[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Bursa Yuksek Ihtisas Training and Research Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":290},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,46,75,97,124,151,186,214,240,269],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100649829","suprainguinal-fascia-iliaca-block-vs-adductor-canal-block-for-analgesia-after-total-knee-arthroplasty-100649829",false,"NCT07739108","Suprainguinal Fascia Iliaca Block vs. Adductor Canal Block for Analgesia After Total Knee Arthroplasty","Comparing Suprainguinal Fascia Iliaca Block Versus Adductor Canal Block for Postoperative Pain Control Following Total Knee Arthroplasty;A Prospective, Double-Blind Controlled Trial","Inclusion Criteria:\n\n* ASA Physical Status I, II, or III\n* Scheduled for elective unilateral primary total knee arthroplasty\n* Able to understand and operate the PCA device\n* Written informed consent provided\n\nExclusion Criteria:\n\n* Pre-existing lower-extremity neurological deficit or motor weakness (e.g., severe diabetic neuropathy)\n* Chronic opioid use (\\>30 mg oral morphine equivalents\u002Fday for \\>3 months)\n* Infection at the block site or systemic sepsis\n* Coagulopathy or bleeding diathesis\n* Allergy to local anesthetics or study medications\n* Revision TKA or bilateral knee procedures\n* Cognitive impairment or inability to perform mobility\u002Fpain assessments","ALL","45 Years","100 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study evaluates the analgesic efficacy and motor-sparing properties of ultrasound-guided Suprainguinal Fascia Iliaca Block (S-FIB) compared with Adductor Canal Block (ACB) in patients undergoing primary total knee arthroplasty (TKA). The main hypothesis is that ACB better preserves quadriceps muscle strength, allowing earlier functional mobilization, while providing comparable (non-inferior) analgesia to S-FIB.",[27,28],"Arthroplasty","Knee Osteoarthritis",[30,31,32,33],"Suprainguinal Fascia Iliaca Block","Adductor Canal Block","Ultrasound-Guided Nerve Block","Regional Anesthesia","NOT_YET_RECRUITING","2026-07-31",{"date":37,"type":38},"2026-08-03","ACTUAL",{"date":40,"type":21},"2026-08-12",{"date":42,"type":21},"2027-09-12",{"name":44,"class":45},"Bursa Yuksek Ihtisas Training and Research Hospital","OTHER_GOV",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},"100649967","paraspinal-nmes-and-spinopelvic-alignment-after-knee-arthroplasty-100649967","NCT07741162","Paraspinal NMES and Spinopelvic Alignment After Knee Arthroplasty","Effect of Paraspinal Neuromuscular Electrical Stimulation Added to Rehabilitation Program on Spinopelvic Alignment Parameters After Total Knee Arthroplasty: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 40 and 80 years\n* Diagnosis of primary knee osteoarthritis scheduled for total knee arthroplasty\n* Radiographic evidence of Kellgren-Lawrence grade 3-4 knee osteoarthritis\n* Preoperative knee flexion contracture ≥ 5°\n* Measurable spinopelvic malalignment, defined as meeting at least one of the following criteria: pelvic tilt (PT) \\> 20°, sagittal vertical axis (SVA) \\> 50 mm, or lumbar lordosis (LL) \\\u003C 40°\n* IIntact cognitive function based on clinical judgment, sufficient to understand and follow verbal commands, cooperate with the rehabilitation program, and reliably comply with functional assessment procedures\n* Provision of written informed consent\n* Able to stand independently and undergo standing lateral radiography\n\nExclusion Criteria:\n\n* Prior lumbar or thoracic spinal surgery\n* History of hip arthroplasty\n* Prior knee arthroplasty (revision arthroplasty patients)\n* Active inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis)\n* Neurological disease, including stroke, Parkinson's disease, peripheral neuropathy, or spinal cord pathology\n* Contraindications to NMES, including active cardiac pacemaker, implanted defibrillator, deep vein thrombosis, skin integrity impairment, malignancy, or epilepsy\n* Severe hip osteoarthritis or other lower extremity pathology significantly affecting spinopelvic alignment (e.g., leg length discrepancy, developmental hip dysplasia, contracture)\n* Inability to complete the standard rehabilitation protocol due to postoperative complications\n* Osteoporotic vertebral fracture or significant osteoporosis (T-score \\\u003C -2.5 at L1-L4)\n* Active treatment for malignancy\n* Psychiatric or medical condition that would prevent completion of the follow-up period\n* General contraindications to exercise","40 Years","80 Years",{"count":56,"type":21},80,[24],"Total knee arthroplasty (TKA) is a widely performed surgical procedure for patients with severe knee osteoarthritis. Following TKA, changes in lower extremity alignment and gait mechanics may influence the spinopelvic sagittal alignment, and postoperative rehabilitation programs traditionally focus on the knee joint without addressing the lumbopelvic chain.