[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Gazi University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":718},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,71,0,25,[9,52,84,115,141,165,190,214,244,277,307,328,353,381,418,444,477,508,537,561,588,611,635,660,689],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100651658","acute-effects-of-functional-inspiratory-muscle-training-in-elite-male-volleyball-players-100651658",false,"NCT07763002","Acute Effects of Functional Inspiratory Muscle Training in Elite Male Volleyball Players","Acute Effects of Functional Inspiratory Muscle Training on Exercise Capacity, Muscle Oxygenation, Balance, and Agility in Elite Male Volleyball Players","Inclusion Criteria:\n\n* Male, aged 18 to 25 years\n* Regular participation in volleyball training\n* University student actively playing on an elite-level volleyball team\n* Regular training during the previous 3 months\n* Willing and able to provide written informed consent\n\nExclusion Criteria:\n\n* Current smoking or regular alcohol use\n* Regular use of medication or vitamin supplements\n* History of upper respiratory tract infection or COVID-19 within the previous 3 months\n* Lower-extremity or shoulder surgery within the previous 6 months\n* An acute respiratory or musculoskeletal condition that prevents safe completion of the protocol\n* Inability to complete the assessment or training procedures","MALE","18 Years","25 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized controlled trial evaluates the acute effects of a single session of functional inspiratory muscle training on muscle oxygenation, exercise capacity, dynamic balance, and agility in elite male volleyball players aged 18 to 25 years. Thirty participants will be randomly assigned in a 1:1 ratio to an intervention group or a no-intervention control group. The intervention group will perform 60 resisted breaths at 50% of maximal inspiratory pressure using a POWERbreathe device during a sport-specific fixed-ball throwing drill. Both groups will complete assessments before and immediately after the intervention period on the same day. Quadriceps muscle oxygen saturation and total hemoglobin will be measured using a Moxy near-infrared spectroscopy monitor during the Incremental Shuttle Walk Test. Exercise capacity, dynamic balance, and agility will be assessed using the Incremental Shuttle Walk Test, Star Excursion Balance Test, and T-Test, respectively.",[28],"Athletic Performance",[30,31,32,33,34,35,36,37,38],"functional inspiratory muscle training","inspiratory muscle training","elite volleyball players","muscle oxygenation","near-infrared spectroscopy","Moxy Monitor","Incremental Shuttle Walk Test","dynamic balance","agility","RECRUITING","2026-08-10",{"date":42,"type":43},"2026-08-13","ACTUAL",{"date":45,"type":43},"2026-05-01",{"date":47,"type":22},"2027-06-01",{"name":49,"class":50},"Gazi University","OTHER",1,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":12,"sex":59,"minAge":18,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":78,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":51},"100651617","donor-ankle-sensorimotor-recovery-after-acl-reconstruction-with-a-peroneus-longus-tendon-autograft-100651617","NCT07762989","Donor Ankle Sensorimotor Recovery After ACL Reconstruction With a Peroneus Longus Tendon Autograft","Recovery of Donor Ankle Sensorimotor Function Following Anterior Cruciate Ligament Reconstruction Using Peroneus Longus Tendon Autograft: A Prospective Longitudinal Study","Inclusion Criteria:\n\n* Age 18 to 55 years.\n* Unilateral primary anterior cruciate ligament tear confirmed by clinical examination and magnetic resonance imaging.\n* Primary anterior cruciate ligament reconstruction performed using a peroneus longus tendon autograft.\n* Able and willing to attend the postoperative assessments at 6-8 weeks, 3 months, and 6 months.\n* Written informed consent provided before study participation.\n\nExclusion Criteria:\n\n* Multiligament knee injury.\n* Previous surgery on the index knee or donor ankle.\n* Pre-existing ankle instability or major foot or ankle pathology.\n* Neurological or neuromuscular disease.\n* Inflammatory or systemic disease that may affect the assessments.\n* Major lower-extremity deformity that may affect the assessments.\n* Unable to complete the postoperative rehabilitation program or scheduled follow-up assessments.","ALL","55 Years",{"count":62,"type":22},20,"OBSERVATIONAL","This prospective longitudinal observational cohort study will characterize recovery of donor-ankle sensorimotor function in adults who have undergone primary anterior cruciate ligament reconstruction using a peroneus longus tendon autograft. Twenty participants aged 18 to 55 years will be evaluated at postoperative 6-8 weeks, 3 months, and 6 months. The donor limb and the contralateral non-donor limb will be compared using surface electromyography of the peroneus longus, force-platform measures of postural control, inertial-sensor gait analysis, active ankle joint-position sense testing, and clinical and patient-reported foot and ankle function measures. The study does not assign the surgical procedure or rehabilitation treatment.",[66,67,68],"Anterior Cruciate Ligament Injury","Anterior Cruciate Ligament Reconstruction","Donor Site Complication",[70,71,72,73,74,75,76],"peroneus longus tendon autograft","donor ankle","sensorimotor function","surface electromyography","postural control","proprioception","gait analysis","NOT_YET_RECRUITING",{"date":42,"type":43},{"date":80,"type":22},"2026-08-22",{"date":82,"type":22},"2027-10-01",{"name":49,"class":50},{"id":85,"slug":86,"hasResults":12,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":59,"minAge":18,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":51},"100617411","clinical-and-functional-outcomes-after-acl-reconstruction-versus-primary-repair-100617411","NCT07318272","Clinical and Functional Outcomes After ACL Reconstruction Versus Primary Repair","Comparison of Clinical and Functional Outcomes After Anterior Cruciate Ligament Reconstruction and Primary Repair Surgery","Inclusion Criteria for the ACL Reconstruction Group\n\n* Age 18-40 years\n* History of complete ACL rupture treated with ACL reconstruction\n* Surgery performed at Gazi University Department of Orthopedics and Traumatology\n* At least 12 months postoperative at the time of evaluation\n* Ability to comply with all study procedures\n* Signed informed consent\n\nExclusion Criteria for the ACL Reconstruction Group\n\n* Previous surgery for partial or chronic ACL tear\n* Concomitant multi-ligament knee injuries\n* Prior surgery on the ipsilateral or contralateral knee\n* Lower extremity malalignment (e.g., significant varus\u002Fvalgus)\n* Tibial avulsion-type ACL injury\n* Neurological or musculoskeletal disorders affecting lower limb function\n* Any medical condition that may interfere with test performance or safety\n\nInclusion Criteria for the Primary ACL Repair Group\n\n* Age 18-40 years\n* Complete ACL rupture treated with arthroscopic primary ACL repair\n* Surgery performed at Gazi University Department of Orthopedics and Traumatology\n* Minimum 12 months postoperative at the time of assessment A-bility to follow and complete study procedures\n* Signed informed consent\n\nExclusion Criteria for the Primary ACL Repair Group\n\n* Previous surgery for partial or chronic ACL injury\n* Multi-ligament knee injuries\n* History of surgery on either knee\n* Lower extremity malalignment\n* Tibial avulsion-type ACL rupture\n* Neuromuscular or musculoskeletal diseases affecting lower limb function or balance\n* Any condition that may affect participation or compromise safety\n\nInclusion Criteria for the Healthy Control Group\n\n* Age 18-40 years\n* No significant lower-extremity malalignment (e.g., varus\u002Fvalgus deformity)\n* No history of lower-extremity injury within the past 12 months\n* No known chronic systemic disease\n* No history of knee surgery or diagnosed knee pathology\n* Ability to understand and comply with study procedures\n* Signed informed consent\n\nExclusion Criteria for the Healthy Control Group\n\n* Presence of clinically significant lower-extremity malalignment\n* Lower-extremity musculoskeletal injury within the last 12 months\n* Any chronic systemic or metabolic disease\n* History of knee injury, knee surgery, or diagnosed knee pathology\n* Neurological, vestibular, or musculoskeletal disorder affecting balance or gait\n* Inability to complete study procedures",true,"40 Years",{"count":94,"type":22},45,"The anterior cruciate ligament (ACL) is the primary structure responsible for controlling anterior-posterior translation and rotational stability of the knee joint. Although ACL reconstruction has long been considered the gold standard among surgical interventions following ACL injury, arthroscopic primary repair techniques have recently regained interest. With advances in minimally invasive surgical procedures, refined patient selection criteria, and improved rehabilitation strategies, the clinical effectiveness of primary repair is once again being re-evaluated. However, there remains a limited body of literature directly comparing the medium- to long-term effects of these two surgical techniques on neuromuscular performance, fatigue tolerance, and functional outcomes.