[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Boston University Charles River Campus\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":625},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,30,0,25,[9,45,75,100,122,151,172,192,213,237,255,274,304,327,340,368,395,422,444,468,489,514,538,565,597],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100647273","a-novel-digital-music-based-autonomous-personalized-walking-intervention-to-improve-gait-and-walking-automaticity-in-parkinson-disease-100647273",false,"NCT07705373","A Novel Digital Music-based Autonomous Personalized Walking Intervention to Improve Gait and Walking Automaticity in Parkinson Disease","MyMusiQ","Inclusion Criteria:\n\n* Self-report of diagnosis of typical Parkinson disease determined by a medical doctor\n* ≥ 40 years of age\n* Community-dwelling (e.g. home, independent living, senior housing)\n* Have stable PD medications for at least two weeks prior to enrollment\n* Modified Hoehn and Yahr stages 1-3 per physical exam by a licensed physical therapist\n* Able to walk independently without physical assistance for at least 10 minutes (assistive devices allowed with reciprocal gait pattern)\n* Willing and able to provide informed consent\n* Provide HIPAA Authorization to allow communication with the primary healthcare provider for communication (as needed) during the study period\n\nExclusion Criteria:\n\n* \\\u003C 40 years of age\n* Diagnosis of atypical Parkinsonism\n* Modified Hoehn and Yahr stages 4-5\n* Significantly disturbing freezing episodes during daily walking based on the New Freezing of Gait Questionnaire (Part III Item 7)\n* Fall frequencies \\>1x\u002Fweek on average, over the past month.\n* Currently participating in physical therapy for Parkinson gait rehabilitation\n* Currently performing walking exercise at moderate intensities or higher for at least 30 min. per session ≥ 3x\u002Fweek\n* Self-reported cardiac problems that interfere with the ability to safely exercise (e.g., congestive heart failure, uncontrolled cardiac arrhythmias, chest pain;\n* Orthopedic problems in the lower extremities or spine that may limit walking distance (e.g., severe arthritis, spinal stenosis, or significant pain)\n* Any other medical conditions that would preclude successful participation as determined by the researcher\u002F physical therapist\n* Cognitive impairment (i.e., Montreal Cognitive Assessment, MoCA \\\u003C 21)\n* Unable to walk independently (i.e., without physical assistance) at a comfortable speed ≥ 0.4m\u002Fs as measured using the 10-meter Walk Test (10mWT) as examined in Baseline #1\n* Resting tachycardia (\\> 100 beats\u002Fmin) or uncontrolled blood pressure (resting systolic BP \\> 160 mmHg or diastolic BP \\>100 mmHg)) as measured by the researcher\u002F physical therapist\n* Unable to independently use the music-based digital therapeutic during training\n* Significant hearing impairment","ALL","40 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this research study is to examine the effects of a 3-month personalized community-based walking program called MyMusiQ. The study uses music cues delivered through a digital device in people with Parkinson disease (PD). The investigators want to know if personalized music cueing through the digital device can improve walking quality, walking ability, daily walking amount and intensity, and quality of life, while helping walking feel more automatic and require less mental effort. Participants will take part in this research study for approximately 18 weeks in total. During this time, participants will complete 4 study visits at designated research centers at Boston University, Washington University in St. Louis, or the University of Utah, depending on the site of enrollment.",[27],"Parkinson's Disease (PD)",[29,30,31,32,27],"Music-based intervention","Gait quality","Walking capacity","Gait automaticity","RECRUITING","2026-08-20",{"date":36,"type":37},"2026-08-21","ACTUAL",{"date":34,"type":37},{"date":40,"type":21},"2029-02-28",{"name":42,"class":43},"Boston University Charles River Campus","OTHER",3,{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},"100652862","physiology-of-liberation-100652862","NCT07780266","Physiology of Liberation","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Lives in the United States\n* Able to read and understand English well enough to provide informed consent and to complete study surveys and instructions\n* Has a compatible smartphone and the required study application\n* Willing to complete ecological momentary assessment (EMA) and assigned study procedures\n\nExclusion Criteria:\n\n* Cannabis or other illicit drug use within the past 30 days\n* Any current pattern of substance use that would prevent informed consent or the safe and reliable completion of study procedures\n* Inability or unwillingness to complete core study procedures\n* Lack of a compatible smartphone or the required study application",true,"18 Years",{"count":54,"type":21},20,[24],"This academic study examines how everyday experiences are related to short-term physiological reactivity and recovery and whether one or more brief standardized mindfulness\u002Fattention-instruction sessions change these patterns. Adults living in the United States who can read and understand the English study materials participate for up to 4 weeks and complete 5 to 7 brief smartphone surveys per day on 14 total ecological momentary assessment (EMA) days during waking hours. The 14 EMA days may be consecutive or divided into two 7-day measurement bursts. Surveys include current experiences and recent alcohol and nicotine use; these reports are analyzed as contextual variables and are not automatic exclusion criteria. Some participants also use assigned non-invasive wearable sensors or blood-pressure monitors during prespecified measurement windows. Device output is used only for research measurement, not diagnosis, treatment, real-time medical decision-making, or patient management. In study waves with a randomized comparison, participants are randomized after consent to one or more brief mindfulness\u002Fattention-instruction sessions or time-matched no-instruction comparison sessions. Session duration, schedule, and allocation probabilities are specified before each study wave begins and applied consistently within that wave.",[58],"Psychophysiological Reactivity and Recovery",[60,61,62,63,64,65],"ecological momentary assessment","mindfulness","psychophysiology","autonomic recovery","wearable sensors","ambulatory monitoring","NOT_YET_RECRUITING","2026-08-18",{"date":36,"type":37},{"date":70,"type":21},"2026-09",{"date":72,"type":21},"2028-09",{"name":42,"class":43},1,{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":51,"sex":17,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":74},"100642131","use-of-a-mobile-brain-body-imaging-approach-to-evaluate-the-effects-of-rhythmic-auditory-stimulation-on-gait-and-brain-function-in-alzheimers-disease-100642131","NCT07659964","Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease","Inclusion Criteria:\n\nGeneral Inclusion (both healthy and AD populations):\n\n* Community-dwelling\n* Capable of walking short community distances (approximately 10-15 minutes at a time) without assistance from another person or a device (such as a cane).\n* Able to communicate with researchers\n* Age 50-90 (inclusive)\n\nPopulation-specific Inclusion criteria:\n\n* Healthy -\n\n  * No diagnosis of AD\n* AD population-\n\nCERAD score of \\\u003C1.5 SD from age + education adjusted norms on delayed recall domain or one or more other cognitive domains (i.e. language, attention).\n\nMoCA score between 20-30 MMSE score between 25-30\n\nExclusion Criteria:\n\n* Presence of significant hearing impairment\n* Current orthopedic, neurologic or other medical condition that limits the ability to walk.