\n\nThis study aims to investigate whether adding paraspinal neuromuscular electrical stimulation (NMES) to a standard postoperative rehabilitation program (which includes quadriceps NMES) affects spinopelvic sagittal alignment parameters in patients undergoing TKA for primary knee osteoarthritis, compared with standard rehabilitation and quadriceps NMES alone.\n\nIn this single-center, prospective, randomized, single-blind (outcome assessor-blinded) controlled trial, eligible participants aged 40-80 years with primary knee osteoarthritis scheduled for TKA and with measurable spinopelvic malalignment will be randomly assigned in a 1:1 ratio to receive either standard rehabilitation with quadriceps NMES plus paraspinal NMES (intervention group) or standard rehabilitation with quadriceps NMES alone (control group) for 4 weeks (20 sessions).\n\nThe primary outcome is the change in radiographic spinopelvic parameters - including pelvic tilt, sacral slope, pelvic incidence, lumbar lordosis, sagittal vertical axis, and spinosacral angle - measured on standing lateral whole-spine radiographs at baseline (preoperative), before rehabilitation, after the 4-week intervention, and at 6-month follow-up. Secondary outcomes include knee and back pain (VAS), functional and quality-of-life measures (WOMAC, Knee Society Score, Forgotten Joint Score, Oswestry Disability Index, Nottingham Health Profile), performance-based tests (Timed Up and Go, 6-Minute Walk Test), and knee range of motion.\n\nThe investigators hypothesize that adding paraspinal NMES to standard rehabilitation will result in greater improvement in spinopelvic alignment parameters, and potentially in clinical\u002Ffunctional outcomes, compared with standard rehabilitation alone.",[28,60],"Postoperative Rehabilitation",[62,63,64,65,66],"Total knee arthroplasty","Spinopelvic alignment","Neuromuscular electrical stimulation","Postoperative rehabilitation","Paraspinal muscles","2026-07-27",{"date":37,"type":38},{"date":70,"type":21},"2026-07-30",{"date":72,"type":21},"2027-07-30",{"name":44,"class":45},1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":82,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100648643","aerobic-exercise-effects-in-lower-extremity-lymphedema-100648643","NCT07726277","Aerobic Exercise Effects in Lower Extremity Lymphedema","Effects of Aerobic Exercise on Ultrasonographic Parameters, Functional Status, Balance, and Quality of Life in Patients With Lower Extremity Lymphedema","Inclusion Criteria:\n\n* Diagnosis of lower extremity lymphedema (unilateral or bilateral)\n* Age ≥18 years\n* Absence of cognitive impairment\n* Provision of written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Cognitive impairment\n* Presence of general contraindications to exercise (e.g., hemodynamic instability, uncontrolled hypertension, decompensated heart failure, recent myocardial infarction, or unstable angina pectoris)\n* Presence of neurological diseases affecting the lower extremities that would preclude participation in the exercise program\n* Presence of unhealed fractures in the lower extremities preventing exercise therapy\n* Active systemic infection or local infection in the treatment area, such as cellulitis, erysipelas, or thrombophlebitis in the lower extremities\n* Acute venous thromboembolic events involving the lower extremities\n* Heart failure or renal failure that may cause lower extremity edema\n* Presence of concomitant lipedema\n* Presence of venous insufficiency\n* Ongoing chemotherapy or radiotherapy (among patients with malignancy-related lymphedema)\n* Pregnancy","18 Years",{"count":84,"type":21},50,[24],"Lower extremity lymphedema negatively affects patients' functional status, quality of life, and activities of daily living. Complete decongestive therapy (CDT) is considered the gold-standard conservative treatment for patients with lymphedema. CDT consists of manual lymph drainage (MLD), skin care, compression bandaging, and exercise. Several studies have demonstrated the effectiveness of CDT in patients with lower extremity lymphedema. However, the results of studies investigating the effectiveness of different types of exercise are inconsistent. Moreover, most of these studies have been conducted in patients with upper extremity lymphedema, and the outcome measures have generally been limited to limb circumference measurements and quality of life assessments.