\n\nThe aim of this study is to comparatively investigate postoperative muscle strength and endurance, isokinetic fatigue response, muscle oxygenation, proprioception, knee stability, postural control, and patient-reported outcome measures in individuals who have undergone ACL reconstruction or primary repair. Assessments will include low- and high-velocity tests performed on the Cybex Norm isokinetic dynamometer, a 33-repetition fatigue protocol at 300°\u002Fs, muscle oxygenation analysis using Train.Red NIRS, knee laxity measurement via the GNRB arthrometer, single-leg balance and landing evaluations using the KFORCE force platform, and subjective outcome measures (IKDC, ACL-RSI).\n\nThe findings of this study are expected to provide a more comprehensive understanding of how surgical technique influences physiological, biomechanical, and functional outcomes. This knowledge may contribute to the development of individualized rehabilitation approaches and evidence-based return-to-sport criteria.",[97,67,98],"Anterior Cruciate Ligament (ACL) Tear","Isokinetic Test",[100,101,102,103,104,105,106],"ACL Injury","Anterior Cruciate Ligament","ACL Reconstruction","ACL Primary Repair","Postoperative Outcomes","Muscle Oxygenation","Isokinetic Testing","2026-08-09",{"date":109,"type":43},"2026-08-11",{"date":111,"type":43},"2026-08-04",{"date":113,"type":22},"2027-11-30",{"name":49,"class":50},{"id":116,"slug":117,"hasResults":12,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":12,"sex":59,"minAge":122,"maxAge":4,"enrollmentInfo":123,"targetDuration":4,"studyType":23,"phases":125,"briefSummary":126,"conditions":127,"keywords":130,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":51},"100651228","montessori-based-interventions-for-older-adults-100651228","NCT07758478","Montessori-Based Interventions for Older Adults","The Effects of Montessori-Based Interventions on Cognitive Function and Activities of Daily Living in Older Adults: Randomized Controlled Trial","Inclusion Criteria:\n\n* Being 65 years of age or older\n* Having a Mini-Mental State Examination (MMSE) score of 18 or higher\n* Voluntarily agreeing to participate in the study\n\nExclusion Criteria:\n\n* Having a history of severe orthopedic or neurological disorders (e.g., stroke, Parkinson's disease, advanced osteoporosis)\n* Having severe sensory impairments (e.g., advanced vision or hearing loss)\n* Having severe physical activity restrictions due to cardiovascular diseases","65 Years",{"count":124,"type":22},60,[25],"The aim of this study is to evaluate the effect of Montessori-based interventions on cognitive function and activities of daily living in older adults.",[128,129],"Activities, Daily Living","Cognitive Function",[131,132,133,128],"Older People","Montessori","Cognitive","2026-08-06",{"date":109,"type":43},{"date":137,"type":22},"2026-08-24",{"date":139,"type":22},"2026-10-19",{"name":49,"class":50},{"id":142,"slug":143,"hasResults":12,"nctId":144,"briefTitle":145,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":91,"sex":59,"minAge":147,"maxAge":148,"enrollmentInfo":149,"targetDuration":4,"studyType":23,"phases":151,"briefSummary":152,"conditions":153,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":4},"100650718","improving-pediatric-nursing-undergraduate-education-an-escape-room-on-dehydration-in-children-100650718","NCT07752537","Improving Pediatric Nursing Undergraduate Education: An Escape Room on Dehydration in Children","Inclusion Criteria:\n\n* • Being a 3rd-year nursing student,\n* • Having a GPA above 2,\n* • Completing theoretical courses,\n* • Completing practical courses,\n* • Agreeing to participate in the study,\n* • Completing the escape room practice.\n\nExclusion Criteria:\n\n* • Retaking the Pediatric Nursing course,\n* • Having a high school, associate's, or bachelor's degree in a health-related field,\n* • Having prior escape room experience.","20 Years","32 Years",{"count":150,"type":22},84,[25],"Nursing education aims to equip students with the knowledge, skills, attitudes, and behaviors required for safe and effective professional practice. However, traditional teacher-centered approaches are often insufficient for developing competencies such as critical thinking, problem-solving, decision-making, communication, and teamwork.Consequently, innovative student-centered teaching strategies are increasingly being integrated into nursing education.Game-based learning is one such strategy that enhances engagement, motivation, active participation, and collaborative learning. Among GBL approaches, the educational escape room combines gamification with problem-solving by requiring students to work collaboratively under time constraints to solve realistic clinical scenarios. This method promotes active learning while strengthening communication, teamwork, leadership, and clinical reasoning skills. Educational escape rooms have been successfully implemented in several areas of nursing education, including women's health, pediatric care, geriatric nursing, cardiovascular diseases, clinical skills, teamwork, and leadership. Despite these developments, evidence regarding their use in pediatric nursing education remains limited.Dehydration is one of the most common pediatric health problems and requires nurses to accurately assess hydration status, recognize clinical findings, and implement appropriate nursing interventions. Competence in dehydration management is therefore essential for pediatric nursing students. To date, no published study has evaluated an educational escape room designed specifically to teach pediatric dehydration management.\n\nThis study aims to examine the effectiveness of an educational escape room implemented during a pediatric nursing laboratory simulation on nursing students' hydration knowledge, teamwork, and anxiety levels. It is expected that this innovative educational approach will enhance students' knowledge acquisition and teamwork skills while reducing anxiety during learning.",[154,155,156],"Pediatric","Nursing Student","Escape Room","2026-08-03",{"date":159,"type":43},"2026-08-07",{"date":161,"type":22},"2026-09-01",{"date":163,"type":22},"2026-11-01",{"name":49,"class":50},{"id":166,"slug":167,"hasResults":12,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":91,"sex":59,"minAge":172,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":176,"conditions":177,"keywords":181,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":184,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":51},"100650570","impact-of-smoking-on-immune-responses-in-peri-implant-health-and-disease-100650570","NCT07750171","Impact of Smoking on Immune Responses in Peri-implant Health and Disease","Impact of Smoking on Th1\u002FTh2-M1\u002FM2 Cytokine Balance and B-Cell Immune Responses in Peri-Implant Health and Disease","Inclusion Criteria:\n\n* willingness to participate in the study;\n* having at least one dental implant that has been in function for at least one year;\n* having an implant diagnosed with peri-implant health, peri-implant mucositis, or initial peri-implantitis according to the study definitions; for the initial peri-implantitis group, having an implant with PD of 6-7 mm.\n\nExclusion Criteria:\n\n* having received periodontal therapy, oral decontamination treatment, antibiotics, or steroids within the last six months before study initiation;\n* being pregnant or breastfeeding;\n* having rheumatoid arthritis, lupus erythematosus, or poorly controlled systemic diseases such as diabetes or hypertension;\n* having a history of radiation therapy or cancer therapy.","21 Years","75 Years",{"count":175,"type":22},216,"Peri-implant diseases are inflammatory conditions affecting the gums and bone around dental implants. Peri-implant mucositis causes inflammation in the gums, while peri-implantitis can also lead to bone loss and, in severe cases, implant failure. Smoking is an important risk factor for these conditions because it may change how the immune system responds to inflammation and infection.