[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Centre Hospitalier Intercommunal Aix-Pertuis\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":67},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100649983","monitoring-of-neuromuscular-blockade-in-the-intensive-care-unit-a-reliability-study-100649983",false,"NCT07741851","Monitoring of Neuromuscular Blockade in the Intensive Care Unit: a Reliability Study","CURAREA","Inclusion Criteria:\n\n* Adult patients\n* Patients admitted to the intensive care unit who have been receiving neuromuscular blocking agents for at least 24 hours during their stay - Consent obtained from the patient or emergency consent obtained from family members\n* Patients covered by the French social security system, regardless of the specific plan\n\nExclusion Criteria:\n\n* Patients who have already been exposed to prolonged neuromuscular blockade or who have been receiving continuous neuromuscular blockade for less than 24 hours\n* Allergy to neuromuscular blocking agents\n* Patients with a neurological condition that alters the interpretation of neuromuscular blockade or contraindicates the use of neuromuscular blocking agents\n* Patients enrolled in an interventional study\n* Patients who object to the collection of their medical data for this study\n* Patients under the age of 18\n* Patients deprived of their liberty, under guardianship, or under conservatorship\n* Pregnant or breastfeeding women","ALL","18 Years",{"count":19,"type":20},160,"ESTIMATED","INTERVENTIONAL",[23],"NA","The objective of this clinical trial is to evaluate the reliability of neuromuscular blockade monitoring in adult intensive care patients depending on the clinical context.\n\nThe main questions it aims to answer are as follows:\n\n* Detection of an anomaly at ulnar \"TOF\" stimulation in patients without neuromuscular blockade\n* Absence of adverse events during clinical monitoring of neuromuscular blockade (every 24 hours): absence of respiratory effort movements or patient-ventilator asynchrony (safety)",[26],"Neuromuscular Blockade Monitoring",[28,29,30,31],"intensive care","neuromusculare blockade monitoring","cisatracurium","TOF","RECRUITING","2026-07-28",{"date":35,"type":36},"2026-08-03","ACTUAL",{"date":38,"type":36},"2026-04-02",{"date":40,"type":20},"2027-01",{"name":42,"class":43},"Centre Hospitalier Intercommunal Aix-Pertuis","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":44},"100562737","immunity-markers-in-intensive-care-patients-and-ventilator-associated-pneumonia-100562737","NCT06607055","Immunity Markers in Intensive Care Patients and Ventilator-associated Pneumonia","Monitoring of Immunity Markers in Intensive Care Patients and Link with Recurrence and Relapse of Ventilator-associated Pneumonia","IMMUNAIX","Inclusion Criteria:\n\n* Patient over 18 years old\n* Patient admitted in the Intensive Care Unit of the CHIAP\n* Patient under mechanical ventilation\n* Patient with infectious pneumonia\n* Informed Consent Form (ICF) obtained from the patient or emergency ICF obtained from close relatives\n* Patient beneficiary of French social security, whatever the regime\n\nExclusion Criteria:\n\n* Patient under 18 years old\n* Patient with severe neutropenia (neutrophils \\\u003C 0.5 G\u002FL)\n* Patient under immunosuppressive treatment\n* Use of corticosteroids (intravenous or oral) prior to ICU admission\n* Use of therapeutic antibodies\n* Onco-hematological disease (e.g. lymphoma, leukemia...) under treatment or treated in the 5 years prior to inclusion\n* End of chemotherapy 6 months prior to inclusion\n* Patients with innate or acquired immune deficiency (e.g., severe combined immunodeficiency, HIV or AIDS, at any stage)\n* Patients with a decision to limit or discontinue active therapies, at the time of inclusion\n* Patients with an estimated ICU stay of less than 48 hours\n* Participation in an interventional study\n* Patient deprived of their liberty\n* Patient under tutorship or curatorship\n* Pregnant or breastfeeding woman",{"count":54,"type":20},40,"OBSERVATIONAL","The goal of this observational study is to show the direct correlation between the occurrence of recurrence of VAP and postagressive immunoparalysis, monitored by HLA-DR rate below litterature-acknowledged threshold, in a well conducted antibiotherapy context, in patient admitted in the Intensive Care Unit.\n\nThe main questions it aims to answer are:\n\n* evaluation of the association between death and persistence of immunoplegia using HLA-DR monitoring\n* search an association between immunoplegia depth and severity of the initial state of shock\n* search an association between immunoplegia depth and viral reactivation\n* compare association of immunoplegia duration and HLA-DR nadir and VAP occurrence Blood samples will be taken from participants to HLA-DR dosage, at the time of inclusion and once a week then.",[58],"Pneumonia, Ventilator-Associated","2024-09-18",{"date":61,"type":36},"2024-09-23",{"date":63,"type":36},"2023-10-04",{"date":65,"type":20},"2025-09",{"name":42,"class":43},""]