\n\nTo the best of our knowledge, no previous study has comprehensively evaluated the effects of aerobic exercise on both ultrasonographic parameters (quantitative data) and functional outcomes in patients with lower extremity lymphedema, as planned in the present study. Therefore, this study was designed to contribute to the existing literature by investigating these effects.",[88],"Lower Extremity Lymphedema","2026-07-22",{"date":91,"type":38},"2026-07-24",{"date":93,"type":21},"2026-08-01",{"date":95,"type":21},"2027-03-15",{"name":44,"class":45},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":82,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":107,"conditions":108,"keywords":111,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":4},"100644915","hfnc-for-postoperative-atelectasis-after-laparoscopic-surgery-100644915","NCT07676760","HFNC for Postoperative Atelectasis After Laparoscopic Surgery","The Role of High-Flow Nasal Cannula in Monitoring Postoperative Atelectasis With Lung Ultrasonography After Laparoscopic Surgery: A Prospective Observational Study","Inclusion Criteria:\n\n* Adult patients aged 18 years and older\n* Patients scheduled for elective laparoscopic surgery (general surgery, urology, gynecology)\n* Patients undergoing mechanical ventilation under general anesthesia\n* ASA physical status I-III\n* Patients providing written informed consent\n\nExclusion Criteria:\n\n* Severe or uncontrolled chronic obstructive pulmonary disease, asthma, or other chronic pulmonary diseases\n* Patients with atelectasis or pleural effusion detected on preoperative lung ultrasonography\n* Patients requiring intraoperative recruitment maneuver\n* ASA physical status IV or above\n* Patients receiving spinal or epidural anesthesia\n* Cases requiring conversion to laparoscopy or laparotomy\n* Patients refusing to participate",{"count":105,"type":21},90,"OBSERVATIONAL","Pneumoperitoneum and Trendelenburg positioning during laparoscopic surgery promote atelectasis development, which has been reported in up to 90% of patients under general anesthesia and increases the risk of postoperative pulmonary complications. High-flow nasal cannula (HFNC) oxygen therapy may reduce post-extubation atelectasis through alveolar recruitment. This prospective observational cohort study aims to evaluate the role of HFNC in postoperative atelectasis monitored by lung ultrasonography (LUS) in patients undergoing elective laparoscopic surgery.",[109,110],"Postoperative Atelectasis","Postoperative Pulmonary Complications",[112,113,109,114,115],"High-Flow Nasal Cannula","Lung Ultrasonography","Laparoscopic Surgery","Pneumoperitoneum","2026-06-27",{"date":118,"type":38},"2026-06-30",{"date":120,"type":21},"2026-07",{"date":122,"type":21},"2027-07",{"name":44,"class":45},{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":131,"minAge":82,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":135,"conditions":136,"keywords":139,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":74},"100643852","vnotes-vs-laparoscopy-respiratory-mechanics-and-hemodynamics-100643852","NCT07667907","vNOTES vs Laparoscopy: Respiratory Mechanics and Hemodynamics","Comparison of the Effects of vNOTES and Laparoscopic Gynecological Surgery on Intraoperative Respiratory Mechanics and Hemodynamics: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Female patients aged 18 to 75 years\n* Patients scheduled for elective gynecological surgery\n* Patients undergoing mechanical ventilation under general anesthesia\n* ASA physical status I-III\n* Patients providing written informed consent\n\nExclusion Criteria:\n\n* Severe or uncontrolled chronic obstructive pulmonary disease, asthma, or other chronic pulmonary diseases\n* Cardiac arrhythmia\n* ASA physical status IV or above\n* Patients developing intraoperative hemodynamic instability\n* Patients receiving spinal or epidural anesthesia\n* Cases requiring conversion to laparoscopy or laparotomy\n* Patients refusing to participate","FEMALE","75 Years",{"count":134,"type":21},30,"Pneumoperitoneum and Trendelenburg position are unavoidable in laparoscopic surgery and are known to have adverse effects on intraoperative respiratory mechanics and hemodynamics. These conditions increase the risk of ventilator-induced lung injury (VILI) and highlight the importance of lung-protective ventilation strategies.