[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":96},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100649468","early-phase-1-the-effectiveness-of-itraconazole-pulse-therapy-vs-topical-2-ketoconazole-in-the-treatment-of-moderate-to-severe-seborrheic-dermatitis-of-scalp-100649468",false,"NCT07734441","The Effectiveness of Itraconazole Pulse Therapy vs Topical 2% Ketoconazole in the Treatment of Moderate to Severe Seborrheic Dermatitis of Scalp.","The Effectiveness of Itraconazole Pulse Therapy vs Topical 2% Ketoconazole in the Treatment of Moderate to Severe Seborrheic Dermatitis of Scalp. A Randomized Control Trial","Inclusion Criteria:\n\n* Patients who are interested in taking part in research are between the ages of 14-17 with people who have scalp SD ranging from moderate to severe.\n\nExclusion Criteria:\n\n* Patients with heart disease. Pregnant women or lactating women liver disease patients as itraconazole can be hepatotoxic uncontrolled hypertension patient taking multiple drugs like oral antidiabetics, lipid lowering drugs, sedatives patient has history to hypersensitvity to either of drugs.","ALL","18 Years","65 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","This study is a randomized controlled trial comparing the effectiveness of oral itraconazole pulse therapy versus topical 2% ketoconazole shampoo in treating moderate to severe scalp seborrheic dermatitis (SD). SD is a chronic inflammatory skin condition associated with Malassezia yeast, characterized by scaling, itching, and redness, significantly affecting quality of life.\n\nA total of 80 participants aged (14-70 years) with moderate to severe scalp SD will be enrolled and divided into two groups. Group A will receive oral itraconazole (pulse regimen over 6 months), while Group B will use ketoconazole shampoo (initial daily use followed by twice weekly application). Outcomes will be assessed using the Scalp Seborrheic Dermatitis (SSD) score, Clinical Global Impression (CGI) scale, and Patient Global Impression (PGI) scale.\n\nThe study aims to compare:\n\nTreatment effectiveness Frequency of disease relapses Patient satisfaction Side-effect profiles Data will be analyzed using statistical tests (t-tests and chi-square), with significance set at p \\\u003C 0.05.\n\nThe hypothesis is that oral itraconazole pulse therapy is more effective than topical ketoconazole in controlling symptoms and preventing relapses in scalp SD.",[27],"Seborrheic Dermatitis",[29,30,31],"seborrheic dermatitis","scalp seborrheic dermatitis","moderate to severe disease","RECRUITING","2026-07-24",{"date":35,"type":36},"2026-07-29","ACTUAL",{"date":38,"type":36},"2026-01-07",{"date":40,"type":21},"2026-09-07",{"name":42,"class":43},"Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":44},"100633774","early-phase-1-comparison-of-effectiveness-of-intralesional-injectioms-of-5-flourouracil-alone-verses-its-cpmbination-with-cryotherapy-in-the-treatment-of-keloids-100633774","NCT07531056","Comparison Of Effectiveness Of Intralesional Injectioms Of 5 Flourouracil Alone Verses Its Cpmbination With Cryotherapy In The Treatment Of Keloids","A Randomized Controlled Trial Comparing The Effectiveness And Safety Of iIntralesional 5 Flourouracil Monotherapy Verses 5 Flourouracil Combined With Cryotherapy; In The Treatment Of Keloid Scars","Inclusion Criteria:\n\n* Patients willing to participate in the study\n* Patients of age group of 18 -50 years.\n* Patients having symptomatic keloids i.e., having pain, pruritus, restriction of movement, scar tension or disfigurement.\n\nExclusion Criteria\n\n:• Pregnant women or lactating women\n\n* Patients with history of hepatic, renal, cardiac diseases or chronic diarrhea.\n* Patients on immunosuppressant medications due to other diseases\n* Patients having myelosuppression checked by CBC.\n* Patient taking warfarin.