\n\nThis study will compare smokers and non-smokers with healthy dental implants, peri-implant mucositis, or peri-implantitis. Fluid samples will be collected from around the implants to measure proteins involved in inflammation, healing, and immune responses. The aim is to better understand how smoking affects the body's response to peri-implant diseases and to identify biological markers that may help assess disease risk and severity in the future.",[178,179,180],"Peri-Implant Health","Peri Implant Mucositis","Peri-implantitis",[180,182,183],"Host immune response","Smoking",{"date":134,"type":43},{"date":186,"type":43},"2026-06-01",{"date":188,"type":22},"2026-12-01",{"name":49,"class":50},{"id":191,"slug":192,"hasResults":12,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":91,"sex":59,"minAge":18,"maxAge":197,"enrollmentInfo":198,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":200,"conditions":201,"keywords":203,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":208,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":51},"100623312","assessment-of-exercise-capacity-muscle-oxygenation-and-aortic-stiffness-in-patients-with-mitral-stenosis-100623312","NCT07394998","Assessment of Exercise Capacity, Muscle Oxygenation and Aortic Stiffness in Patients With Mitral Stenosis","Comparison of Exercise Capacity, Muscle Oxygenation and Aortic Stiffness in Patients With a History of Mitral Valve Intervention for Mitral Stenosis With Healthy Subjects","Inclusion Criteria:\n\nPatients;\n\n* Between the ages of 18-80\n* Patients who have undergone mitral valve intervention due to mitral stenosis\n* At least 3 months have passed since the intervention\n\nHealthy controls;\n\n* Between the ages of 18 and 80\n* Agreeing to participate voluntarily in the study\n\nExclusion Criteria:\n\nPatients;\n\n* Patients who have undergone aortic valve intervention other than mitral valve intervention\n* Acute infection\n* Orthopedic, neurological or psychological disorders that will affect functional capacity\n\nHealthy Controls;\n\n* diagnosed chronic disease,\n* acute infection\n* A smoking history of at least 10 packs×years or more","80 Years",{"count":199,"type":22},40,"Heart valve diseases are the most common cause of mortality and morbidity after coronary artery disease, hypertension, and heart failure. In patients with mitral stenosis, the narrowed valve restricts blood flow, causing symptoms such as shortness of breath, fatigue, exertional dyspnea, orthopnea, and paroxysmal nocturnal dyspnea. These patients may experience decreased exercise capacity and physical activity levels, deterioration in quality of life, and deterioration in respiratory function. When reviewing the literature, we see that the study groups evaluating these factors are generally not homogeneous, and most studies conducted in patients with mitral stenosis evaluate patients who have undergone percutaneous mitral balloon valvuloplasty.",[202],"Mitral Stenosis",[204,205,33,206,207],"cardiopulmonary exercise test","aortic stiffness","physical activity","mitral stenosis",{"date":111,"type":43},{"date":210,"type":43},"2025-01-13",{"date":212,"type":22},"2026-12",{"name":49,"class":50},{"id":215,"slug":216,"hasResults":12,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":91,"sex":59,"minAge":18,"maxAge":60,"enrollmentInfo":222,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":224,"conditions":225,"keywords":230,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":243,"locationsCount":51},"100610542","the-role-of-pectoralis-minor-tightness-in-the-development-of-rotator-cuff-tears-100610542","NCT07228936","The Role of Pectoralis Minor Tightness in the Development of Rotator Cuff Tears","The Role of Pectoralis Minor Muscle Tightness in the Development of Rotator Cuff Tears: A Propensity Score Matched Case-Control Study","PMinor-Rotator","Inclusion criteria consisted of patients aged 18-55 years who were scheduled to undergo surgical treatment for a partial-thickness rotator cuff tear (case group) and individuals aged 18-55 years with no evidence of rotator cuff or other shoulder pathology on magnetic resonance imaging (control group). Patients were excluded if they had a history of trauma, thoracic outlet syndrome, systemic inflammatory disease, prior surgery on the affected shoulder, and declined participation in the examination.",{"count":223,"type":22},90,"This study investigates whether tightness of a small chest muscle called the pectoralis minor is associated with the development of partial rotator cuff tears in the shoulder. Using a propensity score matched case-control design, the study compares patients with rotator cuff tears (case group, n=45) to patients with intact rotator cuffs (control group, n=45).\n\nAdults aged 18-55 who are evaluated by MRI and\u002For shoulder arthroscopy at Gazi University Hospital may be invited. The case group includes patients found to have partial rotator cuff tears during arthroscopy. The control group includes patients whose rotator cuff was documented as intact by MRI. Groups are matched 1:1 on age, sex, BMI, and dominant side.\n\nBefore surgery, two trained clinician measures shoulder posture and pectoralis minor length using simple external tools (a digital caliper and ruler-like square). For arthroscopy patients, the surgeon records general arthroscopic findings. No extra procedures are added for research.\n\nWe expect to include 90 participants total. The primary hypothesis is that pectoralis minor tightness is more prevalent in patients with rotator cuff tears compared to controls. A secondary hypothesis is that tears in patients with pectoralis minor tightness more often partial-thickness bursal side rotator cuff tear. Results may help clinicians understand shoulder mechanics and improve prevention or rehabilitation strategies.",[226,227,228,229],"Shoulder Impingement Syndrome","Rotator Cuff Injuries","Pectoralis Minor Tightness","Pectoralis Minor Muscle Tension",[231,227,232,233,234,235,236,237],"rotator cuff","Posture","Scapula","Pectoralis Muscles","Arthroscopy","Shoulder Joint","Pectoralis Minor","2026-08-01",{"date":111,"type":43},{"date":241,"type":43},"2025-06-18",{"date":157,"type":22},{"name":49,"class":50},{"id":245,"slug":246,"hasResults":12,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":250,"eligibilityCriteria":251,"healthyVolunteers":12,"sex":59,"minAge":18,"maxAge":197,"enrollmentInfo":252,"targetDuration":4,"studyType":23,"phases":253,"briefSummary":254,"conditions":255,"keywords":259,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":51},"100646983","medium-cut-off-and-high-flux-membranes-on-mineral-and-bone-metabolism-in-hemodialysis-patients-100646983","NCT07685223","Medium Cut-Off and High-Flux Membranes on Mineral and Bone Metabolism in Hemodialysis Patients","Prospective Comparative Evaluation of the Effects of Medium Cut-Off and High-Flux Hemodialysis Membranes on Mineral and Bone Metabolism Biomarkers and Body Composition in Maintenance Hemodialysis Patients","MBD-HD","Inclusion Criteria:\n\n* Age 18 to 80 years.\n* Receiving maintenance hemodialysis for at least 6 months.\n* Clinically stable and receiving thrice-weekly hemodialysis.\n* Able to comply with study procedures, questionnaires, and scheduled assessments.\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Acute infection at screening or enrollment.\n* Major surgery within the previous 3 months.\n* Active malignancy requiring ongoing treatment.\n* Terminal illness with limited life expectancy.\n* Physical or cognitive impairment preventing completion of study procedures or questionnaires.\n* Inability or unwillingness to provide written informed consent.",{"count":21,"type":22},[25],"This study aims to compare the effects of medium cut-off (MCO) and high-flux hemodialysis membranes on mineral and bone metabolism biomarkers in patients receiving maintenance hemodialysis. Chronic kidney disease-mineral and bone disorder (CKD-MBD) is characterized by disturbances in biomarkers such as fibroblast growth factor-23 (FGF-23) and sclerostin, which are associated with bone turnover, vascular calcification, and adverse clinical outcomes.\n\nThis is a single-center, prospective, randomized, open-label, two-sequence, two-period crossover clinical study. Thirty adult patients receiving maintenance hemodialysis will be randomized to receive either MCO membrane treatment followed by high-flux membrane treatment or the reverse sequence, with each treatment period lasting three months.\n\nSerum FGF-23 and sclerostin levels will be measured at baseline, Month 3, and Month 6. Additional assessments will include pulse wave velocity (PWV), body composition monitoring (BCM), handgrip strength, health-related quality of life (KDQOL-36), pruritus severity (UP-Dial), and pain assessment (SF-MPQ). The study will evaluate whether MCO membranes provide additional benefits compared with conventional high-flux membranes regarding CKD-MBD-related biomarkers and patient-centered outcomes.",[256,257,258],"End Stage Kidney Disease (ESKD)","Hemodialysis","Chronic Kidney Disease Mineral and Bone Disorder",[260,261,262,263,264,265,266,267,268],"End-Stage Kidney Disease","High-Flux Hemodialysis","Medium Cut-Off Membrane","Pulse Wave Velocity","Body Composition Monitor","Handgrip Strength","FGF-23","Sclerostin","CKD-MBD","2026-06-30",{"date":271,"type":43},"2026-07-06",{"date":273,"type":22},"2026-07",{"date":275,"type":22},"2027-01",{"name":49,"class":50},{"id":278,"slug":279,"hasResults":12,"nctId":280,"briefTitle":281,"officialTitle":282,"acronym":4,"eligibilityCriteria":283,"healthyVolunteers":91,"sex":59,"minAge":18,"maxAge":197,"enrollmentInfo":284,"targetDuration":286,"studyType":63,"phases":4,"briefSummary":287,"conditions":288,"keywords":291,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":304,"leadSponsor":306,"locationsCount":51},"100646683","cardiovascular-and-bone-mineral-markers-in-dialysis-patients-and-healthy-controls-100646683","NCT07686978","Cardiovascular and Bone Mineral Markers in Dialysis Patients and Healthy Controls","Prospective Comparative Evaluation of the Biochemical and Clinical Effects of Different Dialysis Modalities on Cardiovascular Status and Bone Mineral Metabolism","Inclusion Criteria:\n\n* Age 18 to 80 years.