization","Spinal Manipulation","Conventional Physiotherapy","Manual Therapy","2026-08-02",{"date":124,"type":35},"2026-08-06",{"date":126,"type":21},"2026-08-30",{"date":128,"type":21},"2026-11-30",{"name":41,"class":42},{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":137,"targetDuration":4,"studyType":111,"phases":139,"briefSummary":140,"conditions":141,"keywords":148,"overallStatus":156,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":43},"100649402","aerobic-exercise-and-guided-imagery-in-low-anterior-resection-syndrome-100649402","NCT07732894","Aerobic Exercise and Guided Imagery in Low Anterior Resection Syndrome","\"The Effects of Aerobic Exercise and Guided Imagery on Low Anterior Resection Syndrome After Rectal Cancer Surgery: A Randomized Controlled Study\"","Inclusion Criteria:\n\n* Upper-Middle-Lower Rectal Cancer\n* Having undergone surgery with TMJ\n* Having a protective ileostomy and a closed stoma\n* Being tumor-free according to laboratory reports (carcinoembryonic antigen), endoscopic findings, and abdominal ultrasonography and\u002For computed tomography data\n* Having at least minor LARS scores (\"between 21\" and \"42\") according to the -LARS scoring questionnaire\n* Having the ability to perform voluntary perineal traction contractions with perineal palpation\n* Being a volunteer with informed consent\n\nExclusion Criteria:\n\n* History of incontinence or defecation disorder not related to rectal cancer\n* Having another type of surgery for rectal cancer (Hartmann procedure, abdominoperineal excision, transanal endoscopic microsurgical resection, or sigmoid resection)\n* Deterioration in general health, neurological disease and\u002For physical disability\n* BMI \\> 30 kg\u002Fm2 (obese individuals)\n* Inability to answer questions or make interventions due to mental disorder",{"count":138,"type":21},50,[113],"Low Anterior Resection Syndrome (LARS) is a common complication after sphincter-preserving rectal cancer surgery and may negatively affect bowel function and quality of life. Although exercise has been shown to improve physical function and well-being in cancer survivors, evidence regarding its effects on LARS symptoms remains limited.\n\nThis randomized controlled, multicenter study aims to evaluate the effects of an aerobic exercise program combined with guided imagery on bowel symptoms, quality of life, physical activity level, functional capacity, and psychological well-being in patients with LARS after rectal cancer surgery. Participants will be randomly assigned to either an intervention group receiving aerobic exercise and guided imagery in addition to standard care or a control group receiving standard care alone. Outcomes will be assessed at baseline and after the intervention period using validated clinical and patient-reported outcome measures.\n\nThe findings of this study may contribute to the development of evidence-based rehabilitation strategies for improving bowel function and quality of life in patients with LARS following rectal cancer surgery.",[142,143,144,145,146,147],"Rectal Cancer","Fecal Incontinence and Constipation","Aerobic Exercise","Guided Imagery Exercise","Pelvic Floor Physical Therapy","Pelvic Floor Muscle Training",[149,150,151,152,153,154,155],"rectal cancer","low anterior resection syndrome","aerobic exercise","guided imagery","pelvic floor muscle training","pelvic floor rehabilitation","pelvic floor physical therapy","RECRUITING","2026-07-23",{"date":159,"type":35},"2026-07-29",{"date":161,"type":35},"2025-12-30",{"date":163,"type":21},"2027-05-30",{"name":41,"class":42},{"id":166,"slug":167,"hasResults":12,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":172,"targetDuration":4,"studyType":111,"phases":174,"briefSummary":175,"conditions":176,"keywords":178,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":43},"100644529","effects-of-adjunctive-synbiotic-supplementation-to-non-surgical-periodontal-therapy-in-smokers-with-periodontitis-100644529","NCT07672379","Effects of Adjunctive Synbiotic Supplementation to Non-Surgical Periodontal Therapy in Smokers With Periodontitis","Effects of Adjunctive Synbiotic Supplementation to Non-Surgical Periodontal Therapy on Clinical, Immunological, and Microbiological Parameters in Smokers With Periodontitis","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Diagnosis of generalized Stage III\u002FIV Grade B\u002FC periodontitis\n* Willingness to participate in the study and provide informed consent\n* No periodontal treatment within the last 3 months\n* No use of antibiotics or anti-inflammatory drugs within the last 3 months\n* Not being pregnant or breastfeeding\n* Presence of at least 20 teeth\n* Body mass index (BMI) between 18.5 and 30 kg\u002Fm²\n\nExclusion Criteria:\n\n* Failure to meet voluntary participation requirements\n* Presence of systemic diseases affecting the periodontium or immune response\n* Use of additional dietary supplements\n* Pregnancy or breastfeeding\n* Use of immunosuppressive medications Individuals who may have difficulty complying with the study protocol",{"count":173,"type":21},92,[113],"The aim of this study is to evaluate the effects of adjunctive synbiotic supplementation combined with non-surgical periodontal therapy in smokers with periodontitis. The main questions this study aims to answer are:\n\nDoes adjunctive synbiotic supplementation improve clinical periodontal parameters in smokers with periodontitis? Does adjunctive synbiotic supplementation affect immunological and microbiological parameters associated with periodontal disease?\n\nSystemically healthy smokers and non-smokers diagnosed with generalized Stage III-IV Grade B\u002FC periodontitis will be included in the study. Participants will first be divided into two main groups according to smoking status (smokers and non-smokers). These groups will then be further divided into two subgroups according to the use of synbiotic or placebo capsules. Therefore, the study will consist of four groups in total. The sample size of the study was determined as 92 participants, with 23 participants included in each group.\n\nAll participants will receive non-surgical periodontal therapy (NSPT) at baseline. In addition to NSPT, participants will use either synbiotic or placebo capsules once daily for 90 days.\n\nTo evaluate clinical periodontal, immunological, and microbiological parameters, periodontal measurements will be performed, and saliva and subgingival plaque samples will be collected. In addition, stool samples will be collected from participants to evaluate the effects of synbiotic supplementation on the gastrointestinal microbiota, and microbiota analyses will be performed.\n\nAll samples will be collected again and evaluated at the third month following non-surgical periodontal therapy.",[177],"Periodontal Disease",[179,180,181,182],"Periodontitis","Non-surgical periodontal treatment","Synbiotic","Probiotic","2026-06-24",{"date":185,"type":35},"2026-06-26",{"date":187,"type":21},"2026-07-06",{"date":189,"type":21},"2027-10-06",{"name":41,"class":42},{"id":192,"slug":193,"hasResults":12,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":51,"sex":17,"minAge":198,"maxAge":199,"enrollmentInfo":200,"targetDuration":202,"studyType":22,"phases":4,"briefSummary":203,"conditions":204,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":4},"100644379","machine-learning-prediction-of-respiratory-muscle-changes-and-ventilatory-responses-after-incretin-based-therapy-in-obesity-100644379","NCT07663591","Machine Learning Prediction of Respiratory Muscle Changes and Ventilatory Responses After Incretin-Based Therapy in Obesity","Prediction of Changes in Pulmonary Function, Respiratory Muscle Performance, and Ventilatory Responses Following Incretin-Based Therapy in Individuals With Obesity Using Machine Learning","Inclusion Criteria:\n\n* Individuals aged 25-60 years\n* Individuals with a body mass index (BMI) ≥ 30 kg\u002Fm² according to the World - Health Organization (WHO) classification of obesity\n* Individuals who voluntarily agree to participate in the study\n\nExclusion Criteria:\n\nCharlson Comorbidity Index (CCI) score ≥ 3 Uncontrolled arrhythmia, hypertension, heart failure, diabetes mellitus, or unstable angina pectoris Cognitive, orthopedic, or neurological conditions that may interfere with study assessments or treatment procedures History of lower extremity injury or surgery within the previous 6 months Diagnosis of diabetes mellitus with complications such as