[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Friedhelm Hummel\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":83},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100653928","phase-2-non-invasive-deep-brain-stimulation-for-upper-limb-recovery-after-stroke-nimbus-100653928",false,"NCT07792811","Non-Invasive Deep Brain Stimulation for Upper Limb Recovery After Stroke (NIMBUS)","Non-Invasive neuroModulation of Deep Brain Structures for Upper Limb Recovery After Stroke by Transcranial Temporal Interference Electric Stimulation.","NIMBUS","Inclusion Criteria:\n\n1. Informed Consent signed by the participant\n2. Age ≥ 18 years old\n3. First ever ischemic stroke with motor impairment\n4. Stroke incident ≥ 12 weeks at consent\n5. Moderate to severe motor impairment (Fugl-Meyer Assessment (FMA) \\>20 and \\\u003C58)\n\nExclusion Criteria:\n\n1. Unable to provide informed consent due to cognitive, psychiatric, or medical conditions impairing decision-making capacity\n2. Severe neuropsychiatric (e.g., major depression, schizophrenia) or medical disease (e.g., progressive cancer, unstable systemic disease, neurodegenerative disease)\n3. Severe cognitive, sensory or musculoskeletal dysfunctions prohibiting to understand instructions or to perform the rehabilitative tasks\n4. Contraindications for NIBS or MRI\n\n   a. Electronic or ferromagnetic medical implants\u002Fdevice, non-MRI compatible metal implant, b. Fully or partially implanted conductive objects i. Passive implants: stents, orthopedic\u002Forthodontic implants, screws, shunts, etc.\n\n   ii. Active implants: cochlear implants, deep brain stimulation leads and electrodes, fully implanted brain monitoring devices iii. Partially implanted devices: monitoring electrodes (e.g., stereoelectroencephalography, electrocortigraphy, etc.\n\n   iv. Surface-mounted conductive objects: conductive low-impedance structure mounted to the skin that may introduce shortcuts.\n\n   c. History of seizures d. Medication that significantly interacts with NIBS being benzodiazepines, tricyclic antidepressants and antipsychotics.\n\n   e. Non-intact skin where electrodes are intended ot be placed\n5. Pregnancy\n6. Regular use of narcotic drugs or abusive alcohol consumption\n7. Integral and bilateral lesion of the striatum\n8. Concomittant participation in another clinical trial\n9. Active request of not being informed in case of incidental findings","ALL","18 Years",{"count":20,"type":21},84,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE2","PHASE3","NIMBUS is a clinical study evaluating a new, non-invasive brain stimulation treatment to improve arm and hand function in people with long-term effects of stroke. The treatment uses a personalized method to stimulate deeper areas of the brain through the scalp, without surgery, while participants undergo intensive physiotherapy rehabilitation. Physiotherapy in combination with the brain stimulation will occur three times a day over the course of a week. In the study, participants are randomly assigned to receive either the active treatment or a sham (inactive) version, so researchers can compare the outcomes fairly. The study will assess whether the treatment is safe, feasible, and effective by measuring changes in arm movement, daily activities, and brain function before and after the treatment. The goal is to determine whether this approach can enhance recovery after stroke and support the development of improved rehabilitation therapies.",[28,29],"Stroke","Stroke Assessment",[31,32,33,34,35,36,37],"Stroke Rehabilitation","Upper Extremity Motor Recovery","Noninvasive Brain Stimulation","Transcranial electrical temporal interference stimulation (tTIS)","Neuroplasticity","Personalized medicine","Randomized controlled trial","NOT_YET_RECRUITING","2026-08-25",{"date":41,"type":42},"2026-08-28","ACTUAL",{"date":44,"type":21},"2026-09-13",{"date":46,"type":21},"2030-12",{"name":48,"class":49},"Friedhelm Hummel","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":5},"100613817","non-invasive-deep-brain-stimulation-to-improve-spatial-navigation-abilities-in-individuals-following-traumatic-brain-injury-100613817","NCT07271524","Non-invasive Deep Brain Stimulation to Improve Spatial Navigation Abilities in Individuals Following Traumatic Brain Injury","Investigation of the Plasticity of Deep Brain Structures in Mild Cognitive Impairment and Healthy Aging (PlasMA)","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Clinical diagnosis of TBI\n* No history of other severe neurological or psychiatric disorders\n\nExclusion Criteria:\n\n* Unable to consent\n* Severe neuropsychiatric (e.g., major depression, severe dementia) or unstable systemic diseases (e.g., severe progressive and unstable cancer, life threatening infectious diseases)\n* Severe sensory or cognitive impairment or musculoskeletal dysfunctions prohibiting to understand instructions or to perform the experimental tasks\n* Inability to follow or non-compliance with the procedures of the study\n* Contraindications for NIBS or MRI:\n\n  * Electronic or ferromagnetic medical implants\u002Fdevice, non-MRI compatible metal implant\n  * History of seizures\n  * Medication that significantly interacts with NIBS being benzodiazepines, tricyclic antidepressants and antipsychotics\n* Regular use of narcotic drugs\n* Pregnancy\n* Request of not being informed in case of incidental findings\n* Concomitant participation in another trial involving probing of neuronal plasticity",{"count":59,"type":21},25,[61],"NA","Impairments in spatial memory and spatial navigation are commonly reported amongst patients presenting post-traumatic brain injury (TBI). In this study, the investigators examine the effect of non-invasive deep brain stimulation of the hippocampal-entorhinal complex (HC-EC), a key region supporting navigation abilities, on spatial navigation performance in TBI patients. Using a virtual reality task where participants must first encode and later recall the location of objects in a virtual arena, the investigators contrast performance while active versus control stimulation is applied to the HC-EC. The investigators additionally record brain activity using electroencephalography (EEG) prior to, during, and after task performance to characterize the neural correlates of spatial navigation abilities in TBI patients, and how they are affected by stimulation.",[64],"Traumatic Brain Injury",[66,67,68,69,70,71,72,73,74],"non-invasive brain stimulation","deep brain stimulation","subcortical","memory","neuro-imaging","transcranial temporal interference stimulation","spatial navigation","electroencephalography","traumatic brain injury","2025-12-05",{"date":77,"type":42},"2025-12-09",{"date":79,"type":21},"2025-12",{"date":81,"type":21},"2027-12",{"name":48,"class":49},""]