[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"GCS Ramsay Santé pour l'Enseignement et la Recherche\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":529},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,81,0,25,[9,42,64,86,109,130,151,169,187,206,226,244,264,284,302,321,337,352,370,389,413,435,456,476,498],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100614058","superb-microvascular-imaging-smi-and-two-dimensional-endoscopic-ultrasound-guided-shear-wave-elastography-2d-swe-eus-in-differential-diagnosis-of-pancreatic-adenocarcinoma-pa-from-other-pancreatic-solid-lesions-psls-and-pancreatic-neuroendocrine-tumors-pnets-malignancy-100614058",false,"NCT07274657","Superb Microvascular Imaging (SMI) and Two-Dimensional Endoscopic Ultrasound Guided Shear Wave Elastography (2D-SWE-EUS) in Differential Diagnosis of Pancreatic Adenocarcinoma (PA) From Other Pancreatic Solid Lesions (PSLs) and Pancreatic neuroendocrinE Tumors (pNETs) Malignancy","SMILE","Inclusion Criteria:\n\n* Patient, male or female, age ≥ 18 years old\n* Patient with diagnosed pancreatic solid or mixed (cystic component ≤25 % of tumor volume) lesion\n* Patient with adequate understanding of written and spoken French, able to sign written informed consent\n* Patient affiliated with a social security system\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding woman\n* Patient with usual contraindications to EUS- TA\n* Patient with usual contraindications to SonoVue® administration\n* Patient with a genetic syndrome associated pancreatic lesion (multiple neuroendocrine neoplasia type 1 (MEN1), type 1 neurofibromatosis (NF), Von-Hippel Lindau (VHL) disease)\n* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision.\n* Patient unable to perform the monitoring","ALL","18 Years",{"count":20,"type":21},150,"ESTIMATED","INTERVENTIONAL",[24],"NA","Pancreatic adenocarcinoma (PA) is the most common tumor of the pancreas. Given its poor prognosis and the major therapeutic consequences, the discrimination between PA and other pancreatic solid lesions is mandatory.\n\nEndoscopic ultrasound (EUS) is admitted as the most sensitive imaging procedure for the detection and characterization of pancreatic tumors. Over the past 30 years, EUS-guided tissue acquisition (EUS-TA), or more recently fine needle biopsy (EUS-FNB), has demonstrated its efficiency for tissue sampling and remains the gold standard for the pathologic diagnosis of pancreatic lesions.\n\nThe assessment of pancreatic tumor enhancement using ultrasound contrast agents (UCAs) in real time with imaging specific methods seems useful to improve their characterization either by contrast-enhanced EUS (CE-EUS) or, more recently, by contrast-harmonic EUS (CH-EUS). CH-EUS was already demonstrated useful to differentiate pancreatic adenocarcinoma from other pancreatic lesions.\n\nEUS-Elastography (EUS-E) is another EUS image enhancement technique, which rational based on the difference in elasticity between the tissues. There are two types of elastographies: strain elastography (SE) and shear wave elastography (SWE). SE has proved useful for the characterization of pancreatic lesions and lymph nodes. However, this technique was demonstrated difficult to perform with adequate accuracy and reproducibility for pancreatic lesions and have many limitations. In some recent publications SWE was demonstrated moderate reliability.\n\nPancreatic neuroendocrine tumors (pNETs) are rare tumors, but according to the last epidemiological data, their incidence and prevalence are steadily rising.\n\nSurgical resection is generally performed for pNETs due to their malignant potential. However, with increasing use of high-resolution conventional imaging, the significant incidence of small (≤ 2 cm) pancreatic neuroendocrine incidentaloma (pNET) has risen in recent decades.\n\nEUS is recognized as the most sensitive procedure for the detection and characterization of pNETs. Overall sensitivity of EUS-TA for the diagnosis of pNETs is high, reaching 95.1% in recently published study, appearing higher in small lesions (≤ 20 mm) than in large lesions (\\> 20 mm).\n\nThe overall concordance rate for EUS-TA and surgical specimens grading varies from 58% to 86.4% and is higher for lesions ≤ 10 mm, 10-20 mm, comparing to lesions \\> 20 mm. These results confirm the risk of under or over-grading of pNETs on the EUS-TA specimen, independently of the needle size which used for the TA.\n\nCH-EUS was also demonstrated accurate in the prediction of pNETs malignancy and useful for decision-making management of these tumors.\n\nHypothesis\n\nTwo new image enhancement EUS technologies were recently developed, able to assess precisely tumor microvascular density and the stiffness of pancreatic lesions, that is correlated to tumor's stroma fibrosis, and thus help to characterize and predict the malignancy, and accordingly, the management of the pancreatic solid lesions. It's particularly useful in overcoming EUS false-negative cases of PA and small pNETs malignancy diagnosis.\n\nSuperb Microvascular Imaging (SMI) is a novel doppler technique that enhances the range of visible blood flow, by revealing low velocity microvascular flow, enabling the capture of a higher-quality microvascular flow images. Based on the same principle as CH-EUS, which assesses tumor microvascularization, this technique is expected to be also useful for the PSLs malignancy diagnosis.\n\nShear Wave Elastography (SWE) relies on the properties of shear-wave propagation to offer an advanced assessment of their velocity",[27,28],"Pancreas Adenocarcinoma (MSI-H)","Pancreatic Neuroendocrine Tumors (pNET)","RECRUITING","2026-08-19",{"date":32,"type":33},"2026-08-20","ACTUAL",{"date":35,"type":33},"2026-02-24",{"date":37,"type":21},"2028-06-30",{"name":39,"class":40},"GCS Ramsay Santé pour l'Enseignement et la Recherche","OTHER",1,{"id":43,"slug":44,"hasResults":12,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":58,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":41},"100613798","3d-mri-assessment-of-femoroacetabular-impingement-in-patients-with-acl-rupture---exploratory-study-100613798","NCT07271277","3D MRI Assessment of Femoroacetabular Impingement in Patients With ACL Rupture - Exploratory Study","IMAHANCHE","Inclusion Criteria:\n\n* Patient, male or female, aged 18 years or older\n* Patient with a primary complete ACL rupture\n* Patient affiliated with or covered by a social security scheme\n* Patient who speaks French and has signed an informed consent form\n\nExclusion Criteria:\n\n* Patient with multi-ligament injury\n* Patients with a history of hip fracture\n* Patients with a history of hip surgery\n* Patients with a contraindication to MRI\n* Protected individuals: adults under guardianship, curatorship or other legal protection, deprived of their liberty by judicial or administrative decision\n* Pregnant or breastfeeding women",{"count":50,"type":21},50,[24],"Anterior cruciate ligament (ACL) tears are among the most common sports injuries. Numerous studies have shown that reduced hip rotation may play a role in ACL tears. The same question may also arise for hip injuries such as femoroacetabular impingement (FAI).\n\nThis research is based on the hypothesis that there is a relationship between FAI and ACL injury. In this context, 3D MRI of the hip would provide morphological details of the hip that are not currently available with other imaging techniques, thereby enabling early identification of FAI. This is the reason why this research has been initiated.",[54],"Femoroacetabular Impingement",[56],"femoroacetabular impingement","NOT_YET_RECRUITING",{"date":32,"type":33},{"date":60,"type":21},"2026-10-01",{"date":62,"type":21},"2028-01-31",{"name":39,"class":40},{"id":65,"slug":66,"hasResults":12,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":81,"startDateStruct":82,"completionDateStruct":83,"leadSponsor":85,"locationsCount":4},"100612135","description-of-return-to-sport-in-amateur-athletes-who-underwent-several-functional-tests-k-starts-vertical-jumps-and-soleus-muscle-strength-after-initial-acl-reconstruction-100612135","NCT07249645","Description of Return to Sport in Amateur Athletes Who Underwent Several Functional Tests (K-STARTS, Vertical Jumps and Soleus Muscle Strength) After Initial ACL Reconstruction","Description of Return to Sport in Amateur Athletes Who Underwent Several Functional Tests (K-STARTS, Vertical Jumps and Soleus Muscle Strength) After Initial ACL Reconstruction.","K-STARTS +","Inclusion Criteria:\n\n* Patient, male or female, aged between ≥ 18 and ≤ 30 years old\n* Amateur athlete with a Tegner score ≥ 5\n* Patient with primary ACL reconstruction dating back 6 months\n* Patients with ACL damage in one knee only\n* Patients who have undergone an isokinetic strength test with results that do not contraindicate functional testing\n* Patients affiliated with or covered by a social security scheme\n* French-speaking patients who have signed an informed consent form\n\nExclusion Criteria:\n\n* Patients treated for bilateral ACL reconstruction\n* Patients who are professional athletes or compete at a national level\n* Patients with severe associated disorders (neurological, connective tissue, congenital diseases)\n* Patients with multiple ligament defects or associated osteotomy\n* Patients already included in another study\n* Protected patients: adults under guardianship, curatorship or other legal protection, deprived of their liberty by judicial or administrative decision","30 Years",{"count":74,"type":21},230,[24],"ACL injuries are incapacitating for both professional and amateur athletes, with long-term repercussions on performance and return to sport (RTS).