\n* For dialysis cohorts: diagnosis of end-stage kidney disease and receiving maintenance hemodialysis or peritoneal dialysis.\n* For dialysis cohorts: receiving regular hemodialysis, continuous ambulatory peritoneal dialysis, or automated peritoneal dialysis for at least 6 months.\n* For healthy controls: no known kidney disease, with estimated glomerular filtration rate greater than 90 mL\u002Fmin\u002F1.73 m².\n* For healthy controls: no known systemic inflammatory disease or active malignancy.\n* Able to comply with planned study procedures, including pulse wave velocity measurement, Body Composition Monitor assessment, questionnaires, and biomarker measurements.\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Inability to comply with study measurements or questionnaire assessments.\n* Refusal or inability to provide written informed consent.\n* Age younger than 18 years or older than 80 years.\n* Acute infection.\n* Recent major surgical intervention.\n* Active malignancy.\n* Terminal illness with limited life expectancy.\n* Mental, cognitive, physical, or clinical condition preventing participation in study procedures.",{"count":285,"type":22},100,"1 Year","This observational study will compare cardiovascular status, bone mineral metabolism, systemic inflammation, body composition, functional status, quality of life, pruritus, and pain among patients receiving different renal replacement therapy modalities and healthy controls.\n\nAdult participants will be included in four groups: maintenance hemodialysis, continuous ambulatory peritoneal dialysis, automated peritoneal dialysis, and healthy controls. No new treatment, drug, dialysis modality, or experimental device will be assigned as part of the study. Participants will continue their routine clinical care.\n\nSerum interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), fibroblast growth factor-23 (FGF-23), and sclerostin levels will be measured. Arterial stiffness will be assessed using pulse wave velocity (PWV), and body composition will be assessed using the Body Composition Monitor (BCM). Handgrip strength, quality of life, pruritus, and pain scores will also be evaluated.\n\nThe study will also explore correlations between biochemical biomarkers, arterial stiffness, body composition, and patient-reported outcomes. In the automated peritoneal dialysis group, objective treatment adherence will additionally be assessed using the Sharesource (Baxter\u002FVantive) cloud-based remote patient monitoring platform.",[289,257,290],"End-Stage Kidney Disease (ESKD)","Peritoneal Dialysis (PD)",[257,292,293,294,295,267,296,297,263,264,298,299,300],"Continuous Ambulatory Peritoneal Dialysis","Automated Peritoneal Dialysis","Sharesource","Fibroblast Growth Factor-23","Interleukin-6","Vascular Cell Adhesion Molecule-1","Kidney Disease Quality of Life-36","Uremic Pruritus in Dialysis Patients","Short-Form McGill Pain Questionnaire",{"date":302,"type":43},"2026-07-07",{"date":273,"type":22},{"date":305,"type":22},"2027-07",{"name":49,"class":50},{"id":308,"slug":309,"hasResults":12,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":313,"eligibilityCriteria":251,"healthyVolunteers":12,"sex":59,"minAge":18,"maxAge":197,"enrollmentInfo":314,"targetDuration":4,"studyType":23,"phases":315,"briefSummary":316,"conditions":317,"keywords":320,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":326,"leadSponsor":327,"locationsCount":51},"100645108","randomized-cross-over-comparison-of-medium-cut-off-and-high-flux-hemodialysis-membranes-100645108","NCT07679763","Randomized Cross-Over Comparison of Medium Cut-Off and High-Flux Hemodialysis Membranes","Randomized Cross-Over Evaluation of Medium Cut-Off and High-Flux Hemodialysis Membranes on Inflammation and Cardiovascular Function in Maintenance Hemodialysis Patients","MCO-HD",{"count":21,"type":22},[25],"Patients receiving maintenance hemodialysis are at increased risk of cardiovascular disease, chronic inflammation, endothelial dysfunction, and impaired quality of life. Medium cut-Off (MCO) hemodialysis membranes have been developed to enhance the removal of middle-molecular-weight uremic toxins compared with conventional high-flux membranes, which may improve inflammatory status and cardiovascular health.\n\nThe aim of this study is to compare the effects of MCO and high-flux hemodialysis membranes on inflammatory biomarkers and cardiovascular function in adult patients receiving maintenance hemodialysis. The primary outcomes are changes in serum interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1) levels. Secondary outcomes include arterial stiffness assessed by pulse wave velocity (PWV), body composition assessed by Body Composition Monitor (BCM), handgrip strength, and patient-reported outcomes including quality of life, pruritus, and pain scores.\n\nThis is a prospective, randomized, open-label, two-sequence, two-period crossover study conducted at Gazi University Faculty of Medicine. Thirty adult hemodialysis patients will be randomized to one of two treatment sequences. Participants in Sequence A will receive MCO dialysis membranes for the first 3 months followed by high-flux membranes for the next 3 months. Participants in Sequence B will receive high-flux membranes for the first 3 months followed by MCO membranes for the next 3 months. Blood samples and clinical assessments will be performed at baseline, month 3, and month 6.\n\nThe study is expected to provide evidence regarding the effects of different dialysis membrane technologies on inflammation and cardiovascular health and may contribute to optimizing membrane selection in routine hemodialysis practice.",[256,257,318,319],"Cardiovascular Diseases (CVD)","Inflammation",[260,261,262,296,321,319,322,263,264],"VCAM-1","Cardiovascular Function",{"date":324,"type":43},"2026-07-01",{"date":273,"type":22},{"date":275,"type":22},{"name":49,"class":50},{"id":329,"slug":330,"hasResults":12,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":4,"eligibilityCriteria":334,"healthyVolunteers":12,"sex":59,"minAge":18,"maxAge":4,"enrollmentInfo":335,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":337,"conditions":338,"keywords":343,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":349,"completionDateStruct":350,"leadSponsor":352,"locationsCount":4},"100645011","ivc-window-agreement-study-100645011","NCT07676968","IVC Window Agreement Study","Are Subcostal, Transhepatic, and Coronal Windows Interchangeable for IVC Ultrasonography? A Multicenter Prospective Agreement Study","Inclusion Criteria:\n\n* Adult patients (≥18 years) requiring ultrasonographic assessment of intravascular volume status will be consecutively enrolled.\n\nExclusion Criteria:\n\n* Pregnancy, refusal to participate, and inability to obtain any IVC image via the SC approach.",{"count":336,"type":22},900,"Ultrasonographic evaluation of the inferior vena cava (IVC) is widely used in emergency and critical care settings for noninvasive assessment of intravascular volume status. The subcostal (SC) window is the standard approach; however, it is frequently limited by obesity, bowel distension, or postoperative anatomical changes. In such cases, the right coronal (RC) and anterior transhepatic (aTH) windows have been proposed as alternatives.",[339,340,341,342],"Emergency Care","Volume Assessment","POCUS","Venous Hemodynamics",[344,345,346,341],"inferior vena cava","ultrasonography","volume status","2026-06-24",{"date":269,"type":43},{"date":238,"type":22},{"date":351,"type":22},"2026-12-30",{"name":49,"class":50},{"id":354,"slug":355,"hasResults":12,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":359,"eligibilityCriteria":360,"healthyVolunteers":12,"sex":361,"minAge":18,"maxAge":362,"enrollmentInfo":363,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":365,"conditions":366,"keywords":370,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":374,"startDateStruct":376,"completionDateStruct":378,"leadSponsor":380,"locationsCount":4},"100644102","female-sexual-function-after-surgery-for-benign-perianal-diseases-100644102","NCT07666035","Female Sexual Function After Surgery for Benign Perianal Diseases","Prospective Evaluation of Female Sexual Function Following Surgical Treatment of Benign Perianal Diseases: A Single-Center Observational Cohort Study","PERISEX","Inclusion Criteria:\n\n* Female patients aged 18-70 years\n* Sexually active during the previous 4 weeks\n* Diagnosed with chronic anal fissure, hemorrhoidal disease, or cryptoglandular anal fistula\n* Scheduled for surgical treatment according to routine clinical indications\n* Able to understand and complete study questionnaires\n* Willing to provide written informed consent\n\nExclusion Criteria:\n\n* Inflammatory bowel disease (Crohn's disease or ulcerative colitis)\n* Pregnancy\n* Postpartum period within the previous 12 months\n* Pelvic organ prolapse\n* Previous treatment for female sexual dysfunction\n* Current antidepressant medication use\n* Active psychiatric disorder\n* Gynecological malignancy\n* Previous pelvic radiotherapy\n* Inability or unwillingness to complete study questionnaires\n* Refusal to provide informed consent","FEMALE","70 Years",{"count":364,"type":22},120,"Benign perianal diseases such as chronic anal fissure, hemorrhoidal disease, and cryptoglandular anal fistula may negatively affect female sexual function through pain, bleeding, discharge, discomfort, and impairment in quality of life. Although improvement in male sexual function after surgery for benign anorectal disorders has been reported, data regarding female sexual function remain limited.