\n\nThe MOCA, MMSE and CERAD tests will be completed in-person after the participant consents into the study. If the participant is determined to be ineligible based on their performance on these tests (compared to inclusion requirements listed above), they will be informed that they are not eligible for this study and the study visit will be cancelled. They will then be withdrawn from the study; their clinical tests and study documentation will be maintained for the purposes of completeness, but will not be used for any study analyses.","50 Years","90 Years",{"count":84,"type":21},40,[24],"Alzheimer's Disease (AD) is associated with impairments in both gait and cognition, significantly increasing fall risk. Falls are a leading cause of injury-related disability in older adults, and individuals with AD experience a nearly threefold higher rate of falls compared to neurotypical older adults. There is an urgent need for fall prevention interventions tailored to the unique deficits of individuals with AD. Converging evidence suggests that interventions aiming to reduce fall risk in AD should target both gait and cognition. Rhythmic music interventions, such as Rhythmic Auditory Stimulation (RAS) can harness global brain activation and auditory-motor entrainment to facilitate high-intensity exercise to alleviate AD-related neurocognitive and gait dysfunction. This study aims to assess the neural correlates of gait dysfunction in people with AD, evaluate if baseline neurocognitive impairment is predictive of the effects of RAS, and evaluate RAS benefits for individuals with AD.",[88,89],"Alzheimer Disease (AD)","Mild Cognitive Impairment (MCI)",[91],"RAS","2026-08-12",{"date":94,"type":37},"2026-08-13",{"date":96,"type":37},"2026-06-01",{"date":98,"type":21},"2026-12",{"name":42,"class":43},{"id":101,"slug":102,"hasResults":12,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":74},"100651172","feasibility-of-cough-skill-training-in-individuals-with-head-and-neck-cancer-100651172","NCT07756684","Feasibility of Cough Skill Training in Individuals With Head and Neck Cancer","Inclusion Criteria:\n\n* Prior diagnosis of head and neck cancer at least 6 months post-diagnosis\n* Completed treatment for head and neck cancer, including surgery, radiation, or chemotherapy\n* Medically stable and able to follow commands and produce a voluntary cough\n* English speaking\n\nExclusion Criteria:\n\n* Unable to provide informed consent assessed by a Montreal Cognitive Assessment (MoCA) score of \\\u003C20\n* Unable to follow study instructions\n* Unable to produce a voluntary cough\n* History of neurologic disease\n* Recent laryngeal surgery or vocal fold injury\n* Active respiratory infection or febrile illness within the past 14 days\n* Chronic, severe, or unstable respiratory disease\n* Asthma or bronchitis\n* Smoking within the past five years\n* Uncontrolled hypertension\n* Recent myocardial infarction, unstable angina, stroke, or hospitalization for heart failure within the past 6 months\n* Significant uncontrolled arrhythmia",{"count":107,"type":21},10,[24],"This preliminary study will examine the feasibility of a cough skill training treatment approach to rehabilitate voluntary cough function in people with head and neck cancer. Cough skill training focuses on practicing cough as a compensatory strategy for when food or liquid enters the airway. Primary outcomes will be feasibility and immediate treatment effects. The investigators hypothesize that the treatment will be feasible and will result in improvements to voluntary cough peak expiratory flow rate.",[111],"Head and Neck Cancers",[113],"cough skill training","2026-08-07",{"date":116,"type":37},"2026-08-11",{"date":118,"type":21},"2026-10",{"date":120,"type":21},"2027-09",{"name":42,"class":43},{"id":123,"slug":124,"hasResults":12,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":12,"sex":17,"minAge":129,"maxAge":130,"enrollmentInfo":131,"targetDuration":4,"studyType":22,"phases":133,"briefSummary":134,"conditions":135,"keywords":137,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":150},"100650597","enhancing-cognitive-and-workschool-outcomes-in-first-episode-psychosis-using-cognitive-self-management-strategies-100650597","NCT07749105","Enhancing Cognitive and Work\u002FSchool Outcomes in First Episode Psychosis Using Cognitive Self-Management Strategies","Enhancing Cognitive and Work\u002FSchool Outcomes in People With First Episode Psychosis: Testing the Effectiveness of Cognitive Self-Management Strategies","Inclusion Criteria:\n\n1. currently in their first 18 months of enrollment in the CSC program\n2. at least 15 years of age\n3. receiving SEE services but not employed or enrolled in school\n4. have the desire to work or resume school.\n\nExclusion Criteria:\n\n1\\) Young adults who are not fluent in english","15 Years","32 Years",{"count":132,"type":21},60,[24],"The goal of this pilot cluster randomized trial is to understand if adding a standardized cognitive self-management program, Thinking Skills for Work-Cognitive Self-Management Strategies (CSM) to Coordinated Specialty Care Supported Employment and Education (SEE) programs improves the work and school outcomes of young adults experiencing first episode psychosis. The main questions it aims to answer are:\n\n* Does adding the CSM program to usual SEE services lead to improved work and school outcomes, such as ability to find a job or enroll in school, or ability to keep a job or stay in school?\n* Does adding the CSM program to usual SEE services improve cognition and cognitive self-efficacy? Researchers will recruit six research sites and these will be randomized to either treatment as usual, where they will offer regular SEE services, or the experimental groups, where they will offer regular SEE services plus the CSM program.\n\nParticipants in both groups will be asked to complete a brief assessment at baseline, 6-months, 12-months, and 18-months. Participants in the experimental group will be asked to participate in the 12-session CSM program in addition to their regular SEE services.",[136],"First Episode Psychosis (FEP)",[138,139,140,141],"Young adults","First Episode Psychosis","Supported Employment and Education","Cognitive remediation","2026-08-01",{"date":144,"type":37},"2026-08-06",{"date":146,"type":37},"2025-08-10",{"date":148,"type":21},"2029-05-31",{"name":42,"class":43},4,{"id":152,"slug":153,"hasResults":12,"nctId":154,"briefTitle":155,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":51,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":22,"phases":159,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":74},"100482869","using-machine-learning-to-optimize-user-engagement-and-clinical-response-to-digital-mental-health-interventions-100482869","NCT05567640","Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions","Inclusion Criteria:\n\n* English-speaking adults\n* Ages 18 or older\n* Have a device that can connect to the internet.",{"count":158,"type":21},1800,[24],"Digital mental health interventions are a cost-effective and efficient approach to expanding the accessibility and impact of psychological treatments; however, little guidance exists for selecting the most effective program for a given individual. In the proposed study, decision rules will develop for selecting the digital program that is most likely to be the optimal intervention for each user. These treatment recommendations can be implemented in the context of large healthcare delivery systems to improve the delivery of digital mental health interventions at scale.\n\nThe overarching aim of the current study is to better understand for whom and how leading digital interventions work in a large healthcare setting. The study builds on the existing literature and follows expert recommendations by using machine learning (ML) methods to develop precision treatment rules (PTRs) for three leading digital interventions for emotional disorders (e.g., anxiety, depression, and related mental health disorders). Specifically, ML methods will be used to develop PTRs to optimize clinical outcomes and associated intervention engagement. This study will leverage a unique partnership between Boston University (BU), SilverCloud Health (SC)--a leading provider of digital mental health care--and Kaiser Permanente (KP)--one of America's leading health care providers.\n\nA clinical trial (RCT) will be conducted to evaluate the relative effectiveness of three distinct empirically supported digital mental health interventions (from SC's existing library of programs) in a sample recruited from KP primary care and other clinical settings. Data from this trial will be used to develop theoretically and empirically informed, reliable selection algorithms for managing treatment delivery decisions. Algorithms will be validated in a separate \"holdout\" dataset by examining whether allocation to predicted optimal treatment is associated with superior outcomes compared to allocation to a non-optimal treatment. The role of user engagement will be determined, and other mechanisms in treatment outcome.",[162,163],"Anxiety Disorders and Symptoms","Depressive Symptoms","2026-07-30",{"date":166,"type":37},"2026-07-31",{"date":168,"type":37},"2023-04-12",{"date":170,"type":21},"2027-07",{"name":42,"class":43},{"id":173,"slug":174,"hasResults":12,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":12,"sex":17,"minAge":81,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":180,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":74},"100572804","transcranial-stimulation-combined-with-auditory-training-100572804","NCT06738030","Transcranial Stimulation Combined With Auditory Training","Inclusion Criteria:\n\n* 50 years of age or older\n* Audiometric thresholds that do not exceed 90 dB HL at any frequency from 250-6000 Hz\n* Able to provide informed consent and understand experimental instructions\n* Able to read print on a computer screen\n* Difficulty with speech-on-speech understanding\n* Access to computer or mobile phone with access to internet that can play sound (for the at-home training)\n\nExclusion Criteria:\n\n* Non-native speakers of English\n* History of skull fracture, scalp tissue damage, metallic implants around the head, seizures, neurological disorders, or traumatic brain injury, current or suspected pregnancy",{"count":179,"type":21},94,[24],"The goal of this clinical trial is to learn if non-invasive brain stimulation (called transcranial stimulation) can enhance the benefits from auditory training in people who struggle to understand one talker when many people are talking at the same time. The main questions it aims to answer are:\n\n* Does transcranial stimulation improve speech-on-speech understanding in people who struggle with this task?