\n\nSurgical reconstruction of the ACL is the main treatment option. Despite this, recurrence rates are high. Half of all recurrences occur within 8 months of reconstruction, and 70% within the first 6 months after RTS. Decision to RTS is therefore an important one, as returning too early can increase the risk of recurrence, while returning too late delays a return to pre-injury performance levels. As described by the Bern Consensus, RTS consists of three phases :\n\n* Phase 1: Return to participation (RTp)\n* Phase 2: Return to sport (RTS)\n* Phase 3: Return to performance (RTP)\n\nRTS decision must be based on multiple factors, including psychological, athletic and functional components, as well as specific nature of the patient's activities. However, few individual tests have been associated with a specific level of RTS. Furthermore, the majority of studies rely on subjective and non-objective assessments to determine whether the athlete has returned to their pre-injury level.\n\nIt would therefore be relevant to study the RTS time of patients who have performed a combination of several objective functional tests whose results could be complementary, in particular the K-STARTS, the CMJ, the DJ and the measurement of soleus muscle strength.",[78],"ACL - Anterior Cruciate Ligament Rupture",[80],"Return To Sport ACL injury",{"date":32,"type":33},{"date":60,"type":21},{"date":84,"type":21},"2029-07-31",{"name":39,"class":40},{"id":87,"slug":88,"hasResults":12,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":12,"sex":17,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":22,"phases":97,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":103,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":41},"100608857","comparison-of-wear-between-two-dual-mobility-acetabular-cups-in-patients-undergoing-total-hip-arthroplasty-100608857","NCT07207005","Comparison of Wear Between Two Dual-mobility Acetabular Cups in Patients Undergoing Total Hip Arthroplasty","CUPUSURE","Inclusion Criteria:\n\n* Patient, male or female, aged between 55 and 80.\n* Patient with a life expectancy \\> 5 years at the time of inclusion.\n* Patient scheduled to undergo primary total hip arthroplasty with a dual-mobility cup prosthesis.\n* Patient affiliated with or beneficiary of a social security scheme.\n* Patient who speaks French and has signed an informed consent form.\n\nExclusion Criteria:\n\n* Patients with a contraindication mentioned in the instructions for use of the medical device under investigation\n* Patients with an ASA score of 4\n* Protected patients: adults under guardianship, curatorship or other legal protection, deprived of their liberty by judicial or administrative decision\n* Patients participating in another clinical study whose objectives could interfere with this study","55 Years","80 Years",{"count":96,"type":21},96,[24],"In 2022, data from the UK's National Joint Registry (NJR) and the American Joint Replacement Registry (AJRR) indicated that Total Hip Replacement (THR) is the most commonly performed orthopaedic joint surgery.\n\nThe NJR has observed that between 10 and 20% of hip implants require revision within the first 10 years. The main reasons for these revisions include implant fractures, joint incompatibility, aseptic loosening, dislocation and wear of the polyethylene (PE) insert.\n\nTo address this problem, highly cross-linked polyethylene (HXLPE) inserts have been developed. Cross-linking helps to limit wear on polyethylene prostheses in total hip arthroplasty. However, there are concerns about the loss of elasticity of HXLPE and oxidation after implantation.\n\nA new generation of inserts based on highly cross-linked polyethylene (irradiation dose ≥100 Kgy), enriched with vitamin E, has been developed. This PE, called ECIMA, was developed to maintain mechanical properties, minimise PE wear and improve long-term oxidation resistance.\n\nIn the HAS evaluation report on highly cross-linked polyethylene inserts dated 24 January 2023, data from the literature show less wear of highly cross-linked polyethylene compared to conventional polyethylene.\n\nNevertheless, the use of highly cross-linked polyethylene is not yet the gold standard. Furthermore, the data in the literature mainly concern single-mobility cups but not double-mobility cups. Finally, new imaging protocols now make it possible to assess the wear of prosthesis materials more accurately.\n\nIn this context, it seems appropriate to conduct a French study comparing double-mobility cups containing highly cross-linked polyethylene or conventional polyethylene inserts.",[100],"Hip Arthroplasty Replacement",[102],"Hip Arthroplasty Insert",{"date":32,"type":33},{"date":105,"type":33},"2026-07-30",{"date":107,"type":21},"2038-12-31",{"name":39,"class":40},{"id":110,"slug":111,"hasResults":12,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":12,"sex":116,"minAge":18,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":22,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":125,"startDateStruct":126,"completionDateStruct":127,"leadSponsor":129,"locationsCount":41},"100608856","assessment-of-a-24-hour-preoperative-course-of-antibiotic-therapy-for-endoscopic-urological-surgery-in-case-of-positive-urine-culture-100608856","NCT07206992","Assessment of a 24-hour Preoperative Course of Antibiotic Therapy for Endoscopic Urological Surgery in Case of Positive Urine Culture","ANTIBIURO","Inclusion Criteria:\n\n* Patients over 18 years of age\n* Patients scheduled for urological endoscopy for one of the following indications: endoscopic surgery of the upper urinary tract (diagnostic, for treatment of stones or ureteral strictures), endoscopic prostate surgery (with or without laser: enucleation, vaporisation, resection), endoscopic surgery of the bladder and urethra (particularly tumours, strictures and foreign bodies) and ureteral stent surgery\n* Patients with a positive preoperative urine culture (presence of bacteria at more than 103\u002FmL)\n* Asymptomatic patients (no signs of urinary tract infection in particular)\n* Patients affiliated with or covered by a social security scheme\n* French-speaking patients who have signed an informed consent form\n\nExclusion Criteria:\n\n* Patient participating in another clinical trial\n* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision\n* Patient with an immune deficiency\n* Patient presenting symptoms of preoperative pyelonephritis (fever)","MALE",{"count":118,"type":21},894,[24],"Endourology poses the problem of post-operative infections. The need to obtain a negative urine culture prior to surgery is accepted, and the effectiveness of this measure in reducing the risk of post-operative infection has been proven.\n\nCurrent French recommendations are unanimous in favour of preventive treatment for asymptomatic bacteriuria (positive urine culture) prior to urological procedures involving contact with urine. These same recommendations specify that treatment should be brief, with a preoperative course of antibiotics lasting 48 hours.\n\nHowever, the scientific literature on the subject does not provide an answer to the question of whether 48 hours is the optimal duration of preoperative antibiotic treatment to avoid the risk of postoperative infection.\n\nIn this context, it is interesting to evaluate a duration of preoperative antibiotic therapy limited to 24 hours, as no study can confirm that 24 hours of treatment is insufficient to prevent post-operative infection.",[122],"Urologic Surgery",[124],"Urologic Surgery Preoperative Antibiotic Therapy",{"date":32,"type":33},{"date":60,"type":21},{"date":128,"type":21},"2028-11-30",{"name":39,"class":40},{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":137,"sex":17,"minAge":18,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":145,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":41},"100594243","mri-assessment-of-knee-kinematics-from-extension-to-flexion---exploratory-study-100594243","NCT07016906","MRI Assessment of Knee Kinematics From Extension to Flexion - Exploratory Study","FLEXIGEN","Inclusion Criteria:\n\n* Healthy volunteers (no damage to either knee)\n* Male or female, aged between 18 and 40\n* Healthy volunteer affiliated to or benefiting from a social security scheme\n* A healthy French-speaking volunteer who has signed an informed consent form.