[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Centre for Chronic Disease Control, India\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":104},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100648353","cardiovascular-kidney-metabolic-syndrome-registry-100648353",false,"NCT07718789","Cardiovascular-Kidney-Metabolic Syndrome Registry","CKMS Registry","Inclusion Criteria:\n\n1. Adults ≥18 years visiting select tertiary care hospitals AND\n2. Presenting with signs and\u002For symptoms of CKMS :\n\n   2.1. Adiposity i.e., Body Mass Index \\> 23, and\u002For large waist circumference \\[women: ≥ 80 cm; men: ≥ 90 cm\\] AND\u002FOR 2.2. Metabolic syndrome i.e., new or a known case of hypertension, type-2 diabetes, dyslipidaemia, chronic kidney disease, and\u002For PCOS.\n\n   AND\u002FOR 2.3. Presenting with signs of subclinical CVD and\u002For with a history of clinical CVD with metabolic syndrome AND\n3. Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n1. Stage 0 CKMS i.e., a healthy state characterized by normal body weight, absence of metabolic risk factors such as hypertension, type-2 diabetes, dyslipidemias, preserved kidney function with no evidence of CKD, and no subclinical or clinical manifestations of CVDs.\n2. Neuro-cognitive, psychiatric, or any surgical conditions which prevents in obtaining reliable clinical data.\n3. Any surgical and\u002For medical condition that is likely to prevent the participant from complying with the requirements of the study or completing the study.\n4. Participants already taking part in another clinical trial.\n5. Pregnant and\u002For lactating women.","ALL","18 Years",{"count":19,"type":20},2250,"ESTIMATED","1 Year","OBSERVATIONAL","The goal of this observational registry study is to learn about cardiovascular-kidney-metabolic syndrome, also called CKMS, among adults receiving care at tertiary care hospitals in India. CKMS describes the close relationship between excess body weight, metabolic conditions such as high blood pressure and diabetes, kidney disease, and cardiovascular disease.\n\nThe main questions this study aims to answer are:\n\n* What proportion of participants are in each stage of CKMS when they enter the study?\n* How do participants' CKMS stage and related health factors change over 12 months?\n* How does participants' quality of life change over time?\n* What are the prescription practices for CKMS?\n\nParticipants will:\n\n* Provide information about their general health, medical history, lifestyle, current medicines, family history, and quality of life.\n* Have measurements taken, including height, weight, waist circumference, and blood pressure.\n* Provide blood and urine samples for tests related to blood sugar, cholesterol, kidney function, inflammation, and heart health.\n* Undergo an electrocardiogram, also called an ECG, and a coronary artery calcium scan according to the study schedule.\n* Return for follow-up visits at 6 months and 12 months after joining the study. Participants will continue to receive their usual medical care as decided by their treating doctor. No experimental medicine or treatment will be provided as part of this study.\n\nThis multi-centre registry will include approximately 2250 adults from five tertiary care hospitals in India. The information collected will help researchers understand the burden, progression, risk factors, quality of life, and treatment patterns of CKMS in India.",[25],"Cardiovascular Kidney Metabolic Syndrome",[27,28,29,30,31,32,33,34,35,36],"Cardiovascular-Kidney-Metabolic Syndrome (CKMS)","Cardiovascular Disease","Cardiometabolic Health","Chronic Kidney Disease","Type 2 Diabetes Mellitus","Hypertension","Hyperglyceridaemia","Obesity","CKMS Staging","Registry","NOT_YET_RECRUITING","2026-07-16",{"date":40,"type":41},"2026-07-22","ACTUAL",{"date":43,"type":20},"2026-07-24",{"date":45,"type":20},"2027-12-31",{"name":47,"class":48},"Centre for Chronic Disease Control, India","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":73,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},"100640770","national-institute-for-health-and-care-research-global-health-research-centre-for-multiple-long-term-conditions-100640770","NCT07582380","National Institute for Health and Care Research Global Health Research Centre for Multiple Long-Term Conditions","NIHR-GHRC MLTC","Inclusion Criteria:\n\n* Adults aged 40 years or above\n* Attending the Primary Health Centre (PHC) during the enrollment period\n* Diagnosed with two or more of the following chronic conditions:\n\n  1. Hypertension\n  2. Diabetes mellitus\n  3. Depression\n  4. Anxiety\n  5. Chronic obstructive pulmonary disease (COPD)\n  6. Asthma\n  7. Vision impairment\n  8. Hearing impairment\n  9. Osteoarthritis\n  10. Chronic back pain\n\nExclusion Criteria:\n\n* Age \\\u003C 40 years\n* Presence of only one or none of the listed chronic conditions\n* Pregnant or breastfeeding women\n* Severe cognitive impairment or dementia that prevents informed consent or or reliable participation\n* Bedridden or terminally ill individuals with a life expectancy \\\u003C 6 month\n* Current participation in another clinical or interventional research study may interfere with study outcomes\n* Severe psychiatric illness (e.g., psychosis or bipolar disorder) other than depression or anxiety\n* Unable or unwilling to provide written informed consent\n* Severe communication barriers that prevent participation in interviews or questionnaires, even with assistance","40 Years","100 Years",{"count":59,"type":20},3600,"INTERVENTIONAL",[62],"NA","Multiple Long-Term Conditions (MLTC), defined as the coexistence of two or more chronic conditions, is increasingly prevalent in India. Despite this, the healthcare system remains largely focused on single-disease management, underscoring the urgent need for integrated, patient-centred approaches that are context-specific, equitable, and resource-sensitive.\n\nIndia's public health infrastructure is undergoing significant reform through the Ayushman Bharat Yojana, which aims to upgrade 150,000 sub-centres and primary health centres into Health and Wellness Centres (HWCs). These centres are designed to provide comprehensive care including prevention, treatment, and rehabilitation to underserved populations. This transformation presents a strategic opportunity to embed multi-morbidity care into the evolving system, supported by the establishment of a Global Health Research Centre dedicated to MLTC.