[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"David Levinthal\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100614164","brain-stomach-circuits-in-chronic-nausea-100614164",false,"NCT07276035","Brain-Stomach Circuits in Chronic Nausea","TMS Neuromodulation of Brain-to-Stomach Circuits in Chronic Nausea","Inclusion Criteria:\n\n* Adults between ages 21-60 years old, with and without CNVS diagnosis per self-report.\n\nExclusion Criteria:\n\n* body mass index (BMI) \\> 30\n* pregnancy or intention to become pregnant\n* past or present chemotherapy\n* diagnosis of gastric (stomach) cancer\n* any kind of gastric (stomach) surgery\n* current use of GLP-1 receptor agonists (e.g. Ozempic, Trulicity)\n* medications which significantly lower seizure thresholds (e.g. bupropion (Wellbutrin), fluoxetine (Prozac), or tramadol (Ultram))\n* implantable devices, such as a pacemakers or nerve stimulators\n* history of head injury that required hospitalization, metal in the skull, or neurologic disease such as stroke, history of seizures or history of syncope (fainting or passing out)\n* neurodegenerative disease (Multiple Sclerosis, Parkinson's or Alzheimer's Disease)\n* ongoing psychosis or altered cognitive status status (e.g. hearing sounds or seeing visions that are not there, or feeling confused or suffering from memory lapses)\n* history of cardiovascular (i.e., heart attack), pulmonary (i.e., need for supplemental oxygen), or endocrine disease (e.g. diabetes)\n* current enrollment in another study using Transcranial Magnetic Stimulation (TMS)\n* current use of drugs such as amphetamines, methamphetamine, Ecstasy, Ketamine, Angel Dust\u002FPCP, cocaine, or drinking 3 or more alcoholic drinks per day\n* For healthy subjects only: chronic history of gastrointestinal symptoms (e.g., nausea, indigestion, bloating, abdominal pain)\n* For CNVS subjects only: diagnosis of gastric motility disorder (e.g. gastroparesis\u002Fslow stomach emptying) or history of bowel obstruction (i.e., chronic partial small bowel obstruction)",true,"ALL","21 Years","60 Years",{"count":21,"type":22},219,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this study is to determine whether stimulation of the brain-stomach connection can influence stomach activity in healthy adults and in individuals suffering from chronic nausea. The main questions it aims to answer are:\n\n* What are the best brain sites to influence the stomach?\n* What are the effects of different stimulation patterns on stomach activity?\n* Does the stimulation affect the sensation of nausea in participants suffering from chronic nausea?\n\nResearchers will use a non-invasive method of brain stimulation called Transcranial Magnetic Stimulation (TMS) and will record stomach responses with skin electrodes on the abdomen.\n\nParticipants will:\n\n* Visit the clinic at least once, and for up to 9 times more over the course of several months.\n* Receive TMS while sitting in a chair similar to a dentist's chair.\n* Drink water or consume a test meal during each study visit.",[28],"Chronic Nausea and Vomiting Syndrome",[30],"Chronic unexplained nausea and vomiting","RECRUITING","2026-07-22",{"date":34,"type":35},"2026-07-24","ACTUAL",{"date":37,"type":35},"2026-01-28",{"date":39,"type":22},"2031-07",{"name":41,"class":42},"David Levinthal","OTHER",""]