\n* Does transcranial stimulation enhance the benefits of a commercially available auditory training program?\n\nResearchers will compare transcranial stimulation to sham stimulation (no stimulation is applied during the listening task).\n\nParticipants will:\n\n* Receive login information to an online auditory training program to complete at home over 2 weeks\n* Visit the laboratory 4 times to receive transcranial stimulation while listening to speech-on-speech: once before at-home training, two times during the at-home training period, and once after at-home training has ended",[183],"Difficulties Understanding Speech in Noise","2026-07-28",{"date":186,"type":37},"2026-07-29",{"date":188,"type":37},"2025-11-07",{"date":190,"type":21},"2027-03",{"name":42,"class":43},{"id":193,"slug":194,"hasResults":12,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":199,"enrollmentInfo":200,"targetDuration":4,"studyType":22,"phases":202,"briefSummary":203,"conditions":204,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":210,"leadSponsor":212,"locationsCount":4},"100650049","self-management-training-among-individuals-with-tbi-100650049","NCT07741149","Self-Management Training Among Individuals With TBI","Chronic Disease Self-Management Among Individuals With TBI","Inclusion Criteria:\n\n* Aged ≥18 years at time of first TBI\n* At least one year since the most recent TBI\n* Received care at BMC's Concussion\u002FTBI program for a TBI or concussion\n* At least partially involved in Self-care\n* Able to provide consent\n* Able to speak and understand English\n* Available for study duration.\n\nExclusion Criteria:\n\n* • Aged \\\u003C18 at the time of their first TBI\n\n  * Severe mental, cognitive, social, or emotional difficulties due to another neurologic, developmental, psychological condition, or active substance use disorder\n  * Participating in another interventional clinical trial\n  * Planned major surgery in the next 4 months.\n  * Pregnancy (self-report).\n  * Suspected or known drugs or alcohol abuse\n  * Endorses suicidal ideation\n  * All individuals with reduced decision-making capacity, an assigned LAR, or conservator.","100 Years",{"count":201,"type":21},85,[24],"Traumatic brain injury (TBI) can have long-term and chronic effects on an individual's physical, social, and emotional health, impacting quality of life and the ability to engage in meaningful life roles. Despite the potential for long-term effects, much of the care for individuals with TBI is front-loaded in the weeks to months post-injury. Self-management and self-management training are key components of long-term care for many chronic health conditions, but they are not standard parts of care for individuals with TBI.\n\nIn this study the investigators will address two objectives: 1) identify self-management priorities from the perspectives of individuals with chronic TBI, families, and health care providers and 2) pilot test an existing virtual community-based self-management training program (the Chronic Disease Self-Management Program (CDMSP)), to a) evaluate changes in quality of life, self-management self-efficacy, and other patient-reported outcomes before and after participating in the training, and b) identify barriers and facilitators to participating in community-based self-management training.",[205],"Traumatic Brain Injury","2026-07-27",{"date":208,"type":37},"2026-08-03",{"date":120,"type":21},{"date":211,"type":21},"2029-03",{"name":42,"class":43},{"id":214,"slug":215,"hasResults":12,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":4,"eligibilityCriteria":219,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":220,"enrollmentInfo":221,"targetDuration":4,"studyType":22,"phases":223,"briefSummary":224,"conditions":225,"keywords":227,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":74},"100532980","harness-based-mobility-intervention-for-infants-with-down-syndrome-100532980","NCT06219863","Harness-based Mobility Intervention for Infants With Down Syndrome","Feasibility and Outcome Measures for Infants With Down Syndrome: Advancing Clinical Trial Readiness for a Harness-based Mobility Intervention","Inclusion Criteria:\n\n* confirmed diagnosis of Trisomy 21\n* younger than 24 months\n* English is the primary language of the home (due to use of standardized language assessments normed on English-speaking children)\n* able to sit without support\n* not yet taking any independent steps.\n\nExclusion Criteria:\n\n* Mosaic or Translocation Down syndrome\n* severe, uncontrolled medical problems (including heart disease with cardiovascular instability, uncontrolled epilepsy)\n* severe uncorrected hearing or vision impairments","2 Years",{"count":222,"type":21},6,[24],"The emergence of crawling and walking is significantly delayed in infants with Down syndrome (DS), but the development of independent mobility provides infants with new opportunities for exploring the environment and interacting with objects and people that are important foundations for early learning. Increasing infant mobility early in development with body weight supported harness systems may support infant exploration, communication, and social interaction. This project will set the stage for the first clinical trial of a mobility-related intervention specifically tailored for infants with DS by testing the feasibility of harness systems with infants and families and identifying measures that will serve as primary outcome variables. Upon completion of this pilot project, necessary preliminary data and experience required for an in-home, high-impact clinical trial for infants with DS will have been obtained.",[226],"Down Syndrome",[228],"infant","2026-07-23",{"date":231,"type":37},"2026-07-24",{"date":233,"type":37},"2024-07-31",{"date":235,"type":21},"2027-12",{"name":42,"class":43},{"id":238,"slug":239,"hasResults":12,"nctId":240,"briefTitle":241,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":243,"enrollmentInfo":244,"targetDuration":4,"studyType":22,"phases":245,"briefSummary":246,"conditions":247,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":249,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":74},"100470476","neural-mechanisms-of-spatial-representations-beyond-the-self-100470476","NCT05406349","Neural Mechanisms of Spatial Representations Beyond the Self","Inclusion Criteria:\n\n* Between 18 and 70 years of age\n* Adequate visual and auditory acuity to allow neuropsychological testing\n* Have undergone depth electrode placement for the purpose of epilepsy evaluation\u002Ftreatment OR have NeuroPace RNS System implanted for epilepsy treatment\n\nExclusion Criteria:\n\n* All DSM-V Axis I and II disorders other than nicotine-dependence\n* History of brain damage","70 Years",{"count":132,"type":21},[24],"Spatial navigation is a fundamental human behavior, and deficits in navigational functions are among the hallmark symptoms of severe neurological disorders such as Alzheimer's disease. Understanding how the human brain processes and encodes spatial information is thus of critical importance for the development of therapies for affected patients. Previous studies have shown that the brain forms neural representations of spatial information, via spatially-tuned activity of single neurons (e.g., place cells, grid cells, or head direction cells), and by the coordinated oscillatory activity of cell populations. The vast majority of these studies have focused on the encoding of self-related spatial information, such as one's own location, orientation, and movements. However, everyday tasks in social settings require the encoding of spatial information not only for oneself, but also for other people in the environment. At present, it is largely unknown how the human brain accomplishes this important function, and how aspects of human cognition may affect these spatial encoding mechanisms. This project therefore aims to elucidate the neural mechanisms that underlie the encoding of spatial information and awareness of others. Specifically, the proposed research plan will determine how human deep brain oscillations and single-neuron activity allow us to keep track of other individuals as they move through our environment. Next, the project will determine whether these spatial encoding mechanisms are specific to the encoding of another person, or whether they can be used more flexibly to support the encoding of moving inanimate objects and even more abstract cognitive functions such as imagined navigation. Finally, the project will determine how spatial information is encoded in more complex real-world scenarios, when multiple information sources (e.g., multiple people) are present. To address these questions, intracranial medial temporal lobe activity will