\n\nThis prospective observational cohort study aims to evaluate changes in Female Sexual Function Index (FSFI) scores following surgical treatment of benign perianal diseases. Female patients undergoing surgery for chronic anal fissure, hemorrhoidal disease, or cryptoglandular anal fistula will be assessed preoperatively and at postoperative 3 and 6 months using the FSFI, Cleveland Clinic Incontinence Score (CCIS\u002FWexner), and Visual Analog Scale (VAS).\n\nThe primary objective is to determine whether female sexual function improves following surgical treatment. Secondary objectives include evaluating the relationship between symptom improvement, continence status, pain reduction, and changes in female sexual function.",[367,368,369],"Chronic Anal Fissure","Hemorrhoidal Disease","Cryptoglandular Anal Fistula",[369,367,368,371,372,373],"FSFI","Sexual Functions","Perianal Pain",{"date":375,"type":43},"2026-06-26",{"date":377,"type":22},"2026-08",{"date":379,"type":22},"2028-02",{"name":49,"class":50},{"id":382,"slug":383,"hasResults":12,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":387,"eligibilityCriteria":388,"healthyVolunteers":12,"sex":59,"minAge":18,"maxAge":4,"enrollmentInfo":389,"targetDuration":390,"studyType":63,"phases":4,"briefSummary":391,"conditions":392,"keywords":398,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":411,"lastUpdatePostDateStruct":412,"startDateStruct":414,"completionDateStruct":415,"leadSponsor":417,"locationsCount":51},"100643888","glp-1-receptor-agonists-and-early-proctologic-effects-in-morbid-obesity-100643888","NCT07668765","GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity","Early Proctologic Effects of GLP-1 Receptor Agonist Therapy in Morbidly Obese Patients: A Prospective Cohort Study With Baseline and 3-Month Proctologic Assessment","GLP-PROCT","Inclusion Criteria:\n\n* Age ≥18 years\n* Morbid obesity (BMI ≥40 kg\u002Fm² or BMI ≥35 kg\u002Fm² with obesity-related comorbidities)\n* Newly prescribed GLP-1 receptor agonist therapy\n* Ability and willingness to provide written informed consent\n* Ability to attend 3-month follow-up visit\n\nExclusion Criteria:\n\n* Inflammatory bowel disease\n* Perianal Crohn's disease\n* History of anorectal malignancy\n* Previous pelvic radiotherapy\n* Anorectal surgery within the previous 3 months\n* Pregnancy\n* Neurogenic bowel dysfunction\n* Inability to comply with follow-up visits\n* Discontinuation of GLP-1 receptor agonist therapy before follow-up assessment\n* Active anorectal infection or abscess",{"count":285,"type":22},"3 Months","Prospective observational cohort study evaluating the early proctologic effects of GLP-1 receptor agonist therapy in morbidly obese patients. Participants will undergo baseline and 3-month anorectal symptom assessment and proctologic examination to evaluate newly developed proctologic diseases and changes in pre-existing symptoms.",[393,394,395,396,397],"Morbid Obesity","Anorectal Diseases","Drug-Related Side Effects and Adverse Reactions","Constipation","Diarrhea",[399,400,401,402,403,404,405,406,407,408,409,410],"GLP-1 receptor agonist","obesity","anorectal symptoms","hemorrhoids","anal fissure","constipation","semaglutide","tirzepatide","proctologic examination","bowel habits","anorectal disease","proctology","2026-06-23",{"date":413,"type":43},"2026-06-25",{"date":377,"type":22},{"date":416,"type":22},"2027-05",{"name":49,"class":50},{"id":419,"slug":420,"hasResults":12,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":4,"eligibilityCriteria":424,"healthyVolunteers":12,"sex":59,"minAge":425,"maxAge":4,"enrollmentInfo":426,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":427,"conditions":428,"keywords":432,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":436,"lastUpdatePostDateStruct":437,"startDateStruct":439,"completionDateStruct":441,"leadSponsor":443,"locationsCount":51},"100643541","physical-therapy-program-and-treatment-expectations-in-knee-osteoarthritis-100643541","NCT07618403","Physical Therapy Program and Treatment Expectations in Knee Osteoarthritis","Evaluating The Predictive Effect of Treatment Expectations on Response to A Physical Therapy Program in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Agreeing to participate in the study\n* Being over 50 years of age\n* Having a clinically and radiographically confirmed diagnosis of knee osteoarthritis\n* Having grade 2-3-4 knee osteoarthritis according to the Kellgren-Lawrence grading system\n* Being literate\n\nExclusion Criteria:\n\n* Previous knee surgery\n* Conditions that prevent exercise (such as incurable malignancy, active systemic infection, non-union fracture)\n* Presence of accompanying neurological disease affecting the lower extremity\n* Severe cognitive impairment (neuropsychiatric disease or condition that will impede cooperation, such as psychosis, dementia)\n* History of having received injections or other procedures to the knee joint or physical therapy within the last 6 months","50 Years",{"count":150,"type":22},"To our knowledge, no studies have been conducted in the literature investigating the relationship between the success of physical therapy programs applied in knee osteoarthritis and patients' pre-treatment expectations. The rationale for this study is to demonstrate the possible relationship between treatment expectations and the benefits seen from conventional physical therapy programs in patients with knee osteoarthritis, and to provide clinicians with a different perspective in knee osteoarthritis treatment planning.",[429,430,431],"Gonarthrosis; Primary","Physical Therapy","Patients' Expectations",[433,434,435],"treatment expectations","gonarthrosis","physical treatment","2026-06-08",{"date":438,"type":43},"2026-06-10",{"date":440,"type":43},"2026-01-01",{"date":442,"type":22},"2027-09-15",{"name":49,"class":50},{"id":445,"slug":446,"hasResults":12,"nctId":447,"briefTitle":448,"officialTitle":449,"acronym":4,"eligibilityCriteria":450,"healthyVolunteers":12,"sex":59,"minAge":18,"maxAge":197,"enrollmentInfo":451,"targetDuration":4,"studyType":23,"phases":453,"briefSummary":454,"conditions":455,"keywords":461,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":469,"lastUpdatePostDateStruct":470,"startDateStruct":472,"completionDateStruct":474,"leadSponsor":476,"locationsCount":51},"100638885","extracorporeal-shock-wave-therapy-in-lower-extremity-lymphedema-100638885","NCT07626645","Extracorporeal Shock Wave Therapy in Lower Extremity Lymphedema","Efficacy of Extracorporeal Shock Wave Therapy (ESWT) in Lower Extremity Lymphedema: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 to 80 years\n* Clinical diagnosis of lower extremity lymphedema established at least 6 months prior to enrollment\n* Completion of at least one cycle of CDT Phase 1 (intensive decongestive phase) within the preceding six months\n* Currently in CDT Phase 2 (maintenance phase) with active use of compression garments\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Active chemotherapy or radiotherapy\n* Active infection\n* Lower extremity vascular diseases including deep vein thrombosis or arterial insufficiency\n* Presence of a cardiac pacemaker\n* Pregnancy\n* Bleeding disorders",{"count":452,"type":22},36,[25],"Lower extremity lymphedema is a chronic and progressive condition associated with significant functional impairment and reduced quality of life. The current gold-standard treatment is Complex Decongestive Therapy (CDT); however, a substantial proportion of patients continue to experience persistent symptoms during the maintenance phase. This prospective, randomized, double-blind, placebo-controlled clinical trial aims to evaluate the effectiveness of Extracorporeal Shock Wave Therapy (ESWT) as an adjunct to standard CDT maintenance therapy in patients with lower extremity lymphedema. Participants will be randomly