nephropathy, retinopathy, or neuropathy Presence of chronic respiratory disease Acute infection at the time of assessment Middle ear pathologies (e.g., tympanic membrane rupture or otitis) History of spontaneous or traumatic pneumothorax Current smoking Pregnancy STOP-Bang score ≥ 3 Participation in a structured weight-loss diet program or receipt of medical treatment for weight reduction during the assessment period History of endoscopic weight-loss procedures and\u002For bariatric surgery within the previous 12 months","25 Years","60 Years",{"count":201,"type":21},48,"6 Months","This study aims to evaluate changes in respiratory function, respiratory muscle performance, and ventilatory responses following incretin-based therapy in individuals with obesity, and to identify predictors of these changes through the application of machine learning methods.",[205],"Obesity (BMI>30)","2026-06-17",{"date":208,"type":35},"2026-06-23",{"date":210,"type":21},"2026-07-01",{"date":212,"type":21},"2026-07-30",{"name":41,"class":42},{"id":215,"slug":216,"hasResults":12,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":12,"sex":52,"minAge":18,"maxAge":221,"enrollmentInfo":222,"targetDuration":4,"studyType":111,"phases":224,"briefSummary":225,"conditions":226,"keywords":228,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":232,"completionDateStruct":233,"leadSponsor":235,"locationsCount":43},"100632136","exercise-programs-in-women-with-pcos-100632136","NCT07509762","Exercise Programs in Women With PCOS","Investigation of the Effectiveness of a Digital Rehabilitation-Supported Combined Exercise Program in the Management of Polycystic Ovary Syndrome","Inclusion Criteria:\n\n* Women aged 18-40 years diagnosed with PCOS according to the Rotterdam criteria (Rotterdam, 2003) and by a specialist physician.\n\nThe presence of at least two of the following three criteria will be considered sufficient for a diagnosis of PCOS according to the Rotterdam criteria: (i) history of irregular menstruation with oligo\u002Fanovulation, (ii) clinical and\u002For biochemical signs of hyperandrogenism, (iii) detection of polycystic ovary images on ultrasonography.\n\n* Having sufficient technological skills to participate in the treatment online (ability to use video conferencing applications)\n* Voluntary participation in the study\n\nExclusion Criteria:\n\n* Pregnant and breastfeeding women\n* Individuals with acute infections\n* Uncontrolled arrhythmia, hypertension, diabetes, and unstable angina pectoris\n* Impaired cooperation, orthopedic and neurological problems that may hinder assessment and program participation\n* Individuals with a history of lower extremity injury or surgery in the last six months\n* Individuals with class III obesity according to WHO classification (BMI \\> 40 kg\u002Fm2) (WHO, 2000)\n* Individuals receiving medical treatment for weight loss (liraglutide, semaglutide, orlistat, bupropion\u002Fnaltrexone, thizzpatide) or participating in a structured diet program during the study period\n* Individuals actively participating in another exercise program\n* Individuals taking antihypertensive, insulin-sensitizing, or hormonal contraceptive drugs in the last 3 months","40 Years",{"count":223,"type":21},33,[113],"This study aims to investigate the effectiveness of a digital rehabilitation-supported combined exercise program in women with Polycystic Ovary Syndrome (PCOS). Participants aged 18-40 years will be randomly assigned to one of three groups: a digital rehabilitation group, a face-to-face exercise group, and a physical activity counseling group. The intervention will last 8 weeks, with exercise performed three times per week. Outcomes will include DNA methylation, hormonal and metabolic parameters, anthropometric measurements, body composition, muscle strength, basal metabolic rate, physical activity level, quality of life, menstrual cycle regularity, exercise adherence and satisfaction.",[227],"Polycystic Ovarian Syndrome (PCOS)",[229],"PCOS, Digital rehabilitation, combined exercise, DNA methylation","2026-06-16",{"date":206,"type":35},{"date":37,"type":21},{"date":234,"type":21},"2027-03-25",{"name":41,"class":42},{"id":237,"slug":238,"hasResults":12,"nctId":239,"briefTitle":240,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":243,"conditions":244,"keywords":249,"overallStatus":156,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":265,"completionDateStruct":266,"leadSponsor":268,"locationsCount":43},"100641636","validity-and-reliability-of-the-turkish-version-of-the-impact-of-brachial-plexus-injury-questionnaire-imbpiq-100641636","NCT07654504","Validity and Reliability of the Turkish Version of the Impact of Brachial Plexus Injury Questionnaire (IMBPIQ)","Inclusion Criteria:\n\n* Being 18 years of age or older.\n* Having a diagnosis of brachial plexus birth palsy.\n* Having the ability to read, write, speak, and understand Turkish.\n* Agreeing to participate voluntarily in the study and signing the informed consent form.\n\nExclusion Criteria:\n\n* Having a neurological disease.\n* Having another orthopedic problem or a history of trauma in the affected upper extremity.\n* Having a severe cognitive or communication impairment that may prevent completion of the questionnaires or understanding of the study instructions.\n* Having a history of systemic disease requiring an acute attack or hospitalization within the last three months.\n* Being pregnant or being in the postpartum period of less than 6 months.",{"count":138,"type":21},"The aim of this methodological study is to translate the Impact of Brachial Plexus Injury Questionnaire (IMBPIQ) into Turkish, culturally adapt it, and evaluate its validity and reliability for use in adults with brachial plexus birth palsy. The study will include 50 adult participants aged 18 years and older with a diagnosis of brachial plexus birth palsy. Participants will complete the Turkish version of the IMBPIQ, as well as the Disabilities of the Arm, Shoulder and Hand questionnaire and the Short Form-36. The psychometric properties of the Turkish IMBPIQ will be examined using reliability and validity analyses, including internal consistency, test-retest reliability, and construct validity.",[245,246,247,248],"Brachial Plexus Birth Palsy","Brachial Plexus Palsy","Brachial Plexus Palsy Due to Birth Trauma","Obstetric Brachial Plexus Injury",[250,251,245,252,253,254,255,256,257,258,259,260,261,262],"Impact of Brachial Plexus Injury Questionnaire","IMBPIQ","Obstetric Brachial Plexus Palsy","Turkish Version","Validity","Reliability","Cultural Adaptation","Patient-Reported Outcome Measure","DASH","Short Form-36","Test-Retest Reliability","Internal Consistency","Construct Validity","2026-06-13",{"date":206,"type":35},{"date":96,"type":21},{"date":267,"type":21},"2026-12-01",{"name":41,"class":42},{"id":270,"slug":271,"hasResults":12,"nctId":272,"briefTitle":273,"officialTitle":273,"acronym":4,"eligibilityCriteria":274,"healthyVolunteers":51,"sex":17,"minAge":18,"maxAge":221,"enrollmentInfo":275,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":277,"conditions":278,"keywords":279,"overallStatus":156,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":293,"completionDateStruct":294,"leadSponsor":295,"locationsCount":43},"100642228","evaluation-of-pain-upper-extremity-function-and-social-appearance-anxiety-in-adults-with-obstetric-brachial-plexus-palsy-who-underwent-shoulder-tendon-transfer-surgery-100642228","NCT07655271","Evaluation of Pain, Upper Extremity Function, and Social Appearance Anxiety in Adults With Obstetric Brachial Plexus Palsy Who Underwent Shoulder Tendon Transfer Surgery","Inclusion and Exclusion Criteria\n\nInclusion Criteria for Individuals With Brachial Plexus Birth Palsy:\n\n* Being between 18 and 40 years of age.\n* Having a diagnosis of unilateral brachial plexus birth palsy.\n* Having undergone shoulder tendon transfer surgery using the Modified Hoffer Technique.\n* Having at least 5 years elapsed since the last surgery.\n* Having a cognitive and communication level sufficient to comply with the assessment process.\n* Agreeing to participate voluntarily in the study and signing the informed consent form.\n\nInclusion Criteria for Healthy Individuals:\n\n* Being between 18 and 40 years of age.\n* Having no history of upper extremity-related surgery within the last 5 years.\n* Having a cognitive and communication level sufficient to comply with the assessment process.\n* Agreeing to participate voluntarily in the study and signing the informed consent form.