[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Evangelismos Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":136},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,77,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100645565","energy-expenditure-and-nutrition-after-pancreatic-surgery-100645565",false,"NCT07703813","Energy Expenditure and Nutrition After Pancreatic Surgery","Resting Energy Expenditure, Nutritional Intake, and Postoperative Outcomes in Patients Undergoing Total or Partial Pancreatectomy for Pancreatic Tumors: A Prospective Observational Cohort Study","NUTRI-PD","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled to undergo total or partial pancreatectomy (including pancreaticoduodenectomy\u002FWhipple procedure or distal pancreatectomy) for a pancreatic tumor\n* Able to complete indirect calorimetry measurement by canopy or face mask for the required duration\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Age under 18 years, greater than 75 years\n* Pregnancy\n* Inability to tolerate the calorimetry canopy or mask for the duration required for a valid measurement\n* Unable or unwilling to provide informed consent\n* patients already on preoperative enteral nutrition or unable to feed orally preoperatively","ALL","18 Years","75 Years",{"count":21,"type":22},150,"ESTIMATED","12 Months","OBSERVATIONAL","This prospective observational cohort study examines the energy requirements and nutritional care of patients undergoing total or partial pancreatectomy for pancreatic tumors. Patients undergoing pancreatectomy face major metabolic stress, a high burden of preoperative malnutrition, and frequent exocrine or endocrine insufficiency, yet procedure-specific nutritional guidance is limited. The study measures resting energy expenditure (REE) directly by indirect calorimetry during the early postoperative period and compares it with widely used predictive equations (Harris-Benedict, Schofield) and simplified weight-based targets (25 and 30 kcal\u002Fkg) to determine how accurately clinicians can estimate energy needs when calorimetry is unavailable. In the same patients, the study records the route of postoperative nutrition (enteral, parenteral, or combined), energy and protein intake relative to requirements, and diet-related symptoms, and follows postoperative complications, hospital readmission, mortality, and changes in body weight and body mass index through 3-6 months after surgery. By capturing measured energy expenditure and nutritional delivery in one cohort, the study aims to clarify whether adequacy of energy and protein intake, feeding route, or both influence recovery, and to provide primary data for developing individualized nutritional support protocols in this high-risk surgical population.",[27,28,29,30],"Whipple Procedures","Pancreatic Cancer","Pancreaticoduodenectomy","Pancreatic Neoplasms",[32,33,34,29,35,36],"Nutrition","Nutrition support","Indirect calorimetry","Surgical oncology nutrition","Postoperative nutrition","RECRUITING","2026-07-09",{"date":40,"type":41},"2026-07-14","ACTUAL",{"date":43,"type":41},"2017-01-10",{"date":45,"type":22},"2028-11-10",{"name":47,"class":48},"Evangelismos Hospital","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":49},"100570467","cpet-guided-rehab-vs-physiotherapy-in-patients-with-dysfunctional-breathing-100570467","NCT06707623","CPET Guided Rehab vs Physiotherapy in Patients With Dysfunctional Breathing","Cardiopulmonary Exercise Testing Guided Physiotherapy During Pulmonary Rehabilitation in Patients With Dysfunctional Breathing, a Randomized Controlled Trial","DB-REHAB","Inclusion Criteria:\n\n* Dysfunctional breathing (DB) diagnosed with CPET.\n* Adult patients (\\>18 years of age)\n* Able and willing to attend an outpatient multidisciplinary, supervised rehabilitation program of a total duration of two months (8 weeks).\n* Able and willing to attend 5 physiotherapy sessions over a period of 9 weeks.\n* Sign an informed consent.\n\nExclusion Criteria:\n\n* No underling pathology explaining dyspnea and DB in CPET (e.g normal dead space to tidal volume ratio (VD\u002FVt) and normal alveolar-arterial (A-a) gradient.)\n* Patients with COPD\n* Patients with uncontrolled asthma\n* Patients with post-exertional malaise (PEM).\n* Patients that cannot attend an outpatient rehabilitation program like suffering from dementia, chronically paralyzed, with paraplegia, multiple injuries, or other serious orthopaedic problems that cause disability or suffer from very serious underlying diseases such as end-stage cancer, and patients with neurological diseases that cause disability, require specialized rehabilitation clinics and special interventions (speech therapy, kinesiotherapy, etc.).",{"count":59,"type":22},78,"INTERVENTIONAL",[62],"NA","In this study the efficacy of a pulmonary rehabilitation program tailored to the needs of patients with dysfunctional breathing (DB) will be investigated using cardiopulmonary exercise testing. The pulmonary rehabilitation program will be compared with physiotherapy which is currently