\n\nThe NIHR Global Health Research Centre for Multiple Long-Term Conditions aims to transform the health system in India and Nepal by improving care for individuals living with MLTC. With chronic conditions on the rise due to epidemiological transitions, particularly among adults aged ≥40, there is an urgent need for integrated, people-centred care models. This project is being implemented in Anakapalli district (Andhra Pradesh), Jodhpur (Rajasthan), Sonipat (Haryana) and Nepal, encompassing both rural and urban contexts.\n\nThe study is conducted among adult patients with MLTCs attending rural primary providers (Medical officers and Staff Nurse) delivering services at these facilities in India and Nepal. The intervention comprises an electronic decision support system (EDSS) to facilitate evidence-based clinical decision-making, assisted telemedicine model to enable timely specialist consultations, and a patient-facing mobile application-supported by community champions and care coordinators to enhance care coordination, self-management, and treatment adherence.\n\nAt this stage, we have completed the case-mix and health facility assessments, alongside the in-depth interviews to identify challenges faced by patients, caregivers, and health care providers. Currently, we are pilot testing the health intervention in 4 PHCs in India and 2 PHCs in Nepal among 180 participants (30 participants per site). Findings from this pilot will inform refinement of the intervention, study tools, and implementation strategies, and will provide critical evidence on contextual adaptability to support the design of a subsequent cluster randomized controlled trial (RCT).\n\nIn the full RCT, we will evaluate the effectiveness of a health system intervention comprising an electronic clinical decision support system, assisted telemedicine, a patient-facing application, and community champions. The study will be conducted across selected sites in India and Nepal using a cluster randomized controlled design, in which Primary Health Centres (PHCs) are allocated to either the intervention or usual care arm. The intervention includes structured clinical workflows, a digital decision support system, assisted telemedicine, and patient-facing mobile health tools to strengthen continuity and coordination of care.\n\nParticipants will engage with these components over a six-month implementation period. Data collection will include participant surveys and qualitative interviews, complemented by routine supervision checklists and system usage analytics to assess implementation processes and usability.\n\nThe study findings will generate robust evidence to inform scalable and context-appropriate models of integrated care for multiple long-term conditions (MLTCs) in primary care settings in low- and middle-income countries. By embedding digital tools and strengthening PHC systems, the intervention aims to improve quality of life, reduce fragmentation of care, and establish a sustainable model for MLTC management.",[65,66,67,68,69,70,71,72],"Chronic Conditions, Multiple","Diseases of the Circulatory System","Diseases of the Respiratory System","Endocrine, Nutritional and Metabolic Diseases","Mental, Behavioral and Neurodevelopmental Disorders","Diseases of the Musculoskeletal System and Connective Tissue","Diseases of the Ear and Mastoid Process","Diseases of the Eye and Adnexa",[74],"Multiple long term conditions, MLTC, digital health, mHealth","2026-05-07",{"date":77,"type":41},"2026-05-12",{"date":79,"type":20},"2026-05-05",{"date":81,"type":20},"2028-08-30",{"name":47,"class":48},120,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},"100623707","assessing-feasibility-of-a-digital-health-intervention-for-multiple-long-term-condition-care-in-primary-health-settings-in-india-and-nepal-100623707","NCT07400133","Assessing Feasibility of a Digital Health Intervention for Multiple Long-Term Condition Care in Primary Health Settings in India and Nepal","NIHR Global Health Research Centre for Multiple Long-Term Conditions Pilot Study to Assess the Acceptability, Feasibility, Fidelity and Usability of a Co-designed Intervention to Improve Management of Multiple Long-term Conditions","NIHR GHRC MLTC",{"count":92,"type":20},180,"This observational, non-randomized, single-arm pilot study aims to assess the acceptability, feasibility, usability, and implementation fidelity of a co-designed multi-component digital health intervention to support the management of multiple long-term conditions (MLTCs) in Government primary health care settings. The study is conducted among adult patients with MLTCs attending rural primary health centres and the primary care providers (Medical officers and Staff Nurse) delivering services at these facilities in India and Nepal.\n\nThe intervention comprises an electronic decision support system (EDSS) to facilitate evidence-based clinical decision-making, assisted telemedicine model to enable timely specialist consultations, and a patient-facing mobile application-supported by community champions to enhance care coordination, self-management, and treatment adherence. Participants will engage with these components over a three month implementation period and will complete surveys and qualitative interviews, alongside routine supervision checklists and system-usage analytics, to generate implementation and usability data.\n\nThe study will be implemented across six rural primary health centres in Jodhpur (Rajasthan) and Anakapalli (Andhra Pradesh), India, and Kathmandu, Nepal, enrolling approximately 30 patients per site along with all participating health care providers. Findings from this pilot will inform refinement of the intervention, study tools, and implementation strategies, and will provide critical evidence on contextual adaptability to support the design of a subsequent cluster randomized controlled trial under the NIHR Global Health Research Centre for Multiple Long-Term Conditions.",[66,67,68,69,70,72,71],"2026-02-03",{"date":97,"type":41},"2026-02-10",{"date":99,"type":20},"2026-02-15",{"date":101,"type":20},"2026-05-30",{"name":47,"class":48},6,""]