\n\nExclusion Criteria:\n\n* Contraindication to MRI\n* Joint osteoarthritis\n* BMI \\> 30\n* Previous trauma or surgery to the knee\n* Recurrence of sprains\n* Knee trauma other than sprain\n* Protected person: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision.\n* Pregnant or breast-feeding woman",true,"40 Years",{"count":140,"type":21},36,[24],"During flexion of the knee, internal rotation of the tibia associated with translation of the tibial plateaus in relation to the femoral condyles is automatically induced. This mechanism combines a sliding phenomenon and a rolling phenomenon of the condyles on the plate, the latter being known as 'roll-back'. In 2024, imaging analyses of the knee, and in particular MRI, are carried out with the leg in extension.\n\nMRI of the knee at different degrees of flexion would enable to assess the sliding and roll-back phenomena, in order to gain a better understanding of knee kinematics.\n\nHowever, MRI of the knee at different degrees of flexion is limited by the size of the MRI machines and especially by the knee antennae, which are narrow and do not allow flexion beyond 30°. In this context, the only solution for carrying out an MRI study on knees in flexion would be to carry out this examination with an antenna that allows the knee to be positioned at different angles of flexion. This particular type of antenna only exists in veterinary schools, where they are used in particular for horses.\n\nConsequently, this study is based on the assumption that the kinematics of the knee can be assessed using MRI with an antenna for veterinary use.",[144],"Healthy Volunteer",{"date":32,"type":33},{"date":147,"type":33},"2025-07-08",{"date":149,"type":21},"2026-09-30",{"name":39,"class":40},{"id":152,"slug":153,"hasResults":12,"nctId":154,"briefTitle":155,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":161,"conditions":162,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":163,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":41},"100593665","microbiological-molecular-profile-of-the-knee-joint-during-primary-reconstruction-or-revision-surgery-of-the-acl-100593665","NCT07009392","Microbiological Molecular Profile of the Knee Joint During Primary Reconstruction or Revision Surgery of the ACL","INFECTIOGEN","Inclusion Criteria:\n\n* Patient undergoing primary ACL reconstruction or revision surgery\n* Patient for whom access to the operative report of the primary ACL reconstruction is available\n* Patient affiliated with or beneficiary of a social security system\n* Patient who speaks French and has signed informed consent\n\nExclusion Criteria:\n\n* Patients with preoperative signs or a history of knee joint infection\n* Patients suffering from diabetes, cancer, or a chronic inflammatory disease\n* Patients receiving immunosuppressive therapy\n* Patients with elevated serum inflammatory markers\n* Patients who have used intravenous drugs in the 3 months prior to surgery\n* Patients who have used antibiotics in the 3 months prior to surgery\n* Protected patients: adults under guardianship, curatorship, or other legal protection, persons deprived of their liberty by a judicial or administrative decision, persons under a protective measure, persons admitted to a health or social care facility for purposes other than research, and persons unable to express consent\n* Pregnant or breastfeeding women",{"count":159,"type":21},100,[24],"Anterior cruciate ligament (ACL) reconstructions are common surgical procedures, but a significant number fail for reasons that are not fully understood.\n\nSilent infections have been shown to cause failure after other orthopedic surgical procedures such as fracture fixation and joint replacement. Silent and subclinical infections, as well as disruptions in the knee joint microbiome, could therefore be potential causes of failure after ligament reconstruction.\n\nTraditional infection diagnostic methods (microbiological cultures) are often inadequate to detect these silent infections due to a lack of sensitivity. New molecular techniques such as high-throughput sequencing or NGS (next-generation sequencing) overcome this sensitivity problem and have proven effective in diagnosing polymicrobial infections.\n\nIncreased sensitivity compared to traditional culture has been reported in numerous studies, with some demonstrating the ability of NGS to isolate the infectious organism(s) in up to 82% of culture-negative cases.\n\nThese studies demonstrate the importance of advanced sequencing technologies for the diagnosis and management of infections after ACL reconstruction, offering promising prospects for improving clinical outcomes.\n\nAt the Jean Mermoz Private Hospital, ACL reconstruction is performed using a graft that is previously immersed in vancomycin. In this context, this study will characterize the knee joint microbiome in the context of ACL reconstruction with a graft treated with antibiotics.",[78],{"date":32,"type":33},{"date":165,"type":33},"2025-06-25",{"date":167,"type":21},"2027-09-30",{"name":39,"class":40},{"id":170,"slug":171,"hasResults":12,"nctId":172,"briefTitle":173,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":177,"briefSummary":178,"conditions":179,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":181,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":41},"100593664","pillow-brace-assessment-on-sleep-quality-of-patients-undergoing-arthroscopic-rotator-cuff-surgery-100593664","NCT07009379","Pillow Brace Assessment on Sleep Quality of Patients Undergoing Arthroscopic Rotator Cuff Surgery","PILLOW BRACE","Inclusion Criteria:\n\n* Patient undergoing arthroscopic rotator cuff repair surgery confirmed by clinical diagnosis and preoperative imaging tests.\n* Patient able to understand the instructions for using the brace.\n* Patient able to perform activities of daily living with or without a brace, ensuring proper use of the brace.\n* Patient affiliated with or beneficiary of a social security system\n* French speaking patient, having signed an informed consent form\n\nExclusion Criteria:\n\n* Patient with an uncertain diagnosis\n* Patient undergoing rotator cuff revision surgery.\n* Patient with complex or surgical fractures of the shoulder, humerus, or ribs\n* Patient with multiple fractures, open fractures, or those with pinning\n* Patient who has undergone multiple surgeries in the last 6 months.\n* Patient with shoulder pathologies unrelated to the rotator cuff, such as severe arthritis or capsulitis.\n* Patient on long-term morphine treatment\n* Patient with known allergies to splint materials\n* Protected patient: adult under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative order\n* Pregnant woman\n* Patient hospitalized without consent\n* Patient already enrolled and participating in another clinical study",{"count":159,"type":21},[24],"Rotator cuff surgery is an increasingly popular procedure in France. It is a common procedure for patients with shoulder tendon injuries, aimed at restoring mobility and reducing pain. Although arthroscopic techniques have improved functional outcomes, managing postoperative pain, particularly at night, and its consequences remains a major challenge.\n\nStudies highlight that postoperative nighttime pain can significantly affect sleep quality, delaying functional recovery and patient satisfaction. However, standard splints used for postoperative immobilization do not offer an optimal solution to this problem, leaving a significant gap in the care of these patients.\n\nGiven this observation, a splint incorporating a support cushion system could meet the specific needs expressed by patients who have undergone rotator cuff surgery, namely improving sleep quality by minimizing nighttime pain. This splint, called the \"Pillow Brace,\" was developed internally at the Jouvenet Clinic. It therefore does not have CE marking.\n\nNevertheless, this study is based on the hypothesis that the use of a \"Pillow Brace\" could significantly improve sleep quality compared to standard splints, thus making a significant contribution to orthopedic medicine, postoperative rehabilitation, and patient quality of life.",[180],"Rotator Cuff Injury",{"date":32,"type":33},{"date":183,"type":33},"2025-12-17",{"date":185,"type":21},"2027-07-31",{"name":39,"class":40},{"id":188,"slug":189,"hasResults":12,"nctId":190,"briefTitle":191,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":194,"targetDuration":4,"studyType":22,"phases":196,"briefSummary":197,"conditions":198,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":200,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":41},"100588730","long-term-evaluation-of-sports-activity-in-patients-whose-ankle-was-treated-by-anatomical-reconstruction-or-arthroscopic-repair-following-chronic-lateral-instability-100588730","NCT06945198","Long-term Evaluation of Sports Activity in Patients Whose Ankle Was Treated by Anatomical Reconstruction or Arthroscopic Repair Following Chronic Lateral Instability","ANKLE STAB","Inclusion Criteria:\n\n* Patient, male or female, aged ≥ 18 years\n* Patient with chronic ankle instability defined by:\n* A history of trauma including a severe ankle sprain.