be recorded from two rare participant groups: (1) Participants with permanently implanted depth electrodes for the treatment of focal epilepsy through responsive neurostimulation (RNS), who provide a unique opportunity to record deep brain oscillations during free movement and naturalistic behavior; and (2) hospitalized epilepsy patients with temporarily implanted intracranial electrodes in the epilepsy monitoring unit (EMU), from whom joint oscillatory and single-neuron activity can be recorded.",[248],"Epilepsy Intractable",{"date":206,"type":37},{"date":251,"type":37},"2022-08-06",{"date":253,"type":21},"2027-04-30",{"name":42,"class":43},{"id":256,"slug":257,"hasResults":12,"nctId":258,"briefTitle":259,"officialTitle":259,"acronym":4,"eligibilityCriteria":260,"healthyVolunteers":51,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":261,"targetDuration":4,"studyType":22,"phases":263,"briefSummary":264,"conditions":265,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":74},"100515634","neuromodulation-for-a-novel-ocd-biomarker-and-treatment-100515634","NCT05994053","Neuromodulation for a Novel OCD Biomarker and Treatment","Inclusion Criteria:\n\n(1) a primary DSM-5 diagnosis of OCD, (2) a score of 16 or greater on the YBOCS (3) at least 18 years of age; and (4) willingness and ability to provide informed consent and comply with the requirements of the study protocol.\n\nExclusion Criteria:\n\n(1) a lifetime history of bipolar or psychotic disorders; (2) history of Tourette syndrome; (3) psychosurgery; (4) substance abuse or dependence (other than nicotine) in the past 3 months; (5) organic brain syndrome, mental retardation or other potentially interfering cognitive dysfunction; (6) severe depression (MADRS score of 30 or greater); (7) suicidal risk as determined by moderate or greater score on the Columbia Suicide Severity Rating Scale (C-SSRS); (8) pregnancy or lactation; (9) changes to pharmacotherapy for OCD or the initiation of cognitive-behavior therapy within the last 3 months; and (10) specific to the tACS and EEG procedures no metal implants in head, any implanted electronic devices, any skin sensitivity, color blindness or impaired vision despite correction, claustrophobia, and any history of epilepsy or neurological disorder.",{"count":262,"type":21},90,[24],"Although multiple treatments for OCD exist, slow symptom decrease, high remission, and significant side effects for some OCD patients limit their efficacy. More research into the precise neural mechanisms and linked cognitive functions in OCD is also necessary. To address both concerns, this study by Dr. Reinhart and his team will test a new, non-invasive, and well-tolerated neuromodulation method for reducing OCD symptoms, based on reward-related rhythms of the orbitofrontal cortex (OFC; a brain region responsible for reward, decision making and other crucial functions that is affected by OCD). This proposal is based on highly encouraging preliminary data in both subsyndromal and treatment-resistant populations that shows rapid reductions in OCD behaviors that last at least 1-3 months. Using high-definition transcranial alternating current stimulation (HD-tACS) guided by EEG brain wave recordings, the study will test whether repetitive modulation of relevant rhythm activity in the OFC can lead to rapid (within five days) and sustainable (up to three months) OCD symptom reduction. This research aims to increase knowledge of OCD and development of effective treatment with minimal side effects.",[266],"OCD","2026-07-22",{"date":229,"type":37},{"date":270,"type":37},"2024-07-01",{"date":272,"type":21},"2027-08-31",{"name":42,"class":43},{"id":275,"slug":276,"hasResults":12,"nctId":277,"briefTitle":278,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":51,"sex":17,"minAge":52,"maxAge":81,"enrollmentInfo":280,"targetDuration":4,"studyType":22,"phases":282,"briefSummary":283,"conditions":284,"keywords":286,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":298,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":74},"100491752","neural-markers-of-treatment-mechanisms-and-prediction-of-treatment-outcomes-in-social-anxiety-100491752","NCT05683223","Neural Markers of Treatment Mechanisms and Prediction of Treatment Outcomes in Social Anxiety","Inclusion criteria for all participants:\n\n(1) Any gender or race between 18-50 years old.\n\nAdditional inclusion criteria for healthy controls:\n\n(1) Liebowitz Social Anxiety Scale (LSAS; Mennin et al., 2002) score \\\u003C= 30, does not currently meet criteria for an Axis I psychiatric condition, as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5; American Psychiatric Association, 2013).\n\nAdditional inclusion criteria for the social anxiety disorder (SAD) group:\n\n1. Outpatients with a primary psychiatric complaint (designated by the patient as the most important source of current distress) of social anxiety with social interaction fear as defined by an Liebowitz Social Anxiety Scale (LSAS) score \\>= 60.\n2. Overall clinical severity of at least mild as defined by Clinical Global Impressions Scale (CGI-S; Zaider et al., 2003) of at least 3.\n3. Medical history interview and laboratory findings without clinically significant abnormalities.\n4. Willingness and ability to participate in the informed consent process and comply with the requirements of the study protocol.\n\nExclusion criteria:\n\n1. A lifetime history of bipolar disorder, schizophrenia, psychosis, delusional disorders or obsessive-compulsive disorder; an eating disorder in the past 6 months; organic brain syndrome, intellectual disability, or other cognitive dysfunction that could interfere with capacity to engage in therapy; a history of substance or alcohol abuse or dependence (other than nicotine) in the last 6 months or otherwise unable to commit to refraining from alcohol, marijuana, and stimulant use during the acute period of study participation.\n2. . Patients with significant suicidal ideation Montgomery-Åsberg Depression Rating Scale (10 items, self-report) or who have enacted suicidal behaviors within 6 months prior to intake will be excluded from study participation and referred for appropriate clinical intervention.\n3. Patients can be taking a concurrent psychotropic medication (e.g., antidepressants, anxiolytics, beta blockers, sertraline), but the dose must be stabilized for at least 2 weeks prior to initiation of randomized treatment.\n4. Significant personality dysfunction likely to interfere with study participation.\n5. Serious medical illness, associated treatment, or other instability for which hospitalization may be likely within the next year, or which may alter fMRI or EEG measurements. Participants with a history of serious medical illness or treatments that may alter fMRI measurements may enroll in the study 12 months after the condition has been remitted and ending treatment.\n6. Patients with a current or past history of seizures.\n7. Pregnant women, lactating women, and women of childbearing potential who may become pregnant.\n8. Any concurrent psychotherapy initiated within 3 months of baseline, or ongoing psychotherapy of any duration directed specifically toward treatment of the social anxiety is excluded. Individuals with prior CBT experience or treatments that included cognitive and behavioral skills and exposure procedures (e.g., assertiveness and social skills trainings) will be excluded. General supportive or insight-oriented therapy initiated \\> 3 months prior is acceptable.\n9. Prior non-response to adequately-delivered exposure (i.e., as defined by the patient's report of receiving specific and regular exposure assignments as part of a previous treatment).\n10. Patients with a history of head trauma causing loss of consciousness, seizure or ongoing cognitive impairment.\n11. Contraindications for MRI including metal implants, surgical clips, probability of metal fragments, braces, or claustrophobia.",{"count":281,"type":21},240,[24],"The purpose of this clinical trial is to answer the question: can the investigators predict which adults with social anxiety disorder (SAD) will successfully respond to treatment? To answer this question, the investigators plan to recruit 190 adult participants who experience extreme forms of social anxiety to undergo brain imaging before and after 12 weeks of group cognitive behavioral therapy (CBT). Adults in the SAD group who do not respond enough to group CBT may be offered the opportunity to complete an additional 12 weeks of individual CBT while receiving SSRI medication (sertraline, see below) for SAD.