[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Freiburger Medizintechnik GmbH\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100648421","study-on-the-treatment-of-dental-implants-using-the-ambijet-system-for-peri-implantitis-and-peri-implant-mucositis-100648421",false,"NCT07722715","Study on the Treatment of Dental Implants Using the AmbiJet System for Peri-implantitis and Peri-implant Mucositis","Randomized, Controlled, Exploratory Study on the Treatment of Dental Implants Using the AmbiJet System for Peri-implantitis and Peri-implant Mucositis (AmbiJet-FIH)","AmbiJet-FIH","Inclusion Criteria:\n\nGeneral criteria:\n\n* Men or women aged \\>= 18 and \\\u003C= 65 years.\n* For women of childbearing age: a form of contraception recognized by conventional medicine during the study.\n* Written consent has been obtained from each patient for the study.\n\nDental criteria:\n\n* Current X-ray of the implant region available (\\\u003C= 6 months prior to first treatment).\n* One to five implants with bone loss from the start of the part of the implant intended for osseointegration (X-ray findings).\n* Bleeding and\u002For suppuration after or without probing at the implant in question (peri-implant mucositis\u002Fperi-implantitis).\n* Clinical signs of inflammation (swelling, redness, soft tissue) on the implant in question (peri-implant mucositis\u002Fperi-implantitis).\n* Average oral hygiene (i.e., brushing teeth at least twice a day).\n\nExclusion Criteria:\n\nGeneral criteria:\n\n* Known allergies to materials used in the study (gold, copper, polyimide).\n* Diabetes (type I or type II), vasculitis, osteoporosis, osteomalacia.\n* Smokers (\\>1 cigarette\u002Fweek).\n* Use of medications to modulate bone metabolism (e.g., bisphosphonates).\n* Eating disorders such as bulimia or anorexia nervosa.\n* Use of antibiotics within the last 2 months prior to the start of the study.\n* Application of local antibiotics in the oral cavity within the last 2 months prior to the start of the study.\n* Use of antimicrobial mouthwashes within the last month before the start of the study.\n* Anti-inflammatory medication within the last month before the start of the study.\n* Pregnancy or breastfeeding.\n* Alcoholism or drug abuse.\n* Wound healing disorders.\n* Immunosuppression.\n* Condition following insertion of an electrical, electrically active, or electronic implant.\n\nDental criteria:\n\n* An implant with bone loss \\>6 mm from the start of the part of the implant intended for osseointegration (X-ray findings) (peri-implantitis).\n* Pathological changes in the oral mucosa or gingiva, such as oral lichen planus, chronic recurrent aphthae, melanotic macula, precancerous lesions (e.g., leukoplakia), melanomas.\n* Use of medically unacceptable types of treatment, therapies, or substances (off-label use of treatments for peri-implant mucositis or peri-implantitis).","ALL","18 Years","65 Years",{"count":21,"type":22},26,"ESTIMATED","INTERVENTIONAL",[25],"NA","Inflammation of the tissue surrounding a dental implant (peri-implantitis or peri-implant mucositis) can lead to implant loss in advanced stages. The AmbiJet system utilizes cold atmospheric plasma (CAP), a physical procedure with a strong antibacterial effect. This clinical trial investigates whether the additional application of cold plasma directly on the patient following conventional mechanical cleaning of the implants is safe, well-tolerated, and resolves inflammation more quickly compared to standard treatment.",[28,29],"Peri Implant Mucositis","Peri Implantitis",[31,32,33],"Plasma Medicine","Cold Atmospheric Plasma","AmbiJet","RECRUITING","2026-07-23",{"date":37,"type":38},"2026-07-24","ACTUAL",{"date":40,"type":38},"2026-02-14",{"date":42,"type":22},"2026-11-20",{"name":44,"class":45},"Freiburger Medizintechnik GmbH","INDUSTRY",""]