\n* Clinical symptoms persisting for at least 3 months at the time of inclusion: pain, swelling, sensation of 'giving way', sensation of instability, recurrent sprains; Clinical tests (drawer test, varus provocation test) confirming grade III laxity; Imaging results (MRI) confirming clinically suspected ligament damage.\n* Patient affiliated to or benefiting from a social security scheme\n* French-speaking patient who has signed an informed consent form\n\nExclusion Criteria:\n\n* Patient with deltoid ligament injury, severe fracture or open trauma\n* Patient with insufficient ligament remnant and\u002For in too poor a condition to allow Broström-type repair.\n* Patient with a symptomatic osteochondral lesion\n* Patient with ankle hyperlaxity (Beighton score \\> 3)\n* Patient with early ankle arthropathy (Takakura arthritis classification ≥ stage 3)\n* Patient with neuromuscular disorders, systemic inflammatory disorders or tumours.\n* Patient requiring surgery on both ankles\n* Patients with a bony deformity of the ankle or foot on the affected side;\n* Patients with professional athlete status\n* Patient already included in another study\n* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision",{"count":195,"type":21},200,[24],"The goal of this clinical trial is to compare at 5 years the sporting activity of patients whose ankle had been treated by reconstruction or repair following chronic lateral instability. The main question it aims to answer is:\n\nWhat is the long-term sporting activity status of patients whose ankle had been treated by reconstruction or repair following chronic lateral instability ?\n\nParticipants will visit the clinic once every year during 5 years for clinical checkup.",[199],"Ankle Instability",{"date":32,"type":33},{"date":202,"type":33},"2026-04-29",{"date":204,"type":21},"2031-06-30",{"name":39,"class":40},{"id":207,"slug":208,"hasResults":12,"nctId":209,"briefTitle":210,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":12,"sex":116,"minAge":138,"maxAge":213,"enrollmentInfo":214,"targetDuration":4,"studyType":22,"phases":216,"briefSummary":217,"conditions":218,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":220,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":41},"100588728","comparison-of-prostate-cancer-related-quality-of-life-in-sexually-active-men-with-favourable-intermediate-risk-localised-prostate-cancer-treated-with-total-prostatectomy-or-focal-hifu-100588728","NCT06945172","Comparison of Prostate Cancer-related Quality of Life in Sexually Active Men With Favourable Intermediate-risk Localised Prostate Cancer Treated With Total Prostatectomy or Focal HIFU","QUALIFY","Inclusion Criteria:\n\n* Patient, male, aged between ≥ 40 and ≤ 75 years\n* Patient with a life expectancy \\> 10 years at the time of inclusion.\n* Patient with a therapeutic strategy (prostatectomy or focal HIFU) defined during a PCR.\n* Patient with a diagnosis of localised prostate cancer at favourable intermediate risk\n* Patient able to tolerate general anaesthesia or type IV sedation\n* Patient with normal urinary continence status\n* Patient with satisfactory erectile function allowing penetration:\n* Patient with targeted biopsies and systematic biopsies\n* Patient affiliated to or benefiting from a social security scheme\n* French-speaking patients who do not object to the use of their data.\n\nExclusion Criteria:\n\n* Patients with a contraindication to MRI\n* Stage T3a or b on MRI\n* Patient on long-term anticoagulants and unable to stop them.\n* Patient already included in another study\n* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision","75 Years",{"count":215,"type":21},102,[24],"The goal of this trial is to assess the impact of focal HIFU therapy on quality of life in patients with favourable intermediate-risk localised prostate cancer. The main question it aims to answer is:\n\nWhat is the prostate cancer-related quality of life in patients with favourable intermediate-risk localised cancer treated by total prostatectomy or focal HIFU ?\n\nResearchers will compare patients with favourable intermediate-risk localised cancer treated by total prostatectomy to patients with favourable intermediate-risk localised cancer treated by focal HIFU to see their quality of life.\n\nParticipants will answer EPIC-CP questionnaire 6 months, 12 months and 24 months after treatment",[219],"Prostate Cancer",{"date":32,"type":33},{"date":222,"type":33},"2025-09-01",{"date":224,"type":21},"2028-12-31",{"name":39,"class":40},{"id":227,"slug":228,"hasResults":12,"nctId":229,"briefTitle":230,"officialTitle":230,"acronym":231,"eligibilityCriteria":232,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":233,"enrollmentInfo":234,"targetDuration":4,"studyType":22,"phases":236,"briefSummary":237,"conditions":238,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":239,"startDateStruct":240,"completionDateStruct":241,"leadSponsor":243,"locationsCount":41},"100588725","correlation-study-between-the-classification-of-arthrogenic-motor-inhibition-ami-and-clinical-assessment-after-acl-rupture-100588725","NCT06945133","Correlation Study Between the Classification of Arthrogenic Motor Inhibition (AMI) and Clinical Assessment After ACL Rupture","AMIVAL","Inclusion Criteria:\n\n* Patient, male or female, aged ≥ 18 years and \\\u003C 45 years\n* Patient with an ACL rupture confirmed by MRI\n* Patient with an ACL rupture ≤ 30 days old\n* French speaking patient who does not object to the use of his\u002Fher data\n\nExclusion Criteria:\n\n* Patient with previous ipsi or contralateral knee injury\u002Fsurgery\n* Patient with multi-ligament injury\n* Pregnant or breastfeeding woman","44 Years",{"count":235,"type":21},90,[24],"The goal of this interventional study is to measure medial vastus inhibition and associate it with AMI classification in patients with ACL rupture. The main question it aims to answer is:\n\nIs there a correlation between AMI classification and clinical assessment after ACL rupture ? Participants will undergo surface EMG and Myotonometry.",[78],{"date":32,"type":33},{"date":60,"type":21},{"date":242,"type":21},"2028-04-30",{"name":39,"class":40},{"id":245,"slug":246,"hasResults":12,"nctId":247,"briefTitle":248,"officialTitle":248,"acronym":249,"eligibilityCriteria":250,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":251,"enrollmentInfo":252,"targetDuration":4,"studyType":22,"phases":254,"briefSummary":255,"conditions":256,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":258,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":41},"100568240","ultrasound-guided-release-of-the-median-nerve-at-the-elbow-in-patients-with-lacertus-syndrome-100568240","NCT06678646","Ultrasound-guided Release of the Median Nerve at the Elbow in Patients With Lacertus Syndrome","LACECHOCHIR","Inclusion Criteria:\n\n* Patient, male or female, aged ≥ 18 years and \\\u003C 70 years\n* Patient with isolated or bilateral Lacertus syndrome (no associated procedure on the day of surgery).\n* Patient with a normal EMG\n\nExclusion Criteria:\n\n* Patient with previous elbow surgery\n* Patient with a history of elbow fracture\n* Patient taking part in another study","70 Years",{"count":253,"type":21},107,[24],"Lacertus syndrome is an orthopaedic condition that occurs when the median nerve is compressed where it passes under the lacertus fibrosus.\n\nTreatment for lacertus syndrome is generally aimed at relieving compression of the median nerve and reducing associated symptoms. Treatment options vary according to the severity of the condition and the patient's individual needs.\n\nSectioning the Lacertus fibrosus frees the median nerve. It is performed as an outpatient procedure under local anaesthetic, and the patient can resume his or her activities immediately. Lacertus fibrosus section has been described as an open procedure, i.e. with a horizontal scar in the elbow crease.\n\nUltrasound guided surgery is an innovative technique that has proved its effectiveness for nerve releases such as the median nerve in the carpal tunnel or the ulnar nerve in the elbow. This technique was tested on a series of 18 cadavers and then on a series of 15 patients with a lacertus syndrome. The patients underwent the operation without any immediate surgical or anaesthetic complications. Muscle strength returned immediately and persisted. Pain was reduced and all patients who were working were able to carry out their professional activities from the very first week. The millimetric skin incision healed without hypertrophic scar tissue. A small haematoma appeared at week 1 and resolved spontaneously. No other late complications were observed.