\n\nData collected from participants who experience anxiety will be compared to a group of 50 participants with little or no social anxiety, who will serve as a comparison group.",[285],"Social Anxiety Disorder",[287,288,289,290,291,292,293,294,295,296,297],"social anxiety disorder","sertraline","exposure therapy","social cost","MRI","EEG","structural connectivity","functional connectivity","cognitive control system","positive valence system","negative valence system",{"date":229,"type":37},{"date":300,"type":37},"2023-05-26",{"date":302,"type":21},"2027-06-30",{"name":42,"class":43},{"id":305,"slug":306,"hasResults":12,"nctId":307,"briefTitle":308,"officialTitle":309,"acronym":4,"eligibilityCriteria":310,"healthyVolunteers":51,"sex":17,"minAge":311,"maxAge":4,"enrollmentInfo":312,"targetDuration":4,"studyType":22,"phases":314,"briefSummary":315,"conditions":316,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":4},"100648473","memory-enhancement-in-aging-with-closed-loop-tacs-100648473","NCT07722598","Memory Enhancement in Aging With Closed-Loop tACS","Personalized Memory Enhancement in Aging: Pattern-Optimized tACS With Closed-Loop Precision Modulation","Inclusion Criteria:\n\n* 65 years of age or older\n* normal or corrected-to-normal vision\n* color vision\n\nExclusion Criteria:\n\n* pregnant\n* metal implants in head\n* implanted electronic devices\n* history of neurological problems or head injury\n* skin sensitivity\n* claustrophobia\n* dementia (normal Montreal Cognitive Assessment \\> 25)\n* depression (normal Geriatric Depression Scale \\\u003C 10)\n* history of psychosis\n* cognitive deficits (MoCA\\>25)\n* any psychoactive medication","65 Years",{"count":313,"type":21},160,[24],"This project optimizes high-resolution tACS to improve memory in healthy older adults, advancing drug-free approaches for ADRD. We test stimulation schedules and develop an adaptive, brain-guided tACS system to strengthen memory-supporting networks.",[317,318,319],"Aging","Noninvasive Brain Stimulation","Memory","2026-07-21",{"date":229,"type":37},{"date":323,"type":21},"2028-05-01",{"date":325,"type":21},"2031-01-31",{"name":42,"class":43},{"id":328,"slug":329,"hasResults":12,"nctId":330,"briefTitle":331,"officialTitle":309,"acronym":4,"eligibilityCriteria":310,"healthyVolunteers":51,"sex":17,"minAge":311,"maxAge":4,"enrollmentInfo":332,"targetDuration":4,"studyType":22,"phases":333,"briefSummary":334,"conditions":335,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":336,"startDateStruct":337,"completionDateStruct":338,"leadSponsor":339,"locationsCount":74},"100628434","memory-enhancement-in-aging-with-optimal-dosing-100628434","NCT07461584","Memory Enhancement in Aging With Optimal Dosing",{"count":281,"type":21},[24],"This project optimizes high-resolution transcranial Alternating Current Stimulation (tACS) to improve memory in healthy older adults, advancing drug-free approaches for Alzheimer's disease and related dementia (ADRD). We test stimulation schedules and develop an adaptive, brain-guided tACS system to strengthen memory-supporting networks.",[317,318,319],{"date":267,"type":37},{"date":96,"type":37},{"date":325,"type":21},{"name":42,"class":43},{"id":341,"slug":342,"hasResults":12,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":51,"sex":17,"minAge":52,"maxAge":81,"enrollmentInfo":347,"targetDuration":4,"studyType":22,"phases":348,"briefSummary":349,"conditions":350,"keywords":354,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":367},"100628297","investigating-individual-differences-in-speech-motor-skills-in-neurotypical-speakers-and-persons-with-disordered-speech-100628297","NCT07459803","Investigating Individual Differences in Speech Motor Skills in Neurotypical Speakers and Persons With Disordered Speech","Brain Mechanisms Underlying Neurotypical and Disordered Speech","Inclusion Criteria:\n\n* Native speakers of American English\n* Adults age 18-50\n* Age-appropriate cognitive and receptive vocabulary skills\n* Age-appropriate hearing\n* Adults with dyslexia will have a history of dyslexia or report of ongoing reading difficulties that will be confirmed at the first screening visit\n* Adults who stutter will have a history of stuttering that will be confirmed at the first screening visit\n\nExclusion Criteria:\n\n* History of neurological disorder, including a history of seizures\n* Major brain injury, brain surgery, or stroke\n* Orthodontia or atypical oral structure (e.g., cleft palate) that interferes with speech\n* Fluency disorder (except those in the persons who stutter cohort), apraxia of speech, or dysarthria\n* Language or reading disorder (except those in persons with dyslexia cohort)\n* Standardized score below 80 on the Kaufman Brief Intelligence Test\n* Standardized score below 1 standard deviation on the NIH Toolbox Picture Vocabulary Test\n* Pregnancy\n* Severe claustrophobia\n* Presence of magnetically or mechanically active implant, or other ferromagnetic material embedded in any part of the body\n* Significant scalp lesions that would prevent transcranial direct stimulation",{"count":262,"type":21},[24],"This study aims to understand how people use different types of feedback to control their speech. When an individual speaks, the brain relies on several systems at the same time, such as sensory systems that monitor an individuals own voice and the movements of their speech muscles, and a motor system that builds and reads out learned motor patterns. The investigators are studying how these systems work together and how they differ across individuals.\n\nInvestigators will test 90 adults between 18 and 50 years old, including people who stutter, people with dyslexia, and people with typical speech and reading development. Participants will complete several short speech tasks in which the sounds they hear or the movements of their jaw or larynx are briefly changed. These responses will be used to measure each person's speech motor skills and to estimate the settings of a computer model called \"SimpleDIVA,\" which simulates how the brain controls speech.\n\nParticipants will also complete an MRI scan so investigators can measure the structure and connectivity of different brain regions. These measures will help investigators understand how individual differences in the brain relate to the speech motor control skills we observe. Participants will also complete sessions with noninvasive brain stimulation (transcranial current stimulation, or tCS) to examine how stimulation of specific areas of the brain affects responses during the speech tasks.\n\nThe knowledge gained from this study will help researchers understand why speech motor skills vary across people and how differences in neural function may contribute to conditions such as stuttering and dyslexia.",[351,352,353],"Stuttering, Developmental","Dyslexia","Healthy Participants",[355,356,357,358,359,352],"Stuttering Developmental","Magnetic Resonance Imaging","Speech Motor Learning","Speech Disorders","Neurocomputational Modeling","2026-07-20",{"date":320,"type":37},{"date":363,"type":37},"2026-06-12",{"date":365,"type":21},"2030-03",{"name":42,"class":43},2,{"id":369,"slug":370,"hasResults":12,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":374,"eligibilityCriteria":375,"healthyVolunteers":12,"sex":17,"minAge":81,"maxAge":4,"enrollmentInfo":376,"targetDuration":4,"studyType":22,"phases":377,"briefSummary":378,"conditions":379,"keywords":382,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":389,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":394,"locationsCount":367},"100588395","a-pilot-randomized-controlled-trial-of-the-hopeful-and-healthy-living-program-100588395","NCT06940843","A Pilot Randomized Controlled Trial of the Hopeful and Healthy Living Program","Enhancing Social Connection, Health, and Aging in Older Persons: A Pilot Randomized Trial of the Hopeful and Healthy Living (HHL) Program","(HHL)","Inclusion Criteria:\n\n50 years or older, diagnosis of a serious mental illness, and a member of Center Club or Transitions of Boston\n\nExclusion Criteria:\n\nDiagnosis of dementia or other progressive neurological disorder",{"count":132,"type":21},[24],"The goal of this clinical trial is to learn if a novel psychosocial intervention is effective in helping adults over 50 with serious mental illness (SMI) increase their social connections and participate in more healthy lifestyle activities. The Hopeful and Healthy Living (HHL) intervention combines social skills training and training in cognitive self-management strategies in order to help older adults build healthy lifestyle and social routines. We predict that:\n\n* Individuals who participate in the HHL intervention will improve more in perceived social support (i.e., what people get from relationships such as reliance, reassurance of worth, attachment) and loneliness at the 4-, 8-, and 12-month follow-up assessments than those who receive treatment as usual (TAU).\n* Individuals who participate in the HHL intervention will improve more in overall psychosocial functioning at the 4-, 8-, and 12-month follow-up assessments than those who receive TAU.\n* Individuals who participate in the HHL intervention will improve more in cognitive functioning at the 4-, 8-, and 12-month follow-up assessments than those who receive TAU.\n* Individuals who participate in the HHL intervention will improve more in healthy behaviors (sleep, activity, diet) at the 4-, 8-, and 12-month follow-up assessments than those who receive TAU.