\n\nvNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery) is a minimally invasive technique that requires less Trendelenburg tilt and lower insufflation pressures compared to conventional laparoscopic surgery, and may therefore offer a more favorable intraoperative profile.\n\nThis prospective, observational, single-center, parallel-group cohort study aims to compare respiratory mechanics parameters (Ppeak, Pplateau, DP, MPtot, MPdyn, Crs) and hemodynamic parameters (MAP, HR, vasopressor requirement) between vNOTES (n=15) and laparoscopic gynecological surgery (n=15) groups at four intraoperative time points.",[137,138],"Respiratory Mechanics","Hemodynamics",[140,141,137,138,115,142],"vNOTES","Laparoscopy","Trendelenburg","2026-06-19",{"date":145,"type":38},"2026-06-25",{"date":147,"type":21},"2026-07-01",{"date":149,"type":21},"2027-07-01",{"name":44,"class":45},{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":158,"enrollmentInfo":159,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":161,"conditions":162,"keywords":166,"overallStatus":177,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":74},"100641311","socio-cultural-level-health-literacy-and-parental-ct-demand-in-paediatric-minor-head-trauma-100641311","NCT07655310","Socio-Cultural Level, Health Literacy, and Parental CT Demand in Paediatric Minor Head Trauma","The Relationship Between Family Socio-Cultural Level, Health Literacy, and Parental Demand for Computed Tomography in PECARN-Stratified Children Presenting With Minor Head Trauma: A Single-Centre Prospective Observational Cohort Study","Inclusion Criteria:\n\n1. Age less than 18 years at time of emergency department presentation\n2. Presenting complaint of head trauma sustained within the preceding 24 hours\n3. Classified as minor head trauma at triage, defined as a Glasgow Coma Scale (GCS) score of 14 or 15 at initial assessment\n4. Accompanied by a parent or legal guardian with capacity to provide written informed consent\n\nExclusion Criteria:\n\n1. GCS score 13 or less at presentation (moderate or severe head injury)\n2. Transfer from another medical facility\n3. Head trauma sustained more than 24 hours before emergency department presentation\n4. Known coagulopathy, anticoagulant therapy, or bleeding disorder\n5. Ventriculoperitoneal shunt in situ\n6. Previous intracranial neurosurgery\n7. Pre-existing neurological disorder affecting GCS interpretation (e.g., cerebral palsy, developmental delay)\n8. Clinical suspicion of abusive head trauma (non-accidental injury) identified by the treating physician\n9. Concurrent multi-system trauma\n10. No accompanying parent or guardian available for consent and socio-cultural assessment","17 Years",{"count":160,"type":21},200,"Minor head trauma is one of the most frequent reasons for paediatric emergency department visits worldwide. The PECARN (Paediatric Emergency Care Applied Research Network) clinical decision rule stratifies children with minor head trauma into low-, intermediate-, and high-risk categories for clinically important traumatic brain injury (ciTBI) and provides evidence-based guidance on computed tomography (CT) ordering. Despite its high diagnostic accuracy, real-world CT utilisation frequently diverges from PECARN recommendations. Non-clinical family-level factors - including socio-cultural characteristics and health literacy - may drive part of this divergence, particularly through their influence on whether families explicitly request CT imaging.\n\nThis prospective observational cohort study will enrol 200 children with minor head trauma presenting to the emergency department of SBU Bursa Yuksek Ihtisas EAH, Bursa, Turkey. The primary aim is to determine whether family socio-cultural level (composite index incorporating education, occupation, income, and housing; scored 0-10) and health literacy (Newest Vital Sign-Turkish, NVS-TR) independently predict parental demand for CT imaging. Secondary aims include determining whether parental CT demand and family socio-cultural characteristics predict CT ordering by the treating physician, describing PECARN algorithm adherence patterns in this setting, and examining parental health-seeking behaviour at 7-day telephone follow-up.",[163,164,165],"Craniocerebral Trauma","Brain Injuries, Traumatic","Head