\n\nExclusion Criteria for All Participants:\n\n* Having a neurological disease.\n* Having another orthopedic problem or a history of trauma in the affected upper extremity.\n* Having a history of systemic disease requiring an acute attack or hospitalization within the last 3 months.\n* Pregnancy or being less than 6 months postpartum.",{"count":276,"type":21},80,"This observational study aims to evaluate pain and upper extremity function in adults with obstetric brachial plexus palsy who underwent shoulder tendon transfer surgery using the Modified Hoffer technique during childhood. Data on the long-term clinical outcomes of this surgical procedure in adulthood are limited. Participants with obstetric brachial plexus palsy and healthy age-matched individuals will be assessed in a single session. The evaluations will include pain, range of motion, muscle strength, upper extremity functional status, social appearance anxiety, and role performance. The study aims to describe the clinical profile of adults with obstetric brachial plexus palsy after Modified Hoffer tendon transfer and compare their outcomes with healthy peers.",[245,246,247],[252,245,280,281,282,283,284,285,286,287,288,289,290],"Adults","Long-Term Outcomes In Adulthood","Modified Hoffer Technique","Tendon Transfer","Upper Extremity Function","Pain","Range Of Motion","Muscle Strength","Functional Status","Social Appearance Anxiety","Role Performance","2026-06-12",{"date":206,"type":35},{"date":210,"type":21},{"date":267,"type":21},{"name":41,"class":42},{"id":297,"slug":298,"hasResults":12,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":12,"sex":52,"minAge":18,"maxAge":303,"enrollmentInfo":304,"targetDuration":4,"studyType":111,"phases":306,"briefSummary":307,"conditions":308,"keywords":311,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":317,"startDateStruct":318,"completionDateStruct":320,"leadSponsor":322,"locationsCount":43},"100642837","a-modular-cloud-platform-for-fertility-preservation-100642837","NCT07642531","A Modular Cloud Platform For Fertility Preservation","A Modular CLoud Based Platform To Enhance Fertility Preservation Awareness: Design, Pilot Testing And Randomized Controlled Trial","Inclusion Criteria:\n\n* Women of reproductive age between the ages of 18 and 45,\n* Diagnosed with early stage cervical cancer, ovarian cancer, tubal cancer and endometrial cancer and whose treatment has not started,\n* Those who have a smartphone and can use the platform,\n* Volunteering and giving informed consent,\n* Turkish literate,\n* Individuals who do not report mental problems\n* Do not have children,\n* Marital status is married or single.\n\nExclusion Criteria:\n\n* Neurological disease (e.g., stroke, multiple sclerosis) or cognitive impairment,\n* Advanced-stage gynecologic cancers,\n* Failure to complete the follow-up period,\n* Initiation of oncologic treatment during the study period,\n* Non-completion or incomplete completion of the data collection instruments,\n* Non-use of the platform among participants allocated to the intervention group,\n* History of prior cancer treatment.","45 Years",{"count":305,"type":21},140,[113],"The research was designed as a randomized controlled study to determine the effectiveness of a modular cloud-based training platform in increasing awareness of fertility preservation.\n\nThe study aims to develop a free, modular, cloud-based, sustainable digital platform to increase fertility awareness. The platform will provide basic information on fertility preservation methods in plain language to support informed decisions. Content will be based on European Society of Human Reproduction and Embryology (ESHRE) , International Federation of Gynaecology and Obstetrics (FIGO) and Asian Society of Gynecologic Oncology (ASCO) guidelines. The study targets not only cancer patients but also women requesting fertility preservation for medical or social reasons.\n\nIn the first stage, the platform will be designed with the ADDIE instructional design model (Analysis, Design, Development, Implementation, Evaluation) and content created per international guidelines. In the second stage, the prototype will be pilot-tested and revised. In the third stage, effectiveness will be tested through a randomized controlled trial. Educational modules will be provided to the intervention group, while the control group will receive brochures. The study will include women aged 18-45 with early-stage gynecological cancer (cervix, ovary, tube, endometrium) at Prof. Dr. Cemil Tascioglu City Hospital, untreated. Participants must have Turkish literacy and internet access. Sample size, calculated with G\\*Power, is 140 total (70 per group).",[309,310],"Fertility Preservation","Gynecologic Cancers",[312,313,314,315],"fertility","gynecologic cancer","fertility preservation","mobile application","2026-06-11",{"date":291,"type":35},{"date":319,"type":21},"2026-09-02",{"date":321,"type":21},"2027-01-01",{"name":41,"class":42},{"id":324,"slug":325,"hasResults":12,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":4,"eligibilityCriteria":329,"healthyVolunteers":12,"sex":17,"minAge":303,"maxAge":4,"enrollmentInfo":330,"targetDuration":4,"studyType":111,"phases":332,"briefSummary":333,"conditions":334,"keywords":336,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":43},"100638506","blood-flow-restriction-combined-with-aerobic-or-resistance-exercise-in-heart-failure-100638506","NCT07627737","Blood Flow Restriction Combined With Aerobic or Resistance Exercise in Heart Failure","Comparison of the Effects of Aerobic or Resistance Exercises Combined With Blood Flow Restriction on Muscle Oxygenation, Serum BNP Levels, Functional Capacity, and Quality of Life in Patients With Heart Failure","Inclusion Criteria:\n\n* NYHA functional class I-III,\n* HFrEF and\u002For HFmrEF with left ventricular ejection fraction \\\u003C50%,\n* functional capacity that does not prevent participation in exercise, and\n* clinical stability within the last 3 months.\n\nExclusion Criteria:\n\n* history of acute coronary syndrome or revascularization within the last 12 months,\n* uncontrolled hypertension, defined as ≥180\u002F≥110 mmHg or 160-179\u002F100--109 mmHg despite treatment, or uncontrolled arrhythmia,\n* conditions contraindicating the application of blood flow restriction training, such as significant peripheral arterial disease or atherosclerosis obliterans,\n* severe orthopedic or neurological limitations that would prevent exercise,\n* presence of atrial fibrillation or a pacemaker,\n* severe liver disease,\n* impaired renal function, defined as eGFR \\\u003C30 mL\u002Fmin,\n* peripheral neuropathy,\n* dialysis,\n* moderate to severe valvular disease,\n* moderate to severe COPD,\n* hospitalization due to cardiovascular causes within the last 30 days,\n* intracranial aneurysm, arteriovenous malformation, cerebral neoplasm, or abscess,\n* angina pectoris and use of medications known to affect ischemic conditioning\u002Focclusion, such as cyclosporine or glibenclamide,\n* use of dual antiplatelet therapy or anticoagulants, including NOACs, low-molecular-weight heparin, or vitamin K antagonists.",{"count":331,"type":21},40,[113],"The aim of this study is to compare the clinical effects of aerobic and resistance exercise modalities combined with blood flow restriction in patients with stable heart failure, and to determine the most effective, feasible, and evidence-based rehabilitation approach. In individuals with heart failure, limited exercise tolerance increases the importance of training strategies that can induce high physiological adaptations with low mechanical loads. In this context, exercise interventions combined with blood flow restriction have attracted increasing attention due to their low-intensity nature and potential clinical benefits. This study is designed as a prospective, parallel-group, randomized controlled clinical trial to be conducted in 40 patients diagnosed with stable heart failure. Participants will be randomized into two groups: a blood flow restriction- combined aerobic exercise group and a blood flow restriction-combined resistance exercise group, both applied under supervision three times per week for eight weeks. All participants will be assessed before and after the intervention in terms of muscle oxygenation, serum B-type natriuretic peptide (BNP) levels, functional capacity, and quality of life. The expected outcome of this study is to obtain comparative data on