[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dr. Nils B. Kroemer\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":81},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100656202","longitudinal-effects-of-brain-stimulation-on-decision-making-and-reward-learning-100656202",false,"NCT07823218","Longitudinal Effects of Brain Stimulation on Decision-Making and Reward Learning","Longitudinal Effects of Brain Stimulation Techniques (ECT, TMS, VNS, taVNS) on Decision-Making and Reward Learning","Inclusion Criteria:\n\n* Indication for a brain stimulation treatment (ECT, TMS, VNS, taVNS) in the Department of Psychiatry and Psychotherapy at the University Hospital Bonn\n* Be able and willing to provide informed consent.\n\nExclusion Criteria:\n\n* Non-German speakers\n* Unclear ability to give consent to the study participation","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","This study investigates the longitudinal effects of brain stimulation treatments on decision-making and reward learning. Here, we use daily assessments of reinforcement learning behavior in patients with depression who receive neuromodulation treatment to study potential associations between changes in decision-making and reward learning and changes in clinical symptoms.",[24],"Depression \u002F Major Depressive Disorder",[26,27,28,29,30,31,32],"Brain Stimulation","Reinforcement Learning","ECT","repetitive transcranial magnetic stimulation","VNS","tVNS","Depression","NOT_YET_RECRUITING","2026-09-10",{"date":36,"type":37},"2026-09-16","ACTUAL",{"date":39,"type":20},"2026-09",{"date":41,"type":20},"2028-08",{"name":43,"class":44},"Dr. Nils B. Kroemer","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":45},"100629576","tvns-and-approach-avoidance-behavior-in-anhedonia-and-anxiety-100629576","NCT07476469","tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety","Vagus Nerve Stimulation and Approach-Avoidance Behavior in Anhedonia and Anxiety","Inclusion Criteria:\n\n* BMI between 18,5 and 30,0 kg\u002Fm2,\n* between 18 and 40 years of age, and\n* be able and willing to provide informed consent.\n\nExclusion Criteria:\n\n* have a high risk of suicide,\n* have a lifetime diagnosis of severe neurological disorder (incl. ADHD), schizophrenia, bipolar disorder, or severe substance abuse, posttraumatic stress disorder, obsessive-compulsive disorder, diabetes, epilepsy, or coronary heart disease\n* have fulfilled criteria for an eating disorder or somatic symptom disorder within the last 12-months,\n* take medication (except psychopharmacological medication for MDD or anxiety), patients have to be on stable psychopharmacological medication for at least two months before study participation (minimizing confounding effects)\n* contraindications for MRI (metal implants or claustrophobia)\n* for female individuals if they are pregnant or nursing at the time,\n* impaired movement ability or hearing\n* impaired, uncorrected vision (need contact lenses)\n* contraindications for tVNS hearing aids or diseased skin on the right ear.",true,"40 Years",{"count":56,"type":20},104,"INTERVENTIONAL",[59],"NA","This study investigates if anhedonia and anxiety symptoms are associated with alterations in reinforcement learning, effort trade-offs for wins vs. punishments, and foraging behavior under threat. Moreover, it will investigate whether these processes can be influenced by a metabolic load and\u002For transcutaneous vagus nerve stimulation (tVNS). The project consists of (a) an online reinforcement learning study, used to characterize learning, reward sensitivity, and meta-cognition, and (b) a laboratory study in which participants first undergo fMRI while completing an effort-based decision-making task. Second, participants will complete two sessions in VR with randomized active or sham tVNS during a foraging task before and after a caloric load with concurrent physiological recordings.",[62,63,64,65],"Healthy Participants","Anxiety Disorders (With High Anxiety Symptoms)","Depressive Disorders (With High Anhedonia Symptoms)","Comorbid Depression and Anxiety Disorder (With High Anhedonia and High Anxiety Symptoms)",[32,67,68,69,31,70,71],"Anhedonia","Anxiety","Vagusnerv-Stimulation","Virtual Reality","fMRI","RECRUITING","2026-04-20",{"date":75,"type":37},"2026-04-23",{"date":77,"type":37},"2026-03-23",{"date":79,"type":20},"2028-12-31",{"name":43,"class":44},""]