Injuries, Closed",[167,168,169,170,171,172,173,174,175,176],"PECARN","paediatric head trauma","minor head trauma","computed tomography","health literacy","socio-cultural level","clinical decision rule","parental CT demand","emergency medicine","NVS-TR","RECRUITING","2026-06-17",{"date":180,"type":38},"2026-06-22",{"date":182,"type":38},"2024-04-10",{"date":184,"type":21},"2027-08",{"name":44,"class":45},{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":16,"minAge":82,"maxAge":54,"enrollmentInfo":193,"targetDuration":4,"studyType":22,"phases":194,"briefSummary":195,"conditions":196,"keywords":202,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":74},"100640980","parasacral-ischial-plane-block-in-lower-extremity-surgery-100640980","NCT07594197","Parasacral Ischial Plane Block in Lower Extremity Surgery","Evaluation of Sensory and Motor Blockade of Ultrasound-Guided Parasacral Ischial Plane Block in Lower Extremity Surgery","Inclusion Criteria:\n\n1. Ages 18-80\n2. ASA I-III\n3. Patients operated on under regional anesthesia\n4. Patients who provided written informed consent\n5. Patients scheduled for elective lower extremity surgery -\n\nExclusion Criteria:\n\n1. Patients with a history of allergy to local anesthetic drugs\n2. Patients with coagulation disorders\n3. Patients with BMI \\> 40 kg\u002Fm²\n4. Presence of infection at the block application site\n5. Chronic pain syndrome (chronic opioid use)\n6. Pregnant women\n7. Patients who cannot be communicated with\n8. Patients requiring emergency surgery -",{"count":20,"type":21},[24],"The parasacral ischial plane block is a novel fascial plane approach targeting the sacral plexus. This technique is technically less challenging and eliminates the requirement for direct visualization of the sacral plexus. The aim of this prospective observational study is to evaluate the efficacy of the conventional sacral plexus block versus the parasacral ischial plane block in patients undergoing lower extremity surgery.",[197,198,199,200,201],"Patients Scheduled for Elective Lower Extremity Surgery","Ages 18-80","ASA I-III","Patients Operated on Under Regional Anesthesia","Patients Who Provided Written Informed Consent",[203,204,205],"Lumbosacral Plexus","Anesthesia, Conduction","Postoperative Pain","2026-05-14",{"date":208,"type":38},"2026-05-18",{"date":210,"type":21},"2026-05-01",{"date":212,"type":21},"2027-05-01",{"name":44,"class":45},{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":16,"minAge":82,"maxAge":54,"enrollmentInfo":222,"targetDuration":224,"studyType":106,"phases":4,"briefSummary":225,"conditions":226,"keywords":228,"overallStatus":177,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":74},"100627725","optic-nerve-sheath-diameter-and-cognitive-outcomes-in-bentall-surgery-100627725","NCT07452367","Optic Nerve Sheath Diameter and Cognitive Outcomes in Bentall Surgery","Evaluation of the Relationship Between Bilateral Optic Nerve Sheath Diameter (ONSD) Measurements and Postoperative Cognitive Functions in Bentall Surgeries: A Prospective Observational Study","ONCOB","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Scheduled for elective Bentall procedure\n* Requiring cardiopulmonary bypass (CPB)\n* Willing to participate and able to provide informed consent\n* Able to complete the MoCA cognitive assessment test\n\nExclusion Criteria:\n\n* Age below 18 or above 80 years\n* Emergency Bentall surgery\n* Pre-existing diagnosed cognitive impairment or dementia\n* History of prior stroke or neurological disease\n* Significant carotid artery stenosis\n* Inability to complete the MoCA test (language barrier, illiteracy, visual or hearing impairment)\n* Refusal to participate or inability to provide informed consent\n* Patients with known psychiatric disorders\n* Reoperation (redo surgery)\n* Patients with severe renal or hepatic failure",{"count":223,"type":21},100,"1 Month","Bentall surgery is a major cardiac procedure involving replacement of the ascending aorta, aortic root, and aortic valve, typically requiring cardiopulmonary bypass (CPB) and sometimes deep hypothermic circulatory arrest (DHCA). Due to its complexity, it carries a significant risk of postoperative neurological complications including stroke and postoperative cognitive dysfunction (POCD).\n\nThis prospective observational study aims to evaluate the relationship between perioperative bilateral optic nerve sheath diameter (ONSD) measurements obtained by ultrasound and postoperative cognitive functions in patients undergoing elective Bentall surgery. ONSD is a non-invasive surrogate marker of intracranial pressure that can be measured at the bedside using ultrasound.