the mainstream therapy of DB.",[65],"Dysfunctional Breathing",[65,67,68],"Pulmonary Rehabilitation","Breathing retraining","2026-04-13",{"date":71,"type":41},"2026-04-14",{"date":73,"type":41},"2024-11-27",{"date":75,"type":22},"2028-11-30",{"name":47,"class":48},{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":84,"targetDuration":86,"studyType":24,"phases":4,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":49},"100450821","endotyping-prehospital-de-novo-acute-hypoxemic-respiratory-failure-100450821","NCT05150483","EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure","EPIPHANY","Inclusion Criteria:\n\n* Adult patients (aged \\>18 years) presenting in the emergency department\n* De novo acute hypoxemic respiratory failure (requiring oxygen flow rate of 5 liters per minute or more to maintain SpO2 of 90% or more)\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Not admitted to the hospital\n* Postoperative acute respiratory failure (within one week from surgery)\n* Chronic hypoxemic respiratory failure (requiring long term oxygen therapy at home)\n* Hypercapnic respiratory failure\n* Transferred from another hospital or facility\n* Pregnant women\n* Admitted to the hospital purely to facilitate comfort care\n* Lack of informed consent",{"count":85,"type":22},250,"28 Days","We attempt to perform dynamic endotyping of critically ill patients presenting in the emergency department with de novo acute hypoxemic respiratory failure (AHRF). We also attempt to identify what clinical, radiological, physiological and biological variables collected early in the course of AHRF correlate with subsequent mortality and\u002For persistent severe hypoxemia.",[89,90],"Acute Hypoxemic Respiratory Failure","Acute Respiratory Distress Syndrome",[92,93,94,95,96,97,98],"critical illness","intensive care unit","endotypes","phenotypes","emergency department","trajectory","mechanical ventilation","2025-08-04",{"date":101,"type":41},"2025-08-07",{"date":103,"type":41},"2021-12-10",{"date":105,"type":22},"2026-04-30",{"name":47,"class":48},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":60,"phases":116,"briefSummary":117,"conditions":118,"keywords":121,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":49},"100599290","effect-of-ventilation-mode-in-the-pupillary-light-reflex-a-crossover-study-100599290","NCT07082569","Effect of Ventilation Mode in the Pupillary Light Reflex: A Crossover Study","EYE-BREATH","Inclusion Criteria\n\n* Adult patients (≥18 years old)\n* Receiving positive-pressure mechanical ventilation\n* Under light or no sedation (e.g., RASS score between -2 and 0)\n* Clinically assessed by the treating physician as not yet ready for weaning from mechanical ventilation\n* Hemodynamically stable at the time of measurement\n* Presence of an arterial catheter in place for blood gas analysis\n* Written informed consent obtained from the patient's legal representative Exclusion Criteria\n* Acute or chronic neurological disease affecting brainstem function or pupillary responses\n* Dyssynchrony with the ventilator or need for high ventilatory support adjustments\n* Facial injuries, edema, or conditions precluding accurate pupillometry\n* Use of neuromuscular blocking agents within the prior 6 hours\n* Severe metabolic or acid-base imbalances that may influence autonomic regulation\n* Concurrent participation in another interventional study that could affect neurological or autonomic outcomes",{"count":115,"type":22},36,[62],"The goal of this clinical trial is to explore whether different modes of mechanical ventilation affect pupillary constriction velocities in critically ill patients without brain injury. The study aims to determine whether the type of mechanical ventilation (volume control, pressure control, or pressure-regulated volume control) influences the maximum and mean constriction velocity measured by automated pupillometry. The trial also investigates whether changes in pupil dynamics reflect subtle alterations in brainstem-autonomic interaction induced by ventilation mode.\n\nThe comparison involves volume control, pressure control, and pressure-regulated volume control in a randomized crossover design to assess whether ventilation mode has a measurable effect on pupil response.\n\nEligible participants will be intubated ICU patients receiving assist control ventilation who are not yet ready for spontaneous breathing trials. Serial pupillometry measurements will be conducted while participants are ventilated with each mode for at least 15 minutes. Sedation and lighting conditions will remain consistent throughout the protocol. Participants with acute or chronic neurologic conditions or ventilator dyssynchrony will be excluded.",[119,120],"Mechanical Ventilation","Critical Illness",[122,123,124,125,126],"Critical illness","Mechanical ventilation","Pupillary light reflex","Automated pupillometry","Neurological Pupil Index","NOT_YET_RECRUITING","2025-07-23",{"date":130,"type":41},"2025-07-24",{"date":132,"type":22},"2025-07-15",{"date":134,"type":22},"2026-09-30",{"name":47,"class":48},""]