the clinical effectiveness of blood flow restriction- combined exercise interventions in patients with stable heart failure and to identify which exercise modality provides superior clinical benefits. The findings are anticipated to contribute to the development of short-term, low-cost rehabilitation protocols and to provide evidence-based guidance for clinical practice.",[335],"Heart Failure",[337,338,339,151,340,341],"heart failure","cardiopulmonary rehabilitation","blood flow restriction training","resistance exercise","cardiac markers","2026-05-31",{"date":344,"type":35},"2026-06-04",{"date":346,"type":21},"2026-06",{"date":348,"type":21},"2027-09",{"name":41,"class":42},{"id":351,"slug":352,"hasResults":12,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":4,"eligibilityCriteria":356,"healthyVolunteers":51,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":357,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":359,"conditions":360,"keywords":362,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":364,"lastUpdatePostDateStruct":365,"startDateStruct":367,"completionDateStruct":369,"leadSponsor":371,"locationsCount":43},"100640454","reharvested-free-gingival-grafts-3d-shrinkage-and-histological-changes-100640454","NCT07617987","Reharvested Free Gingival Grafts: 3D Shrinkage and Histological Changes","Three-Dimensional Assessment of Graft Shrinkage in Relation to Histological Alterations in Reharvested Free Gingival Grafts From the Same Palatal Donor Site","Inclusion Criteria:\n\n* Individuals aged between 18 and 65 years,\n* Absence of any systemic disease that may adversely affect periodontal health and wound healing,\n* Non-smokers,\n* Periodontally healthy individuals,\n* Mean plaque index (PI) score \\\u003C1 following non-surgical periodontal therapy (NSPT),\n* No use of antibiotics or anti-inflammatory drugs within the last 3 months,\n* Not being pregnant or breastfeeding,\n* Willingness to participate in the study by signing the informed consent form.\n\nExclusion Criteria:\n\n* Presence of any systemic disease contraindicating surgical procedures,\n* Use of medications or supplements affecting bleeding or wound healing,\n* Presence of uncontrolled diabetes mellitus (HbA1c \\>7),\n* Pregnancy or breastfeeding,\n* History of chemotherapy or radiotherapy within the last 6 months,\n* History of antibiotic use within the last 3 months,\n* Palatal mucosal thickness \\\u003C3 mm or presence of palatal torus,\n* Presence of deep and narrow (U-shaped) or shallow palatal vaults interfering with palatal measurements,\n* Non-compliance with treatment or follow-up protocols.",{"count":358,"type":21},20,"The purpose of this study is to evaluate the dimensional stability of free gingival grafts (FGG) and to investigate the relationship between graft shrinkage (GS) and the histological and biochemical characteristics of grafts reharvested from the same palatal donor site. The primary objective is to investigate the relationship between histological alterations in grafts reharvested from the same donor site and graft shrinkage at the recipient site.\n\nThis study is designed as a split-mouth study in which FGGs are applied to contralateral recipient sites within the same patient. Each participant will receive two grafts: an initial graft harvested from the palatal donor site and a second graft reharvested from the same donor site 63 days after the initial procedure.\n\nGraft dimensional changes will be evaluated using three-dimensional digital measurements. Intraoral digital scans will be obtained at baseline, immediately after surgery, and at 1 and 3 months postoperatively. GS will be assessed through superimposition of digital models.\n\nIn addition, histological, histomorphometric, and immunohistochemical analyses will be performed on tissue samples obtained from the donor site to evaluate collagen characteristics and epithelial structure. Furthermore, protein expression levels of specific markers, including collagen type I, collagen type III, and alpha-smooth muscle actin (α-SMA), will be assessed. Early wound healing at the recipient site will be evaluated using the Landry healing index at postoperative days 7, 14, and 28. In addition, biological mediators, including transforming growth factor beta 1 (TGF-β1), vascular endothelial growth factor A (VEGF-A), and platelet-derived growth factor (PDGF), will be analyzed in wound exudate samples obtained from the recipient site to biochemically assess the early healing process.",[361],"Insufficient Keratinized Gingiva",[363],"free gingival graft","2026-05-25",{"date":366,"type":35},"2026-06-01",{"date":368,"type":21},"2026-06-15",{"date":370,"type":21},"2027-09-15",{"name":41,"class":42},{"id":373,"slug":374,"hasResults":12,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":4,"eligibilityCriteria":378,"healthyVolunteers":51,"sex":17,"minAge":198,"maxAge":199,"enrollmentInfo":379,"targetDuration":381,"studyType":22,"phases":4,"briefSummary":382,"conditions":383,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":4},"100640740","body-composition-functional-capacity-and-respiratory-muscle-endurance-in-obesity-with-restrictive-ventilatory-pattern-100640740","NCT07601555","Body Composition, Functional Capacity, and Respiratory Muscle Endurance in Obesity With Restrictive Ventilatory Pattern","Investigation of the Relationship Between Body Composition, Functional Capacity, and Respiratory Muscle Endurance in Individuals With Obesity and a Restrictive Ventilatory Pattern","Inclusion Criteria:\n\n* Individuals aged between 25 and 60 years\n* Individuals with a body mass index (BMI) ≥ 30 kg\u002Fm² according to the World Health Organization (WHO) classification\n* Individuals demonstrating a restrictive ventilatory pattern (FVC \\\u003C 80% predicted)\n* Individuals who voluntarily agree to participate in the study\n\nExclusion Criteria:\n\n* Individuals with a Charlson Comorbidity Index (CCI) score of 3 or higher\n* Individuals with uncontrolled arrhythmia, hypertension, heart failure, diabetes mellitus, or unstable angina pectoris\n* Individuals with cooperation impairments, orthopedic, or neurological conditions that may interfere with assessment or treatment\n* Individuals with a history of lower extremity injury or surgery within the last six months\n* Individuals diagnosed with diabetes mellitus who have complications such as nephropathy, retinopathy, or neuropathy\n* Individuals with concomitant chronic respiratory disease\n* Individuals with acute infection\n* Individuals with middle ear pathologies (e.g., tympanic membrane rupture or otitis)\n* Individuals with a history of spontaneous or trauma-related pneumothorax\n* Current smokers\n* Pregnant individuals\n* Individuals with a STOP-Bang score of 3 or higher\n* Individuals currently participating in a structured weight-loss diet program or receiving medical treatment for weight loss during the assessment period\n* Individuals who have undergone endoscopic intervention and\u002For bariatric surgery within the last year",{"count":380,"type":21},100,"1 Day","This observational cross-sectional study aims to examine the relationship between body composition, functional capacity, and respiratory muscle endurance in individuals with obesity and a restrictive ventilatory pattern. A total of 100 adults aged 25-60 years with a body mass index (BMI) ≥30 kg\u002Fm² and restrictive pulmonary function findings will be enrolled. Participants will evaluate body composition assessment using bioelectrical impedance analysis, pulmonary function testing by spirometry, respiratory muscle strength and endurance measurements, and functional capacity evaluation using the Six-Minute Walk Test (6MWT). The aim of this study is to evaluate the relationships between stem cell count (SCC), a novel anthropometric indicator called WWI, trunk muscle mass, and functional capacity in obese individuals with a restrictive ventilatory pattern.",[384],"Obesity","2026-05-15",{"date":387,"type":35},"2026-05-22",{"date":389,"type":21},"2026-06-30",{"date":391,"type":21},"2026-12-15",{"name":41,"class":42},{"id":394,"slug":395,"hasResults":12,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":4,"eligibilityCriteria":399,"healthyVolunteers":51,"sex":17,"minAge":198,"maxAge":199,"enrollmentInfo":400,"targetDuration":381,"studyType":22,"phases":4,"briefSummary":401,"conditions":402,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":410,"locationsCount":4},"100637947","respiratory-and-exercise-responses-by-body-roundness-index-in-obesity-100637947","NCT07595822","Respiratory