[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"David A. Purger\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100656629","effects-of-transcutaneous-vagus-nerve-stimulation-on-pain-and-brain-activity-in-healthy-adults-100656629",false,"NCT07827690","Effects of Transcutaneous Vagus Nerve Stimulation on Pain and Brain Activity in Healthy Adults","The Effects of Transcutaneous Vagus Nerve Stimulation (tVNS) on Acute Pain Perception and Brain Activity in Healthy Adults","Inclusion Criteria:\n\n* Adults aged 18 to 70 years\n* Healthy, defined as having no history of chronic medical, neurological, or psychiatric conditions\n* Not currently experiencing acute illness or chronic pain\n* Not currently taking medications that influence the nervous system or pain sensitivity\n* Willing and able to provide written informed consent in English\n\nExclusion Criteria:\n\n* History of vagal or vasovagal symptoms\n* Respiratory distress\n* Cardiac arrhythmia\n* Sleep apnea\n* Pregnancy\n* Substance abuse\n* Primary psychiatric disorder\n* Prior vagus nerve stimulation or any implanted medical device\n* Significant acute or chronic neurologic illness that, in the judgment of the Principal Investigator, could compromise participant safety, limit the ability to complete the study, or compromise the objectives of the study",true,"ALL","18 Years","70 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn whether stimulating a nerve in the neck changes how much pain people feel. It also looks at whether this stimulation changes brain activity. The study is being done in healthy adults ages 18 to 70.\n\nThe nerve being studied is called the vagus nerve. It runs through the neck and connects to parts of the brain that handle pain. In this study, the nerve is stimulated from outside the body using a small device placed on the skin. There is no surgery, and nothing is implanted.\n\nThe main questions it aims to answer are: (1) Does stimulating the vagus nerve lower the pain people feel during a cold water test? (2) Does stimulating the vagus nerve change the electrical activity in the brain?\n\nResearchers will compare pain ratings and brain activity under three conditions in the same person: no stimulation, real stimulation over the vagus nerve, and sham stimulation placed nearby on the neck. Sham stimulation feels similar but is not aimed at the nerve.\n\nParticipants will: (1) Come to one visit that lasts about 90 minutes, with no follow-up visits, (2) Wear a cap that records the brain's natural electrical signals for the whole visit, (3) Place both hands in cold water, about 39 degrees Fahrenheit, up to three times for up to 2 minutes each time, (4) Rate their pain after each cold water test, (5) Wear a stimulation device on the neck during two of the three cold water tests, (6) Not be told which of those two is the real stimulation until the visit is over.",[28,29,30],"Acute Pain","Pain Perception","Healthy Adult Participants","NOT_YET_RECRUITING","2026-09-14",{"date":34,"type":35},"2026-09-18","ACTUAL",{"date":37,"type":22},"2026-09",{"date":39,"type":22},"2028-01",{"name":41,"class":42},"David A. Purger","OTHER",""]