[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Elizabeth B Klerman MD PhD\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100651115","relationships-among-pupil-responses-to-light-circadian-rhythms-and-sleep-100651115",false,"NCT07753889","Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep","Documenting Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep in Healthy People and Those With Disorders or Disease","SCOPE","Inclusion Criteria:\n\n* 18-85 years old.\n* stable medically\n* ability to speak, understand and read English at a high school level\n\nExclusion Criteria:\n\n* any history of eye trauma or surgery besides correctable vision abnormalities (e.g., with glasses); any abnormalities on clinical eye exam (e.g., neuritis, Neuromyelitis optica, untreated glaucoma) such that the ophthalmologist recommends the participant not be studied;\n* prescription or non-prescription drugs affecting the pupil (e.g., affecting autonomic function), sleep, melatonin (e.g., lithium, alpha- and beta-adrenergic antagonists), and\u002For circadian rhythms (e.g., beta blockers, non-steroidal anti-inflammatory drugs, tricyclics\\\\\n* shift- or night-work in past three months;\n* crossing more than 2 time zones in past three months;\n* pregnant or less than 6 months post-partum or breastfeeding.",true,"ALL","18 Years","85 Years",{"count":22,"type":23},100,"ESTIMATED","INTERVENTIONAL",[26],"NA","The investigators are studying relationships among eye pathology, pupil responses to light, sleep, circadian rhythms, and hormones in healthy individuals and those with various medical disorders or illnesses.\n\nAll participants will:\n\n* Answer questionnaires about their health\n* Receive an eye exam,\n* For one week at home, participants will track their sleep and wake using actigraphy (wrist worn wearable) and an online sleep diary.\n* Complete a pupillometry session (measuring pupil size in response to different lighting) at MGH\n\nParticipants may also choose to participate in the following additional procedures in any order:\n\n* Within one week of their pupillometry session, an at-home saliva collection under dim light. Saliva melatonin can be analyzed to determine Dim-Light-Melatonin-Onset (DLMO), a marker of circadian timing.\n* If participants participate in one night saliva collection, a second night of at-home saliva collection with a bright light exposure to calculate melatonin suppression in response to light.",[29,30,31],"Circadian Rhythm","Pupillometry","Sleep",[33,34,35,31],"Pupil (eye)","Light","Circadian Rhythms","RECRUITING","2026-08-06",{"date":39,"type":40},"2026-08-10","ACTUAL",{"date":42,"type":23},"2026-09-01",{"date":44,"type":23},"2035-12",{"name":46,"class":47},"Elizabeth B Klerman MD PhD","OTHER",""]