and Exercise Responses by Body Roundness Index in Obesity","Evaluation of Respiratory Performance and Exercise Responses According to Body Roundness Index in Individuals With Obesity","Inclusion Criteria:\n\n* Individuals between 25 and 60 years of age\n* Individuals with a body mass index (BMI) ≥ 30 kg\u002Fm² according to the World Health Organization (WHO) classification\n* Individuals who voluntarily agree to participate in the study\n\nExclusion Criteria:\n\n* Individuals with a Charlson Comorbidity Index (CCI) score of 3 or higher\n* Individuals with uncontrolled arrhythmia, hypertension, heart failure, diabetes mellitus, or unstable angina pectoris\n* Individuals with cooperation difficulties, orthopedic disorders, or neurological problems that may interfere with assessment procedures\n* Individuals with a history of lower extremity injury or surgery within the last six months\n* Individuals diagnosed with diabetes mellitus and presenting complications such as nephropathy, retinopathy, or neuropathy\n* Individuals with concomitant chronic respiratory disease\n* Individuals with acute infection\n* Individuals with middle ear pathologies (e.g., tympanic membrane rupture or otitis)\n* Individuals with a history of spontaneous or trauma-related pneumothorax\n* Current smokers\n* Pregnant individuals\n* Individuals with a STOP-Bang score of 3 or higher\n* Individuals currently participating in a structured weight-loss diet program or receiving medical treatment for weight reduction during the assessment period\n* Individuals who underwent endoscopic intervention and\u002For bariatric surgery within the last year",{"count":56,"type":21},"This observational study aims to evaluate respiratory performance and exercise responses according to Body Roundness Index (BRI) in individuals with obesity. Participants will undergo anthropometric and body composition assessments, respiratory muscle strength testing, pulmonary function evaluation, and a six-minute walk test. Exercise-related ventilatory responses, dyspnea, fatigue perception, oxygen saturation, and heart rate responses will also be assessed. The study seeks to investigate the relationship between BRI and cardiopulmonary performance and to determine whether BRI may serve as a useful indicator of obesity-related functional limitations and exercise capacity.",[384],"2026-05-12",{"date":405,"type":35},"2026-05-19",{"date":407,"type":21},"2026-06-20",{"date":409,"type":21},"2026-12-09",{"name":41,"class":42},{"id":412,"slug":413,"hasResults":12,"nctId":414,"briefTitle":415,"officialTitle":415,"acronym":4,"eligibilityCriteria":416,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":417,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":418,"conditions":419,"keywords":421,"overallStatus":156,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":432,"locationsCount":43},"100636726","investigation-of-macrophage-polarization-in-peri-implant-health-and-peri-implantitis-100636726","NCT07569432","Investigation of Macrophage Polarization in Peri-implant Health and Peri-implantitis","Inclusion Criteria:\n\n* Individuals who is suitable for the peri-implantitis diagnosis according to the classifications of periodontal and peri-implant diseases and conditions established in 2017.\n* Individuals with at least one bone-level dental implant and scheduled to undergo exposure surgery.\n\nExclusion Criteria:\n\n* prior peri-implantitis surgery\n* being diagnosed with autoimmune disease, genetic disorders, bone metabolism disorders, poorly controlled systemic diseases (such as diabetes or hypertension)\n* pregnancy or lactation\n* having a history of oral malignancy, chemotherapy or radiotherapy\n* use of anti-inflammatory drugs within 2 weeks, antibiotics within 3 months,\n* need for prophylactic antibiotics\n* contraindications for dental\u002Fsurgical procedures.",{"count":56,"type":21},"Peri-implantitis is a chronic inflammatory disease characterized by plaque-associated inflammation of the peri-implant mucosa and progressive loss of supporting bone around dental implants, which may ultimately lead to implant failure if left untreated.\n\nIt has been demonstrated that cellular and molecular responses of the host immune defense system play a critical role in the pathogenesis of peri-implantitis. Macrophages are key cells in the host immune response and are generally classified into two phenotypes: pro-inflammatory (M1) and anti-inflammatory (M2). While M1 macrophages are actively involved in the early defense response, a shift toward the M2 phenotype is required for the resolution of inflammation and tissue repair.\n\nSmoking has been shown to adversely affect macrophage polarization and function, thereby exacerbating inflammatory responses. Therefore, in the present study, levels of soluable CD163 (sCD163), B cell activating factor (BAFF), tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a proliferation-inducing ligand (APRIL), interferon-gamma (IFN-γ), interleukin-10 (IL-10), interleukin-34 (IL-34), interleukin-35 (IL-35), and arginase activity (ornithine levels) will be evaluated in peri-implant health and peri-implantitis patients with varying disease severity and different smoking statuses. In addition, a comprehensive proteomic analysis will be performed to investigate the relationships among peri-implantitis severity, smoking, and macrophage polarization-related molecules. Baseline periodontal and peri-implant parameters will be recorded for all participants. In the peri-implant health group, tissue samples will be collected during exposure surgery performed for submerged implants, after which participants will be enrolled in supportive peri-implant care. Participants diagnosed with peri-implantitis will receive non-surgical therapy, during which tissue samples will be collected. Periodontal and peri-implant parameters will be reassessed for all participants at baseline, and at 6 and 12 weeks. Healthy peri-implant samples will be collected from submerged implants during exposure surgery. Peri-implantitis samples (probable pocket depth ≥ 6 mm with bleeding on probing) will be obtained during non-surgical therapy using a single stroke along the pocket wall.",[420],"Peri-implantitis",[422,423,424],"peri-implantitis","smoking","macrophage","2026-05-10",{"date":427,"type":35},"2026-05-13",{"date":429,"type":21},"2026-04",{"date":431,"type":21},"2028-09",{"name":41,"class":42},{"id":434,"slug":435,"hasResults":12,"nctId":436,"briefTitle":437,"officialTitle":437,"acronym":4,"eligibilityCriteria":438,"healthyVolunteers":12,"sex":17,"minAge":439,"maxAge":18,"enrollmentInfo":440,"targetDuration":442,"studyType":22,"phases":4,"briefSummary":443,"conditions":444,"keywords":446,"overallStatus":156,"whyStopped":4,"lastUpdateSubmitDate":450,"lastUpdatePostDateStruct":451,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":457,"locationsCount":43},"100636618","examining-multilevel-factors-affecting-participation-in-physical-activity-among-adolescents-with-type-1-diabetes-using-the-socio-ecological-model-100636618","NCT07568028","Examining Multilevel Factors Affecting Participation in Physical Activity Among Adolescents With Type 1 Diabetes Using the Socio-Ecological Model","Inclusion Criteria:\n\n* Diagnosed with Type 1 diabetes at least 1 year prior to enrollment,\n* Aged between 9 and 18 years,\n* Currently attending school in Istanbul,\n* Willing to participate in the study (with voluntary consent),\n* HbA1c value ≥ 8% within the past year,\n* Reported glucose metabolism biomarkers,\n* Sufficient cognitive ability to understand and complete the questionnaires,\n* Under regular medical follow-up and using at least one glucose monitoring device.\n\nExclusion Criteria:\n\n* Lack of parental consent,\n* Presence of additional neurological, motor, or cognitive disorders,\n* Inadequate mental status or diagnosis of moderate to severe intellectual disability,\n* Presence of systemic comorbid diseases,\n* Failure to report HbA1c data.","9 Years",{"count":441,"type":21},55,"7 Days","The goal of this observational study is to examine the multilevel factors influencing physical activity participation in adolescents with Type 1 diabetes (T1D) within the framework of the Socio-Ecological Model (SEM). Physical activity is a multidimensional behavior shaped by individual, interpersonal, institutional, community, and policy-level influences, and it plays a critical role in diabetes management, metabolic health, and overall well-being in youth with T1D.