\n\nIn this context, this study would consolidate the preliminary results observed and confirm the hypothesis that minimally invasive percutaneous surgery under ultrasound is appropriate for sectioning Lacertus fibrosus safely, rapidly and effectively in Lacertus syndrome.",[257],"Median Nerve Entrapment",{"date":32,"type":33},{"date":260,"type":33},"2025-06-16",{"date":262,"type":21},"2028-08-31",{"name":39,"class":40},{"id":265,"slug":266,"hasResults":12,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":270,"eligibilityCriteria":271,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":272,"targetDuration":4,"studyType":22,"phases":274,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":278,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":41},"100567964","respiratory-variability-in-patients-with-acute-hypoxemic-respiratory-failure-and-placed-on-high-flow-oxygen-therapy-100567964","NCT06675045","Respiratory Variability in Patients With Acute Hypoxemic Respiratory Failure and Placed on High Flow Oxygen Therapy","Description of Respiratory Variability in Patients With Acute Hypoxemic Respiratory Failure and Placed on High Flow Oxygen Therapy - Exploratory Study","HYPOXEVARIA","Inclusion Criteria:\n\n* Patient, male or female, aged ≥ 18 years\n* Patient admitted to intensive care with acute hypoxaemic respiratory failure\n* Patient treated with high-flow oxygen therapy\n\nExclusion Criteria:\n\n* Patient admitted to intensive care with invasive ventilation\n* Patient with therapeutic abstention for intubation\n* Pregnant or breast-feeding women",{"count":273,"type":21},60,[24],"Recommendations from the European Respiratory Society are to use high-flow oxygen therapy rather than conventional oxygen therapy and non-invasive ventilation (NIV) in cases of acute hypoxaemic respiratory failure.\n\nStudies have shown that high-flow oxygen therapy can reduce the need for intubation and the initiation of NIV without reducing mortality. In addition, by improving oxygenation, high-flow oxygen therapy can create a feeling of security which may delay endotracheal intubation.\n\nTwo studies have suggested that mortality is higher in patients receiving delayed intubation (≥ 48 hours) after failure of high flow oxygen therapy. Another study suggests that delayed endotracheal intubation after high-flow oxygen therapy ≥ 48 hours increases the risk of patient mortality independently of comorbidities and severity of illness on admission. Finally, other results suggest that the increased risk of mortality may be significant after 36 hours of high-flow oxygen therapy. It is therefore difficult to determine the right time for intubation and invasive ventilation.\n\nA diagnostic decision aid could be of great use to the attending physician in optimising the patient's respiratory assistance strategy, whether invasive or non-invasive. Consequently, any clinical marker that can provide early detection of altered respiratory status on high-flow oxygen therapy deserves to be evaluated.\n\nRespiratory variability is synonymous with respiratory 'good health'. A decrease in this same variabilitý is pathological and indicates an increase in the level of loads imposed on the respiratory system. It means that the measurement of respiratory variability indices may be one of these markers\n\nThere are devices for non-invasive, continuous monitoring of respiratory variability, with automated frequency analysis of thoracic movement. In this study, respiratory variability indices will be measured in patients admitted to intensive care under high-flow oxygen therapy using an external sensor called REVAMODE.",[277],"Acute Respiratory Insufficiency",{"date":32,"type":33},{"date":280,"type":33},"2026-02-02",{"date":282,"type":21},"2027-10-31",{"name":39,"class":40},{"id":285,"slug":286,"hasResults":12,"nctId":287,"briefTitle":288,"officialTitle":288,"acronym":289,"eligibilityCriteria":290,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":291,"targetDuration":4,"studyType":292,"phases":4,"briefSummary":293,"conditions":294,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":296,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":41},"100550381","creation-of-a-pre-operative-score-the-hass-score-for-injuries-reliable-diagnosis-of-long-biceps-tendon-100550381","NCT06446336","Creation of a Pre-operative Score, the HASS Score, for Injuries Reliable Diagnosis of Long Biceps Tendon","HASS","Inclusion Criteria:\n\n* Patient with operative indication for tenodesis tenotomy, represented by persistence of clinical signs after medical treatment for more than 6 months\n* Patient with shoulder pain lasting more than 6 months\n\nExclusion Criteria:\n\n* Patient with a ruptured LBT on the pre-operative imaging assessment",{"count":195,"type":21},"OBSERVATIONAL","The long biceps tendon (LBT) has a particular anatomical pathway, making it fragile due to repeated microtrauma or trauma which can lead to chronic lesions of LBT.\n\nCurrent issue with this pathology is the absence of preoperative effective clinical and paraclinical tools, allowing confirmed diagnosis, in particular because of its entanglement with other pathologies.\n\nThis diagnostic uncertainty generates an approximation for LBT therapeutic indications so that therapeutic indications are frequently finalized during glenohumeral arthroscopy.\n\nHaving a reliable and reproducible diagnostic tool for LBT pathologies would allow an improvement in their surgical load management .\n\nIn this context, this research is based on the hypothesis that the construction of a pre-operative score, the HASS score, combining pre-operative clinical and paraclinical data would allow to obtain a reliable diagnosis of LBT injuries.",[295],"Biceps Tendon Disorder",{"date":32,"type":33},{"date":298,"type":33},"2024-05-01",{"date":300,"type":21},"2026-12-31",{"name":39,"class":40},{"id":303,"slug":304,"hasResults":12,"nctId":305,"briefTitle":306,"officialTitle":306,"acronym":307,"eligibilityCriteria":308,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":309,"targetDuration":4,"studyType":22,"phases":311,"briefSummary":312,"conditions":313,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":315,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":41},"100536833","assessment-of-collagen-membrane-interest-in-distal-cuff-lesions-repair-100536833","NCT06269965","Assessment of Collagen Membrane Interest in Distal Cuff Lesions Repair","REGENECUFF","Inclusion Criteria:\n\n* Patient, male or female, aged ≥ 18 years\n* Patient candidate for rotator cuff repair affecting supraspinatus tendon (distal lesion) +\u002F- infraspinatus on a non-pseudo-paralytic shoulder +\u002F- proximal lesion of subscapularis\n* Patient with GI ≤ 2 for each muscle\n* Non-smoking patient\n* Patient who is not involved in a work accident\n* Patient candidate for total rotator cuff repair completely covering the footprint during surgery\n\nExclusion Criteria:\n\n* Patient with contraindication to MRI\n* Patient operated for cuff revision",{"count":310,"type":21},204,[24],"Rotator cuff refers to a set of 4 shoulder tendons. These tendons are the sub-scapularis, supra-spinatus, infra-spinatus and teres minor. Rotator cuff tear corresponds to total or partial tendon disinsertion at the greater tuberosity level or a few centimeters in upstream.\n\nRotator cuff surgery is an increasingly popular procedure practiced in France. In limited cuff lesions (distal or intermediates) and in absence of contraindication, absence of tendons' healing is around 10 to 20%. Sofcot estimates that 90% of caps' heals remain healed 10 years after surgery in distal lesions. However, even in case of a healed cuff, if tendon quality is not good, function will be impaired.\n\nBioinductive implant Regeneten® is an advanced healing solution for biological improvement and regeneration of tendons on all types rotator cuff tear. A randomized study was initiated whose main objective was to evaluate integrity of repaired tendon with MRI one year after intervention according to Sugaya's classification. Results showed a recurrence rate of 8.3% in Regeneten® group compared to 25.8% in witness group.