\n\nIn this trial, participants will be either receive the HHL intervention or participate in their regular treatment activities (treatment as usual). HHL vs. TAU will be compared to see if there are any differences in social support, cognition, loneliness, psychosocial functioning, or healthy lifestyle activities including physical activity, sleep, and diet.\n\nParticipants will be asked to complete an interview-based assessment at baseline, 4-months, 8-months, and 12-months. After completing the baseline assessment, those who are in the experimental group will participate in the 16-week long HHL group intervention.",[380,381],"Serious Mental Illness","Older Adults",[383,384,385,386,387],"psychosocial interventions","cognitive interventions","social skills interventions","healthy lifestyle interventions","older adults with SMI","2026-07-17",{"date":360,"type":37},{"date":391,"type":37},"2025-03-12",{"date":393,"type":21},"2028-07-31",{"name":42,"class":43},{"id":396,"slug":397,"hasResults":12,"nctId":398,"briefTitle":399,"officialTitle":400,"acronym":4,"eligibilityCriteria":401,"healthyVolunteers":51,"sex":17,"minAge":402,"maxAge":403,"enrollmentInfo":404,"targetDuration":4,"studyType":22,"phases":406,"briefSummary":407,"conditions":408,"keywords":410,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":416,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":367},"100538298","neural-mechanisms-of-family-focused-treatment-for-youth-depression-100538298","NCT06289010","Neural Mechanisms of Family-Focused Treatment for Youth Depression","Neural Mechanisms of Evidence-Based, Family-Focused Treatment for Youth Depression: Preliminary Open Trial","Inclusion Criteria:\n\n* Children must:\n\n  * Have a current DSM-5 diagnosis of MDD, Persistent DD, or DDNOS (based on K-SADS-PL) OR not meet criteria for any DSM-5 mental health diagnosis (based on K-SADS-PL)\n  * Be ages 7-12\n  * Be living with a parent(s) or guardian willing to participate\n  * Be able and willing to provide informed consent\u002Fassent\n\nParent must:\n\n* Not be currently pregnant\n* Be able to read, understand consent forms, and provide consent on their child's behalf\n* Be the biological parent (or grandparent in parental role) of the participating child \\& have lived with the child for more than 75% of the child's life.\n\nAll participants must:\n\n* Not have a disturbance that would interfere with participation such as autism spectrum disorder, psychosis, current substance dependence, current use of psychotropic medication, OCD, or MRI contraindication such as metal inside the body or claustrophobia\n* Be proficient in English\n\nExclusion Criteria:\n\n* Thought or other disturbance in the child that would interfere with the ability to participate in treatment or assessments (e.g., psychotic disorder, autism spectrum disorder, OCD, active substance abuse\u002Fdependence, intellectual disability, as assessed on KSADS-PL)\n* Severe conduct disorders in the child that threaten the home stability (e.g. juvenile justice or children's protective service involvement as assessed on KSADS-PL) due to the potential impact on retention\n* Youth or primary caregivers do not speak English\n* Either parent or child has contraindications for neuroimaging (e.g., claustrophobia, metal implants, braces, electronically, magnetically, or mechanically activated devices such as cochlear implants)\n* The child is on an antidepressant medication, as it may complicate neuroimaging interpretation.","7 Years","12 Years",{"count":405,"type":21},80,[24],"The goal of this interventional study is to compare the baseline neural mechanisms and parenting in depressed and non-depressed children and to examine baseline neural mechanisms and parenting as predictors of Family-Focused Treatment for Childhood-Depression (FFT-CD) outcomes. The main questions it aims to answer are:\n\n* What are differences between depressed and non-depressed participants on baseline neural and parenting indicators?\n* Do baseline neural and parenting indicators predict response to FFT-CD?\n* Does change in parenting and neural functioning mediate change in depression from baseline to follow-up?\n\nParticipants will:\n\n* complete baseline clinical measures\n* complete neuroimaging tasks via Functional Magnetic Resonance Imaging (fMR)\n* undergo a 12-session course of FFT-CD\n* complete follow up evaluations and neuroimaging",[409],"Childhood Depression",[411,412,413,414,415],"Neural Mechanisms","Depression","Children","Adolescent","Family",{"date":360,"type":37},{"date":418,"type":37},"2024-08-20",{"date":420,"type":21},"2027-11",{"name":42,"class":43},{"id":423,"slug":424,"hasResults":12,"nctId":425,"briefTitle":426,"officialTitle":427,"acronym":4,"eligibilityCriteria":428,"healthyVolunteers":51,"sex":429,"minAge":52,"maxAge":4,"enrollmentInfo":430,"targetDuration":4,"studyType":22,"phases":432,"briefSummary":433,"conditions":434,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":438,"startDateStruct":439,"completionDateStruct":441,"leadSponsor":443,"locationsCount":74},"100495290","alcohol-and-heat-of-the-moment-sexual-decision-making-100495290","NCT05729256","Alcohol and \"Heat of the Moment\" Sexual Decision Making","Alcohol and \"Heat of the Moment\" Sexual Decision Making Among MSM: Identifying Mechanisms of Sexual Risk and Promoting Behavior Change Through Brief Intervention","Inclusion Criteria:\n\n* At least 18 years of age\n* Cisgender man who has had condomless anal intercourse with another man in the past 3 months\n* Engaged in heavy drinking (assessed by either weekly National Institute on Alcohol Abuse and Alcoholism guidelines \\[\\> 14 for men\\], and\u002For a heavy drinking episode in the past month \\[\\> 4 drinks on an occasion\\])\n* Has a smartphone\n\nExclusion Criteria:\n\n* HIV-infection\n* Currently using PrEP\n* In an exclusive monogamous sexual relationship\n* History of bipolar disorder, schizophrenia, other psychotic disorder, or current suicidal intent\n* Current treatment for alcohol use disorder or substance use disorder\n* Unable to provide one or more individuals who can serve as an alternate contact","MALE",{"count":431,"type":21},354,[24],"HIV transmission remains a significant public health concern, especially among men who have sex with men (MSM). Condomless anal intercourse (CAI) continues to be the major route of transmission for MSM. Thus, to reduce the incidence of HIV, it is critical to identify how contextual risk factors influence CAI and develop behavioral strategies that modify risk factors directly or reduce their influence on behavior. This study will examine the mechanisms through which one of the central contextual risk factors, heavy drinking, influences sexual decision processes in the natural environment and test the benefit of a brief intervention designed to reduce sexual risk behavior among those who engage in heavy drinking.",[435,436,437],"Alcohol Drinking","Sex, Unsafe","Hiv",{"date":360,"type":37},{"date":440,"type":37},"2023-11-02",{"date":442,"type":21},"2027-02",{"name":42,"class":43},{"id":445,"slug":446,"hasResults":12,"nctId":447,"briefTitle":448,"officialTitle":448,"acronym":4,"eligibilityCriteria":449,"healthyVolunteers":51,"sex":450,"minAge":129,"maxAge":4,"enrollmentInfo":451,"targetDuration":4,"studyType":22,"phases":453,"briefSummary":454,"conditions":455,"keywords":459,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":463,"completionDateStruct":465,"leadSponsor":467,"locationsCount":367},"100487272","reducing-psychological-barriers-to-prep-persistence-among-pregnant-and-postpartum-women-in-cape-town-south-africa-100487272","NCT05624931","Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa","Inclusion Criteria:\n\n* For participants across all three aims are:\n\n  * Female sex\n  * Aged 15+\n  * Pregnant and presenting antenatal care at the Gugulethu MOU\n  * HIV-negative\n  * Recent PrEP initiation (\\\u003C1 month ago) or PrEP adherence challenges, either documented (\\>2 weeks late to pick up PrEP refill) or self-reported\n  * Moderate to severe symptoms of posttraumatic stress and\u002For depression (defined as a score of ≥31 on PTSD Checklist for DSM-5 (PCL-5) and\u002For a score of ≥13 on the Edinburgh Postnatal Depression Scale (EPDS). Cutoff scores may be adjusted by 3-5 points to facilitate recruitment.\n\nExclusion Criteria:\n\n* There are no exclusion criteria with respect to parity or gravidity.\n\n  * Participants who are unable to provide informed consent or assent in English or Xhosa\n  * Have a significant psychiatric illness (e.g., active psychotic disorder or untreated bipolar disorder) that could interfere with participation will be excluded. Positive symptoms of active psychosis or mania will be assessed by the research assistants. They will be trained to identify delusions, hallucinations, disorganized or pressured speech, flight of ideas, and grandiosity as they speak to potential participants.