\n\nThe main questions it aims to answer are:\n\nDo factors at the individual, interpersonal, institutional, community, and policy levels of the Socio-Ecological Model significantly influence physical activity participation, social participation, and diabetes management in adolescents with Type 1 diabetes? Which modifiable barriers and facilitators at these multiple levels are associated with higher or lower levels of physical activity?\n\nParticipants diagnosed with Type 1 diabetes will complete questionnaires assessing their daily living activities, exercise habits, social participation, psychosocial characteristics, and perceived social and environmental support. Objective measurements related to circadian rhythm patterns and glycemic control will also be collected. The study will analyze how multilevel socio-ecological factors are associated with physical activity behavior, social engagement, and diabetes management outcomes.\n\nThe findings are expected to provide a comprehensive biopsychosocial understanding of physical activity behaviors in adolescents with Type 1 diabetes and to inform the development of supportive, school- and community-based intervention strategies aimed at improving quality of life, self-efficacy, psychological resilience, and sustainable participation in physical activity.",[445],"Type 1 Diabetes Mellitus",[447,448,449],"Type 1 diabetes mellitus","Socio-Ecological Model","Physical Activity","2026-04-28",{"date":452,"type":35},"2026-05-05",{"date":454,"type":35},"2026-01-02",{"date":456,"type":21},"2026-09-13",{"name":41,"class":42},{"id":459,"slug":460,"hasResults":12,"nctId":461,"briefTitle":462,"officialTitle":462,"acronym":4,"eligibilityCriteria":463,"healthyVolunteers":12,"sex":17,"minAge":464,"maxAge":465,"enrollmentInfo":466,"targetDuration":4,"studyType":111,"phases":467,"briefSummary":468,"conditions":469,"keywords":471,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":482,"leadSponsor":484,"locationsCount":43},"100635305","evaluation-of-the-effectiveness-of-hybrid-cardiac-rehabilitation-in-peripheral-artery-disease-100635305","NCT07550959","Evaluation of the Effectiveness of Hybrid Cardiac Rehabilitation in Peripheral Artery Disease","Inclusion Criteria:\n\n* Diagnosis of peripheral artery disease with stable intermittent claudication.\n* Fontaine stage I-II or Rutherford category 1-3.\n* Age between 50 and 70 years.\n* Ability to walk independently without assistive devices.\n* Medically stable and eligible for exercise-based rehabilitation.\n* Willingness to participate in the study and to comply with the exercise program.\n* Provision of written informed consent prior to participation.\n\nExclusion Criteria:\n\n* Critical limb ischemia or rest pain.\n* Recent lower extremity revascularization or major surgery within the past 6 months.\n* Unstable cardiovascular conditions (e.g., unstable angina, uncontrolled arrhythmias).\n* Severe pulmonary, neurological, or musculoskeletal disorders limiting exercise participation.\n* Severe cognitive impairment or psychiatric conditions affecting compliance.\n* Participation in another structured exercise or rehabilitation program within the past 3 months.\n* Any medical condition deemed by the investigator to interfere with safe participation in the study.","50 Years","70 Years",{"count":331,"type":21},[113],"Peripheral artery disease (PAD) is a common atherosclerotic condition characterized by reduced blood flow to the lower extremities, leading to intermittent claudication, decreased walking capacity, and impaired quality of life. Supervised exercise therapy is recommended as the first-line non-invasive treatment for patients with PAD; however, participation in center-based programs is often limited due to accessibility, time constraints, and symptom-related barriers.\n\nThis randomized controlled study aims to evaluate the clinical effectiveness of a hybrid cardiac rehabilitation program compared with conventional supervised exercise therapy in individuals diagnosed with peripheral artery disease. Participants will be randomly assigned to either a hybrid cardiac rehabilitation group or a supervised exercise therapy group.\n\nThe hybrid cardiac rehabilitation program will combine center-based supervised exercise sessions with home-based telerehabilitation, supported by remote monitoring and wearable activity tracking devices. The supervised exercise therapy group will receive a fully center-based, physiotherapist-supervised exercise program. Both interventions will be delivered over a 12-week period.\n\nPrimary outcomes will include walking performance and functional capacity. Secondary outcomes will assess exercise adherence, symptom severity, physical activity levels, and quality of life. The results of this study are expected to provide evidence on the feasibility and effectiveness of hybrid cardiac rehabilitation as an alternative rehabilitation model for patients with peripheral artery disease.",[470],"Peripheral Arterial Disease",[472,473,474,475,476],"peripheral arterial disease","Hybrid Cardiac Rehabilitation","Supervised Exercise Therapy","Telerehabilitation","Intermittent Claudication","2026-04-22",{"date":479,"type":35},"2026-04-24",{"date":481,"type":21},"2026-09-16",{"date":483,"type":21},"2027-04-16",{"name":41,"class":42},{"id":486,"slug":487,"hasResults":12,"nctId":488,"briefTitle":489,"officialTitle":490,"acronym":4,"eligibilityCriteria":491,"healthyVolunteers":12,"sex":17,"minAge":202,"maxAge":492,"enrollmentInfo":493,"targetDuration":4,"studyType":111,"phases":494,"briefSummary":495,"conditions":496,"keywords":500,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":506,"startDateStruct":508,"completionDateStruct":510,"leadSponsor":512,"locationsCount":43},"100631374","synchronous-vs-asynchronous-telerehabilitation-for-high-risk-infants-100631374","NCT07499843","Synchronous vs. Asynchronous Telerehabilitation for High-Risk Infants","Family-Centered Early Intervention Program Under Physiotherapist Coaching for High-Risk Infants: A Comparison of Synchronous and Asynchronous Telerehabilitation Models","Inclusion Criteria:\n\n* Gestational age ≤32 weeks and\u002For birth weight ≤1500 grams.\n* Corrected age between 6 and 9 months at the time of enrollment.\n* Referral to a pediatric neurology clinic and\u002For current follow-up by a pediatric neurologist due to developmental risk.\n* A total score of ≤73 on the Hammersmith Infant Neurological Examination (HINE) (Romeo et al., 2021; Novak et al., 2017).\n* A score ≤5th percentile on the Alberta Infant Motor Scale (AIMS) (Fuentefria et al., 2017).\n* Parental willingness to participate and signing of the \"Informed Consent Form.\"\n* Access to the minimum technological infrastructure required for telerehabilitation (smartphone, tablet, or computer with video calling capability and active internet access).\n\nExclusion Criteria:\n\n* Presence of diagnosed genetic syndromes or metabolic diseases known to directly affect neuro-motor development.\n* Major congenital malformations causing significant movement restriction or exercise intolerance.\n* History of symptomatic hypoglycemia associated with severe brain injury during the neonatal period.\n* Sensory impairments (bilateral blindness or severe bilateral hearing loss not correctable with hearing aids) that prevent participation in assessments and exercises based on visual and auditory stimuli.\n* Acute or unstable clinical conditions that preclude the safe conduct of the intervention (e.g., continuous mechanical ventilation, hemodynamic instability, uncontrolled seizures, or active acute infections).\n* Non-adherence to the study protocol, defined as missing more than 6 intervention sessions.","9 Months",{"count":201,"type":21},[113],"Premature birth, low birth weight, and a history of neonatal intensive care history are significant risk factors associated with long-term neurodevelopmental adverse outcomes in infants. Family-centered early intervention programs play a critical role in minimizing the impact of these risks and optimizing developmental potential. Currently, telerehabilitation (TR) has emerged as a cost-effective solution that facilitates access to early intervention services. However, there is limited literature directly comparing the efficacy and feasibility of synchronous (real-time) and asynchronous (store-and-forward) parent coaching-based TR models specifically within the at-risk infant population.