\n\nIn this context, this study is based on hypothesis that adding Regeneten® during rotator cuff repair could be beneficial on tendon healing rate but also on tendon quality healing.",[314],"Cuff Rotator Syndrome",{"date":32,"type":33},{"date":317,"type":33},"2024-04-23",{"date":319,"type":21},"2028-10-31",{"name":39,"class":40},{"id":322,"slug":323,"hasResults":12,"nctId":324,"briefTitle":325,"officialTitle":325,"acronym":326,"eligibilityCriteria":327,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":328,"targetDuration":4,"studyType":292,"phases":4,"briefSummary":329,"conditions":330,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":332,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":336,"locationsCount":41},"100529801","5-years-follow-up-assessment-of-surgical-repair-for-acl-proximal-rupture-100529801","NCT06178497","5 Years' Follow-up Assessment of Surgical Repair for ACL Proximal Rupture","RUPTUPROX","Inclusion Criteria:\n\n* Patient, male or female, aged ≥ 18 years\n* Patient with no history of knee surgery except meniscal surgery\n* Patient with an isolated proximal Sherman 1 or 2 ACL tear\n* Patient with a proximal Sherman 1 or 2 ACL tear associated to a meniscal lesion\n* Patient with a proximal ACL tear associated with an injury to the MCL or LCL grade 1 or 2 but not grade 3\n* Patient whose period is less than 3 months between the date of the accident and the surgery\n* Patient who received surgical repair between January 2019 and July 2021\n\nExclusion Criteria:\n\n* Patient with contralateral ACL tear\n* Patient with ACL tear Sherman 3 or 4\n* Patient with a surgical history on the knee concerned, other than meniscal surgery",{"count":20,"type":21},"Isolated ruptures of ACL (anterior cruciate ligament) are ligament injuries that can be proximal, central or distal. Treatment of patients with proximal lesions should be graded. Functional treatment can be reserved for low-demanding patients in whom the practice level is limited and progression risk to a functionally unstable knee less marked. In athletes, the risk of a new sprain must be explained and the patient will choose functional treatment or surgical treatment.\n\nSurgical treatment generally involves ligamentoplasty at the expense of a knee tendon to replace the ruptured ACL. In the context of proximal ACL rupture, the patient can be offered surgical repair of the ACL. There are numerous studies on ACL ligamentoplasties results but literature is poor on modern ACL repair outcomes.\n\nIn this context, this study aims to describe the relapse rate at 5 years of patients operated for a proximal ACL tear.",[331],"ACL - Anterior Cruciate Ligament Deficiency",{"date":32,"type":33},{"date":334,"type":33},"2023-12-01",{"date":300,"type":21},{"name":39,"class":40},{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":341,"acronym":342,"eligibilityCriteria":343,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":344,"targetDuration":4,"studyType":292,"phases":4,"briefSummary":346,"conditions":347,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":348,"startDateStruct":349,"completionDateStruct":350,"leadSponsor":351,"locationsCount":41},"100529800","comparison-of-surgical-repair-versus-functional-treatment-in-patients-with-proximal-acl-tear-100529800","NCT06178484","Comparison of Surgical Repair Versus Functional Treatment in Patients With Proximal ACL Tear","SUTUFONC","Inclusion Criteria:\n\n* Patient, male or female, aged ≥ 18 years\n* Patient with no history of knee surgery except meniscal surgery\n* Patient whose period is less than 3 months between the date of the accident and the surgery\n* Patient with an isolated proximal Sherman 1 or 2 ACL tear\n* Patient with a proximal Sherman 1 or 2 ACL tear associated to a stable meniscal lesion or to an MCL or LCL lesion grade 1 or 2 but not grade 3\n* Patient practicing a non-contact pivot sport (sliding sports, board sports,racket)\n\nExclusion Criteria:\n\n* Patient with contralateral ACL tear\n* Patient practicing a pivot sport with contacts\n* Patient presenting external rotary jumps ++ and +++\n* Patient with an ACL tear Sherman 3 or 4\n* Patient with meniscal lesions in the shape of a bucket handle or tabs unstable meniscals\n* Patient with a surgical history on the knee concerned",{"count":345,"type":21},144,"Isolated ruptures of the anterior cruciate ligament (ACL) can be proximal, distal or occur in the middle of the ACL.\n\nTreatment of patients with proximal lesions should be graded. Functional treatment can be reserved for low-demanding patients in whom the practice level is limited and the risk of progression to a knee functionally unstable less marked. In athletes, the risk of a new sprain must be explained and the patient will choose a functional treatment or a surgical treatment.\n\nFew studies exist in the literature on the superiority of surgical treatment compared to functional treatment. In this context, this study is based on the hypothesis that patients undergoing ACL surgical repair have better functional scores and more intense sport activity than patients with functional treatment.",[331],{"date":32,"type":33},{"date":334,"type":33},{"date":300,"type":21},{"name":39,"class":40},{"id":353,"slug":354,"hasResults":12,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":358,"eligibilityCriteria":359,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":360,"targetDuration":4,"studyType":22,"phases":361,"briefSummary":362,"conditions":363,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":365,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":369,"locationsCount":41},"100526364","respiratory-variability-and-postoperative-complications-during-thoracic-lung-resection-100526364","NCT06133777","Respiratory Variability and Postoperative Complications During Thoracic Lung Resection.","Description of Respiratory Variability and Postoperative Complications During Thoracic Lung Resection - Exploratory Study.","RESPIVARIA","Inclusion Criteria:\n\n* Patient, man or woman, who signed informed consent\n* Patient older than 18 years old\n* Patient admitted for planned thoracic resection surgery (lobectomy, bi-lobectomy, pneumonectomy) whatever the etiology is\n\nExclusion Criteria:\n\n\\- None (medical aspects)",{"count":273,"type":21},[24],"Postoperative respiratory complications (PRC) represent a major public health issue. Majority of PRCs occur once the patient leaves the post-interventional monitoring room.\n\nIdentifying patients at risk for PRC is therefore an important step for improving their post-operative care. In this context, any clinical marker making it possible to detect early alteration of the respiratory state in the postoperative phase deserves to be evaluated.\n\nThis study is based on the hypothesis that measuring indices of respiratory variability which is synonymous with \"good respiratory health\" can be part of these markers.\n\nThe measurement of respiratory variability will be done in patients with thoracic lung resection surgery before anesthetic induction and in the postoperative phase after extubation. It will be measured using a belt equipped with an external sensor allowing automatic and continuous analysis of thoracic movement by frequency analysis",[364],"Lung Injury",{"date":32,"type":33},{"date":367,"type":33},"2024-10-28",{"date":149,"type":21},{"name":39,"class":40},{"id":371,"slug":372,"hasResults":12,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":376,"eligibilityCriteria":377,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":378,"targetDuration":4,"studyType":22,"phases":380,"briefSummary":381,"conditions":382,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":384,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":388,"locationsCount":41},"100427726","analysis-of-the-evolution-of-suvmax-by-quantitative-analysis-method-of-bisphosphonate-scintigraphy-100427726","NCT04849754","Analysis of the Evolution of SUVmax by Quantitative Analysis Method of Bisphosphonate Scintigraphy","Analysis of the Evolution of SUVmax by Quantitative Analysis Method of Bisphosphonate Scintigraphy for the Follow-up of Patients With Transthyretin Amyloidosis Treated With Tafamidis","QUANTI-SUV","Inclusion Criteria:\n\n* Patient, male or female, over 18 years of age\n* Patient diagnosed with transthyretin cardiac amyloidosis confirmed by scintigraphy\n* Patient with signed consent\n\nExclusion Criteria:\n\n* Patients with systemic AL amyloidosis\n* Protected patient : major under guardianship, tutorship or other legal protection, deprived of liberty by judicial or administrative decision\n* Pregnant or breastfeeding woman",{"count":379,"type":21},30,[24],"Recently, treatment with tafamidis in patients with cardiac ATTR lead to a significant reduction in mortality. The Perugini score is commonly used on planar bone scans to differentiate cardiac ATTR from other amyloidosis or normal patients but fails to evaluate amyloid burden and patient prognosis. Although semi-quantitative methods have been suggested to evaluate the amyloid burden, there a need for quantitative methods for longitudinal assessment of the disease.",[383],"Cardiac Amyloidosis",{"date":32,"type":33},{"date":386,"type":33},"2021-02-25",{"date":300,"type":21},{"name":39,"class":40},{"id":390,"slug":391,"hasResults":12,"nctId":392,"briefTitle":393,"officialTitle":394,"acronym":395,"eligibilityCriteria":396,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":93,"enrollmentInfo":397,"targetDuration":4,"studyType":22,"phases":398,"briefSummary":399,"conditions":400,"keywords":402,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":41},"100652262","assesment-of-epidural-platelet-rich-plasma-prp-injection-during-uniportal-endoscopic-lumbar-disc-herniation-excision-on-residual-neuropathies-an-exploratory-study-100652262","NCT07770750","Assesment