[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Fabio Ferrarelli\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":64},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100447168","enhancing-prefrontal-oscillations-and-working-memory-in-early-course-schizophrenia-100447168",false,"NCT05102929","Enhancing Prefrontal Oscillations and Working Memory in Early-course Schizophrenia","Enhancing Prefrontal Oscillatory Activity and Working Memory Performance With Noninvasive Brain Stimulation in Early-course Schizophrenia","REDOCS","Inclusion Criteria:\n\n1. ages 18-40 years\n2. DSM diagnoses of Schizophrenia Spectrum Axis I disorders\n3. a duration of less than three years from beginning of psychosis, defined by report of symptoms and\u002For history of treatment, based on clinical guidelines employed in our UPMC psychoses clinics in Pittsburgh.\n\nExclusion Criteria:\n\n1. DSM intellectual developmental disorder\n2. significant head injury\n3. medical illness affecting brain structure or function\n4. significant neurologic disorder (e.g. seizure disorder)\n5. personal history or family history of epilepsy\n6. inability to provide informed consent\n7. concussion with loss of consciousness (LOC) greater than 10 minutes\n8. history of electroconvulsive therapy\n9. diabetes with associated seizures, loss of sensation\u002Fweakness in arms or legs, or momentary LOC\n10. pregnancy or postpartum (\\\u003C6 weeks after delivery or miscarriage), as determined by self-report\n11. a psychotic illness with a temporal relation to substance use or head injury.\n12. current or past co-morbidity for alcohol or psychoactive substance dependence\n13. substance abuse, other than cannabis and\u002For alcohol, within the past one year","ALL","18 Years","40 Years",{"count":21,"type":22},75,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will investigate the effects of intermittent Theta Burst Stimulation (iTBS) on natural oscillatory frequency of the dorsolateral prefrontal cortex (DLPFC) and working memory in early-course schizophrenia (EC-SCZ). Transcranial magnetic stimulation (TMS) will be used to evoke oscillatory activity, and EEG will record the responses of EC-SCZ participants. A working memory task will also be incorporated in order to determine how DLPFC natural frequency (NF) is related to working memory performance. iTBS (active or sham) will be administered, then the oscillatory activity of DLPFC and working memory performance will be reassessed. The overarching goal is to determine whether iTBS can acutely enhance the oscillatory activity of the DLPFC and to evaluate the relationship between changes in the DLPFC and working memory performance.",[28],"Schizophrenia","RECRUITING","2026-08-07",{"date":32,"type":33},"2026-08-11","ACTUAL",{"date":35,"type":33},"2021-11-05",{"date":37,"type":22},"2026-10",{"name":39,"class":40},"Fabio Ferrarelli","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":41},"100512784","restoring-spindle-and-thalamocortical-efficiency-in-early-course-schizophrenia-patients-using-auditory-stimulation-100512784","NCT05956951","Restoring Spindle and Thalamocortical Efficiency in Early-Course Schizophrenia Patients Using Auditory Stimulation","Restoring Spindle and Thalamocortical Efficiency in Early-Course Schizophrenia Patients Using Closed-Loop Auditory Stimulation","RESPITE","Inclusion Criteria:\n\nEarly-course schizophrenia (EC-SCZ):\n\n1. ages 18-40 years\n2. current DSM-IV defined diagnosis of schizophrenia, schizophreniform or schizoaffective disorder, not drug-induced, with no previously reported psychotic episode\n3. duration of ≤5 years from beginning of psychosis, defined by report of symptoms and\u002For history of treatment according to clinical guidelines employed in our University of Pittsburgh Medical Center (UPMC) psychoses clinics in Pittsburgh\n4. lifetime exposure to antipsychotic medications ≤5 years\n\nHealthy controls (HC):\n\n1. ages 18-40 years\n2. no lifetime history of psychiatric disorders\n3. no first-degree family history of schizophrenia spectrum disorder or mood disorder with psychotic features.\n\nExclusion Criteria:\n\nGeneral exclusion criteria:\n\n1. DSM-IV intellectual disability\n2. significant head injury\n3. medical illness affecting brain function or structure\n4. pregnancy or postpartum (\\\u003C6 weeks after delivery or miscarriage)\n5. significant neurological disorder (e.g. seizure disorder)\n6. inability to provide informed consent\n7. current or past co-morbidity for alcohol or psychoactive substance dependence\n8. substance abuse other than cannabis and\u002For alcohol within the past one year\n\nFor EC-SCZ:\n\na) a psychotic illness with a temporal relation to substance use or head injury\n\nFor healthy controls (HC):\n\n1. difficult falling and\u002For staying asleep for more than half the nights of a week, on average\n2. diagnosis of sleep apnea or restless leg syndrome\n3. sleeping less than 5 hours or more than 10 hours daily, on average",true,{"count":52,"type":22},200,[25],"The purpose of this research is to identify differences in brain activity during sleep between health individuals and individuals with schizophrenia, schizophreniform, or schizoaffective disorder. This study will also investigate whether tones played during deep sleep can enhance specific features of sleep and whether enhancing such features is related to an improvement in cognitive performance.",[28],"2026-06-03",{"date":58,"type":33},"2026-06-04",{"date":60,"type":33},"2023-07-20",{"date":62,"type":22},"2028-06",{"name":39,"class":40},""]