\n\nThe primary objective of this project is to comparatively examine the effects of synchronous and asynchronous TR programs on motor development levels, individualized goal attainment, and parental self-efficacy in infants aged 6-9 months (corrected age) at risk of developmental delay, against a standard home program (control group). Designed as a randomized controlled trial, the study will include 45 high-risk infants meeting the inclusion criteria, who will be randomly allocated into three groups: Synchronous TR, Asynchronous TR, and Control. In the Synchronous group, parents will receive real-time coaching via video conferencing for 12 weeks, whereas the Asynchronous group process will be managed through video analysis and delayed feedback mechanisms. The Control group will be provided with standard digital educational materials.\n\nThe primary outcome measures of the study include Goal Attainment Scaling (GAS) scores, the Parental Self-Efficacy Instrument, and the Parenting Stress Index. Secondary measures will include the Bayley Scales of Infant and Toddler Development (Bayley-IV), the Alberta Infant Motor Scale (AIMS), and the Hammersmith Infant Neurological Examination (HINE). Data will be collected at baseline (T0) and post-intervention (T1) by an assessor blinded to group allocation. The findings obtained from this study aim to demonstrate the clinical efficacy of different TR models, thereby providing guidance for the planning and dissemination of remote healthcare services for high-risk infants.",[497,498,499],"Risky Baby","Premature Birth of Newborn","Motor Delay",[501,502,475,503,504],"At-risk infant","Early intervention","Parent coaching","Motor development","2026-03-25",{"date":507,"type":35},"2026-03-30",{"date":509,"type":21},"2026-05-04",{"date":511,"type":21},"2027-07-04",{"name":41,"class":42},{"id":514,"slug":515,"hasResults":12,"nctId":516,"briefTitle":517,"officialTitle":518,"acronym":4,"eligibilityCriteria":519,"healthyVolunteers":51,"sex":17,"minAge":18,"maxAge":520,"enrollmentInfo":521,"targetDuration":4,"studyType":111,"phases":523,"briefSummary":524,"conditions":525,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":530,"lastUpdatePostDateStruct":531,"startDateStruct":533,"completionDateStruct":535,"leadSponsor":536,"locationsCount":43},"100631043","comparison-of-the-effects-of-free-weight-and-machine-based-exercises-on-muscular-parameters-100631043","NCT07495540","Comparison of the Effects of Free Weight and Machine-Based Exercises on Muscular Parameters","Comparison of Free Weight and Machine-Based Exercise Effects on Muscular Parameters","Inclusion Criteria:\n\n* Being an individual between the ages of 18-30 years\n* Being physically inactive according to the International Physical Activity Questionnaire short form (\\\u003C600 MET-min\u002Fweek)\n* Residing in Istanbul\n* Voluntary participation in the study.\n\nExclusion Criteria:\n\n* Having a neurological or cardiopulmonary system problem that prevents exercise.\n* Having mental dysfunction.\n* Having an acute musculoskeletal injury which limits exercise participant\n* Being pregnant.\n* Having answered \"YES\" to any question on the Exercise Readiness Questionnaire.","30 Years",{"count":522,"type":21},26,[113],"The aim of our study is to compare and investigate the effects of resistance exercises performed with free weights and those performed using machine systems on muscular parameters and neuromuscular control.",[526,527,528,529],"Resistance Exercise","Neuromuscular Adaptations","Muscle","Adult","2026-03-21",{"date":532,"type":35},"2026-03-27",{"date":534,"type":21},"2026-03-23",{"date":366,"type":21},{"name":41,"class":42},{"id":538,"slug":539,"hasResults":12,"nctId":540,"briefTitle":541,"officialTitle":542,"acronym":4,"eligibilityCriteria":543,"healthyVolunteers":51,"sex":52,"minAge":199,"maxAge":544,"enrollmentInfo":545,"targetDuration":4,"studyType":111,"phases":547,"briefSummary":548,"conditions":549,"keywords":555,"overallStatus":156,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":563,"completionDateStruct":565,"leadSponsor":567,"locationsCount":43},"100626282","video-game-intervention-in-older-adults-100626282","NCT07433608","Video Game Intervention In Older Adults","The Effects Of A Video-Based Game Intervention On Cognitive, Physical And Psychosocial Outcomes In Older Adults","Inclusion Criteria:\n\nAge 60 years or older A score of 24 or higher on the Mini Mental State Examination (MMSE) Ability to understand and follow verbal instructions Willingness to participate voluntarily\n\nExclusion Criteria:\n\nPresence of a neurological, orthopedic, or psychiatric diagnosis Medical contraindications to exercise Diagnosis of dementia Acute orthopedic injury Visual or hearing impairment that would interfere with participation Inability to attend sessions regularly","69 Years",{"count":546,"type":21},32,[113],"The purpose of this clinical trial is to investigate the effects of a rehabilitative game-based intervention on self-efficacy, balance, and visual-motor integration in individuals aged 60 years and older.\n\nThe primary research questions are:\n\nDoes the rehabilitative game-based intervention improve balance and visual-motor integration? Does the rehabilitative game-based intervention improve self-efficacy levels?\n\nResearchers will compare a rehabilitative game intervention group with a control group. Participants will complete baseline and post-intervention assessments. Individuals in the intervention group will participate in rehabilitative game sessions twice per week for 6 weeks, while the control group will not receive any intervention.",[550,551,552,553,554],"Healhty","Aging","Balance","Self Efficacy","Visual Motor Integration",[556,557,558,552,559],"Virtual Reality","Visual-Motor Integration","Older Adults","Self-Efficacy","2026-03-03",{"date":562,"type":35},"2026-03-06",{"date":564,"type":35},"2026-02-17",{"date":566,"type":21},"2026-04-07",{"name":41,"class":42},{"id":569,"slug":570,"hasResults":12,"nctId":571,"briefTitle":572,"officialTitle":573,"acronym":4,"eligibilityCriteria":574,"healthyVolunteers":51,"sex":17,"minAge":221,"maxAge":575,"enrollmentInfo":576,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":578,"conditions":579,"keywords":581,"overallStatus":156,"whyStopped":4,"lastUpdateSubmitDate":583,"lastUpdatePostDateStruct":584,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":590,"locationsCount":43},"100625614","gait-physical-activity-and-sleep-in-parkinsons-disease-100625614","NCT07424924","Gait, Physical Activity, and Sleep in Parkinson's Disease","The Relationship Between Balance and Gait Impairments, Physical Activity Level, and Sleep Quality in Parkinson's Disease","Inclusion Criteria:\n\nFor Patients with Parkinson's Disease:\n\nA confirmed diagnosis of Parkinson's disease according to the United Kingdom (UK) Brain Bank Criteria and classified as Hoehn and Yahr stages 1-3\n\nAbility to walk independently on a flat surface without assistive devices (Functional Ambulation Scale ≥3)\n\nStable medication regimen during the past month\n\nBeing in the \"on\" phase of medication\n\nFor Healthy Individuals:\n\nNo diagnosis of neurological and\u002For neurodegenerative disease\n\nExclusion Criteria:\n\n(For both Parkinson's patients and healthy individuals)\n\nSevere hearing or visual impairments\n\nPresence of other neurological, cardiovascular, or orthopedic conditions that may affect walking ability\n\nAny additional neurological disorder (e.g., dementia, cerebrovascular disease)\n\nEducation level less than 5 years\n\nVascular pathologies affecting the lower extremities\n\nLack of smartphone use","75 Years",{"count":577,"type":21},34,"This study aims to investigate the relationship between balance and gait impairments, physical activity levels, and sleep status in individuals with Parkinson's disease (PD). Both motor and non-motor symptoms of PD significantly affect quality of life, yet these dimensions are often evaluated separately. By examining gait, balance, physical activity, and sleep parameters together and comparing patients with healthy individuals of similar age, the study seeks to clarify how these variables interact and whether observed impairments are disease-specific or related to natural aging. The findings are expected to contribute to a more comprehensive understanding of PD and support the development of more effective management strategies.",[580],"Parkinson Disease",[582],"gain, functionality, quality of