of Epidural Platelet-Rich Plasma (PRP) Injection During Uniportal Endoscopic Lumbar Disc Herniation Excision on Residual Neuropathies","Assesment of Epidural Platelet-Rich Plasma (PRP) Injection During Uniportal Endoscopic Lumbar Disc Herniation Excision on Residual Neuropathies: An Exploratory Study.","HERDISPLA","Inclusion Criteria:\n\n* Patients, male or female, aged ≥ 18 and ≤ 55\n* Patients with a diagnosis of a single-level lumbar disc herniation confirmed by MRI\n* Patients in whom conservative treatment has failed for at least 6 weeks\n* Patients for whom monoportal endoscopic lumbar disc herniation excision is indicated\n* Patients with lower-limb radicular pain of an intensity ≥ 3\u002F10 on the Numerical Pain Scale\n* Patients affiliated with or covered by a social security scheme\n* French-speaking patients who have signed an informed consent form\n\nExclusion Criteria:\n\n* Patients with a history of lumbar spine surgery or epidural injection\n* Patients with progressive neurological deficits or cauda equina syndrome\n* Patients with coagulopathy or systemic hematological disorders\n* Patients with an active infection or autoimmune disease\n* Patients with multilevel disc herniation or concomitant cervical spine pathology\n* Patients with scoliosis \\> 40°.\n* Patients already enrolled in another clinical study\n* Protected patients: adults under guardianship, curatorship, or other legal protection measures; patients deprived of liberty by judicial or administrative decision\n* Patients hospitalized without consent\n* Patients receiving psychiatric care\n* Patients unable to provide informed consent.\n* Pregnant or breastfeeding women, including parturient women",{"count":50,"type":21},[24],"The aim of this study is to assess neuropathic pain in the lower limb at 6 months post-operation in patients who have undergone surgery for a lumbar disc herniation using single-port endoscopic discectomy combined with an epidural PRP injection.\n\nThis study is based on the hypothesis that intraoperative epidural administration of PRP during discectomy may improve healing, reduce nerve inflammation and potentially minimise post-operative pain and complications.\n\nParticipants will perform an epidural PRP injection and questionnaires as part of this research.",[401],"Lumbar Herniated Disc",[403,404,405],"PRP injection","Uniportal endoscopic","Lumbar Disc Herniation Excision","2026-08-18",{"date":32,"type":33},{"date":409,"type":21},"2026-09-01",{"date":411,"type":21},"2028-09-01",{"name":39,"class":40},{"id":414,"slug":415,"hasResults":12,"nctId":416,"briefTitle":417,"officialTitle":418,"acronym":419,"eligibilityCriteria":420,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":421,"targetDuration":4,"studyType":22,"phases":423,"briefSummary":424,"conditions":425,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":427,"lastUpdatePostDateStruct":428,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":41},"100523737","anterior-cruciate-ligament-reconstruction-100523737","NCT06099600","Anterior Cruciate Ligament Reconstruction","Randomized Study Evaluating the Value of a Pre-habilitation Stay and Digital Follow-up, Compared With Standard Management, in Anterior Cruciate Ligament Reconstruction","Préhab-LCA","Inclusion Criteria:\n\n* Age\\>18;\n* Partial or complete tear of the anterior cruciate ligament;\n* Scheduled anterior cruciate ligament reconstructive surgery;\n* Patient with a tablet, computer or smartphone with an internet connection;\n* Patient able to understand and read French;\n* Willingness to complete questionnaires at regular intervals;\n* Membership of a social security scheme;\n* Signed informed consent.\n\nExclusion Criteria:\n\n* History of anterior cruciate ligament surgery within the past 5 years;\n* Stage III collateral ligament injury;\n* Osteotomy;\n* Neurological (motor and\u002For sensory), vestibular or rheumatic pathology;\n* Pregnant or breast-feeding woman;\n* Protected adult patient (under guardianship, curatorship or deprivation of liberty).",{"count":422,"type":21},84,[24],"This study evaluates the effectiveness of a pre-habilitation stay via digital monitoring on patients' short-term post-operative anxiety, compared with conventional management.",[426],"Ligament Rupture","2026-07-27",{"date":429,"type":33},"2026-07-28",{"date":431,"type":33},"2025-06-26",{"date":433,"type":21},"2027-12-31",{"name":39,"class":40},{"id":436,"slug":437,"hasResults":12,"nctId":438,"briefTitle":439,"officialTitle":439,"acronym":440,"eligibilityCriteria":441,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":442,"targetDuration":4,"studyType":292,"phases":4,"briefSummary":443,"conditions":444,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":448,"startDateStruct":450,"completionDateStruct":452,"leadSponsor":454,"locationsCount":455},"100641700","preoperative-stress-assessment-in-patients-undergoing-surgery-for-rotator-cuff-tendinopathy-100641700","NCT07658326","Preoperative Stress Assessment in Patients Undergoing Surgery for Rotator Cuff Tendinopathy","Tendistress","Inclusion Criteria:\n\n* Patient, male or female, over 18 years of age\n* First-line surgery for rotator cuff tendinopathy (torn and untorn)\n* Subject affiliated with or covered by a social security scheme\n* Collection of the patient's non-opposition to participate in the study\n\nExclusion Criteria:\n\n* Patients with medical history of adhesive capsulitis or complex regional pain syndrome (CRPS)\n* Patients with a history of diabetes or thyroid dysfunction\n* Patients with a history of fibromyalgia\n* Patients with a history of mental illness (PMD, schizophrenia)\n* Patients taking antidepressants or similar medications\n* Patients participating in another clinical trial\n* Protected patients: adults under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision;\n* Pregnant, breastfeeding, or parturient women;\n* Patients hospitalized without their consent.",{"count":159,"type":21},"Orthopedic surgery of the limbs presents a unpredictable postoperative course, which can be more or less lengthy in terms of functional recovery and resumption of personal or professional activities. Not uncommon, convalescence can require many months with dramatic personal and\u002For socio-professional consequences (disability, unemployment, etc.), particularly in the postoperative development of complex regional pain syndrome (CRPS) and\u002For adhesive capsulitis.\n\nAmong the suspected contributing factors, the existence of an unfavorable preoperative psychological context in patients is often mentioned.\n\nThis research is based on the hypothesis that a high level of preoperative stress in patients could contribute to the occurrence of more significant postoperative complications in patients who have undergone shoulder surgery.\n\nThe main objective is to measure the level of preoperative stress in patients undergoing surgery for rotator cuff tendinopathy.",[445,446],"Stress","Tendinopathy Rotator Cuff","2026-07-15",{"date":449,"type":33},"2026-07-16",{"date":451,"type":33},"2023-09-28",{"date":453,"type":21},"2026-09",{"name":39,"class":40},3,{"id":457,"slug":458,"hasResults":12,"nctId":459,"briefTitle":460,"officialTitle":460,"acronym":461,"eligibilityCriteria":462,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":463,"enrollmentInfo":464,"targetDuration":4,"studyType":22,"phases":466,"briefSummary":467,"conditions":468,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":470,"startDateStruct":471,"completionDateStruct":473,"leadSponsor":475,"locationsCount":41},"100641470","evaluation-of-the-impact-of-self-rehabilitation-after-foot-surgery-via-a-connected-application-100641470","NCT07653828","Evaluation of the Impact of Self-rehabilitation After Foot Surgery Via a Connected Application","M-First","Inclusion Criteria:\n\n* Age \\> 18 years and \\\u003C 85 years,\n* Patient, male or female, undergoing surgery for unilateral and isolated Hallux valgus with procedure of the 1st ray,\n* First-line surgery,\n* Persistent mobility of the metatarsophalangeal joint of the hallux,\n* Patient in possession of a smartphone or tablet,\n* Patient affiliated with or beneficiary of a social security scheme,\n* Patient who has signed the free and informed consent.\n\nExclusion Criteria:\n\n* Patient not having a smartphone or tablet,\n* Rheumatoid foot,\n* Hallux rigidus\u002FMTP1 osteoarthritis,\n* Gestures on the lateral rays\n* Surgical or traumatic history influencing MTP1 mobility.