allocated to either an active ESWT group or a sham ESWT group, with both groups continuing standard CDT maintenance throughout the study. ESWT will be administered twice weekly for five sessions. Changes in limb volume, skin thickness and subcutaneous tissue thickness assessed by ultrasonography, pain, functional status, and quality of life will be evaluated at baseline, after treatment, and at one-month follow-up.",[456,457,458,459,460],"Lymphedema, Lower Limb","Extracorporeal Shock Wave Therapy","Edema Leg","Sham-controlled","Placebo Control Design",[462,463,464,465,466,467,468],"Lower Extremity Lymphedema","Extracorporeal Shock Wave Therapy (ESWT)","Complex Decongestive Therapy (CDT)","Limb Volume","Ultrasonography","skin and subcutaneous tissue thickness","Quality of Life","2026-06-02",{"date":471,"type":43},"2026-06-04",{"date":473,"type":22},"2026-06-22",{"date":475,"type":22},"2027-02-01",{"name":49,"class":50},{"id":478,"slug":479,"hasResults":12,"nctId":480,"briefTitle":481,"officialTitle":482,"acronym":483,"eligibilityCriteria":484,"healthyVolunteers":12,"sex":59,"minAge":18,"maxAge":4,"enrollmentInfo":485,"targetDuration":487,"studyType":63,"phases":4,"briefSummary":488,"conditions":489,"keywords":492,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":506,"locationsCount":507},"100623240","real-world-comparison-of-chemo-immunotherapy-regimens-in-metastatic-nsclc-with-pd-l1-50-alcg-01-100623240","NCT07394062","Real-World Comparison of Chemo-Immunotherapy Regimens in Metastatic NSCLC With PD-L1 \u003C50% (ALCG-01)","A Prospective Observational Study Comparing Chemotherapy Plus Pembrolizumab Versus Nivolumab Plus Ipilimumab With Chemotherapy in Patients With Metastatic Non-Small Cell Lung Cancer and PD-L1 Expression Below 50%","ALCG-01","Inclusion Criteria:\n\n* Age ≥18 years.\n* Histologically or cytologically confirmed non-small cell lung cancer.\n* Metastatic (stage IV) disease at the time of study entry.\n* Tumor PD-L1 expression \\\u003C50%.\n* Initiation of first-line systemic treatment with either chemotherapy plus pembrolizumab or nivolumab plus ipilimumab in combination with chemotherapy, according to routine clinical practice.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Prior systemic therapy for metastatic non-small cell lung cancer.\n* Participation in an interventional clinical trial that mandates treatment assignment.\n* Presence of another active malignancy requiring systemic treatment.\n* Inability to comply with routine clinical follow-up or data collection.",{"count":486,"type":22},400,"18 Months","Patients with metastatic non-small cell lung cancer (NSCLC) and programmed death-ligand 1 (PD-L1) expression below 50% are commonly treated with different chemo-immunotherapy regimens in routine clinical practice. Although these regimens are widely used, comparative real-world data on survival outcomes and patient-reported quality of life are limited.\n\nThis prospective observational study aims to compare two commonly used treatment approaches in patients with metastatic NSCLC and PD-L1 expression \\\u003C50%: chemotherapy plus pembrolizumab versus nivolumab plus ipilimumab combined with chemotherapy. Patients will receive treatment according to routine clinical decisions made by their treating physicians; no treatment assignment or intervention will be performed as part of the study.\n\nThe primary outcomes of the study are progression-free survival and overall survival. In addition, health-related quality of life will be assessed using validated patient-reported outcome questionnaires during routine follow-up.\n\nExploratory analyses will examine treatment outcomes in relation to selected clinical and patient-related factors, such as biological age, antibiotic exposure, and dietary patterns, in subsets of patients with available data.\n\nThe results of this study are expected to provide real-world evidence on survival and quality of life outcomes associated with commonly used chemo-immunotherapy strategies in metastatic NSCLC.",[490,491],"Nonsmall Cell Lung Cancer, Stage IV","Metastatic Nonsmall Cell Lung Cancer",[493,494,495,496,497,498,468,499],"NSCLC","Metastatic Lung Cancer","Chemo-Immunotherapy","PD-L1","Progression-Free Survival","Overall Survival","Patient-Reported Outcomes","2026-05-14",{"date":502,"type":43},"2026-05-18",{"date":504,"type":43},"2026-02-01",{"date":379,"type":22},{"name":49,"class":50},2,{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":514,"eligibilityCriteria":515,"healthyVolunteers":12,"sex":59,"minAge":390,"maxAge":516,"enrollmentInfo":517,"targetDuration":4,"studyType":23,"phases":519,"briefSummary":520,"conditions":521,"keywords":525,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":529,"lastUpdatePostDateStruct":530,"startDateStruct":532,"completionDateStruct":534,"leadSponsor":536,"locationsCount":51},"100638936","safe-early-intervention-for-at-risk-infants-100638936","NCT07596147","SAFE Early Intervention for At-Risk Infants","Investigation of the Effectiveness of the SAFE Early Intervention Approach on Upper Extremity Function, Fine Motor Skills, and Quality of Life in High-Risk Infants","SAFE-EFFECT","Inclusion Criteria:\n\n* Infants aged between 3 and 12 months corrected age Presence of neurodevelopmental risk factors including perinatal stroke, perinatal asphyxia, hypoxic-ischemic encephalopathy, germinal matrix hemorrhage, intraventricular hemorrhage, periventricular leukomalacia, or prematurity at or below 37 weeks of gestation Admission to the Developmental Pediatrics and Pediatric Physiotherapy and Rehabilitation Unit of Gazi University Faculty of Health Sciences Parent or legal guardian willing to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Presence of any congenital anomaly Diagnosis of a genetic disorder Any orthopedic problem affecting upper extremity function Families unable to communicate in Turki","12 Months",{"count":518,"type":22},34,[25],"This randomized controlled study aims to investigate the effects of the SAFE early intervention approach on upper extremity function, fine motor skills, and developmental outcomes in high-risk infants aged 3-12 months. Thirty high-risk infants admitted to the Developmental Physiotherapy and Pediatric Rehabilitation Unit of Gazi University Faculty of Health Sciences will be randomly assigned to either the SAFE early intervention group or the Neurodevelopmental Treatment (NDT) group.\n\nInfants in the intervention group will receive the SAFE early intervention program for 8 weeks under the supervision of an experienced pediatric physiotherapist. The SAFE approach includes age-appropriate activities focusing on environmental enrichment, promotion of voluntary and goal-directed movements, sensory stimulation, fine motor skill development, postural control, transitional movements, and enhancement of infant-parent interaction through daily routines and home-based activities.\n\nInfants in the control group will receive conventional Neurodevelopmental Treatment (NDT) for 8 weeks. The NDT program includes age-specific activities targeting postural control, muscle tone regulation, facilitation of motor development, hand function, balance, weight transfer, and fine motor skills.\n\nFamilies will receive education regarding home-based activities and facilitation techniques specific to their infant's developmental needs. Follow-up will include home visits and weekly telephone monitoring to ensure adherence to the intervention program. Assessments will be performed before the intervention and after the 8-week intervention period by a physiotherapist blinded to group allocation.",[522,523,524],"High Risk Infant","Neurodevelopmental Disorder (Diagnosis)","Preterm",[526,527,528],"early intervention","high risk infant","upper limb function","2026-05-13",{"date":531,"type":43},"2026-05-19",{"date":533,"type":43},"2026-02-16",{"date":535,"type":22},"2026-07-16",{"name":49,"class":50},{"id":538,"slug":539,"hasResults":12,"nctId":540,"briefTitle":541,"officialTitle":542,"acronym":543,"eligibilityCriteria":544,"healthyVolunteers":91,"sex":59,"minAge":4,"maxAge":4,"enrollmentInfo":545,"targetDuration":4,"studyType":23,"phases":547,"briefSummary":548,"conditions":549,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":556,"completionDateStruct":558,"leadSponsor":560,"locationsCount":4},"100635128","mind-mapping-impact-on-critical-thinking-and-problem-solving-skills-100635128","NCT07548658","Mind Mapping: Impact on Critical Thinking and Problem-Solving Skills","Visualizing Thought Through Mind Mapping: A Randomized Controlled Trial on Critical Thinking and Problem-Solving Skills Among Nursing Students","Mind mapping","Inclusion Criteria:\n\n* Students who are enrolling in the Critical Thinking in Nursing course for the first time and\n* who volunteer to participate in the study\n\nExclusion Criteria:\n\n* Students who have previously taken the critical thinking course\n* The student's refusal to continue participating in the study or failure to complete the data collection forms.",{"count":546,"type":22},65,[25],"This randomized controlled trial aims to evaluate the effectiveness of the mind mapping method in enhancing critical thinking and problem-solving skills among nursing students. The study will be conducted with 65 nursing students enrolled in a \"Critical Thinking in Nursing\" course at Gazi University during the 2025-2026 academic year. Participants will be assigned to experimental and control groups using stratified randomization based on pre-test scores from the \"Marmara Critical Thinking Tendencies Scale\" and the \"Problem-Solving Inventory.