life","2026-02-16",{"date":585,"type":35},"2026-02-20",{"date":587,"type":35},"2026-01-05",{"date":589,"type":21},"2026-05-20",{"name":41,"class":42},{"id":592,"slug":593,"hasResults":12,"nctId":594,"briefTitle":595,"officialTitle":596,"acronym":4,"eligibilityCriteria":597,"healthyVolunteers":51,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":598,"targetDuration":4,"studyType":111,"phases":599,"briefSummary":600,"conditions":601,"keywords":4,"overallStatus":156,"whyStopped":4,"lastUpdateSubmitDate":603,"lastUpdatePostDateStruct":604,"startDateStruct":606,"completionDateStruct":608,"leadSponsor":610,"locationsCount":43},"100539527","impact-of-keratinized-mucosa-augmentation-on-treatment-outcomes-of-peri-implant-mucositis-100539527","NCT06305000","Impact of Keratinized Mucosa Augmentation on Treatment Outcomes of Peri-implant Mucositis","Impact of Keratinized Mucosa Augmentation Following Non-surgical Therapy on Treatment Outcomes of Peri-implant Mucositis.","Inclusion Criteria:\n\n* Individual dental implants with a fixed prosthetic restoration that has been functional for at least 1 year\n* No systemic disease and medication use that may affect periodontal or peri-implanter tissues\n* Not receiving periodontal treatment in the last 6 months\n* Volunteering to participate in the study\n\nExclusion Criteria:\n\n* Prosthetic restorations with an excessive contour which do not allow peri-implant pocket measurement\n* Being pregnant or breastfeeding,\n* Autoimmune and\u002For inflammatory diseases of the oral cavity,\n* Active periodontal disease\n* Smokers (≥ 10 cigarettes per day)\n* Improperly positioned implants",{"count":201,"type":21},[113],"This study aims to observe the effects of keratinized mucosa width on peri-implant tissues by evaluating clinical and biochemical parameters. The main question it aims to answer is:\n\nWould increasing the width of the keratinized mucosa with free gingival graft (FGG) in peri-implant mucositis be beneficial in terms of clinical periodontal parameters and peri-implant crevicular fluid levels of inflammatory cytokines compared to non-surgical therapy alone?\n\nOur study consists of 4 groups:\n\nPeri-implant healthy group with sufficient keratinized mucosa (≥ 2mm) (n=16), peri-implant mucositis group with sufficient keratinized mucosa (n=16), peri-implant mucositis group with insufficient keratinized mucosa (\\\u003C 2mm) receiving only non-surgical treatment (n=16), peri-implant mucositis group with insufficient keratinized mucosa receiving FGG in addition to non-surgical treatment (n=16). Clinical and biochemical measurements will be recorded at the baseline, 1st month, 4th month and 7th month of the study. Peri-implant crevicular fluid samples will be collected at baseline, 1st month, 4th month and 7th month. IL-1β, RANKL, OPG levels, and RANKL\u002FOPG ratio will be analyzed from collected samples.\n\nResearchers will evaluate the possible benefits of FGG application in addition to non-surgical therapy by comparing the biochemical and clinical changes in areas with and without FGG application in the treatment of peri-implant mucositis.",[602],"Peri-implant Mucositis","2026-02-06",{"date":605,"type":35},"2026-02-10",{"date":607,"type":35},"2024-03-27",{"date":609,"type":21},"2026-09-10",{"name":41,"class":42},{"id":612,"slug":613,"hasResults":12,"nctId":614,"briefTitle":615,"officialTitle":616,"acronym":4,"eligibilityCriteria":617,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":618,"targetDuration":4,"studyType":111,"phases":619,"briefSummary":620,"conditions":621,"keywords":624,"overallStatus":156,"whyStopped":4,"lastUpdateSubmitDate":628,"lastUpdatePostDateStruct":629,"startDateStruct":630,"completionDateStruct":632,"leadSponsor":633,"locationsCount":43},"100623640","music-augmented-rhythmic-gait-training-in-multiple-sclerosis-100623640","NCT07399262","Music-Augmented Rhythmic Gait Training in Multiple Sclerosis","Music-Augmented Versus Non-Music Technology-Based Rhythmic Gait Training in Multiple Sclerosis: A Randomized Controlled Trial of Gait Performance and Clinical Outcomes","Inclusion Criteria:\n\n* Expanded Disability Status Scale (EDSS) score between 0 and 4.0\n\nAccess to the internet via a high-speed smartphone or computer\n\nA score of at least 21 on the Montreal Cognitive Assessment (MoCA)\n\nFunctional Ambulation Scale score of Stage 3 or higher\n\nExclusion Criteria:\n\n* Presence of hearing or visual impairments\n\nCurrent participation in any structured exercise program\n\nPresence of other neurological, cardiovascular, or orthopedic disorders\n\nHistory of MS relapse or change in disease-modifying treatment within the last 6 months\n\nPhysical conditions preventing safe participation in the exercise program\n\nComorbid conditions that adversely affect oxygen transport (e.g., severe anemia, peripheral arterial disease)",{"count":546,"type":21},[113],"This randomized controlled trial aims to compare the effects of technology-based rhythmic gait training performed with and without music on walking performance and clinical outcomes in individuals with multiple sclerosis (MS). Thirty-two participants with mild to moderate disability will be randomly assigned to either a music-assisted rhythmic gait training group or a non-music control group, with both interventions delivered via telerehabilitation. Outcomes related to gait performance, balance, fatigue, and cognitive function will be assessed before and after a four-week intervention period.",[622,623],"Multiple Sclerosis","Rehabilitation",[622,625,626,475,627],"Rhythmic Gait Training","Music-Based Exercise","Gait Performance","2026-02-05",{"date":605,"type":35},{"date":631,"type":35},"2026-01-20",{"date":212,"type":21},{"name":41,"class":42},{"id":635,"slug":636,"hasResults":12,"nctId":637,"briefTitle":638,"officialTitle":638,"acronym":4,"eligibilityCriteria":639,"healthyVolunteers":51,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":640,"targetDuration":4,"studyType":111,"phases":641,"briefSummary":642,"conditions":643,"keywords":646,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":651,"lastUpdatePostDateStruct":652,"startDateStruct":654,"completionDateStruct":655,"leadSponsor":657,"locationsCount":4},"100622766","a-vision-based-characterization-of-human-movement-scaling-in-large-amplitude-tasks-100622766","NCT07387887","A Vision-Based Characterization of Human Movement Scaling in Large-Amplitude Tasks","Inclusion Criteria:\n\nAbility to stand, walk, reach, step, and perform sit-to-stand movements independently without assistance.\n\nNo self-reported or clinically diagnosed neurological, musculoskeletal, or vestibular disorders.\n\nNormal or corrected-to-normal vision sufficient to follow visual instructions.\n\nExclusion Criteria:\n\n* History of neurological disorders (e.g., Parkinson's disease, stroke, multiple sclerosis, traumatic brain injury).\n\nHistory of major musculoskeletal injury or surgery affecting upper or lower extremities that limits movement.\n\nPresence of balance disorders or vestibular dysfunction.\n\nCardiovascular, respiratory, or metabolic conditions that may limit safe participation in physical exercise.\n\nCurrent pain, dizziness, or excessive fatigue during movement or exercise.\n\nPregnancy or any condition for which moderate-intensity physical activity is contraindicated.\n\nUse of assistive devices for walking or balance.\n\nRefusal or inability to provide consent for RGB video recording.",{"count":522,"type":21},[113],"This pilot study investigates the feasibility of objectively quantifying movement amplitude and amplitude decay during large-amplitude exercises using RGB camera-based video analysis in healthy volunteers. Six large-amplitude exercises are recorded across repeated trials, with the first repetition clinically confirmed as the individual's maximum reference. Movement amplitude is quantified using pose-based kinematic measures and complemented by an exploratory self-supervised visual transformer approach to characterize repetition-wise changes relative to the reference execution. The study aims to determine whether camera-based methods can detect amplitude decay patterns and identify moments requiring clinical verbal cues, thereby supporting future objective monitoring and feedback in large-amplitude exercise training.",[644,645],"Digital Technology","Healthy",[647,648,649,650],"Exercise","Motion Analysis","Video-recording","artificial intelligence","2026-01-30",{"date":653,"type":35},"2026-02-04",{"date":651,"type":21},{"date":656,"type":21},"2026-05-30",{"name":41,"class":42},""]