\n* Minors\n* Adults under guardianship, curatorship or other legal protection, deprived of liberty by judicial decision or administrative;\n* Pregnant, breastfeeding or parturient woman; - Hospitalized without consent","85 Years",{"count":465,"type":21},188,[24],"Hallux valgus is the most common forefoot deformity and primarily affects women. Surgical treatment involves an osteotomy of the first metatarsal to reduce the M1-M2 angle. Often, an osteotomy of the first phalanx of the big toe is performed in conjunction to reduce the M1-P1 angle.\n\nOnce the deformity has been corrected, the second objective is to restore the foot's function, particularly mobility and plantar flexion strength. To achieve this, rehabilitation is prescribed, but inconsistently due to the lack of clear guidelines and limited patient participation, especially outside of the physiotherapist's scheduled appointments.\n\nContinuous passive range of motion exercises can accelerate the return to standard footwear and normal joint mobility. This study is based on the hypothesis that an application connected with rehabilitation exercises to be done outside of sessions with a physiotherapist reproduces this mechanism of continuous passive mobility. In this context, it is hoped that patients benefiting from self-rehabilitation of the foot via the connected application, in addition to traditional care with a physiotherapist, will achieve better postoperative mobility of the metatarsophalangeal joint of the hallux compared to traditional care with a physiotherapist in patients undergoing hallux valgus surgery, with an isolated procedure on the first ray.\n\nThe main objective is to compare the mobility of the metatarsophalangeal joint of the hallux 6 months after an operation for isolated hallux valgus by osteotomy in patients benefiting from optimized rehabilitation with a physiotherapist using a connected application compared to patients receiving standard care with a physiotherapist.",[469],"Hallux Valgus",{"date":449,"type":33},{"date":472,"type":33},"2021-06-28",{"date":474,"type":21},"2026-12",{"name":39,"class":40},{"id":477,"slug":478,"hasResults":12,"nctId":479,"briefTitle":480,"officialTitle":481,"acronym":482,"eligibilityCriteria":483,"healthyVolunteers":12,"sex":484,"minAge":18,"maxAge":485,"enrollmentInfo":486,"targetDuration":4,"studyType":22,"phases":487,"briefSummary":488,"conditions":489,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":492,"startDateStruct":493,"completionDateStruct":495,"leadSponsor":497,"locationsCount":41},"100629004","impact-of-surgery-for-deep-posterior-endometriosis-on-ovarian-reserve-endoro-100629004","NCT07469007","Impact of Surgery for Deep Posterior Endometriosis on Ovarian Reserve (ENDORO)","Impact of Surgery for Deep Posterior Endometriosis on Ovarian Reserve","ENDORO","Inclusion Criteria:\n\n* Female, aged 18 to 39 years old;\n* Suspected severe deep posterior pelvic endometriosis on reference pelvic MRI (ovarian kissing, obliteration of the pouch of Douglas) with concordant clinical examination, or confirmed severe deep posterior pelvic endometriosis during exploratory laparoscopy;\n* Patient affiliated with or covered by a social security plan;\n* Patient having been informed and having given her free, informed, and written consent\n\nExclusion Criteria:\n\n* Presence of ovarian involvement defined by the presence of at least one endometrioma \\>5 mm;\n* History of surgery for severe deep endometriosis;\n* Severe preoperative premature ovarian insufficiency (defined by AMH \\\u003C1ng\u002FmL and antral follicle count \\\u003C8);\n* Concurrent use of GnRH agonist therapy at or within the preceding 3 months of enrollment;\n* BMI \\>35 kg\u002Fm²;\n* Menopausal status;\n* Patient participating in another trial with an exclusion period that has not yet expired at the time of screening;\n* Protected patient: adult under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision;\n* Pregnant, breastfeeding, or postpartum woman.","FEMALE","39 Years",{"count":159,"type":21},[24],"Endometriosis is a chronic condition typically affecting women of reproductive age and often responsible for chronic pelvic pain and\u002For infertility.\n\nIts prevalence is estimated at 10% of the female population. Deep endometriosis is a specific phenotype of the disease, defined histologically by infiltration of the peritoneum exceeding 5 mm or by fibromuscular plaques infiltrating the muscularis propria of the abdominopelvic organs. It affects approximately 12 to 20% of patients with endometriosis.\n\nSurgery is one of the treatment options. Its aim is anatomical restoration, notably through complete macroscopic resection of the lesions and the release of adhesions, particularly those affecting the adnexa. While the negative impact of cystectomies on ovarian reserve is well known, the impact of surgery for severe deep endometriosis without ovarian involvement has never been studied. Yet, these procedures are regularly performed, and in the vast majority of cases on women of reproductive age. Moreover, the impression gathered in routine practice suggests a decrease in reserve parameters of around 5%. Therefore, understanding the actual impact of the procedure on ovarian reserve would, if it were concrete, allow for expanding the indications for preoperative fertility preservation to this subgroup of patients.\n\nThe main objective is to evaluate the impact of complete macroscopic resection of severe deep posterior pelvic endometriosis on the change in AMH levels at 12 months compared to an unexposed group.",[490,491],"Endometriosis","Ovarian Reserve",{"date":449,"type":33},{"date":494,"type":33},"2025-02-11",{"date":496,"type":21},"2028-02-11",{"name":39,"class":40},{"id":499,"slug":500,"hasResults":12,"nctId":501,"briefTitle":502,"officialTitle":502,"acronym":503,"eligibilityCriteria":504,"healthyVolunteers":12,"sex":17,"minAge":505,"maxAge":506,"enrollmentInfo":507,"targetDuration":4,"studyType":22,"phases":508,"briefSummary":509,"conditions":510,"keywords":512,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":523,"startDateStruct":524,"completionDateStruct":526,"leadSponsor":528,"locationsCount":41},"100603739","diagnostic-interest-of-bone-tomoscintigraphy-in-the-search-for-cervical-pseudarthrosis-100603739","NCT07140432","Diagnostic Interest of Bone Tomoscintigraphy in the Search for Cervical Pseudarthrosis","BOSCAR","Inclusion Criteria:\n\n* Patients over 21 years of age\n* Patients who have undergone cervical arthrodesis and are being treated at Clinique de la Sauvegarde or Clinique Convert\n* Patients with a NDI clinical score at 1 year greater than 5\n* Patient affiliated to\u002F or beneficiary of a Social Security scheme as definied by the law\n\nExclusion Criteria:\n\n* Patients whose clinical condition requires rapid treatment that can't wait for examinations to be carried out\n* Pregnancy and breastfeeding\n* Protected person (curatorship, guardianship, safeguard of justice)\n* History of hypersensitivity to the active substance ( sodium oxidronate) or to any of its constituents","21 Years","99 Years",{"count":159,"type":21},[24],"Cervical pseudarthrosis is a classic complication and a challenge for challenge for spine surgeons. The rate of pseudarthrosis can range from 3 to 15%, and depend greatly on the patient, the approach the number of levels operated on.\n\nAlthough some patients remain asymptomatic, most require revision surgery instability, cervical or radicular pain. Diagnosis of cervical pseudarthrosis remains difficult. The clinical presentation is non-specific, and there is no consensus on the imaging imaging. Radiographic evaluation lacks sensitivity. The dynamic images require prior calibration and anatomical landmarks difficult to visualize. Angle measurement lacks reproducibility and sensitivity. CT scans, currently considered the gold standard as the gold standard, provides valuable morphological data but does not provide information on the functional nature of bone bridges the functional nature of bone bridges and apparent consolidation, particularly incomplete.\n\nAt the same time, functional imaging using bone scintigraphy has been historically limited by lack of spatial resolution, absence of anatomical and radiation attenuation for deep structures.The advent of hybrid imaging makes it possible to these limitations. Recently, the 6 to 16 scanners fitted to gamma cameras enable a detailed study correlations between functional and anatomical data.\n\nInterpretation criteria remain unestablished, however, and only one study reports the use of hydric bone imaging in the study of cervical pseudarthrosis. All patients were positive on scintigraphy. However, given the absence of \"healthy\" patients and the small number of patients the diagnostic value of bone scintigraphy in this indication.",[511],"Cervical Pseudarthrosis",[513,514,515,516,517,518,519,520,521,522],"cervical pseudarthrosis","imagining","hydric bone imagining","bone bridges","CT scans","diagnosis","cervical pain","bone scintigraphy","clinical presentation","diagnostic value",{"date":449,"type":33},{"date":525,"type":33},"2024-12-31",{"date":527,"type":21},"2027-02-28",{"name":39,"class":40},""]