[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Fatma Cigdem Ozakin\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":82},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100659554","spinal-anesthesia-versus-general-anesthesia-plus-tap-block-for-laparoscopic-inguinal-hernia-repair-100659554",false,"NCT07866885","Spinal Anesthesia Versus General Anesthesia Plus TAP Block for Laparoscopic Inguinal Hernia Repair","Comparison of Spinal Anesthesia and General Anesthesia Plus Transversus Abdominis Plane Block in Laparoscopic Total Extraperitoneal Inguinal Hernia Repair: A Prospective Randomized Double-Blind Clinical Trial","Inclusion Criteria\n\n* Age \\>18 and \\\u003C65 years\n* Scheduled for laparoscopic TEP inguinal hernia repair\n* Primary inguinal hernia\n* No known neuropathy\n\nExclusion Criteria\n\n* History of previous lower abdominal surgery\n* Complicated inguinal hernia, including irreducible, obstructed, or strangulated hernia\n* Recurrent inguinal hernia\n* Coagulation disorder\n* Musculoskeletal deformity","ALL","18 Years","65 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective, randomized, double-blind clinical trial compares spinal anesthesia with general anesthesia combined with ultrasound-guided transversus abdominis plane (TAP) block in adult patients undergoing laparoscopic total extraperitoneal (TEP) inguinal hernia repair. Patients will be randomly assigned to one of two anesthesia groups. The primary outcome is postoperative pain assessed using the Visual Analog Scale (VAS) at 1 hour after surgery. Postoperative pain at additional time points, analgesic requirements, opioid consumption, and postoperative complications will also be evaluated.",[27,28],"Transversus Abdominis Plane Block (TAP Block)","Laparoscopic Inguinal Hernia Repair",[28,30,31,32,33,34,35,36,37],"Spinal Anesthesia","General Anesthesia","Transversus Abdominis Plane Block","TAP Block","Postoperative Pain","Visual Analog Scale","Analgesic Consumption","Opioid Consumption","RECRUITING","2026-10-05",{"date":41,"type":42},"2026-10-08","ACTUAL",{"date":44,"type":42},"2026-09-01",{"date":46,"type":21},"2027-04-03",{"name":48,"class":49},"Fatma Cigdem Ozakin","OTHER_GOV",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":78,"completionDateStruct":79,"leadSponsor":81,"locationsCount":50},"100658941","perioperative-biomarkers-and-postoperative-delirium-in-older-adults-undergoing-abdominal-cancer-surgery-100658941","NCT07859488","Perioperative Biomarkers and Postoperative Delirium in Older Adults Undergoing Abdominal Cancer Surgery","Perioperative Melatonin and Other Neuroinflammatory Biomarkers for Predicting Postoperative Delirium in Older Adults Undergoing Elective Abdominal Cancer Surgery","Inclusion Criteria:\n\n* Age 65 years or older.\n* Scheduled for elective abdominal surgery for malignancy.\n* American Society of Anesthesiologists (ASA) physical status II or III.\n* Surgery planned under general anesthesia.\n* Eligible for thoracic epidural analgesia without contraindications to epidural catheter placement.\n* Provision of written informed consent.\n\nExclusion Criteria:\n\n* Preoperative dementia, Alzheimer disease, Parkinson disease, other known neurodegenerative disease, or a history of preoperative cognitive impairment.\n* Emergency surgery.\n* Contraindication to epidural analgesia or refusal of epidural catheter placement.\n* Chronic use of corticosteroids, melatonin preparations, or medications affecting the serotonergic system, including selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, monoamine oxidase inhibitors, or tricyclic antidepressants.\n* Parenteral or high-dose oral vitamin B12 treatment within the previous 3 months.\n* Diagnosis of pernicious anemia.\n* Communication impairment preventing delirium assessment.\n* Advanced liver or kidney failure.\n* Intraoperative mean arterial pressure below 65 mmHg.\n* Surgical duration longer than 240 minutes.\n* Refusal to participate in the study.",{"count":59,"type":21},100,"OBSERVATIONAL","This prospective observational cohort study aims to investigate the relationship between perioperative endogenous melatonin levels and postoperative delirium in patients aged 65 years or older undergoing elective abdominal cancer surgery. The study will also evaluate serotonin, kynurenine, kynurenic acid, and vitamin B12 as potential biomarkers associated with postoperative delirium.\n\nParticipants will undergo routine standardized general anesthesia and thoracic epidural analgesia. Venous blood samples will be obtained preoperatively and on postoperative day 3. In participants who develop delirium, an additional blood sample will be obtained as soon as possible after delirium is detected. Postoperative delirium will be assessed using the Confusion Assessment Method (CAM) on postoperative days 1, 3, and 5. No experimental drug or additional therapeutic intervention will be administered as part of the study.",[63,64],"Postoperative Delirium (POD)","Abdominal Neoplasms",[66,67,68,69,70,71,72,73,74,75],"Postoperative delirium","Melatonin","Serotonin","Kynurenine","Kynurenic acid","Vitamin B12","Neuroinflammation","Geriatric surgery","Abdominal cancer surgery","Confusion Assessment Method","2026-09-30",{"date":39,"type":42},{"date":44,"type":42},{"date":80,"type":21},"2027-09-06",{"name":48,"class":49},""]