\"\n\nThe five-week intervention focuses on five clinical case studies: infection control, medication administration, patient safety, ethical issues, and systematic approaches. While both groups receive the same theoretical content, they follow different practical methodologies:\n\nThe Control Group will engage in standard case analysis methods. The Experimental Group will work in small teams (4-5 students) to create and present visual mind maps for each case study, using either traditional or digital tools.\n\nFollowing the intervention, both groups will complete post-tests to assess changes in their critical thinking and problem-solving competencies.",[550,551,552],"Mind Mapping","Nursing Students","Critical Thinking","2026-04-23",{"date":555,"type":43},"2026-04-29",{"date":557,"type":22},"2026-04-22",{"date":559,"type":22},"2026-05-29",{"name":49,"class":50},{"id":562,"slug":563,"hasResults":12,"nctId":564,"briefTitle":565,"officialTitle":565,"acronym":4,"eligibilityCriteria":566,"healthyVolunteers":12,"sex":59,"minAge":18,"maxAge":122,"enrollmentInfo":567,"targetDuration":4,"studyType":23,"phases":569,"briefSummary":570,"conditions":571,"keywords":577,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":557,"lastUpdatePostDateStruct":582,"startDateStruct":584,"completionDateStruct":585,"leadSponsor":587,"locationsCount":51},"100635371","the-effect-of-art-based-intervention-on-fatigue-anxiety-perception-of-nurse-presence-and-quality-of-life-in-patients-with-hematological-cancers-100635371","NCT07551817","The Effect of Art-Based Intervention on Fatigue, Anxiety, Perception of Nurse Presence, and Quality of Life in Patients With Hematological Cancers","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Speaking and understanding Turkish\n* Being literate\n* Having a diagnosis of hematological cancer,\n* Receiving chemotherapy in an inpatient ward,\n* Not having a psychiatric diagnosis,\n* Having an ECOG score of 1 or 2,\n\nExclusion Criteria:\n\n* Having vision loss and hearing loss,\n* Having an ECOG score of 3 or 4\n* Patients who wanted to leave the study\n* Failure to attend at least two sessions of art therapy.",{"count":568,"type":22},52,[25],"This study will be conducted in a randomized controlled experimental design to examine The effect of art-based intervention on fatigue, anxiety, perception of nurse presence, and quality of life in patients with hematological cancer. The study will be conducted with 52 patients (26 intervention, 26 control groups) treated in the Hematology department of a training and research hospital between May 2025 and October 2026. Art-based intervention will be applied to the intervention group for 2 week (3 sessions per week), No application will be made to the control group. The data collection tools in the study are the Patient Identifier Information Form, Cancer Fatigue Scale, Functional Assessment of Cancer Therapy-General Scale (FACT-G), Hospital Anxiety and Depression Scale (HADS), and Nurse Presence Scale (PONS).",[572,573,574,468,575,576],"Art-based Intervention","Hematological Cancer","Nurse Presence","Fatigue","Anxiety",[578,579,580,581,575,576],"Art-based intervention","Hematological cancer","Nurse presence","Quality of life",{"date":583,"type":43},"2026-04-27",{"date":45,"type":22},{"date":586,"type":22},"2026-12-31",{"name":49,"class":50},{"id":589,"slug":590,"hasResults":12,"nctId":591,"briefTitle":592,"officialTitle":593,"acronym":4,"eligibilityCriteria":594,"healthyVolunteers":91,"sex":59,"minAge":595,"maxAge":596,"enrollmentInfo":597,"targetDuration":4,"studyType":23,"phases":599,"briefSummary":600,"conditions":601,"keywords":603,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":605,"lastUpdatePostDateStruct":606,"startDateStruct":607,"completionDateStruct":609,"leadSponsor":610,"locationsCount":4},"100634775","the-effect-of-health-education-on-childrens-healthy-lifestyle-skills-100634775","NCT07544069","The Effect of Health Education on Children's Healthy Lifestyle Skills","The Effect of Health Education on Children's Healthy Lifestyle Skills: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Enrolled at Şehit Yavuz Başayar Primary School\n* Currently attending 2nd, 3rd, or 4th grade\n* Willing to participate in the study\n* Having parental consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Lack of parental consent\n* Inability to complete the data collection tools","8 Years","10 Years",{"count":598,"type":22},526,[25],"Childhood is a critical period for the development of lifelong health behaviors, and early interventions play an essential role in promoting long-term health and preventing future health problems. This study is planned to evaluate the effect of health education on children's healthy lifestyle skills.",[602],"Healthy Lifestyle Behaviors",[604],"Health Education, Child, Primary School, Health Behavior, Nursing","2026-04-18",{"date":557,"type":43},{"date":608,"type":22},"2026-04-15",{"date":269,"type":22},{"name":49,"class":50},{"id":612,"slug":613,"hasResults":12,"nctId":614,"briefTitle":615,"officialTitle":616,"acronym":4,"eligibilityCriteria":617,"healthyVolunteers":91,"sex":59,"minAge":92,"maxAge":197,"enrollmentInfo":618,"targetDuration":619,"studyType":63,"phases":4,"briefSummary":620,"conditions":621,"keywords":625,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":629,"lastUpdatePostDateStruct":630,"startDateStruct":632,"completionDateStruct":633,"leadSponsor":634,"locationsCount":51},"100634487","effects-of-cognitive-dual-task-on-gait-in-parkinsons-disease-100634487","NCT07540325","Effects of Cognitive Dual-Task on Gait in Parkinson's Disease","Investigating the Effects of Cognitive Dual-Task on Gait in Individuals With Parkinson's Disease","Inclusion Criteria for Individuals with Parkinson's Disease:\n\n* A clinical diagnosis of Parkinson's Disease confirmed by a neurologist according to the United Kingdom Parkinson's Disease Society Brain Bank diagnostic criteria\n* Classified between stages 1 and 3 according to the Modified Hoehn and Yahr Staging Scale\n* Aged between 40 and 80 years\n* A score of at least 21 on the Montreal Cognitive Assessment (MoCA)\n* Ability to walk continuously for at least 10 minutes without interruption and without the use of any assistive walking device\n* Having received at least 5 years of formal education\n\nExclusion Criteria for Individuals with Parkinson's Disease:\n\n* Presence of any neurological disorder other than Parkinson's Disease\n* Presence of any cardiopulmonary or musculoskeletal condition that may impair safe ambulation\n* A score of ≥10 for anxiety and ≥7 for depression on the Hospital Anxiety and Depression Scale (HADS)\n* Presence of visual or auditory impairments that cannot be corrected with assistive devices\n\nInclusion Criteria for Healthy Individuals:\n\n* Aged between 40 and 80 years\n* A score of at least 21 on the Montreal Cognitive Assessment (MoCA)\n\nExclusion Criteria for Healthy Individuals:\n\n* Presence of any neurological disorder\n* Presence of any cardiopulmonary or musculoskeletal condition that may affect safe ambulation\n* A score of ≥10 for anxiety and ≥7 for depression on the Hospital Anxiety and Depression Scale (HADS)\n* Presence of visual or auditory impairments that cannot be corrected with assistive devices",{"count":21,"type":22},"2 Days","The aim of this study is to evaluate gait in individuals diagnosed with PD under tasks involving different cognitive domains, to compare the results with those of age and sex-matched healthy individuals, and to determine which cognitive function has the greatest impact on gait in PD.",[622,623,624],"Parkinson's Disease (PD)","Cognition","Gait Disorders",[626,129,627,628],"Gait","Dual-Task","Parkinson's Disease","2026-04-17",{"date":631,"type":43},"2026-04-20",{"date":631,"type":22},{"date":586,"type":22},{"name":49,"class":50},{"id":636,"slug":637,"hasResults":12,"nctId":638,"briefTitle":639,"officialTitle":640,"acronym":641,"eligibilityCriteria":642,"healthyVolunteers":91,"sex":59,"minAge":18,"maxAge":4,"enrollmentInfo":643,"targetDuration":4,"studyType":23,"phases":645,"briefSummary":646,"conditions":647,"keywords":648,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":608,"lastUpdatePostDateStruct":654,"startDateStruct":655,"completionDateStruct":657,"leadSponsor":659,"locationsCount":4},"100634832","puzzle-based-learning-on-nursing-students-parenteral-medication-knowledge-and-motivation-100634832","NCT07544810","Puzzle-Based Learning on Nursing Students' Parenteral Medication Knowledge and Motivation","The Effect of Crossword-Based Learning on Parenteral Drug Administration on Nursing Students' Knowledge Level, Self-Efficacy Perception, and Learning Motivation","→ PIM-Crosswor","Inclusion Criteria:\n\nBeing enrolled as a 2nd-year student in the Nursing Department of the Faculty of Health Sciences at Kütahya Health Sciences University.