\n  * Potential participants will also be asked if they have any health conditions that make it difficult for them to travel to the clinic.","FEMALE",{"count":452,"type":21},118,[24],"Pregnant women in South Africa (SA) are at high risk of HIV acquisition. Pre-exposure prophylaxis (PrEP) use during pregnancy is both safe and effective in preventing HIV. However, posttraumatic stress (associated with intimate partner violence and\u002For other traumas) and depression negatively impact PrEP adherence among women in SA. Addressing posttraumatic stress and depression will likely improve PrEP adherence and persistence (i.e., sustained PrEP adherence over time) during pregnancy and breastfeeding, which are periods of dramatically increased HIV risk. The overarching goal of this proposal is to develop and test the feasibility and acceptability of a cognitive behavioral intervention that targets common underlying factors of posttraumatic stress and depression to improve PrEP adherence and persistence during pregnancy and the postpartum transition. The specific aims of the project are to (1) explore the mechanisms by which posttraumatic stress and depression impact PrEP adherence and persistence during pregnancy via qualitative interviews; (2) develop a brief PrEP adherence and persistence intervention (\\~4 sessions) that reduces the negative impact of psychological mechanisms common to posttraumatic stress and depression on PrEP use, and builds behavioral skills to improve self-care; and (3) evaluate the feasibility, acceptability, and signals of preliminary efficacy of the intervention, which will be integrated into antenatal care, in a pilot randomized controlled trial. All data will be collected in the Midwife Obstetrics Unit (MOU) in Gugulethu, a peri-urban settlement and former township community outside of Cape Town, SA.",[412,456,457,458],"Posttraumatic Stress Disorder","Pregnancy Related","Medication Adherence",[460],"HIV, pregnancy, PrEP","2026-07-15",{"date":388,"type":37},{"date":464,"type":37},"2025-04-17",{"date":466,"type":21},"2027-07-30",{"name":42,"class":43},{"id":469,"slug":470,"hasResults":12,"nctId":471,"briefTitle":472,"officialTitle":473,"acronym":4,"eligibilityCriteria":474,"healthyVolunteers":51,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":475,"targetDuration":4,"studyType":22,"phases":476,"briefSummary":478,"conditions":479,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":481,"lastUpdatePostDateStruct":482,"startDateStruct":484,"completionDateStruct":486,"leadSponsor":488,"locationsCount":74},"100608958","early-phase-1-restructuring-the-alpha-gamma-code-in-aging-vision-100608958","NCT07208318","Restructuring the Alpha-Gamma Code in Aging Vision","Rescuing Visual Perception in Aging Adults by Restructuring the Alpha-Gamma Neural Code","Inclusion Criteria:\n\n* 18+ years of age or older\n* normal or corrected-to-normal visual acuity, color vision, and stereo vision\n\nExclusion Criteria:\n\n* not pregnant,\n* no metal implants in head,\n* no implanted electronic devices,\n* no history of neurological problems or head injury,\n* no skin sensitivity,\n* no claustrophobia,\n* no dementia (normal Mini Mental State Examination between 24-30; Montreal Cognitive Assessment \\> 25)\n* no depression (normal Beck Depression Inventory II \\\u003C13; Geriatric Depression Scale \\\u003C 10)\n* no ophthalmological diseases (e.g., strabismus, glaucoma, cataract, macular degeneration)\n* no history of psychosis\n* no cognitive deficits (MMSE score\\>24; MoCA\\>25)\n* cannot be taking any psychoactive medication.",{"count":281,"type":21},[477],"EARLY_PHASE1","Tests whether age-related visual deficits arise from disrupted alpha-gamma coupling in visual cortex (V1) and MT. Uses fMRI, source-resolved HD-EEG, and personalized complex-waveform HD-tACS to (1) quantify aging effects on phase-amplitude coupling, (2) drive PAC into a preferred \"gamma-at-alpha-troughs\" state, and (3) bidirectionally change perception by aligning gamma to alpha troughs vs peaks. Two five-day, double-blind, sham-controlled studies (n=120 each) target contrast sensitivity (V1) and 3D shape-from-motion (MT), aiming for mechanistic insight and remediation in older adults with implications for ADRD.",[317,480,318],"Visual Perception","2026-07-14",{"date":483,"type":37},"2026-07-16",{"date":485,"type":37},"2026-04-02",{"date":487,"type":21},"2030-08-31",{"name":42,"class":43},{"id":490,"slug":491,"hasResults":12,"nctId":492,"briefTitle":493,"officialTitle":494,"acronym":495,"eligibilityCriteria":496,"healthyVolunteers":51,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":497,"targetDuration":4,"studyType":22,"phases":499,"briefSummary":500,"conditions":501,"keywords":503,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":508,"lastUpdatePostDateStruct":509,"startDateStruct":511,"completionDateStruct":512,"leadSponsor":513,"locationsCount":74},"100602868","assessing-the-performance-of-7-day-vs-1-day-packaging-for-small-quantity-lipid-based-nutrient-supplements-in-ghana-sqlns7d-1d-comparison-100602868","NCT07129109","Assessing the Performance of 7-Day vs 1-Day Packaging for Small Quantity Lipid-Based Nutrient Supplements in Ghana (SQLNS:7D-1D Comparison)","Assessing the Performance of 7-Day vs 1-Day Packaging for Small Quantity Lipid-Based Nutrient Supplements in Ghana (SQLNS:7Dv1D Comparison)","SQLNS:7Dv1D","Inclusion Criteria:\n\n* Primary caregiver of a child aged 6-24 months attending growth monitoring and promotion (GMP) services at one of the participating health facilities\n* Willing and able to provide informed consent\n* Plans to remain in the area for the duration of the study period\n* Agrees to participate in surveys and\u002For interviews related to supplement use\n\nExclusion Criteria:\n\n* Caregiver of a child with a diagnosed severe illness requiring hospitalization\n* Caregiver under the age of 18",{"count":498,"type":21},505,[24],"This cluster-randomized crossover trial evaluates the impact of two different packaging formats for small-quantity lipid-based nutrient supplements (SQ-LNS) on adherence and acceptability among caregivers of young children in Northern Ghana. SQ-LNS are a proven intervention for reducing child malnutrition, but optimizing packaging formats may improve adherence and scalability.\n\nSixteen health facilities participating in growth monitoring services will each receive both formats: a 1-day sachet (20g daily) and a 7-day bulk container (140g weekly), with the order of delivery randomized. Each packaging format will be distributed for one month before cross-over. The primary outcomes are adherence (measured through caregiver self-report and sachet counts) and acceptability (assessed via caregiver interviews). Secondary outcomes include caregiver preference, ease of use, and qualitative insights into feeding practices, beliefs, and packaging usability.\n\nThis implementation research study uses a convergent mixed-methods design, integrating quantitative adherence and acceptability data with in-depth interviews and structured observations to inform real-world program implementation. Findings will guide policy and program decisions for integrating SQ-LNS into child health platforms in Ghana and other low-resource settings.",[502],"Child Malnutrition",[504,505,506,507],"Small-quantity lipid-based nutrient supplements (SQ-LNS)","Ghana","Infant and young child feeding","Growth monitoring and promotion (GMP)","2026-07-09",{"date":510,"type":37},"2026-07-10",{"date":70,"type":21},{"date":98,"type":21},{"name":42,"class":43},{"id":515,"slug":516,"hasResults":12,"nctId":517,"briefTitle":518,"officialTitle":519,"acronym":4,"eligibilityCriteria":520,"healthyVolunteers":51,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":521,"targetDuration":4,"studyType":22,"phases":523,"briefSummary":524,"conditions":525,"keywords":527,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":531,"lastUpdatePostDateStruct":532,"startDateStruct":534,"completionDateStruct":536,"leadSponsor":537,"locationsCount":74},"100605152","project-empower-ocd-100605152","NCT07158801","Project EMPOWER-OCD","A Web-based Single Session Intervention to Reduce Caregiver Distress and Accommodation in Socioeconomically Diverse Caregivers of OCD Patients","Inclusion Criteria:\n\n* be a caregiver for at least one individual with OCD, defined as living in the same household and providing daily care\n* be 18 years old or older\n* the individual they are caring for have clinically significant OCD symptoms, indicated by a score a 16 or above on the self-reported Children's Yale-Brown Obsessive Compulsive Scale - Parent Report (CY-BOCS-PR)\n* speak, read, and write English\n* not be in concurrent family-based CBT treatment for the patient's OCD.