\n\nIn addition to routine hemodynamic monitoring and cerebral oximetry (NIRS), bilateral ONSD will be measured at predefined intraoperative and postoperative time points. Cognitive function will be assessed using the Montreal Cognitive Assessment (MoCA) test preoperatively and postoperatively, and delirium will be evaluated using the CAM-ICU scale during ICU stay. The association between perioperative ONSD values and postoperative cognitive outcomes, extubation time, ICU stay, and neurological complications will be analyzed.",[227],"Postoperative Cognitive Dysfunction",[229,230,231],"Bentall surgery","Optic nerve sheath diameter","Postoperative cognitive dysfunction","2026-03-05",{"date":234,"type":38},"2026-03-06",{"date":236,"type":38},"2025-08-30",{"date":238,"type":21},"2026-08-30",{"name":44,"class":45},{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":246,"eligibilityCriteria":247,"healthyVolunteers":11,"sex":16,"minAge":82,"maxAge":4,"enrollmentInfo":248,"targetDuration":249,"studyType":106,"phases":4,"briefSummary":250,"conditions":251,"keywords":255,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":4},"100623517","ultrasound-based-prediction-of-hemodynamic-instability-during-cvvhdf-initiation-100623517","NCT07397663","Ultrasound-Based Prediction of Hemodynamic Instability During CVVHDF Initiation","Prediction of Intradialytic Hypotension at the Initiation of Continuous Venovenous Hemodiafiltration Using Multimodal Ultrasonographic and Hemodynamic Parameters in Intensive Care Unit Patients","US-CVVHDF","Inclusion Criteria:\n\n* Adult patients (≥18 years) admitted to the intensive care unit\n* Indication for continuous venovenous hemodiafiltration\n* Adequate transthoracic echocardiographic image quality\n* Written informed consent obtained from legal representatives\n\nExclusion Criteria:\n\n* Acute coronary syndrome\n* Severe valvular heart disease or pericardial effusion\n* Significant arrhythmias interfering with Doppler measurements\n* Presence of pacemaker, ICD, or ventricular assist device\n* Poor echocardiographic imaging window\n* Life expectancy less than 24 hours",{"count":56,"type":21},"1 Year","This prospective observational study aims to evaluate the ability of transthoracic echocardiographic and bedside ultrasonographic parameters to predict intradialytic hypotension and hemodynamic instability at the initiation of continuous venovenous hemodiafiltration (CVVHDF) in adult intensive care unit patients.",[252,253,254],"Renal Failure , Chronic","Intradialytic Hypotension","Critical Illness",[253,256,257,258,259,260],"LVOT VTI","CVVHD","Renal Resistive Index","Echocardiography","VExUS","2026-02-11",{"date":263,"type":38},"2026-02-13",{"date":265,"type":21},"2026-02-10",{"date":267,"type":21},"2027-02-10",{"name":44,"class":45},{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":4,"eligibilityCriteria":275,"healthyVolunteers":11,"sex":16,"minAge":82,"maxAge":276,"enrollmentInfo":277,"targetDuration":4,"studyType":22,"phases":278,"briefSummary":279,"conditions":280,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":74},"100600382","effect-of-injection-duration-of-fascial-plane-blocks-on-block-success-100600382","NCT07096765","Effect of Injection Duration of Fascial Plane Blocks on Block Success","Effect of Injection Duration of Fascial Plane Blocks on Block Success and Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Laparoscopic cholecystectomy surgery\n* Patients with ASA (American Society of Anaesthetists) scores I and III will be included.\n\nExclusion Criteria:\n\n* Uncontrolled Arterial Hypertension\n* Uncontrolled Diabetes Mellitus,\n* Mental retardation\n* Antidepressant use\n* Metabolic disorders\n* Bleeding diathesis\n* Patients with a body mass index above 30","65 Years",{"count":223,"type":21},[24],"This prospective observational study aims to evaluate the impact of injection duration during fascial plane blocks on block success and analgesic efficacy in patients undergoing laparoscopic cholecystectomy. The hypothesis is that shorter injection durations increase injection pressure, potentially limiting local anesthetic spread, while longer durations facilitate broader anesthetic distribution.",[281],"Nerve Block","2025-07-24",{"date":284,"type":38},"2025-07-31",{"date":286,"type":21},"2025-08-01",{"date":288,"type":21},"2026-02-01",{"name":44,"class":45},""]