\n\n• Being registered for the \"Fundamental Principles and Practices in Nursing\" course.\n\nExclusion Criteria:\n\n* Not completing the pre-test or post-test data collection forms.\n\n  * Being on medical or academic leave during the study period.\n  * Having previously received structured training related to parenteral medication administration within the past 6 months.\n  * Participating in another educational intervention study at the same time.",{"count":644,"type":22},80,[25],"This randomized, controlled, parallel-group, interventional study aims to evaluate the effects of Crossword-Based Learning for Parenteral Drug Administration on the knowledge level, self-efficacy perception, and learning motivation of Nursing Department students. It is considered original because it examines the effects of crossword-based learning on cognitive and psychosocial outcomes in parenteral drug administration, a skill with a high risk of error in the clinical field. The study will be conducted with 80 (40 Experimental, 40 Control) nursing students selected through a power analysis. Participants will be assigned to groups by random assignment, and the study will be conducted in accordance with the triple-blind principle (participant, data collector, statistician). The experimental group will receive Crossword Activities in four different phases (Initial, Theoretical, Laboratory, and Post-Clinical Practice) in addition to the standard educational content. The control group will only complete the standard education. The primary outcomes of the study are; At the end of the 4th stage, the Parenteral Drug Administration Knowledge Test will be evaluated based on the Safe Parenteral Drug Administration Self-Efficacy Scale (SES-SES) and the Higher Education Learning Motivation Scale (SLS-SES) scores.",[551],[649,650,651,652,653],"nursing student","Crossword puzzle","drug administration","motivation","self-sufficiency",{"date":557,"type":43},{"date":656,"type":22},"2026-04-28",{"date":658,"type":22},"2026-09-15",{"name":49,"class":50},{"id":661,"slug":662,"hasResults":12,"nctId":663,"briefTitle":664,"officialTitle":664,"acronym":665,"eligibilityCriteria":666,"healthyVolunteers":12,"sex":59,"minAge":4,"maxAge":4,"enrollmentInfo":667,"targetDuration":4,"studyType":23,"phases":668,"briefSummary":669,"conditions":670,"keywords":673,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":681,"lastUpdatePostDateStruct":682,"startDateStruct":684,"completionDateStruct":686,"leadSponsor":688,"locationsCount":51},"100632785","the-effect-of-an-artificial-intelligence-supported-virtual-reality-simulation-on-nursing-students-holistic-care-skills-100632785","NCT07518199","The Effect of an Artificial Intelligence-Supported Virtual Reality Simulation on Nursing Students' Holistic Care Skills","AI-VRS","Inclusion Criteria:\n\n* Voluntary participation in the study,\n* Having enrolled for the first time in the courses HEM 402 Professional Practice I and HEM 404 Professional Practice II in the Department of Nursing, Faculty of Health Sciences,\n* Absence of eye conditions affecting depth perception, such as amblyopia (lazy eye), anisometropia(different refractive errors in each eye), and strabismus (squint). (Self- report is accepted.),\n* Academic performance score between 2.00 and 4.00.,\n\nExclusion Criteria:\n\n* Having received training in holistic care skills in addition to their undergraduate nursing degree,\n* Having experience with virtual simulation exercises focused on holistic care skills,\n* Holding a high school, foundation year or undergraduate degree in a health-related field,\n* Having difficulty understanding and speaking Turkish,\n\nCriteria for Exclusion from the Study:\n\n* The participant has not completed or has incompletely completed the required forms and scales,\n* The participant in the experimental group had not taken part in or completed the AI-supported virtual reality simulation,\n* Students in the control group did not take part in the educational case study,\n* Students in the experimental and control groups did not take part in the assessment case study,\n* The participant wishes to withdraw from the study,",{"count":644,"type":22},[25],"This study aims to evaluate the effect of artificial intelligence (AI)-supported virtual reality (VR) simulation on nursing students' holistic care skills. The study is a randomised controlled trial involving fourth-year nursing students, divided into an experimental and a control group. Whilst the experimental group will receive AI-supported VR simulation training, the control group will receive traditional case-based training. Outcomes to be assessed include decision-making, symptom identification, nursing diagnosis, simulation design and satisfaction with the training methods.",[551,671,672],"Decision-Making","Diagnostic Reasoning",[674,675,676,677,678,679,680],"Artificial Intelligence","Simulation Training","Immersive Virtual Reality","Nursing Education","Holistic Care","Nursing Diagnoses","Educational Technology","2026-04-04",{"date":683,"type":43},"2026-04-08",{"date":685,"type":22},"2026-04",{"date":687,"type":22},"2026-05",{"name":49,"class":50},{"id":690,"slug":691,"hasResults":12,"nctId":692,"briefTitle":693,"officialTitle":694,"acronym":695,"eligibilityCriteria":696,"healthyVolunteers":12,"sex":59,"minAge":697,"maxAge":4,"enrollmentInfo":698,"targetDuration":4,"studyType":23,"phases":700,"briefSummary":701,"conditions":702,"keywords":706,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":710,"lastUpdatePostDateStruct":711,"startDateStruct":713,"completionDateStruct":715,"leadSponsor":717,"locationsCount":4},"100631452","gamification-in-stoma-care-education-for-nursing-students-100631452","NCT07500857","Gamification in Stoma Care Education for Nursing Students","The Effect of the Gamification Method on Nursing Students' Learning of Stoma Care","GAME-STOMA","Inclusion Criteria:\n\n* Nursing students who voluntarily agree to participate in the study\n* Students who are enrolled in the \"Nursing Professional Practice\" course for the first time\n* Students who have access to a mobile device (e.g., smartphone or tablet) and internet connection\n\nExclusion Criteria:\n\n* Students who have previously participated in or used any game related to stoma care\n* Students who do not attend the theoretical course\n* Students who do not participate in demonstrations or group activities\n* Students who do not complete any stage of the knowledge assessment\n* Students who do not complete any stage of the skill assessment\n* Students who provide incomplete or careless responses to data collection forms\n* Students who do not use or complete the game-based intervention","17 Years",{"count":699,"type":22},72,[25],"his study aims to determine the effect of a gamification-based educational method on nursing students' learning of stoma care. The research will be conducted as a pretest-posttest, parallel-group randomized controlled experimental study. This research will be prepared under the guidance of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) protocol, and the reporting of the randomized controlled study will be carried out under the Consolidated Standards of Reporting Trials (CONSORT).\n\nParticipants will consist of fourth-year nursing students who voluntarily agree to participate in the study. After obtaining informed consent, participants will complete a descriptive characteristics form and the Stoma Care Knowledge Test. Randomization will be performed based on baseline knowledge levels, and participants will be assigned to experimental and control groups.\n\nStudents' knowledge levels will be assessed using the \"Stoma Care Knowledge Test,\" and their skills will be evaluated using a \"Skills Checklist.\" Following baseline knowledge and skill assessment, the experimental group will receive gamified stoma care education, while the control group will receive standard education. The gamification intervention is designed based on the Werbach D6 Model and aims to enhance students' knowledge and skills in stoma care.\n\nPost-intervention knowledge and skill assessments will be conducted one week after the training. In addition, follow-up measurements will be performed four weeks later to evaluate the retention of knowledge and skills.",[703,704,677,705],"Stoma Care Education in Nursing Students","Gamification","Ostomy - Ileostomy or Colostomy",[707,708,709],"gamification","nursing education","stoma care","2026-03-24",{"date":712,"type":43},"2026-03-30",{"date":714,"type":22},"2026-03-27",{"date":716,"type":22},"2026-04-24",{"name":49,"class":50},""]