\n\nExclusion Criteria:\n\n* does not speak English\n* younger than 18 years old\n* participation in concurrent family-based CBT treatment for the patient's OCD.",{"count":522,"type":21},110,[24],"This research study aims to adapt and evaluate the acceptability and effectiveness of Project EMPOWER-OCD for socioeconomically diverse caregivers of patients with OCD. Designed to reduce obstacles (e.g. months long time commitment, high cost, transportation) to treatment that caregivers may be particularly prone to, project EMPOWER-OCD will provide targeted intervention of accommodation - a well-established, potentially modifiable risk factor for child anxiety, OCD, and its related disorders - in a single, self-guided session via an online format.",[526],"Obsessive-Compulsive Disorder",[528,526,529,530],"Parental Accommodation","Caregiving","Single Session Interventions","2026-06-08",{"date":533,"type":37},"2026-06-10",{"date":535,"type":37},"2025-03-25",{"date":70,"type":21},{"name":42,"class":43},{"id":539,"slug":540,"hasResults":12,"nctId":541,"briefTitle":542,"officialTitle":543,"acronym":544,"eligibilityCriteria":545,"healthyVolunteers":51,"sex":17,"minAge":546,"maxAge":4,"enrollmentInfo":547,"targetDuration":4,"studyType":22,"phases":549,"briefSummary":550,"conditions":551,"keywords":554,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":557,"lastUpdatePostDateStruct":558,"startDateStruct":560,"completionDateStruct":562,"leadSponsor":564,"locationsCount":44},"100572688","future-leaders-program-testing-a-youth-leadership-engagement-and-mindfulness-program-100572688","NCT06736522","Future Leaders Program: Testing a Youth Leadership, Engagement, and Mindfulness Program","Can A Youth Leadership and Mindfulness Program Support Well-being in Adolescence?","FLP","Inclusion Criteria:\n\n* Adolescents ages 14 and older in grades 9-12 during the Fall\u002FWinter or in grades 9-11 during the Spring\n* Enrolled in a partner site in Massachusetts or Illinois\n* Adolescents are only included with parent consent and youth assent if they are under the age of 18. Adolescents at least 18 years old can provide consent.\n\nExclusion Criteria:\n\n* They participated in the pilot phase (UG3)\n* They cannot commit to participation in the full study (e.g., attendance at all intervention sessions)\n* They are not in grades 9-12 at a partner site\n* Parent\u002Fguardian has a preferred consent language other than English or Spanish.","14 Years",{"count":548,"type":21},504,[24],"The current study tests the feasibility and effectiveness of a youth intervention designed to provide meaningful leadership opportunities through the acquisition of leadership skills as well as mindfulness practice, LEAP: Leadership, Engagement, and youth Action Program with Mindfulness.\n\nThe goal of this project is to determine whether the Leadership, Engagement, and youth Action Program with Mindfulness (LEAP) curriculum, which was developed with youth, is a feasible and effective intervention for fostering leadership and well-being. The investigators seek to understand whether LEAP can support wellbeing for youth as a strategy to increase youth mental, emotional, and behavioral (MEB) health.",[552,553],"Adolescent Behavior Problem","Mental Health Wellness 1",[61,555,556],"youth leadership","youth wellbeing","2026-06-02",{"date":559,"type":37},"2026-06-04",{"date":561,"type":37},"2024-12-16",{"date":563,"type":21},"2028-03",{"name":42,"class":43},{"id":566,"slug":567,"hasResults":12,"nctId":568,"briefTitle":569,"officialTitle":570,"acronym":4,"eligibilityCriteria":571,"healthyVolunteers":51,"sex":17,"minAge":572,"maxAge":573,"enrollmentInfo":574,"targetDuration":4,"studyType":22,"phases":575,"briefSummary":576,"conditions":577,"keywords":582,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":589,"lastUpdatePostDateStruct":590,"startDateStruct":592,"completionDateStruct":594,"leadSponsor":596,"locationsCount":74},"100638794","word-learning-in-bilingual-typical-and-late-talking-children-the-role-of-meaning-and-input-100638794","NCT07600242","Word Learning in Bilingual Typical and Late Talking Children: The Role of Meaning and Input","Dual Language Input, Semantic Structure and Word Learning in Typically Developing and Late Talking Bilingual Children","Inclusion Criteria:\n\n* At least 10% exposure to both English and Spanish or at least 90% exposure to English and another language\n\nExclusion Criteria:\n\n* Hearing impairment\n* Uncorrected visual impairment\n* Neurological impairment\n* Genetic syndromes\n* Neurodevelopmental disabilities (e.g. autism)\n* More than 10% exposure to a language other than English or Spanish","24 Months","30 Months",{"count":405,"type":21},[24],"The goal of this clinical trial is to understand how different types of word categories, along with the language children hear from their parents, support bilingual toddlers' word learning. This study will address two main questions: (1) How are the words toddlers know related to the words their parents use? and (2) How does what toddlers already know help them learn new words in two languages? The investigators will compare bilingual toddlers with typical development to those with language delay to determine whether they learn new words in similar ways.\n\nChildren's vocabulary knowledge will be assessed using standardized parent-report checklists. To examine how different types of categories support learning, the study will focus on two early-acquired categories: animals and clothing. The investigators will compare what parents report about their children's vocabulary with how children learn new words within each category.\n\nTo understand the role of parent input, children and their parents will engage in shared book reading and play activities using materials from one of the target categories. Parent-child interactions will be video recorded. Children will also complete an eye-tracking task in which they learn new words in two languages within the same category.",[578,579,580,581],"Bilingualism","Vocabulary Acquisition","Late Talkers","Network Science",[583,584,585,586,587,588],"bilingualism","late talkers","parent input","toddlers","word learning","vocabulary","2026-05-19",{"date":591,"type":37},"2026-05-20",{"date":593,"type":37},"2025-12-16",{"date":595,"type":21},"2029-07-31",{"name":42,"class":43},{"id":598,"slug":599,"hasResults":12,"nctId":600,"briefTitle":601,"officialTitle":602,"acronym":603,"eligibilityCriteria":604,"healthyVolunteers":12,"sex":17,"minAge":81,"maxAge":4,"enrollmentInfo":605,"targetDuration":4,"studyType":22,"phases":607,"briefSummary":608,"conditions":609,"keywords":611,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":617,"lastUpdatePostDateStruct":618,"startDateStruct":620,"completionDateStruct":622,"leadSponsor":624,"locationsCount":74},"100568696","telehealth-exercise-and-mindfulness-for-pain-in-osteoarthritis---stage-1b-100568696","NCT06684587","Telehealth Exercise and Mindfulness for Pain in Osteoarthritis - Stage 1B","Telehealth Exercise and Mindfulness for Pain in Osteoarthritis: A Stage 1B Feasibility Study","TEMPO-1B","Inclusion Criteria:\n\n* Meet National Institute for Health and Clinical Excellence clinical guidelines for knee osteoarthritis (i.e., age ≥ 50 years, presence of activity related pain, no morning knee stiffness or presence of morning knee stiffness ≤ 30 minutes)\n* BMI\\\u003C40\n* Knee pain on most days for 3 months or more\n* Average overall knee pain severity of ≥ 4 on an 11-point numeric rating scale over last 7 days, at least 2 weeks apart\n* Able to attend remote sessions\n* Can speak and understand English at a sufficient level to understand the study procedures and informed consent.\n* Available for study duration\n\nExclusion Criteria:\n\n* Contraindications to exercise\n* Other pain in lower back or legs that is greater than knee pain\n* Received physical therapy treatment for knee OA in the past 6 months or currently receiving physical therapy\n* Received any mindfulness programs such as Tai Chi, meditation, etc. in the past 6 months or currently receiving such program\n* Currently receiving chemotherapy or radiation therapy for cancer except non-melanoma skin cancer\n* History of other disease that may involve the index joint including inflammatory joint disease such as rheumatoid arthritis, seronegative spondyloarthropathy (eg, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease related arthropathy), crystalline disease (eg, gout or pseudogout), lupus erythematosus, knee joint infections, Paget's disease affecting the knee, or knee joint tumors.\n* Any knee surgery in the previous 6 months\n* Joint replacement in either hip or ankle\n* Previous knee osteotomy partial or total knee replacement in either knee\n* Planned major treatment for knee OA (e.g., surgery, injections, physical therapy) during the study period\n* Planned major surgery in the next 6 months\n* Corticosteroid or hyaluronic acid injections in either knee in the previous 3 months\n* Neurological conditions that impacts motor functioning (e.g., stroke, Parkinson's disease, Alzheimer's disease, Multiple Sclerosis, diabetic neuropathy, etc).\n* Pregnancy (self-report)\n* Participation in another clinical trial for any joint or muscle pain\n* Suspected or known drugs or alcohol abuse",{"count":606,"type":21},66,[24],"The goal of this randomized controlled trial (RCT) is to test the feasibility of an 10-week telehealth mindful exercise intervention compared to a telehealth exercise only intervention for people with knee osteoarthritis (OA). This RCT will be fully digital with all recruitment, assessments, and intervention being conducted remotely.",[610],"Knee Osteoarthritis",[612,613,614,615,616],"Telehealth","Exercise","Mindfulness","Pain","Feasibility","2026-04-30",{"date":619,"type":37},"2026-05-06",{"date":621,"type":37},"2025-04-24",{"date":623,"type":21},"2027-08",{"name":42,"class":43},""]