\n* Patients with history of hypersensitivity to 5FU.","50 Years",{"count":54,"type":21},88,[24],"The goal of this clinical trial is to learn how well intralesional 5 fluorouracil with cryotherapy works to treat keloids as compared to intralesional 5 fluorouracil alone on keloids. It will also learn about the safety of both these treatments. The main questions it aims to answer are:\n\n* What well does cryotherapy followed by intralesional 5 fluorouracil (5FU) work to treat keloids as compared to 5 fluorouracil (5FU) alone?\n* What is participant's satisfaction when treated with cryotherapy followed by intralesional 5 fluorouracil (5FU) as compared to 5 fluorouracil (5FU) alone?\n* What skin problems do participants have when treated with cryotherapy followed by intralesional 5 fluorouracil (5FU) and 5 fluorouracil (5FU) alone? Researchers will compare cryotherapy followed by intralesional 5 fluorouracil (5FU) with 5 fluorouracil (5FU) alone to see how well both work.\n\nParticipants will be divided into two groups:\n\nFor Group A: Cryotherapy will be done at lesion site followed by intralesional 5FU every 3 weekly.\n\nFor Group B: Intralesional 5FU will be given at lesion site every 3 weekly. Keloids will be assessed at the start of trial and then after 12 weeks of treatment.",[58],"Keloids",[58,60,61],"Intralesional injectioms","5-FU","2026-04-21",{"date":64,"type":36},"2026-04-24",{"date":66,"type":36},"2025-12-22",{"date":68,"type":21},"2026-09-20",{"name":42,"class":43},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":44},"100623605","early-phase-1-effectiveness-of-micro-needling-with-5-fluorouracil-versus-potent-topical-steroids-in-the-treatment-of-limited-vitiligo-100623605","NCT07398807","Effectiveness of Micro-needling With 5 Fluorouracil Versus Potent Topical Steroids in the Treatment of Limited Vitiligo","Effectiveness of Combining Micro Needling With 5 Fluorouracil Versus Potent Topical Steroids; in Treating Limited Vitiligo- Randomised Controlled Study","Inclusion Criteria:\n\n* Patients willing to participate in the study\n* Patients of age group of 05 -70 years.\n* Vitiligo involving less than or equal to 10% body surface area.\n\nExclusion Criteria:\n\n* Patients using or have used other treatments for vitiligo\n* Pregnant women or lactating women\n* Patients with unstable vitiligo\n* Patients on immunosuppressant medications due to other diseases\n* Patients having anemia, immunosuppression, bleeding disorder, taking anticoagulants or anti-platelet drugs or having epilepsy\n* Patient having history of keloids or hypertrophic scars\n* Patients with history of hypersensitivity to either of the drugs","4 Years","70 Years",{"count":80,"type":21},40,[24],"The goal of this clinical trial is to learn how well 5 fluorouracil (5FU) with micro-needling works to treat limited vitiligo as compared to strong steroid applied on skin. It will also learn about the safety of both these treatments. The main questions it aims to answer are:\n\n* How well does 5FU with microneedling work to treat vitiligo by returning pigmentation in vitiligo patches as compared to steroid?\n* What is participant's satisfaction when treated with 5FU with microneedling as compared to steroid?\n* What skin problems do participants have when treated with FU with microneedling and steroid?\n\nResearchers will compare 5FU with microneedling to steroid application to see how well both work to return pigment in vitiligo patches.\n\nParticipants will be divided into two groups. For Group A, 5 FU will be rubbed and absorbed on the vitiligo patch after micro-needling every 2 weeks.\n\nFor group B, topical 0.05% clobetasol propionate ointment will be applied twice a day on the vitiligo patches for 12 weeks.\n\nVitiligo patches will be assessed at the start of trial and then after 12 weeks of treatment.",[84],"Vitiligo",[84,86,87,61],"Limited","Microneedling","2026-02-12",{"date":90,"type":36},"2026-02-17",{"date":92,"type":36},"2025-08-08",{"date":94,"type":21},"2026-02",{"name":42,"class":43},""]